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FEPD - Ferric enterobactin transport system permease protein FepD
UniProt: P23876 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10296
Length: 334 (316)
Sequences: 6307
Seq/Len: 19.96
FEPD
Paralog alert: 0.86 [within 20: 0.62] - ratio of genomes with paralogs
Cluster includes: BTUC FECC FECD FEPD FEPG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
218_N 277_D 5.257 1.00
72_G 286_L 4.231 1.00
80_L 241_G 3.332 1.00
68_L 290_P 3.197 1.00
233_R 236_R 3.07 1.00
80_L 210_A 3.055 1.00
73_A 248_L 2.997 1.00
67_G 188_L 2.995 1.00
108_G 123_M 2.968 1.00
270_A 288_A 2.936 1.00
73_A 203_V 2.796 1.00
66_A 191_R 2.639 1.00
224_S 238_Q 2.616 1.00
73_A 252_A 2.495 1.00
76_L 286_L 2.473 1.00
29_L 37_A 2.468 1.00
103_F 162_L 2.417 1.00
70_A 256_V 2.397 1.00
39_V 42_E 2.385 1.00
79_A 285_T 2.362 1.00
24_T 64_T 2.272 1.00
68_L 294_L 2.259 1.00
274_V 284_V 2.238 1.00
218_N 278_H 2.179 1.00
70_A 252_A 2.168 1.00
23_A 295_F 2.166 1.00
27_S 64_T 2.093 1.00
103_F 165_L 2.081 1.00
63_R 297_D 2.074 1.00
24_T 68_L 2.005 1.00
83_T 278_H 1.998 1.00
36_P 39_V 1.918 1.00
81_M 245_I 1.916 1.00
76_L 207_G 1.916 1.00
128_A 250_G 1.832 1.00
262_I 293_L 1.816 1.00
65_L 196_L 1.795 1.00
236_R 240_I 1.737 1.00
191_R 195_T 1.731 1.00
299_I 303_I 1.723 1.00
197_K 201_I 1.72 1.00
219_S 232_S 1.706 1.00
216_A 237_T 1.701 1.00
188_L 293_L 1.654 1.00
106_V 166_T 1.654 1.00
270_A 284_V 1.651 1.00
19_L 291_A 1.645 1.00
66_A 255_I 1.622 1.00
266_M 292_L 1.611 1.00
202_P 251_S 1.601 1.00
300_G 310_V 1.599 1.00
278_H 281_S 1.565 1.00
301_R 307_E 1.546 1.00
38_S 42_E 1.523 1.00
270_A 281_S 1.519 1.00
102_S 166_T 1.509 1.00
84_L 241_G 1.509 1.00
192_N 195_T 1.47 1.00
299_I 313_V 1.445 1.00
77_A 248_L 1.434 1.00
75_G 266_M 1.434 1.00
79_A 281_S 1.424 1.00
28_L 64_T 1.386 0.99
209_T 244_A 1.386 0.99
69_L 200_L 1.375 0.99
197_K 200_L 1.369 0.99
67_G 293_L 1.366 0.99
201_I 205_I 1.357 0.99
26_L 29_L 1.352 0.99
235_A 238_Q 1.352 0.99
132_S 246_T 1.338 0.99
297_D 301_R 1.338 0.99
105_I 124_A 1.322 0.99
278_H 283_P 1.293 0.99
79_A 278_H 1.287 0.99
128_A 246_T 1.28 0.99
280_W 283_P 1.271 0.99
131_A 162_L 1.27 0.99
20_L 291_A 1.267 0.99
130_V 134_I 1.259 0.99
72_G 290_P 1.247 0.99
213_L 240_I 1.237 0.98
98_N 249_C 1.232 0.98
206_A 248_L 1.231 0.98
100_G 127_G 1.225 0.98
228_T 235_A 1.219 0.98
98_N 258_P 1.213 0.98
43_A 57_L 1.212 0.98
104_A 123_M 1.21 0.98
67_G 294_L 1.2 0.98
213_L 216_A 1.198 0.98
259_I 293_L 1.196 0.98
27_S 298_I 1.196 0.98
103_F 107_L 1.192 0.98
104_A 127_G 1.19 0.98
133_L 137_F 1.189 0.98
315_A 320_P 1.188 0.98
161_V 319_A 1.186 0.98
64_T 298_I 1.172 0.98
135_V 158_L 1.171 0.98
281_S 285_T 1.167 0.97
69_L 196_L 1.166 0.97
125_F 247_V 1.158 0.97
26_L 30_I 1.155 0.97
236_R 239_L 1.144 0.97
205_I 208_A 1.138 0.97
223_G 227_A 1.135 0.97
102_S 184_Q 1.13 0.97
206_A 247_V 1.122 0.97
40_V 56_V 1.105 0.96
210_A 244_A 1.104 0.96
280_W 284_V 1.103 0.96
226_T 229_A 1.101 0.96
54_T 57_L 1.097 0.96
100_G 131_A 1.095 0.96
270_A 273_L 1.088 0.96
69_L 199_V 1.087 0.96
57_L 61_L 1.086 0.96
63_R 301_R 1.086 0.96
291_A 295_F 1.083 0.96
193_L 196_L 1.082 0.96
299_I 302_V 1.081 0.95
266_M 270_A 1.081 0.95
256_V 259_I 1.076 0.95
79_A 282_L 1.074 0.95
237_T 240_I 1.073 0.95
199_V 203_V 1.072 0.95
300_G 309_R 1.072 0.95
209_T 213_L 1.065 0.95
41_L 45_S 1.06 0.95
213_L 237_T 1.059 0.95
107_L 111_L 1.059 0.95
20_L 287_L 1.051 0.94
283_P 286_L 1.051 0.94
200_L 204_L 1.042 0.94
122_A 126_A 1.037 0.94
321_V 324_F 1.032 0.94
218_N 283_P 1.031 0.94
34_S 37_A 1.026 0.94
110_A 169_I 1.026 0.94
23_A 294_L 1.025 0.93
23_A 291_A 1.023 0.93
199_V 255_I 1.023 0.93
164_G 315_A 1.023 0.93
293_L 314_S 1.016 0.93
107_L 169_I 1.011 0.93
53_C 57_L 1.01 0.93
123_M 127_G 1.007 0.93
219_S 230_L 1.003 0.93
252_A 256_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.9851000.193Contact Map0.81
2nq2A20.97011000.212Contact Map0.83
2qi9A20.95811000.224Contact Map0.819
2l9uA20.08984.10.975Contact Map0.286
4gxbB10.04492.20.978Contact Map
1fftB20.17661.40.98Contact Map0.245
2l2tA20.11081.20.981Contact Map0.137
2l6wA20.10181.20.981Contact Map0.126
2kluA10.12281.10.982Contact Map0.325
2x2vA130.203610.982Contact Map0.637
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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