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FEPG - Ferric enterobactin transport system permease protein FepG
UniProt: P23877 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10298
Length: 330 (309)
Sequences: 6210
Seq/Len: 20.10
FEPG
Paralog alert: 0.86 [within 20: 0.62] - ratio of genomes with paralogs
Cluster includes: BTUC FECC FECD FEPD FEPG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_A 282_A 4.285 1.00
79_I 238_M 3.354 1.00
67_L 286_A 3.255 1.00
230_S 233_R 3.133 1.00
215_R 274_A 3.071 1.00
107_A 121_S 3.043 1.00
66_A 185_L 3.004 1.00
72_A 245_L 2.983 1.00
267_A 284_C 2.957 1.00
79_I 207_A 2.865 1.00
65_M 188_L 2.747 1.00
72_A 200_I 2.704 1.00
221_D 235_R 2.57 1.00
75_V 282_A 2.548 1.00
72_A 249_A 2.509 1.00
28_R 36_T 2.506 1.00
38_Q 41_A 2.472 1.00
69_I 253_A 2.413 1.00
78_A 281_A 2.4 1.00
102_S 158_L 2.393 1.00
67_L 290_L 2.323 1.00
271_S 280_Q 2.241 1.00
69_I 249_A 2.165 1.00
102_S 161_F 2.123 1.00
26_G 63_V 2.098 1.00
62_R 293_D 2.09 1.00
126_G 247_A 1.961 1.00
80_F 242_A 1.948 1.00
75_V 204_L 1.882 1.00
35_E 38_Q 1.878 1.00
259_I 289_L 1.849 1.00
215_R 273_T 1.8 1.00
64_L 193_T 1.8 1.00
194_S 198_P 1.75 1.00
295_C 299_L 1.739 1.00
233_R 237_L 1.734 1.00
267_A 280_Q 1.729 1.00
216_L 229_V 1.692 1.00
213_R 234_S 1.685 1.00
188_L 192_K 1.677 1.00
263_A 288_L 1.668 1.00
297_Q 304_Q 1.666 1.00
105_L 162_N 1.663 1.00
185_L 289_L 1.661 1.00
22_A 291_A 1.658 1.00
296_A 307_V 1.613 1.00
37_S 41_A 1.611 1.00
199_I 248_A 1.584 1.00
65_M 252_L 1.579 1.00
83_L 238_M 1.555 1.00
101_W 162_N 1.514 1.00
189_T 192_K 1.504 1.00
194_S 197_A 1.496 1.00
74_G 263_A 1.485 1.00
78_A 277_G 1.468 1.00
267_A 277_G 1.463 1.00
295_C 310_V 1.46 1.00
210_L 213_R 1.446 1.00
202_L 205_I 1.43 1.00
42_A 56_T 1.415 1.00
210_L 237_L 1.405 0.99
23_G 63_V 1.4 0.99
198_P 202_L 1.399 0.99
48_P 51_M 1.381 0.99
25_W 28_R 1.38 0.99
232_E 235_R 1.366 0.99
130_S 243_V 1.365 0.99
104_V 122_A 1.35 0.99
76_S 245_L 1.35 0.99
276_W 279_T 1.343 0.99
66_A 289_L 1.339 0.99
68_L 197_A 1.335 0.99
293_D 297_Q 1.309 0.99
71_A 286_A 1.309 0.99
27_L 63_V 1.307 0.99
129_T 158_L 1.284 0.99
277_G 281_A 1.266 0.99
225_C 232_E 1.258 0.99
126_G 243_V 1.255 0.99
34_L 55_V 1.254 0.99
206_A 210_L 1.25 0.99
63_V 294_L 1.241 0.98
133_V 154_V 1.237 0.98
97_N 246_T 1.231 0.98
39_V 55_V 1.222 0.98
157_M 316_G 1.218 0.98
256_I 289_L 1.209 0.98
123_M 127_I 1.208 0.98
103_G 121_S 1.205 0.98
38_Q 51_M 1.201 0.98
312_V 317_I 1.187 0.98
190_W 193_T 1.187 0.98
233_R 236_L 1.185 0.98
97_N 255_P 1.184 0.98
206_A 241_V 1.182 0.98
128_V 132_L 1.181 0.98
25_W 29_S 1.181 0.98
123_M 244_V 1.178 0.98
103_G 125_G 1.175 0.98
26_G 294_L 1.172 0.98
203_M 245_L 1.163 0.97
279_T 282_A 1.161 0.97
101_W 181_N 1.156 0.97
68_L 196_S 1.152 0.97
196_S 200_I 1.149 0.97
66_A 290_L 1.146 0.97
102_S 106_V 1.144 0.97
23_G 67_L 1.141 0.97
220_G 224_A 1.14 0.97
78_A 278_L 1.14 0.97
253_A 256_I 1.14 0.97
215_R 279_T 1.138 0.97
296_A 306_P 1.137 0.97
32_V 54_V 1.126 0.97
68_L 193_T 1.123 0.97
106_V 165_L 1.12 0.96
223_T 226_A 1.119 0.96
203_M 244_V 1.113 0.96
40_F 44_M 1.113 0.96
276_W 280_Q 1.099 0.96
99_G 125_G 1.098 0.96
56_T 60_L 1.098 0.96
210_L 234_S 1.097 0.96
267_A 270_I 1.09 0.96
197_A 201_I 1.089 0.96
62_R 297_Q 1.089 0.96
215_R 275_R 1.089 0.96
263_A 267_A 1.086 0.96
287_L 291_A 1.079 0.95
131_L 135_L 1.073 0.95
121_S 125_G 1.067 0.95
210_L 238_M 1.064 0.95
234_S 237_L 1.064 0.95
203_M 241_V 1.056 0.95
289_L 311_T 1.052 0.95
295_C 298_Q 1.047 0.94
120_L 124_V 1.046 0.94
318_Y 321_V 1.04 0.94
74_G 78_A 1.025 0.93
249_A 253_A 1.023 0.93
73_L 259_I 1.023 0.93
313_S 317_I 1.018 0.93
46_D 52_T 1.016 0.93
232_E 236_L 1.015 0.93
98_T 158_L 1.004 0.93
216_L 227_L 1.003 0.93
42_A 52_T 1.002 0.92
164_W 168_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.98791000.157Contact Map0.795
2nq2A20.98791000.177Contact Map0.821
2qi9A20.96061000.187Contact Map0.812
2l9uA20.08795.10.973Contact Map0.542
4gxbB10.042430.976Contact Map
3dh4A40.64551.70.979Contact Map0.165
2kluA10.08481.70.979Contact Map0.001
2l2tA20.10911.70.979Contact Map0.153
2ks1B10.11821.50.979Contact Map0.131
1fftB20.17881.50.979Contact Map0.44
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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