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BTUC - Vitamin B12 import system permease protein BtuC
UniProt: P06609 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10127
Length: 326 (300)
Sequences: 6143
Seq/Len: 20.48
BTUC
Paralog alert: 0.86 [within 20: 0.62] - ratio of genomes with paralogs
Cluster includes: BTUC FECC FECD FEPD FEPG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
212_N 271_D 5.357 1.00
68_A 280_A 4.33 1.00
76_V 235_L 3.397 1.00
64_L 284_A 3.304 1.00
227_P 230_F 3.193 1.00
104_A 120_C 3.177 1.00
69_A 242_M 3.025 1.00
63_V 183_F 3.024 1.00
264_L 282_A 2.982 1.00
62_A 186_V 2.824 1.00
218_E 232_R 2.626 1.00
72_I 280_A 2.567 1.00
32_C 40_P 2.517 1.00
69_A 246_S 2.494 1.00
66_V 250_A 2.429 1.00
75_A 279_C 2.401 1.00
99_V 156_C 2.332 1.00
69_A 197_L 2.307 1.00
76_V 204_I 2.302 1.00
268_G 278_G 2.286 1.00
64_L 288_L 2.271 1.00
27_L 60_T 2.186 1.00
212_N 272_H 2.168 1.00
27_L 64_L 2.15 1.00
59_R 291_D 2.138 1.00
66_V 246_S 2.136 1.00
26_A 289_L 2.131 1.00
99_V 159_L 2.111 1.00
30_S 60_T 2.101 1.00
79_A 272_H 2.026 1.00
125_A 244_G 1.991 1.00
39_S 42_D 1.946 1.00
77_M 239_T 1.916 1.00
61_L 191_S 1.819 1.00
256_I 287_L 1.795 1.00
264_L 278_G 1.765 1.00
230_F 234_V 1.76 1.00
293_V 297_A 1.717 1.00
213_M 226_L 1.689 1.00
183_F 287_L 1.683 1.00
210_P 231_W 1.679 1.00
260_I 286_A 1.673 1.00
102_I 160_M 1.659 1.00
186_V 190_Q 1.654 1.00
192_W 196_A 1.648 1.00
294_A 305_I 1.618 1.00
62_A 249_L 1.58 1.00
199_P 202_L 1.566 1.00
187_D 190_Q 1.548 1.00
295_R 302_E 1.543 1.00
80_L 235_L 1.543 1.00
207_Q 210_P 1.533 1.00
264_L 275_L 1.531 1.00
98_G 160_M 1.515 1.00
272_H 275_L 1.51 1.00
29_L 32_C 1.472 1.00
71_A 260_I 1.459 1.00
65_L 195_L 1.45 1.00
75_A 275_L 1.447 1.00
72_I 201_L 1.445 1.00
293_V 308_V 1.443 1.00
207_Q 234_V 1.429 1.00
73_S 242_M 1.402 0.99
192_W 195_L 1.396 0.99
31_L 60_T 1.395 0.99
229_W 232_R 1.364 0.99
103_A 107_L 1.359 0.99
274_V 277_P 1.355 0.99
63_V 287_L 1.344 0.99
129_T 240_G 1.343 0.99
128_I 156_C 1.317 0.99
101_L 121_A 1.314 0.99
199_P 203_W 1.299 0.99
291_D 295_R 1.28 0.99
125_A 240_G 1.28 0.99
94_S 243_V 1.274 0.99
222_R 229_W 1.262 0.99
272_H 277_P 1.256 0.99
75_A 272_H 1.249 0.99
68_A 284_A 1.24 0.98
100_G 120_C 1.235 0.98
132_L 152_L 1.232 0.98
65_L 191_S 1.224 0.98
100_G 124_G 1.22 0.98
275_L 279_C 1.215 0.98
38_I 52_V 1.215 0.98
30_S 292_I 1.212 0.98
122_I 241_W 1.206 0.98
29_L 33_A 1.203 0.98
207_Q 235_L 1.202 0.98
155_I 314_A 1.202 0.98
230_F 233_N 1.196 0.98
53_W 57_L 1.187 0.98
94_S 252_A 1.182 0.98
274_V 278_G 1.181 0.98
253_I 287_L 1.17 0.97
60_T 292_I 1.17 0.97
196_A 199_P 1.162 0.97
220_S 223_Q 1.158 0.97
98_G 179_M 1.158 0.97
310_A 315_P 1.151 0.97
260_I 264_L 1.146 0.97
63_V 288_L 1.139 0.97
188_W 191_S 1.136 0.97
122_I 126_L 1.132 0.97
96_G 124_G 1.125 0.97
36_Q 51_F 1.123 0.97
103_A 163_A 1.12 0.96
130_L 134_R 1.119 0.96
207_Q 231_W 1.118 0.96
231_W 234_V 1.109 0.96
217_G 221_A 1.108 0.96
65_L 194_M 1.103 0.96
203_W 207_Q 1.102 0.96
293_V 296_L 1.099 0.96
127_I 131_I 1.095 0.96
294_A 304_P 1.088 0.96
264_L 267_C 1.085 0.96
59_R 295_R 1.084 0.96
200_V 238_A 1.084 0.96
246_S 250_A 1.083 0.96
119_L 123_A 1.082 0.96
229_W 233_N 1.07 0.95
268_G 274_V 1.069 0.95
316_V 319_W 1.065 0.95
250_A 253_I 1.065 0.95
96_G 128_I 1.064 0.95
99_V 103_A 1.061 0.95
37_W 40_P 1.056 0.95
95_N 156_C 1.054 0.95
285_S 289_L 1.052 0.95
213_M 224_L 1.039 0.94
212_N 277_P 1.038 0.94
194_M 249_L 1.036 0.94
287_L 309_T 1.032 0.94
162_W 166_F 1.027 0.94
61_L 188_W 1.024 0.93
75_A 276_L 1.021 0.93
277_P 280_A 1.014 0.93
68_A 71_A 1.012 0.93
256_I 309_T 1.011 0.93
120_C 124_G 1.009 0.93
59_R 302_E 1.006 0.93
311_T 315_P 1.004 0.93
99_V 163_A 1.002 0.92
26_A 285_S 1 0.92
32_C 37_W 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.99691000.152Contact Map0.793
2qi9A211000.162Contact Map0.806
2nq2A20.96931000.177Contact Map0.841
2l9uA20.082812.20.967Contact Map0.541
2m20A20.07362.10.977Contact Map0.572
4f35D40.63191.80.978Contact Map0.176
2l2tA20.10121.20.98Contact Map0.189
2l6wA20.09511.10.981Contact Map0.103
2x2vA130.20861.10.981Contact Map0.77
2m8rA10.113510.981Contact Map1
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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