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MURE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
UniProt: P22188 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10621
Length: 495 (489)
Sequences: 4253
Seq/Len: 8.70
MURE
Paralog alert: 0.63 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: MPL MURC MURD MURE MURF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
203_V 318_T 3.897 1.00
24_E 36_D 3.187 1.00
316_L 329_L 3.111 1.00
382_C 406_A 3.094 1.00
389_D 418_T 3.071 1.00
54_Q 58_Q 2.994 1.00
39_V 64_I 2.893 1.00
203_V 314_L 2.875 1.00
480_D 485_V 2.728 1.00
114_V 127_L 2.597 1.00
486_T 489_R 2.592 1.00
301_S 312_L 2.532 1.00
463_V 487_V 2.485 1.00
400_A 404_E 2.451 1.00
325_P 328_D 2.436 1.00
201_A 318_T 2.408 1.00
473_I 476_N 2.381 1.00
26_T 32_A 2.38 1.00
37_L 62_A 2.327 1.00
217_D 220_H 2.321 1.00
130_W 319_L 2.311 1.00
224_A 227_L 2.292 1.00
455_A 461_V 2.287 1.00
170_A 174_D 2.268 1.00
209_R 393_G 2.255 1.00
54_Q 57_A 2.252 1.00
111_L 197_L 2.211 1.00
56_I 82_V 2.19 1.00
136_E 178_T 2.093 1.00
276_A 313_L 2.086 1.00
184_V 194_V 2.068 1.00
390_R 415_N 2.062 1.00
29_S 32_A 2.03 1.00
53_P 57_A 2.022 1.00
126_L 303_L 2.002 1.00
344_E 484_R 1.997 1.00
108_N 173_V 1.996 1.00
139_A 172_L 1.982 1.00
366_E 370_Q 1.979 1.00
278_E 289_R 1.967 1.00
202_S 228_L 1.967 1.00
113_G 184_V 1.938 1.00
441_M 450_C 1.919 1.00
127_L 319_L 1.872 1.00
399_G 428_I 1.87 1.00
443_G 446_E 1.867 1.00
26_T 31_V 1.855 1.00
122_T 308_N 1.848 1.00
191_Q 214_Y 1.836 1.00
55_A 60_V 1.835 1.00
39_V 94_L 1.821 1.00
204_F 207_L 1.821 1.00
46_A 50_R 1.816 1.00
450_C 454_Q 1.813 1.00
292_S 295_G 1.794 1.00
23_R 35_G 1.776 1.00
110_R 200_A 1.773 1.00
114_V 124_T 1.772 1.00
354_V 487_V 1.771 1.00
112_V 322_L 1.756 1.00
169_L 180_C 1.717 1.00
368_A 462_L 1.709 1.00
379_K 459_D 1.693 1.00
32_A 60_V 1.688 1.00
474_V 479_L 1.674 1.00
127_L 203_V 1.666 1.00
52_I 63_I 1.665 1.00
418_T 476_N 1.659 1.00
66_E 90_L 1.649 1.00
33_A 36_D 1.629 1.00
288_I 309_V 1.628 1.00
37_L 64_I 1.614 1.00
127_L 315_A 1.612 1.00
190_V 214_Y 1.61 1.00
276_A 279_V 1.609 1.00
289_R 298_E 1.603 1.00
127_L 318_T 1.587 1.00
381_W 454_Q 1.574 1.00
129_Q 332_T 1.567 1.00
384_F 428_I 1.556 1.00
439_K 450_C 1.552 1.00
26_T 36_D 1.543 1.00
277_T 291_S 1.539 1.00
297_G 330_L 1.539 1.00
15_P 85_I 1.537 1.00
412_T 447_A 1.526 1.00
220_H 223_A 1.526 1.00
42_V 66_E 1.518 1.00
208_S 363_D 1.516 1.00
365_L 464_A 1.514 1.00
486_T 490_L 1.511 1.00
133_L 332_T 1.51 1.00
133_L 335_R 1.506 1.00
56_I 63_I 1.5 1.00
372_A 380_L 1.495 1.00
312_L 333_A 1.494 1.00
423_A 426_N 1.492 1.00
134_L 324_Y 1.488 1.00
126_L 312_L 1.478 1.00
92_E 96_A 1.475 1.00
473_I 478_R 1.474 1.00
441_M 446_E 1.473 1.00
445_A 486_T 1.472 1.00
118_N 361_T 1.472 1.00
381_W 408_V 1.471 1.00
379_K 408_V 1.444 0.99
130_W 315_A 1.437 0.99
184_V 199_F 1.434 0.99
370_Q 405_F 1.434 0.99
273_W 317_A 1.431 0.99
229_Y 237_A 1.43 0.99
115_T 225_K 1.424 0.99
222_E 245_V 1.42 0.99
111_L 180_C 1.413 0.99
319_L 324_Y 1.403 0.99
344_E 356_V 1.401 0.99
238_I 321_A 1.386 0.99
452_V 490_L 1.377 0.99
166_Q 197_L 1.377 0.99
118_N 363_D 1.374 0.99
161_S 164_D 1.37 0.99
201_A 322_L 1.369 0.99
471_Y 478_R 1.368 0.99
226_W 252_K 1.366 0.99
239_I 246_G 1.357 0.99
290_F 316_L 1.354 0.99
172_L 177_A 1.353 0.99
39_V 90_L 1.35 0.99
408_V 454_Q 1.349 0.99
216_G 220_H 1.341 0.99
113_G 199_F 1.341 0.99
200_A 235_G 1.337 0.99
276_A 309_V 1.337 0.99
411_V 428_I 1.336 0.99
450_C 453_M 1.324 0.99
360_H 365_L 1.319 0.99
130_W 329_L 1.318 0.99
222_E 248_R 1.318 0.99
366_E 404_E 1.311 0.99
306_A 370_Q 1.308 0.99
277_T 296_D 1.306 0.99
46_A 51_Y 1.303 0.99
207_L 222_E 1.301 0.99
65_A 84_V 1.298 0.99
401_I 405_F 1.289 0.98
190_V 224_A 1.283 0.98
300_E 334_A 1.282 0.98
201_A 238_I 1.276 0.98
165_V 197_L 1.274 0.98
410_V 447_A 1.269 0.98
55_A 59_G 1.267 0.98
422_R 426_N 1.264 0.98
186_S 215_H 1.261 0.98
123_T 205_T 1.261 0.98
324_Y 328_D 1.257 0.98
112_V 127_L 1.254 0.98
151_K 175_Q 1.25 0.98
288_I 312_L 1.246 0.98
463_V 483_D 1.243 0.98
129_Q 335_R 1.233 0.98
226_W 249_W 1.228 0.98
241_A 246_G 1.223 0.98
320_L 326_L 1.215 0.98
387_G 417_R 1.209 0.97
126_L 336_L 1.209 0.97
223_A 252_K 1.206 0.97
314_L 318_T 1.201 0.97
365_L 384_F 1.2 0.97
288_I 299_I 1.192 0.97
173_V 176_G 1.19 0.97
264_H 314_L 1.188 0.97
192_H 195_A 1.183 0.97
240_N 243_D 1.182 0.97
241_A 271_G 1.182 0.97
309_V 313_L 1.18 0.97
399_G 403_E 1.178 0.97
128_A 147_G 1.176 0.97
239_I 250_L 1.174 0.97
27_L 161_S 1.174 0.97
104_E 107_D 1.167 0.97
422_R 442_E 1.154 0.96
473_I 477_Q 1.149 0.96
392_K 427_D 1.147 0.96
418_T 475_G 1.142 0.96
306_A 374_L 1.142 0.96
108_N 170_A 1.137 0.96
32_A 36_D 1.134 0.96
476_N 479_L 1.128 0.96
128_A 132_Q 1.127 0.96
25_M 39_V 1.125 0.96
7_R 19_S 1.119 0.95
307_F 367_K 1.118 0.95
381_W 459_D 1.117 0.95
370_Q 400_A 1.116 0.95
411_V 425_I 1.114 0.95
133_L 331_K 1.11 0.95
141_M 172_L 1.11 0.95
236_Q 321_A 1.109 0.95
6_L 62_A 1.108 0.95
134_L 328_D 1.108 0.95
129_Q 336_L 1.108 0.95
66_E 89_Q 1.104 0.95
40_A 63_I 1.101 0.95
287_T 300_E 1.1 0.95
131_S 181_A 1.095 0.95
327_A 331_K 1.095 0.95
345_V 353_T 1.094 0.95
330_L 334_A 1.094 0.95
446_E 449_T 1.09 0.94
25_M 37_L 1.089 0.94
376_C 460_V 1.089 0.94
49_R 90_L 1.088 0.94
42_V 67_A 1.086 0.94
49_R 66_E 1.086 0.94
391_D 395_R 1.085 0.94
204_F 229_Y 1.083 0.94
99_G 104_E 1.082 0.94
485_V 489_R 1.074 0.94
379_K 407_D 1.074 0.94
474_V 478_R 1.071 0.94
52_I 56_I 1.07 0.94
201_A 321_A 1.065 0.94
408_V 439_K 1.064 0.93
363_D 367_K 1.063 0.93
124_T 140_V 1.062 0.93
240_N 310_S 1.061 0.93
470_D 480_D 1.061 0.93
445_A 489_R 1.059 0.93
352_P 458_N 1.058 0.93
386_C 415_N 1.052 0.93
208_S 218_M 1.043 0.93
248_R 251_A 1.043 0.93
219_E 223_A 1.042 0.93
110_R 179_F 1.038 0.92
122_T 126_L 1.037 0.92
413_D 421_P 1.032 0.92
227_L 230_S 1.028 0.92
187_H 214_Y 1.025 0.92
367_K 370_Q 1.025 0.92
63_I 82_V 1.022 0.92
134_L 332_T 1.016 0.91
343_M 368_A 1.015 0.91
425_I 440_V 1.014 0.91
286_A 309_V 1.014 0.91
141_M 160_G 1.011 0.91
446_E 450_C 1.011 0.91
372_A 462_L 1.009 0.91
219_E 248_R 1.009 0.91
22_L 37_L 1.009 0.91
383_V 463_V 1.008 0.91
318_T 322_L 1.005 0.91
413_D 425_I 1.004 0.91
47_D 67_A 1.003 0.91
402_A 409_A 1.003 0.91
40_A 52_I 1.002 0.91
365_L 401_I 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4c12A10.96361000.153Contact Map0.802
1e8cA20.99391000.159Contact Map0.807
4bubA20.95151000.172Contact Map0.785
2wtzA40.97781000.176Contact Map0.781
3zm6A10.87681000.311Contact Map0.744
1gg4A20.88481000.32Contact Map0.752
3zl8A10.84041000.331Contact Map0.695
1p3dA20.87881000.496Contact Map0.727
3hn7A10.91521000.499Contact Map0.746
4hv4A20.88281000.504Contact Map0.738
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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