| UniProt: | P17952 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10619 | ||
| Length: | 491 (452) | ||
| Sequences: | 4847 | ||
| Seq/Len: | 10.72 |
| MURC
Paralog alert: 0.93 [within 20: 0.42] - ratio of genomes with paralogs Cluster includes: MPL MURC MURD MURE MURF |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 97_A | 100_E | 3.595 | 1.00 | |
| 262_D | 273_T | 3.59 | 1.00 | |
| 40_A | 65_A | 3.59 | 1.00 | |
| 97_A | 101_A | 3.528 | 1.00 | |
| 124_I | 137_V | 3.209 | 1.00 | |
| 191_I | 303_V | 3.166 | 1.00 | |
| 140_I | 300_A | 3.108 | 1.00 | |
| 330_F | 347_M | 3.044 | 1.00 | |
| 189_V | 303_V | 2.962 | 1.00 | |
| 423_R | 427_R | 2.753 | 1.00 | |
| 141_Y | 172_I | 2.699 | 1.00 | |
| 442_D | 445_R | 2.681 | 1.00 | |
| 21_H | 45_Q | 2.666 | 1.00 | |
| 258_V | 302_A | 2.653 | 1.00 | |
| 137_V | 191_I | 2.538 | 1.00 | |
| 191_I | 299_A | 2.495 | 1.00 | |
| 122_I | 137_V | 2.489 | 1.00 | |
| 136_M | 288_A | 2.483 | 1.00 | |
| 285_T | 319_E | 2.482 | 1.00 | |
| 211_K | 238_E | 2.431 | 1.00 | |
| 374_N | 458_D | 2.43 | 1.00 | |
| 123_A | 187_P | 2.345 | 1.00 | |
| 260_V | 298_A | 2.334 | 1.00 | |
| 143_E | 317_A | 2.273 | 1.00 | |
| 204_Q | 209_N | 2.258 | 1.00 | |
| 301_V | 314_I | 2.257 | 1.00 | |
| 333_E | 347_M | 2.252 | 1.00 | |
| 377_M | 401_V | 2.245 | 1.00 | |
| 205_G | 208_E | 2.241 | 1.00 | |
| 449_M | 452_P | 2.21 | 1.00 | |
| 310_D | 313_A | 2.204 | 1.00 | |
| 137_V | 300_A | 2.202 | 1.00 | |
| 297_A | 318_L | 2.18 | 1.00 | |
| 438_I | 449_M | 2.161 | 1.00 | |
| 231_V | 256_A | 2.161 | 1.00 | |
| 272_F | 297_A | 2.144 | 1.00 | |
| 37_E | 63_L | 2.142 | 1.00 | |
| 454_L | 460_I | 2.122 | 1.00 | |
| 123_A | 175_A | 2.071 | 1.00 | |
| 333_E | 344_G | 2.053 | 1.00 | |
| 143_E | 316_R | 2.04 | 1.00 | |
| 250_Y | 299_A | 2.031 | 1.00 | |
| 143_E | 320_S | 2.012 | 1.00 | |
| 122_I | 307_E | 2.012 | 1.00 | |
| 205_G | 209_N | 1.987 | 1.00 | |
| 139_S | 320_S | 1.972 | 1.00 | |
| 131_T | 324_T | 1.959 | 1.00 | |
| 304_A | 314_I | 1.948 | 1.00 | |
| 137_V | 303_V | 1.923 | 1.00 | |
| 273_T | 283_R | 1.886 | 1.00 | |
| 53_P | 61_M | 1.87 | 1.00 | |
| 440_V | 449_M | 1.816 | 1.00 | |
| 95_I | 99_H | 1.805 | 1.00 | |
| 137_V | 304_A | 1.787 | 1.00 | |
| 406_M | 426_C | 1.787 | 1.00 | |
| 218_L | 227_A | 1.781 | 1.00 | |
| 140_I | 304_A | 1.765 | 1.00 | |
| 449_M | 453_V | 1.753 | 1.00 | |
| 313_A | 316_R | 1.728 | 1.00 | |
| 226_R | 306_E | 1.728 | 1.00 | |
| 305_T | 311_D | 1.718 | 1.00 | |
| 348_L | 451_A | 1.71 | 1.00 | |
| 261_E | 275_L | 1.69 | 1.00 | |
| 330_F | 349_V | 1.679 | 1.00 | |
| 127_T | 198_D | 1.676 | 1.00 | |
| 401_V | 404_L | 1.671 | 1.00 | |
| 230_C | 250_Y | 1.666 | 1.00 | |
| 190_A | 217_F | 1.641 | 1.00 | |
| 330_F | 333_E | 1.632 | 1.00 | |
| 141_Y | 307_E | 1.63 | 1.00 | |
| 58_Q | 61_M | 1.63 | 1.00 | |
| 346_A | 454_L | 1.621 | 1.00 | |
| 192_V | 218_L | 1.62 | 1.00 | |
| 58_Q | 62_N | 1.619 | 1.00 | |
| 403_T | 453_V | 1.618 | 1.00 | |
| 260_V | 294_A | 1.618 | 1.00 | |
| 293_N | 296_N | 1.614 | 1.00 | |
| 190_A | 221_L | 1.589 | 1.00 | |
| 120_H | 188_M | 1.562 | 1.00 | |
| 144_A | 309_I | 1.554 | 1.00 | |
| 189_V | 307_E | 1.548 | 1.00 | |
| 96_V | 99_H | 1.547 | 1.00 | |
| 252_F | 291_R | 1.543 | 1.00 | |
| 370_W | 459_L | 1.542 | 1.00 | |
| 260_V | 263_Y | 1.508 | 1.00 | |
| 272_F | 284_V | 1.507 | 1.00 | |
| 376_V | 453_V | 1.5 | 1.00 | |
| 274_L | 301_V | 1.484 | 1.00 | |
| 328_F | 366_A | 1.482 | 1.00 | |
| 77_R | 101_A | 1.476 | 1.00 | |
| 104_P | 114_E | 1.473 | 1.00 | |
| 170_Y | 307_E | 1.47 | 1.00 | |
| 188_M | 225_G | 1.467 | 1.00 | |
| 196_E | 357_T | 1.463 | 1.00 | |
| 23_H | 79_A | 1.445 | 1.00 | |
| 374_N | 403_T | 1.44 | 1.00 | |
| 139_S | 142_A | 1.431 | 1.00 | |
| 192_V | 195_I | 1.428 | 1.00 | |
| 403_T | 438_I | 1.422 | 1.00 | |
| 215_I | 242_R | 1.414 | 1.00 | |
| 216_N | 219_H | 1.413 | 1.00 | |
| 197_A | 200_M | 1.41 | 1.00 | |
| 207_F | 235_V | 1.409 | 1.00 | |
| 467_N | 470_K | 1.407 | 0.99 | |
| 258_V | 305_T | 1.405 | 0.99 | |
| 140_I | 314_I | 1.393 | 0.99 | |
| 276_R | 305_T | 1.383 | 0.99 | |
| 316_R | 320_S | 1.379 | 0.99 | |
| 404_L | 429_I | 1.375 | 0.99 | |
| 304_A | 309_I | 1.359 | 0.99 | |
| 124_I | 134_T | 1.356 | 0.99 | |
| 212_Q | 242_R | 1.356 | 0.99 | |
| 82_V | 98_A | 1.354 | 0.99 | |
| 423_R | 439_L | 1.353 | 0.99 | |
| 146_L | 169_R | 1.348 | 0.99 | |
| 271_H | 283_R | 1.346 | 0.99 | |
| 132_T | 293_N | 1.334 | 0.99 | |
| 421_D | 424_S | 1.327 | 0.99 | |
| 221_L | 225_G | 1.322 | 0.99 | |
| 144_A | 313_A | 1.321 | 0.99 | |
| 45_Q | 66_T | 1.316 | 0.99 | |
| 195_I | 211_K | 1.311 | 0.99 | |
| 136_M | 297_A | 1.3 | 0.99 | |
| 392_D | 428_T | 1.3 | 0.99 | |
| 96_V | 100_E | 1.295 | 0.99 | |
| 405_L | 453_V | 1.289 | 0.99 | |
| 377_M | 463_Q | 1.289 | 0.99 | |
| 211_K | 235_V | 1.284 | 0.99 | |
| 274_L | 298_A | 1.284 | 0.99 | |
| 226_R | 246_Q | 1.277 | 0.99 | |
| 360_D | 364_K | 1.275 | 0.99 | |
| 422_S | 439_L | 1.258 | 0.99 | |
| 448_E | 452_P | 1.242 | 0.98 | |
| 212_Q | 216_N | 1.235 | 0.98 | |
| 24_F | 39_L | 1.235 | 0.98 | |
| 208_E | 211_K | 1.23 | 0.98 | |
| 120_H | 169_R | 1.225 | 0.98 | |
| 208_E | 212_Q | 1.225 | 0.98 | |
| 25_V | 88_I | 1.223 | 0.98 | |
| 271_H | 285_T | 1.218 | 0.98 | |
| 189_V | 306_E | 1.214 | 0.98 | |
| 90_A | 99_H | 1.213 | 0.98 | |
| 57_T | 61_M | 1.21 | 0.98 | |
| 226_R | 248_T | 1.209 | 0.98 | |
| 231_V | 249_T | 1.209 | 0.98 | |
| 286_L | 297_A | 1.205 | 0.98 | |
| 426_C | 439_L | 1.205 | 0.98 | |
| 252_F | 263_Y | 1.202 | 0.98 | |
| 138_S | 152_N | 1.202 | 0.98 | |
| 139_S | 317_A | 1.201 | 0.98 | |
| 141_Y | 309_I | 1.198 | 0.98 | |
| 57_T | 69_F | 1.191 | 0.98 | |
| 209_N | 212_Q | 1.186 | 0.98 | |
| 128_H | 355_H | 1.185 | 0.98 | |
| 23_H | 47_S | 1.18 | 0.98 | |
| 282_M | 315_L | 1.179 | 0.98 | |
| 251_G | 295_L | 1.175 | 0.98 | |
| 21_H | 80_S | 1.172 | 0.98 | |
| 91_D | 96_V | 1.168 | 0.97 | |
| 355_H | 358_E | 1.167 | 0.97 | |
| 110_E | 184_H | 1.155 | 0.97 | |
| 123_A | 217_F | 1.155 | 0.97 | |
| 230_C | 295_L | 1.153 | 0.97 | |
| 140_I | 144_A | 1.15 | 0.97 | |
| 441_P | 445_R | 1.148 | 0.97 | |
| 450_L | 454_L | 1.145 | 0.97 | |
| 229_M | 240_L | 1.142 | 0.97 | |
| 229_M | 236_I | 1.142 | 0.97 | |
| 133_T | 193_T | 1.136 | 0.97 | |
| 39_L | 111_M | 1.135 | 0.97 | |
| 193_T | 250_Y | 1.133 | 0.97 | |
| 424_S | 427_R | 1.13 | 0.97 | |
| 191_I | 228_V | 1.129 | 0.97 | |
| 128_H | 358_E | 1.128 | 0.97 | |
| 249_T | 257_D | 1.125 | 0.97 | |
| 264_Q | 271_H | 1.117 | 0.96 | |
| 331_L | 473_R | 1.117 | 0.96 | |
| 229_M | 249_T | 1.116 | 0.96 | |
| 27_I | 48_G | 1.114 | 0.96 | |
| 215_I | 239_L | 1.114 | 0.96 | |
| 84_V | 105_V | 1.113 | 0.96 | |
| 203_Y | 213_T | 1.106 | 0.96 | |
| 462_V | 472_A | 1.106 | 0.96 | |
| 131_T | 154_G | 1.106 | 0.96 | |
| 344_G | 457_N | 1.102 | 0.96 | |
| 156_V | 159_A | 1.102 | 0.96 | |
| 334_F | 342_K | 1.101 | 0.96 | |
| 193_T | 299_A | 1.099 | 0.96 | |
| 232_D | 295_L | 1.098 | 0.96 | |
| 180_A | 202_T | 1.095 | 0.96 | |
| 374_N | 455_T | 1.095 | 0.96 | |
| 445_R | 448_E | 1.091 | 0.96 | |
| 22_I | 81_V | 1.09 | 0.96 | |
| 332_G | 476_A | 1.089 | 0.96 | |
| 229_M | 247_T | 1.084 | 0.96 | |
| 30_A | 33_G | 1.084 | 0.96 | |
| 312_E | 316_R | 1.082 | 0.96 | |
| 122_I | 303_V | 1.078 | 0.95 | |
| 37_E | 59_Q | 1.078 | 0.95 | |
| 124_I | 191_I | 1.077 | 0.95 | |
| 378_L | 418_P | 1.075 | 0.95 | |
| 396_N | 399_T | 1.07 | 0.95 | |
| 376_V | 405_L | 1.063 | 0.95 | |
| 328_F | 349_V | 1.062 | 0.95 | |
| 176_D | 179_D | 1.059 | 0.95 | |
| 472_A | 476_A | 1.058 | 0.95 | |
| 230_C | 233_D | 1.057 | 0.95 | |
| 272_F | 294_A | 1.054 | 0.95 | |
| 248_T | 302_A | 1.053 | 0.95 | |
| 38_V | 115_L | 1.053 | 0.95 | |
| 405_L | 446_V | 1.052 | 0.95 | |
| 383_R | 413_G | 1.05 | 0.94 | |
| 120_H | 170_Y | 1.049 | 0.94 | |
| 53_P | 69_F | 1.038 | 0.94 | |
| 140_I | 317_A | 1.03 | 0.94 | |
| 109_A | 175_A | 1.027 | 0.94 | |
| 269_Q | 285_T | 1.018 | 0.93 | |
| 110_E | 114_E | 1.017 | 0.93 | |
| 252_F | 295_L | 1.013 | 0.93 | |
| 128_H | 196_E | 1.012 | 0.93 | |
| 238_E | 241_P | 1.01 | 0.93 | |
| 141_Y | 170_Y | 1.01 | 0.93 | |
| 305_T | 314_I | 1.008 | 0.93 | |
| 207_F | 211_K | 1.005 | 0.93 | |
| 455_T | 458_D | 1.004 | 0.93 | |
| 309_I | 313_A | 1.002 | 0.92 | |
| 231_V | 237_R | 1.002 | 0.92 | |
| 346_A | 457_N | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4hv4A | 2 | 0.9878 | 100 | 0.192 | Contact Map | 0.806 |
| 1p3dA | 2 | 0.9613 | 100 | 0.22 | Contact Map | 0.831 |
| 1j6uA | 1 | 0.9369 | 100 | 0.264 | Contact Map | 0.814 |
| 3hn7A | 1 | 0.9532 | 100 | 0.295 | Contact Map | 0.81 |
| 3lk7A | 1 | 0.888 | 100 | 0.363 | Contact Map | 0.769 |
| 2x5oA | 1 | 0.8676 | 100 | 0.376 | Contact Map | 0.723 |
| 4bucA | 2 | 0.8697 | 100 | 0.388 | Contact Map | 0.679 |
| 4c12A | 1 | 0.8737 | 100 | 0.461 | Contact Map | 0.76 |
| 1gg4A | 2 | 0.8534 | 100 | 0.477 | Contact Map | 0.727 |
| 4bubA | 2 | 0.8615 | 100 | 0.485 | Contact Map | 0.766 |
Sequence Conservation (Image Generated using WebLogo v3)