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MURF - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
UniProt: P11880 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10622
Length: 452 (442)
Sequences: 6395
Seq/Len: 14.47
MURF
Paralog alert: 0.94 [within 20: 0.60] - ratio of genomes with paralogs
Cluster includes: MPL MURC MURD MURE MURF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
180_L 292_L 3.487 1.00
252_N 263_T 3.137 1.00
239_F 288_A 2.983 1.00
290_A 303_I 2.879 1.00
248_F 291_A 2.862 1.00
356_L 384_I 2.824 1.00
26_A 38_C 2.725 1.00
250_A 287_L 2.723 1.00
409_D 412_A 2.614 1.00
299_T 302_A 2.489 1.00
194_S 197_G 2.481 1.00
180_L 288_A 2.463 1.00
178_A 292_L 2.462 1.00
105_L 118_T 2.439 1.00
56_Q 60_G 2.435 1.00
41_V 66_L 2.405 1.00
219_A 246_S 2.353 1.00
275_L 286_A 2.291 1.00
121_I 293_S 2.168 1.00
435_R 440_E 2.116 1.00
122_L 156_V 2.1 1.00
362_A 436_S 2.08 1.00
124_Q 309_N 2.057 1.00
117_M 277_L 2.052 1.00
263_T 272_D 2.037 1.00
121_I 289_A 2.02 1.00
274_L 308_A 2.006 1.00
104_A 159_L 1.994 1.00
377_E 381_A 1.984 1.00
353_Y 427_I 1.967 1.00
262_F 286_A 1.966 1.00
118_T 289_A 1.955 1.00
118_T 180_L 1.953 1.00
251_T 265_Q 1.941 1.00
250_A 253_I 1.939 1.00
193_G 197_G 1.933 1.00
341_T 345_Q 1.912 1.00
113_S 282_N 1.898 1.00
56_Q 59_A 1.868 1.00
421_I 429_I 1.865 1.00
124_Q 306_G 1.842 1.00
101_R 177_E 1.841 1.00
55_D 59_A 1.84 1.00
124_Q 305_A 1.839 1.00
127_N 153_D 1.836 1.00
103_V 296_V 1.831 1.00
104_A 176_P 1.83 1.00
201_A 204_E 1.825 1.00
118_T 292_L 1.823 1.00
416_R 420_L 1.797 1.00
28_T 34_L 1.788 1.00
262_F 283_I 1.767 1.00
250_A 283_I 1.761 1.00
179_A 205_I 1.749 1.00
199_A 226_N 1.724 1.00
102_V 174_T 1.717 1.00
407_F 416_R 1.709 1.00
345_Q 382_A 1.689 1.00
353_Y 386_R 1.682 1.00
177_E 213_G 1.665 1.00
241_P 280_R 1.663 1.00
286_A 307_L 1.658 1.00
214_I 295_S 1.653 1.00
159_L 170_T 1.647 1.00
355_V 386_R 1.639 1.00
58_K 75_L 1.638 1.00
28_T 33_K 1.633 1.00
248_F 294_M 1.631 1.00
206_F 215_A 1.629 1.00
48_F 52_D 1.622 1.00
118_T 293_S 1.608 1.00
39_L 64_A 1.599 1.00
368_S 393_Q 1.598 1.00
125_C 298_A 1.584 1.00
185_A 338_G 1.584 1.00
389_S 398_S 1.581 1.00
395_H 399_T 1.559 1.00
167_I 191_G 1.555 1.00
57_A 62_A 1.538 1.00
178_A 296_V 1.537 1.00
264_L 290_A 1.535 1.00
109_S 336_N 1.532 1.00
209_L 213_G 1.522 1.00
31_T 34_L 1.513 1.00
410_K 441_E 1.507 1.00
35_T 38_C 1.495 1.00
280_R 349_E 1.491 1.00
271_V 304_K 1.487 1.00
293_S 303_I 1.485 1.00
181_V 184_L 1.47 1.00
120_A 309_N 1.466 1.00
319_P 327_L 1.462 1.00
216_I 295_S 1.462 1.00
238_R 247_D 1.461 1.00
197_G 200_K 1.458 1.00
416_R 419_L 1.456 1.00
54_A 65_L 1.446 1.00
294_M 300_L 1.439 1.00
266_T 269_G 1.437 1.00
119_A 131_T 1.432 1.00
353_Y 385_D 1.42 1.00
262_F 273_V 1.411 1.00
25_D 37_G 1.41 1.00
217_M 224_W 1.395 0.99
44_K 68_S 1.393 0.99
261_E 274_L 1.392 0.99
103_V 118_T 1.375 0.99
41_V 87_F 1.375 0.99
178_A 216_I 1.373 0.99
125_C 302_A 1.37 0.99
106_T 202_K 1.369 0.99
388_L 413_L 1.369 0.99
120_A 306_G 1.366 0.99
355_V 420_L 1.366 0.99
68_S 83_T 1.359 0.99
433_G 439_M 1.358 0.99
261_E 272_D 1.356 0.99
390_V 413_L 1.352 0.99
15_G 78_L 1.352 0.99
388_L 420_L 1.35 0.99
405_E 416_R 1.348 0.99
122_L 296_V 1.34 0.99
34_L 62_A 1.338 0.99
199_A 223_D 1.337 0.99
218_N 221_N 1.337 0.99
357_V 390_V 1.335 0.99
161_A 192_F 1.334 0.99
384_I 387_V 1.334 0.99
293_S 298_A 1.317 0.99
386_R 420_L 1.315 0.99
304_K 308_A 1.308 0.99
28_T 38_C 1.306 0.99
219_A 238_R 1.302 0.99
249_T 265_Q 1.297 0.99
166_E 191_G 1.297 0.99
280_R 345_Q 1.288 0.99
184_L 199_A 1.288 0.99
408_A 412_A 1.287 0.99
254_H 261_E 1.286 0.99
181_V 206_F 1.28 0.99
301_D 305_A 1.278 0.99
305_A 309_N 1.278 0.99
266_T 294_M 1.277 0.99
48_F 53_F 1.277 0.99
317_L 347_L 1.268 0.99
121_I 303_I 1.267 0.99
240_S 284_A 1.264 0.99
117_M 286_A 1.258 0.99
105_L 115_K 1.257 0.99
57_A 61_G 1.255 0.99
341_T 378_A 1.248 0.99
39_L 66_L 1.242 0.98
203_G 230_V 1.237 0.98
388_L 416_R 1.218 0.98
345_Q 378_A 1.203 0.98
217_M 238_R 1.201 0.98
298_A 302_A 1.199 0.98
209_L 215_A 1.188 0.98
271_V 300_L 1.187 0.98
196_A 200_K 1.18 0.98
355_V 388_L 1.172 0.98
415_T 419_L 1.166 0.97
438_A 441_E 1.166 0.97
218_N 284_A 1.166 0.97
58_K 65_L 1.165 0.97
214_I 237_W 1.164 0.97
264_L 287_L 1.161 0.97
340_M 358_V 1.155 0.97
347_L 354_R 1.149 0.97
119_A 123_S 1.141 0.97
161_A 167_I 1.14 0.97
122_L 298_A 1.13 0.97
182_N 239_F 1.116 0.96
166_E 201_A 1.114 0.96
85_L 89_E 1.114 0.96
88_G 169_W 1.109 0.96
122_L 154_Y 1.108 0.96
117_M 310_L 1.105 0.96
259_G 274_L 1.104 0.96
109_S 338_G 1.101 0.96
294_M 303_I 1.101 0.96
219_A 225_L 1.099 0.96
93_W 97_Q 1.098 0.96
423_E 426_V 1.098 0.96
203_G 227_W 1.096 0.96
386_R 405_E 1.096 0.96
265_Q 270_S 1.095 0.96
179_A 209_L 1.094 0.96
237_W 291_A 1.092 0.96
108_S 187_A 1.087 0.96
342_A 345_Q 1.085 0.96
128_T 153_D 1.082 0.96
251_T 270_S 1.08 0.95
154_Y 296_V 1.076 0.95
263_T 270_S 1.076 0.95
159_L 176_P 1.075 0.95
186_A 189_L 1.074 0.95
178_A 295_S 1.071 0.95
376_G 397_I 1.068 0.95
318_F 330_D 1.066 0.95
376_G 380_K 1.066 0.95
162_N 166_E 1.066 0.95
373_V 400_A 1.065 0.95
131_T 134_N 1.065 0.95
387_V 401_S 1.059 0.95
41_V 83_T 1.058 0.95
417_L 421_I 1.056 0.95
44_K 69_R 1.056 0.95
217_M 228_Q 1.055 0.95
125_C 306_G 1.051 0.94
283_I 287_L 1.05 0.94
101_R 153_D 1.05 0.94
241_P 250_A 1.042 0.94
114_V 182_N 1.041 0.94
214_I 235_K 1.037 0.94
196_A 223_D 1.034 0.94
168_A 207_S 1.033 0.94
220_D 284_A 1.032 0.94
281_H 342_A 1.031 0.94
231_I 234_R 1.031 0.94
395_H 406_H 1.03 0.94
253_I 283_I 1.028 0.94
282_N 285_N 1.027 0.94
335_A 340_M 1.024 0.93
344_V 382_A 1.022 0.93
302_A 305_A 1.021 0.93
344_V 356_L 1.021 0.93
407_F 413_L 1.017 0.93
200_K 230_V 1.017 0.93
276_P 311_K 1.016 0.93
185_A 195_L 1.01 0.93
251_T 263_T 1.01 0.93
226_N 229_S 1.009 0.93
112_T 313_V 1.006 0.93
414_I 445_A 1.003 0.93
113_S 117_M 1.003 0.93
103_V 292_L 1.003 0.93
220_D 240_S 1.002 0.92
371_C 374_Q 1.001 0.92
8_Q 97_Q 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gg4A20.99561000.128Contact Map0.781
3zm6A10.97121000.175Contact Map0.729
3zl8A10.92921000.186Contact Map0.68
4c12A10.96681000.225Contact Map0.784
2wtzA40.97351000.237Contact Map0.784
4bubA20.95581000.257Contact Map0.782
1e8cA20.97121000.283Contact Map0.747
2x5oA10.91371000.401Contact Map0.646
1p3dA20.93141000.415Contact Map0.802
4hv4A20.93811000.421Contact Map0.792
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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