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OPENSEQ.org
MURD - UDP-N-acetylmuramoylalanine--D-glutamate ligase
UniProt: P14900 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10620
Length: 438 (432)
Sequences: 4226
Seq/Len: 9.78
MURD
Paralog alert: 0.97 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: MPL MURC MURD MURE MURF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_L 51_V 3.942 1.00
84_A 87_D 3.847 1.00
84_A 88_A 3.48 1.00
108_V 123_V 3.114 1.00
126_M 276_A 3.091 1.00
176_T 279_L 3.052 1.00
127_A 156_V 3.009 1.00
110_I 123_V 2.915 1.00
306_V 314_R 2.878 1.00
123_V 176_T 2.835 1.00
124_G 136_V 2.695 1.00
8_N 31_T 2.695 1.00
174_A 279_L 2.629 1.00
375_A 379_A 2.599 1.00
425_Q 429_E 2.592 1.00
309_E 314_R 2.512 1.00
305_E 431_A 2.417 1.00
261_E 295_T 2.41 1.00
309_E 312_G 2.387 1.00
122_L 264_L 2.366 1.00
421_K 425_Q 2.364 1.00
277_L 290_S 2.321 1.00
402_V 408_V 2.3 1.00
343_L 370_F 2.259 1.00
125_E 296_T 2.255 1.00
420_F 429_E 2.249 1.00
117_S 300_L 2.249 1.00
196_R 220_P 2.192 1.00
109_A 172_A 2.183 1.00
390_T 393_Q 2.178 1.00
165_E 198_A 2.171 1.00
397_L 400_P 2.133 1.00
109_A 159_L 2.092 1.00
129_A 293_A 2.081 1.00
240_L 274_L 2.017 1.00
82_L 86_A 1.984 1.00
306_V 316_I 1.981 1.00
339_T 406_D 1.916 1.00
123_V 276_A 1.914 1.00
231_F 275_A 1.897 1.00
286_P 289_S 1.884 1.00
123_V 279_L 1.88 1.00
189_P 194_Q 1.878 1.00
306_V 309_E 1.877 1.00
129_A 296_T 1.877 1.00
126_M 280_A 1.866 1.00
165_E 187_R 1.855 1.00
129_A 292_K 1.842 1.00
280_A 290_S 1.842 1.00
110_I 120_T 1.837 1.00
315_W 399_A 1.815 1.00
273_A 294_L 1.8 1.00
386_E 397_L 1.794 1.00
176_T 275_A 1.773 1.00
281_D 287_R 1.768 1.00
191_G 194_Q 1.759 1.00
177_I 203_Y 1.736 1.00
347_D 372_R 1.712 1.00
269_N 272_N 1.71 1.00
388_T 397_L 1.708 1.00
313_V 402_V 1.703 1.00
238_Y 278_A 1.703 1.00
123_V 280_A 1.702 1.00
108_V 283_A 1.692 1.00
45_D 48_P 1.677 1.00
212_N 231_F 1.672 1.00
113_S 183_D 1.66 1.00
175_A 202_I 1.651 1.00
91_E 101_R 1.648 1.00
83_S 86_A 1.647 1.00
432_R 436_E 1.634 1.00
341_H 368_Y 1.633 1.00
182_E 185_M 1.626 1.00
366_R 401_R 1.611 1.00
181_T 322_T 1.611 1.00
10_V 66_A 1.608 1.00
45_D 49_E 1.591 1.00
301_P 428_N 1.573 1.00
374_G 387_Q 1.514 1.00
213_A 236_G 1.496 1.00
203_Y 209_C 1.485 1.00
397_L 401_R 1.484 1.00
289_S 292_K 1.455 1.00
114_N 323_N 1.45 1.00
197_A 201_R 1.448 1.00
106_P 173_V 1.448 1.00
127_A 283_A 1.447 1.00
125_E 128_K 1.443 1.00
396_R 400_P 1.434 1.00
124_G 134_V 1.426 1.00
201_R 204_E 1.425 1.00
133_N 153_E 1.421 1.00
69_I 85_A 1.398 0.99
416_S 419_Q 1.394 0.99
292_K 296_T 1.381 0.99
362_G 365_V 1.372 0.99
8_N 67_D 1.37 0.99
96_I 159_L 1.36 0.99
174_A 282_A 1.358 0.99
429_E 432_R 1.355 0.99
97_E 169_S 1.353 0.99
180_V 196_R 1.353 0.99
175_A 206_A 1.353 0.99
130_A 289_S 1.338 0.99
127_A 285_L 1.336 0.99
341_H 401_R 1.333 0.99
320_K 323_N 1.324 0.99
25_F 98_L 1.322 0.99
20_S 143_P 1.321 0.99
126_M 130_A 1.319 0.99
428_N 432_R 1.313 0.99
83_S 87_D 1.31 0.99
208_V 227_R 1.305 0.99
240_L 270_Y 1.303 0.99
114_N 320_K 1.302 0.99
354_S 380_L 1.295 0.99
78_A 83_S 1.288 0.99
192_L 217_L 1.283 0.99
193_Q 196_R 1.279 0.99
193_Q 197_A 1.267 0.99
373_D 376_Q 1.266 0.99
109_A 202_I 1.266 0.99
188_Y 198_A 1.266 0.99
14_L 34_V 1.265 0.99
11_I 25_F 1.264 0.99
192_L 196_R 1.262 0.99
12_I 75_I 1.256 0.99
77_L 86_A 1.254 0.99
312_G 405_G 1.254 0.99
177_I 180_V 1.248 0.98
208_V 229_V 1.245 0.98
233_V 267_Q 1.24 0.98
154_L 283_A 1.239 0.98
429_E 433_L 1.239 0.98
44_L 48_P 1.237 0.98
17_T 20_S 1.234 0.98
347_D 417_L 1.23 0.98
130_A 285_L 1.228 0.98
342_L 411_S 1.222 0.98
117_S 138_G 1.218 0.98
20_S 146_M 1.217 0.98
268_H 272_N 1.212 0.98
212_N 271_T 1.208 0.98
211_V 230_S 1.208 0.98
31_T 52_E 1.205 0.98
160_S 163_Q 1.203 0.98
376_Q 379_A 1.183 0.98
164_L 202_I 1.182 0.98
308_L 434_A 1.18 0.98
178_L 275_A 1.173 0.97
9_V 68_L 1.173 0.97
422_N 425_Q 1.173 0.97
24_F 102_E 1.172 0.97
341_H 402_V 1.169 0.97
10_V 33_R 1.166 0.97
375_A 387_Q 1.165 0.97
44_L 55_T 1.163 0.97
252_K 281_D 1.16 0.97
217_L 220_P 1.158 0.97
126_M 290_S 1.156 0.97
106_P 153_E 1.151 0.97
213_A 230_S 1.149 0.97
64_M 88_A 1.143 0.97
39_M 48_P 1.143 0.97
196_R 217_L 1.14 0.97
214_D 271_T 1.14 0.97
304_F 331_L 1.139 0.97
120_T 136_V 1.137 0.97
24_F 145_L 1.137 0.97
126_M 293_A 1.134 0.97
174_A 283_A 1.13 0.97
301_P 431_A 1.123 0.96
325_G 329_A 1.123 0.96
17_T 21_C 1.121 0.96
97_E 101_R 1.119 0.96
389_E 393_Q 1.11 0.96
110_I 176_T 1.103 0.96
249_L 259_V 1.102 0.96
280_A 285_L 1.093 0.96
171_Q 205_N 1.09 0.96
368_Y 388_T 1.089 0.96
393_Q 396_R 1.087 0.95
232_G 271_T 1.085 0.95
208_V 282_A 1.084 0.95
229_V 278_A 1.08 0.95
177_I 221_I 1.079 0.95
118_T 269_N 1.078 0.95
348_G 353_F 1.076 0.95
398_L 402_V 1.071 0.95
197_A 224_A 1.071 0.95
60_D 84_A 1.07 0.95
391_M 420_F 1.067 0.95
338_G 407_M 1.065 0.95
301_P 305_E 1.064 0.95
11_I 32_P 1.062 0.95
348_G 376_Q 1.053 0.94
279_L 283_A 1.05 0.94
313_V 408_V 1.05 0.94
368_Y 398_L 1.046 0.94
250_R 277_L 1.046 0.94
366_R 386_E 1.045 0.94
106_P 154_L 1.044 0.94
122_L 273_A 1.041 0.94
370_F 419_Q 1.041 0.94
162_F 423_F 1.041 0.94
353_F 414_C 1.038 0.94
233_V 271_T 1.036 0.94
121_T 125_E 1.035 0.94
339_T 403_Q 1.033 0.94
108_V 174_A 1.033 0.94
23_D 46_K 1.03 0.93
194_Q 197_A 1.027 0.93
68_L 93_V 1.021 0.93
248_W 273_A 1.021 0.93
125_E 129_A 1.02 0.93
174_A 210_V 1.016 0.93
108_V 279_L 1.015 0.93
71_A 82_L 1.013 0.93
264_L 273_A 1.012 0.93
334_L 407_M 1.007 0.92
321_A 327_T 1.007 0.92
394_A 398_L 1.005 0.92
368_Y 401_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x5oA10.99771000.174Contact Map0.7
3lk7A10.98861000.205Contact Map0.753
4bucA20.95661000.249Contact Map0.672
3hn7A10.97951000.318Contact Map0.77
1p3dA20.96121000.335Contact Map0.788
4hv4A20.96581000.335Contact Map0.762
1j6uA10.9681000.345Contact Map0.775
3eagA20.67351000.483Contact Map0.799
3zm6A10.89731000.493Contact Map0.63
1gg4A20.93381000.495Contact Map0.626
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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