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OPENSEQ.org
SYD - Aspartate--tRNA ligase
UniProt: P21889 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10097
Length: 590 (582)
Sequences: 1660
Seq/Len: 2.85
SYD
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: EPMA SYD SYK1 SYK2 SYN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
278_R 291_E 5.457 1.00
13_H 16_Q 5.249 1.00
151_F 250_A 4.47 1.00
148_V 232_I 3.893 1.00
11_L 91_E 3.891 1.00
47_V 96_A 3.878 1.00
324_P 387_Q 3.871 1.00
488_V 529_A 3.779 1.00
297_D 383_R 3.668 1.00
70_Q 100_T 3.486 1.00
72_T 98_S 3.434 1.00
286_L 426_A 3.286 1.00
106_D 522_K 3.286 1.00
146_S 150_R 3.214 1.00
17_Q 72_T 3.138 1.00
465_A 468_N 3.137 1.00
257_L 263_D 3.12 1.00
164_M 213_V 3.021 1.00
412_K 416_D 2.924 1.00
63_L 69_I 2.888 1.00
155_H 250_A 2.844 1.00
160_I 206_F 2.81 1.00
20_L 94_V 2.805 1.00
511_R 519_D 2.8 1.00
145_T 535_L 2.792 1.00
252_V 476_M 2.749 1.00
140_T 543_T 2.721 1.00
421_D 424_K 2.619 1.00
10_R 13_H 2.618 1.00
164_M 216_F 2.593 1.00
253_R 266_D 2.553 1.00
241_A 472_N 2.465 1.00
176_Y 560_A 2.384 1.00
279_Y 291_E 2.329 1.00
339_N 342_K 2.25 1.00
438_D 442_G 2.197 1.00
461_E 468_N 2.165 1.00
507_E 511_R 2.148 1.00
271_T 274_E 2.135 1.00
236_T 239_M 2.124 1.00
273_A 277_R 2.103 1.00
488_V 491_H 2.095 1.00
274_E 278_R 2.054 1.00
242_P 269_V 2.041 1.00
463_K 501_G 2.006 1.00
176_Y 182_V 1.991 1.00
268_P 426_A 1.979 1.00
444_L 467_E 1.945 0.99
17_Q 97_S 1.94 0.99
432_D 455_K 1.936 0.99
14_V 77_A 1.914 0.99
19_T 72_T 1.912 0.99
296_A 311_A 1.909 0.99
273_A 470_V 1.892 0.99
286_L 428_L 1.889 0.99
196_L 516_F 1.879 0.99
281_S 407_G 1.872 0.99
10_R 88_A 1.847 0.99
17_Q 74_T 1.844 0.99
275_A 281_S 1.83 0.99
147_L 258_E 1.828 0.99
74_T 97_S 1.821 0.99
234_V 531_L 1.814 0.99
573_P 577_A 1.797 0.99
483_V 538_L 1.795 0.99
497_Q 507_E 1.785 0.99
501_G 507_E 1.783 0.99
239_M 244_V 1.781 0.99
137_R 545_T 1.781 0.99
244_V 529_A 1.78 0.99
20_L 45_V 1.778 0.99
463_K 498_T 1.772 0.99
239_M 243_Q 1.766 0.99
159_D 210_Y 1.759 0.99
177_L 571_A 1.747 0.99
144_I 539_T 1.735 0.98
331_R 335_D 1.726 0.98
379_D 382_D 1.708 0.98
45_V 94_V 1.69 0.98
77_A 83_I 1.686 0.98
335_D 338_G 1.683 0.98
139_K 158_L 1.67 0.98
21_C 70_Q 1.664 0.98
83_I 91_E 1.662 0.98
9_L 13_H 1.66 0.98
153_D 210_Y 1.66 0.98
320_A 384_T 1.657 0.98
76_R 95_L 1.657 0.98
493_G 497_Q 1.655 0.98
5_Y 42_E 1.647 0.98
288_N 411_L 1.647 0.98
292_L 319_A 1.644 0.98
248_M 533_F 1.627 0.97
320_A 392_I 1.625 0.97
506_N 509_E 1.625 0.97
142_A 153_D 1.615 0.97
150_R 154_D 1.614 0.97
47_V 71_V 1.614 0.97
505_I 513_K 1.611 0.97
323_V 326_G 1.61 0.97
11_L 14_V 1.61 0.97
298_L 383_R 1.606 0.97
256_W 542_L 1.6 0.97
435_M 499_V 1.589 0.97
147_L 254_H 1.585 0.97
240_T 243_Q 1.552 0.96
373_N 376_I 1.531 0.96
242_P 246_E 1.518 0.96
186_K 570_F 1.516 0.96
245_R 269_V 1.516 0.96
169_T 516_F 1.512 0.95
267_F 428_L 1.506 0.95
356_E 388_D 1.506 0.95
270_M 428_L 1.505 0.95
129_L 204_S 1.498 0.95
9_L 18_V 1.494 0.95
232_I 535_L 1.489 0.95
378_E 382_D 1.48 0.95
146_S 153_D 1.463 0.94
374_A 378_E 1.459 0.94
545_T 550_D 1.448 0.94
353_K 365_N 1.446 0.94
341_V 405_A 1.445 0.94
32_S 51_P 1.442 0.94
303_E 308_A 1.428 0.93
270_M 430_V 1.422 0.93
27_R 64_R 1.412 0.93
139_K 143_K 1.41 0.93
5_Y 45_V 1.409 0.93
152_M 234_V 1.405 0.93
2_R 207_D 1.4 0.92
18_V 94_V 1.388 0.92
386_A 392_I 1.381 0.92
234_V 248_M 1.378 0.92
42_E 207_D 1.378 0.92
42_E 45_V 1.378 0.92
481_Y 547_N 1.377 0.92
54_A 58_K 1.371 0.91
166_T 197_F 1.37 0.91
148_V 535_L 1.366 0.91
462_L 469_A 1.364 0.91
11_L 77_A 1.363 0.91
456_D 472_N 1.36 0.91
295_V 380_I 1.356 0.91
75_V 94_V 1.356 0.91
354_V 392_I 1.347 0.90
239_M 488_V 1.34 0.90
201_L 553_A 1.339 0.90
458_T 470_V 1.338 0.90
9_L 92_I 1.331 0.90
58_K 61_S 1.323 0.89
437_E 447_M 1.321 0.89
341_V 409_L 1.319 0.89
299_L 318_V 1.316 0.89
427_P 478_I 1.315 0.89
143_K 146_S 1.309 0.89
138_L 206_F 1.306 0.88
268_P 286_L 1.302 0.88
399_K 403_A 1.3 0.88
493_G 522_K 1.292 0.88
542_L 547_N 1.291 0.88
151_F 155_H 1.29 0.88
59_L 99_L 1.287 0.87
271_T 432_D 1.28 0.87
145_T 232_I 1.278 0.87
168_A 571_A 1.277 0.87
75_V 92_I 1.277 0.87
154_D 254_H 1.273 0.87
562_C 565_T 1.271 0.87
166_T 564_M 1.27 0.87
492_N 495_M 1.262 0.86
150_R 153_D 1.256 0.86
24_V 69_I 1.255 0.86
196_L 565_T 1.249 0.85
133_E 545_T 1.249 0.85
478_I 483_V 1.241 0.85
381_L 386_A 1.241 0.85
20_L 38_M 1.238 0.85
476_M 533_F 1.236 0.84
350_A 394_F 1.234 0.84
15_G 74_T 1.232 0.84
184_K 580_S 1.23 0.84
147_L 255_L 1.229 0.84
149_R 159_D 1.227 0.84
459_A 495_M 1.221 0.83
49_F 99_L 1.22 0.83
9_L 91_E 1.208 0.83
277_R 294_D 1.204 0.82
9_L 45_V 1.203 0.82
260_K 542_L 1.203 0.82
498_T 501_G 1.199 0.82
13_H 89_T 1.19 0.81
103_N 525_T 1.187 0.81
129_L 206_F 1.186 0.81
241_A 245_R 1.184 0.81
182_V 560_A 1.183 0.81
441_E 445_T 1.17 0.80
38_M 69_I 1.162 0.79
323_V 417_L 1.159 0.79
5_Y 207_D 1.157 0.79
236_T 243_Q 1.15 0.78
56_A 99_L 1.149 0.78
6_C 207_D 1.144 0.78
574_T 577_A 1.143 0.78
270_M 275_A 1.139 0.77
278_R 289_P 1.139 0.77
135_A 139_K 1.134 0.77
58_K 62_E 1.129 0.76
150_R 258_E 1.129 0.76
254_H 258_E 1.125 0.76
295_V 299_L 1.125 0.76
45_V 75_V 1.125 0.76
505_I 510_Q 1.124 0.76
411_L 414_G 1.123 0.76
436_F 499_V 1.122 0.76
79_D 82_N 1.118 0.75
509_E 513_K 1.108 0.74
240_T 472_N 1.107 0.74
62_E 101_I 1.106 0.74
319_A 403_A 1.104 0.74
438_D 441_E 1.099 0.74
400_K 404_D 1.099 0.74
322_R 387_Q 1.093 0.73
36_I 49_F 1.093 0.73
301_S 308_A 1.093 0.73
120_A 123_K 1.093 0.73
274_E 279_Y 1.09 0.73
356_E 359_K 1.088 0.72
155_H 247_V 1.085 0.72
274_E 291_E 1.083 0.72
458_T 461_E 1.082 0.72
256_W 425_W 1.078 0.71
4_E 9_L 1.075 0.71
140_T 259_V 1.072 0.71
319_A 406_M 1.069 0.71
382_D 385_A 1.063 0.70
461_E 464_A 1.062 0.70
299_L 302_V 1.056 0.69
276_E 281_S 1.053 0.69
62_E 104_R 1.05 0.69
135_A 206_F 1.049 0.68
27_R 34_I 1.049 0.68
455_K 470_V 1.048 0.68
167_K 569_S 1.047 0.68
354_V 364_I 1.045 0.68
4_E 13_H 1.044 0.68
7_G 10_R 1.042 0.68
354_V 386_A 1.04 0.68
265_G 268_P 1.04 0.68
69_I 99_L 1.039 0.67
50_D 95_L 1.038 0.67
36_I 69_I 1.038 0.67
322_R 385_A 1.031 0.67
77_A 91_E 1.029 0.66
121_R 128_D 1.029 0.66
187_F 581_I 1.027 0.66
574_T 578_E 1.025 0.66
336_E 339_N 1.017 0.65
96_A 99_L 1.016 0.65
563_L 580_S 1.016 0.65
412_K 415_K 1.014 0.65
132_P 136_Q 1.014 0.65
340_F 344_Y 1.014 0.65
30_L 558_T 1.006 0.64
152_M 251_L 1.006 0.64
295_V 394_F 1.005 0.64
305_A 309_G 1.005 0.64
510_Q 517_L 1.003 0.63
71_V 96_A 1 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1c0aA10.99151000.199Contact Map0.69
4ah6A40.97631000.207Contact Map0.61
1l0wA20.96441000.213Contact Map0.748
4ex5A20.74071000.463Contact Map0.625
4j15A20.74071000.48Contact Map0.695
1eovA10.74581000.488Contact Map0.612
3i7fA20.7391000.489Contact Map0.672
1e1oA10.73391000.49Contact Map0.572
3a74A40.73051000.497Contact Map0.667
4h02A80.76781000.5Contact Map0.72
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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