| UniProt: | P0A8N5 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10553 | ||
| Length: | 505 (488) | ||
| Sequences: | 4629 | ||
| Seq/Len: | 9.49 |
| SYK2
Paralog alert: 0.90 [within 20: 0.02] - ratio of genomes with paralogs Cluster includes: EPMA SYD SYK1 SYK2 SYN |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 125_R | 142_E | 4.822 | 1.00 | |
| 201_R | 296_S | 4.807 | 1.00 | |
| 197_F | 296_S | 4.445 | 1.00 | |
| 97_L | 140_C | 3.945 | 1.00 | |
| 69_S | 125_R | 3.792 | 1.00 | |
| 67_E | 125_R | 3.703 | 1.00 | |
| 199_V | 256_F | 3.621 | 1.00 | |
| 196_Q | 200_A | 3.619 | 1.00 | |
| 123_G | 144_R | 3.353 | 1.00 | |
| 53_F | 66_I | 3.277 | 1.00 | |
| 192_A | 196_Q | 3.27 | 1.00 | |
| 244_L | 255_V | 2.857 | 1.00 | |
| 193_A | 300_T | 2.831 | 1.00 | |
| 193_A | 304_E | 2.742 | 1.00 | |
| 186_V | 487_T | 2.728 | 1.00 | |
| 192_A | 199_V | 2.721 | 1.00 | |
| 67_E | 141_T | 2.719 | 1.00 | |
| 194_I | 278_M | 2.706 | 1.00 | |
| 299_R | 322_K | 2.686 | 1.00 | |
| 210_M | 262_F | 2.673 | 1.00 | |
| 428_S | 473_A | 2.639 | 1.00 | |
| 285_A | 289_D | 2.498 | 1.00 | |
| 51_E | 135_E | 2.487 | 1.00 | |
| 210_M | 259_N | 2.422 | 1.00 | |
| 328_T | 392_E | 2.332 | 1.00 | |
| 97_L | 124_A | 2.313 | 1.00 | |
| 191_L | 479_I | 2.309 | 1.00 | |
| 248_V | 472_T | 2.276 | 1.00 | |
| 418_I | 423_I | 2.235 | 1.00 | |
| 328_T | 331_E | 2.232 | 1.00 | |
| 331_E | 335_K | 2.208 | 1.00 | |
| 46_S | 92_G | 2.195 | 1.00 | |
| 195_R | 205_E | 2.168 | 1.00 | |
| 295_E | 326_K | 2.16 | 1.00 | |
| 353_A | 356_E | 2.142 | 1.00 | |
| 68_V | 138_I | 2.097 | 1.00 | |
| 392_E | 404_N | 2.051 | 1.00 | |
| 197_F | 201_R | 2.047 | 1.00 | |
| 310_K | 317_V | 2.045 | 1.00 | |
| 190_I | 483_I | 2.031 | 1.00 | |
| 95_I | 138_I | 2.027 | 1.00 | |
| 196_Q | 199_V | 2.018 | 1.00 | |
| 327_L | 390_I | 2.002 | 1.00 | |
| 287_Y | 412_D | 1.992 | 1.00 | |
| 282_M | 285_A | 1.98 | 1.00 | |
| 71_A | 123_G | 1.974 | 1.00 | |
| 67_E | 127_T | 1.97 | 1.00 | |
| 290_L | 473_A | 1.963 | 1.00 | |
| 127_T | 141_T | 1.953 | 1.00 | |
| 116_W | 122_I | 1.947 | 1.00 | |
| 292_E | 296_S | 1.946 | 1.00 | |
| 197_F | 297_L | 1.932 | 1.00 | |
| 151_R | 466_E | 1.918 | 1.00 | |
| 188_S | 199_V | 1.912 | 1.00 | |
| 292_E | 326_K | 1.892 | 1.00 | |
| 224_I | 233_D | 1.881 | 1.00 | |
| 286_D | 289_D | 1.879 | 1.00 | |
| 193_A | 301_L | 1.873 | 1.00 | |
| 288_H | 292_E | 1.861 | 1.00 | |
| 442_E | 445_N | 1.854 | 1.00 | |
| 288_H | 326_K | 1.851 | 1.00 | |
| 27_A | 31_Q | 1.84 | 1.00 | |
| 335_K | 341_D | 1.831 | 1.00 | |
| 196_Q | 304_E | 1.827 | 1.00 | |
| 300_T | 304_E | 1.82 | 1.00 | |
| 197_F | 300_T | 1.796 | 1.00 | |
| 28_A | 31_Q | 1.794 | 1.00 | |
| 450_G | 453_E | 1.773 | 1.00 | |
| 298_F | 416_F | 1.766 | 1.00 | |
| 202_G | 254_R | 1.762 | 1.00 | |
| 183_T | 489_S | 1.75 | 1.00 | |
| 291_I | 326_K | 1.742 | 1.00 | |
| 280_L | 475_L | 1.736 | 1.00 | |
| 194_I | 297_L | 1.728 | 1.00 | |
| 70_V | 95_I | 1.722 | 1.00 | |
| 182_Q | 186_V | 1.721 | 1.00 | |
| 129_F | 139_H | 1.714 | 1.00 | |
| 437_A | 441_Q | 1.683 | 1.00 | |
| 185_V | 204_M | 1.67 | 1.00 | |
| 45_T | 48_Q | 1.668 | 1.00 | |
| 65_N | 127_T | 1.653 | 1.00 | |
| 455_M | 463_T | 1.64 | 1.00 | |
| 325_E | 386_Q | 1.639 | 1.00 | |
| 438_E | 442_E | 1.638 | 1.00 | |
| 355_A | 371_I | 1.634 | 1.00 | |
| 200_A | 300_T | 1.633 | 1.00 | |
| 310_K | 319_D | 1.629 | 1.00 | |
| 438_E | 441_Q | 1.625 | 1.00 | |
| 389_F | 416_F | 1.62 | 1.00 | |
| 433_A | 437_A | 1.61 | 1.00 | |
| 332_A | 390_I | 1.605 | 1.00 | |
| 330_R | 334_K | 1.599 | 1.00 | |
| 124_A | 140_C | 1.594 | 1.00 | |
| 50_H | 53_F | 1.589 | 1.00 | |
| 451_D | 454_A | 1.587 | 1.00 | |
| 331_E | 334_K | 1.582 | 1.00 | |
| 404_N | 412_D | 1.581 | 1.00 | |
| 325_E | 335_K | 1.575 | 1.00 | |
| 353_A | 357_S | 1.562 | 1.00 | |
| 189_K | 192_A | 1.559 | 1.00 | |
| 203_F | 282_M | 1.558 | 1.00 | |
| 302_A | 486_F | 1.557 | 1.00 | |
| 437_A | 459_E | 1.553 | 1.00 | |
| 40_F | 123_G | 1.547 | 1.00 | |
| 433_A | 466_E | 1.531 | 1.00 | |
| 89_Q | 94_R | 1.529 | 1.00 | |
| 373_T | 377_D | 1.515 | 1.00 | |
| 198_M | 278_M | 1.511 | 1.00 | |
| 74_M | 122_I | 1.499 | 1.00 | |
| 303_Q | 319_D | 1.484 | 1.00 | |
| 140_C | 143_L | 1.481 | 1.00 | |
| 327_L | 332_A | 1.476 | 1.00 | |
| 330_R | 410_I | 1.472 | 1.00 | |
| 45_T | 92_G | 1.46 | 1.00 | |
| 181_R | 185_V | 1.455 | 1.00 | |
| 285_A | 473_A | 1.452 | 1.00 | |
| 166_R | 173_D | 1.434 | 1.00 | |
| 336_Y | 383_H | 1.426 | 0.99 | |
| 184_F | 497_L | 1.42 | 0.99 | |
| 70_V | 88_L | 1.413 | 0.99 | |
| 194_I | 479_I | 1.407 | 0.99 | |
| 84_S | 109_Y | 1.405 | 0.99 | |
| 405_D | 412_D | 1.4 | 0.99 | |
| 178_D | 182_Q | 1.398 | 0.99 | |
| 69_S | 123_G | 1.398 | 0.99 | |
| 185_V | 189_K | 1.382 | 0.99 | |
| 463_T | 504_Q | 1.38 | 0.99 | |
| 205_E | 256_F | 1.374 | 0.99 | |
| 368_L | 372_V | 1.367 | 0.99 | |
| 428_S | 431_N | 1.364 | 0.99 | |
| 57_D | 60_E | 1.361 | 0.99 | |
| 88_L | 122_I | 1.359 | 0.99 | |
| 374_E | 378_E | 1.358 | 0.99 | |
| 47_D | 51_E | 1.351 | 0.99 | |
| 299_R | 321_G | 1.35 | 0.99 | |
| 206_V | 252_F | 1.349 | 0.99 | |
| 74_M | 86_V | 1.349 | 0.99 | |
| 261_N | 277_M | 1.346 | 0.99 | |
| 333_I | 372_V | 1.34 | 0.99 | |
| 437_A | 462_V | 1.338 | 0.99 | |
| 348_F | 352_K | 1.338 | 0.99 | |
| 87_T | 94_R | 1.326 | 0.99 | |
| 74_M | 116_W | 1.322 | 0.99 | |
| 416_F | 424_G | 1.321 | 0.99 | |
| 240_P | 261_N | 1.307 | 0.99 | |
| 432_D | 435_D | 1.303 | 0.99 | |
| 127_T | 139_H | 1.299 | 0.99 | |
| 206_V | 247_L | 1.299 | 0.99 | |
| 312_T | 315_E | 1.294 | 0.99 | |
| 395_A | 439_R | 1.294 | 0.99 | |
| 381_E | 384_L | 1.289 | 0.99 | |
| 295_E | 323_P | 1.287 | 0.99 | |
| 182_Q | 185_V | 1.282 | 0.99 | |
| 278_M | 479_I | 1.276 | 0.99 | |
| 435_D | 438_E | 1.276 | 0.99 | |
| 403_R | 435_D | 1.272 | 0.99 | |
| 403_R | 432_D | 1.269 | 0.99 | |
| 451_D | 455_M | 1.266 | 0.99 | |
| 324_F | 416_F | 1.264 | 0.99 | |
| 328_T | 391_T | 1.259 | 0.98 | |
| 128_L | 136_L | 1.258 | 0.98 | |
| 186_V | 305_V | 1.253 | 0.98 | |
| 303_Q | 307_G | 1.25 | 0.98 | |
| 254_R | 282_M | 1.248 | 0.98 | |
| 395_A | 403_R | 1.247 | 0.98 | |
| 190_I | 301_L | 1.245 | 0.98 | |
| 184_F | 252_F | 1.227 | 0.98 | |
| 211_M | 234_M | 1.227 | 0.98 | |
| 350_A | 353_A | 1.221 | 0.98 | |
| 349_D | 352_K | 1.221 | 0.98 | |
| 20_R | 24_E | 1.215 | 0.98 | |
| 189_K | 304_E | 1.206 | 0.98 | |
| 309_T | 321_G | 1.203 | 0.98 | |
| 64_L | 130_K | 1.202 | 0.98 | |
| 169_Q | 463_T | 1.202 | 0.98 | |
| 282_M | 293_L | 1.202 | 0.98 | |
| 198_M | 297_L | 1.2 | 0.98 | |
| 198_M | 280_L | 1.2 | 0.98 | |
| 338_P | 369_G | 1.183 | 0.97 | |
| 295_E | 324_F | 1.18 | 0.97 | |
| 347_N | 350_A | 1.174 | 0.97 | |
| 111_D | 114_K | 1.173 | 0.97 | |
| 232_L | 503_P | 1.168 | 0.97 | |
| 189_K | 199_V | 1.167 | 0.97 | |
| 92_G | 253_E | 1.166 | 0.97 | |
| 285_A | 290_L | 1.164 | 0.97 | |
| 193_A | 305_V | 1.162 | 0.97 | |
| 194_I | 301_L | 1.161 | 0.97 | |
| 242_L | 460_D | 1.157 | 0.97 | |
| 463_T | 466_E | 1.144 | 0.97 | |
| 174_L | 184_F | 1.136 | 0.97 | |
| 294_T | 477_I | 1.136 | 0.97 | |
| 128_L | 138_I | 1.134 | 0.96 | |
| 437_A | 466_E | 1.133 | 0.96 | |
| 179_K | 489_S | 1.133 | 0.96 | |
| 49_L | 53_F | 1.13 | 0.96 | |
| 193_A | 196_Q | 1.13 | 0.96 | |
| 441_Q | 451_D | 1.121 | 0.96 | |
| 190_I | 486_F | 1.12 | 0.96 | |
| 240_P | 277_M | 1.114 | 0.96 | |
| 315_E | 488_N | 1.111 | 0.96 | |
| 334_K | 338_P | 1.11 | 0.96 | |
| 296_S | 299_R | 1.109 | 0.96 | |
| 401_A | 427_F | 1.106 | 0.96 | |
| 226_H | 231_D | 1.103 | 0.96 | |
| 354_L | 358_I | 1.097 | 0.95 | |
| 226_H | 233_D | 1.095 | 0.95 | |
| 90_D | 93_G | 1.095 | 0.95 | |
| 99_V | 140_C | 1.091 | 0.95 | |
| 228_N | 231_D | 1.091 | 0.95 | |
| 70_V | 138_I | 1.089 | 0.95 | |
| 45_T | 253_E | 1.088 | 0.95 | |
| 44_H | 48_Q | 1.081 | 0.95 | |
| 86_V | 122_I | 1.066 | 0.95 | |
| 188_S | 192_A | 1.055 | 0.94 | |
| 186_V | 190_I | 1.053 | 0.94 | |
| 123_G | 146_L | 1.049 | 0.94 | |
| 181_R | 252_F | 1.045 | 0.94 | |
| 188_S | 256_F | 1.041 | 0.94 | |
| 24_E | 28_A | 1.036 | 0.93 | |
| 27_A | 30_R | 1.035 | 0.93 | |
| 190_I | 479_I | 1.034 | 0.93 | |
| 240_P | 243_Y | 1.029 | 0.93 | |
| 117_D | 120_D | 1.029 | 0.93 | |
| 224_I | 235_Y | 1.029 | 0.93 | |
| 207_E | 260_R | 1.028 | 0.93 | |
| 186_V | 189_K | 1.024 | 0.93 | |
| 83_A | 98_Y | 1.024 | 0.93 | |
| 423_I | 482_M | 1.024 | 0.93 | |
| 301_L | 305_V | 1.022 | 0.93 | |
| 106_E | 111_D | 1.015 | 0.92 | |
| 48_Q | 52_E | 1.014 | 0.92 | |
| 24_E | 27_A | 1.012 | 0.92 | |
| 19_L | 23_R | 1.009 | 0.92 | |
| 203_F | 254_R | 1.008 | 0.92 | |
| 402_R | 431_N | 1.008 | 0.92 | |
| 99_V | 143_L | 1.007 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4ex5A | 2 | 0.998 | 100 | 0.041 | Contact Map | 0.715 |
| 4h02A | 8 | 0.9723 | 100 | 0.087 | Contact Map | 0.813 |
| 1e1oA | 1 | 0.998 | 100 | 0.094 | Contact Map | 0.688 |
| 3bjuA | 4 | 0.9762 | 100 | 0.095 | Contact Map | 0.775 |
| 3a74A | 4 | 0.9743 | 100 | 0.109 | Contact Map | 0.808 |
| 1l0wA | 2 | 0.8574 | 100 | 0.222 | Contact Map | 0.792 |
| 4ah6A | 4 | 0.8653 | 100 | 0.225 | Contact Map | 0.685 |
| 1c0aA | 1 | 0.8574 | 100 | 0.232 | Contact Map | 0.719 |
| 4j15A | 2 | 0.9129 | 100 | 0.246 | Contact Map | 0.69 |
| 3i7fA | 2 | 0.9069 | 100 | 0.251 | Contact Map | 0.7 |
Sequence Conservation (Image Generated using WebLogo v3)