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OPENSEQ.org
CYSM - Cysteine synthase B
UniProt: P16703 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10193
Length: 303 (292)
Sequences: 10338
Seq/Len: 35.40
CYSM
Paralog alert: 0.92 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
80_A 87_M 4.645 1.00
125_L 128_E 3.667 1.00
26_E 274_V 3.527 1.00
15_K 26_E 3.14 1.00
243_E 247_R 3.034 1.00
194_T 228_E 3.013 1.00
236_D 265_R 3.005 1.00
158_I 276_V 2.949 1.00
86_R 109_E 2.888 1.00
51_E 55_R 2.8 1.00
97_Q 101_A 2.586 1.00
168_H 196_V 2.576 1.00
148_Y 152_T 2.523 1.00
53_E 85_Y 2.494 1.00
201_E 233_H 2.486 1.00
93_D 114_T 2.476 1.00
128_E 132_R 2.472 1.00
151_Y 188_E 2.349 1.00
88_K 109_E 2.347 1.00
10_N 160_Q 2.342 1.00
28_W 274_V 2.341 1.00
50_V 83_K 2.206 1.00
202_E 234_Q 2.204 1.00
259_A 277_A 2.204 1.00
13_L 276_V 2.18 1.00
63_V 88_K 2.15 1.00
183_S 225_L 2.119 1.00
233_H 236_D 2.117 1.00
90_L 129_M 2.068 1.00
127_L 131_N 2.036 1.00
198_L 262_G 1.975 1.00
156_P 185_F 1.948 1.00
88_K 111_I 1.935 1.00
173_M 197_G 1.921 1.00
169_F 186_M 1.906 1.00
169_F 182_V 1.88 1.00
142_N 219_G 1.871 1.00
10_N 161_Q 1.856 1.00
94_N 115_K 1.852 1.00
183_S 195_I 1.816 1.00
196_V 228_E 1.787 1.00
190_S 193_V 1.783 1.00
270_N 273_A 1.772 1.00
187_R 227_D 1.77 1.00
151_Y 184_R 1.762 1.00
68_T 73_G 1.714 1.00
53_E 83_K 1.696 1.00
155_G 185_F 1.689 1.00
228_E 269_A 1.689 1.00
167_T 273_A 1.683 1.00
15_K 28_W 1.681 1.00
37_A 78_M 1.678 1.00
240_T 261_A 1.673 1.00
139_D 142_N 1.661 1.00
46_L 50_V 1.657 1.00
24_G 271_P 1.649 1.00
244_L 252_C 1.604 1.00
114_T 117_Q 1.595 1.00
51_E 145_D 1.569 1.00
28_W 162_T 1.565 1.00
184_R 222_N 1.496 1.00
29_L 279_I 1.494 1.00
167_T 274_V 1.477 1.00
235_R 239_N 1.474 1.00
155_G 182_V 1.45 1.00
243_E 264_L 1.45 1.00
53_E 56_G 1.441 1.00
244_L 260_V 1.412 1.00
166_I 276_V 1.408 1.00
63_V 86_R 1.406 0.99
179_I 226_V 1.405 0.99
2_S 6_Q 1.403 0.99
155_G 186_M 1.4 0.99
201_E 231_D 1.381 0.99
101_A 104_R 1.38 0.99
129_M 133_G 1.378 0.99
236_D 261_A 1.376 0.99
15_K 20_G 1.367 0.99
104_R 109_E 1.36 0.99
168_H 194_T 1.358 0.99
3_T 6_Q 1.357 0.99
168_H 273_A 1.335 0.99
58_I 62_D 1.332 0.99
261_A 265_R 1.331 0.99
240_T 260_V 1.323 0.99
73_G 103_M 1.301 0.99
100_R 112_L 1.301 0.99
22_D 243_E 1.28 0.99
50_V 54_K 1.28 0.99
239_N 243_E 1.276 0.99
179_I 195_I 1.252 0.99
111_I 125_L 1.249 0.99
265_R 268_K 1.247 0.99
91_M 112_L 1.233 0.98
170_V 198_L 1.232 0.98
18_R 21_P 1.231 0.98
47_S 152_T 1.226 0.98
90_L 125_L 1.219 0.98
240_T 264_L 1.212 0.98
51_E 54_K 1.207 0.98
22_D 247_R 1.206 0.98
93_D 117_Q 1.199 0.98
64_L 80_A 1.192 0.98
170_V 266_V 1.191 0.98
252_C 279_I 1.191 0.98
14_V 31_L 1.188 0.98
18_R 248_E 1.182 0.98
100_R 110_L 1.179 0.98
186_M 193_V 1.169 0.97
162_T 276_V 1.167 0.97
232_I 261_A 1.164 0.97
168_H 275_V 1.157 0.97
130_A 137_L 1.156 0.97
103_M 108_A 1.151 0.97
168_H 270_N 1.146 0.97
230_L 262_G 1.14 0.97
230_L 265_R 1.134 0.97
185_F 189_Q 1.129 0.97
17_Q 21_P 1.116 0.96
27_V 263_A 1.111 0.96
182_V 278_I 1.11 0.96
2_S 15_K 1.109 0.96
180_T 220_I 1.108 0.96
196_V 230_L 1.105 0.96
16_L 29_L 1.103 0.96
97_Q 100_R 1.1 0.96
256_S 279_I 1.1 0.96
123_R 127_L 1.094 0.96
13_L 162_T 1.088 0.96
49_I 83_K 1.075 0.95
236_D 239_N 1.068 0.95
118_G 121_G 1.066 0.95
100_R 104_R 1.063 0.95
58_I 64_L 1.062 0.95
117_Q 121_G 1.062 0.95
125_L 129_M 1.06 0.95
18_R 247_R 1.058 0.95
266_V 269_A 1.05 0.94
212_W 258_G 1.043 0.94
78_M 106_Y 1.037 0.94
124_D 128_E 1.036 0.94
159_W 190_S 1.036 0.94
25_S 273_A 1.03 0.94
124_D 127_L 1.026 0.94
152_T 156_P 1.024 0.93
170_V 263_A 1.024 0.93
65_I 129_M 1.02 0.93
91_M 103_M 1.015 0.93
159_W 189_Q 1.014 0.93
162_T 166_I 1.013 0.93
59_K 62_D 1.011 0.93
121_G 124_D 1.005 0.93
119_M 122_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v03A10.99671000.103Contact Map0.793
1y7lA10.97361000.111Contact Map0.79
2pqmA20.99671000.117Contact Map0.837
1z7wA10.99671000.119Contact Map0.816
2eguA10.97691000.125Contact Map0.762
3dwgA20.99671000.125Contact Map0.755
3vc3A60.99671000.127Contact Map0.892
2q3bA10.98021000.127Contact Map0.792
3tbhA10.99671000.13Contact Map0.768
3pc3A10.99671000.13Contact Map0.807
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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