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OPENSEQ.org
CYSK - Cysteine synthase A
UniProt: P0ABK5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10192
Length: 323 (308)
Sequences: 10370
Seq/Len: 33.67
CYSK
Paralog alert: 0.92 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_A 88_L 4.868 1.00
126_K 129_E 3.568 1.00
261_R 265_E 3.207 1.00
254_E 283_K 3.177 1.00
199_I 246_K 3.09 1.00
161_I 296_V 3.046 1.00
87_K 110_N 2.99 1.00
52_D 56_R 2.814 1.00
98_I 102_K 2.777 1.00
129_E 133_S 2.697 1.00
54_E 86_Y 2.687 1.00
151_E 155_K 2.663 1.00
171_V 201_V 2.662 1.00
206_T 251_T 2.549 1.00
94_E 115_E 2.537 1.00
29_L 294_N 2.46 1.00
154_E 191_G 2.42 1.00
89_T 110_N 2.402 1.00
14_H 163_E 2.391 1.00
51_W 84_R 2.326 1.00
17_L 296_V 2.309 1.00
64_E 89_T 2.259 1.00
207_D 252_N 2.256 1.00
277_A 297_V 2.204 1.00
186_S 243_L 2.198 1.00
251_T 254_E 2.184 1.00
134_N 137_K 2.1 1.00
128_E 132_A 2.081 1.00
91_T 130_I 2.068 1.00
145_S 237_A 2.015 1.00
172_F 189_I 2.015 1.00
159_P 188_Y 2.005 1.00
19_R 29_L 1.981 1.00
203_V 280_A 1.953 1.00
89_T 112_V 1.949 1.00
176_V 202_A 1.93 1.00
172_F 185_V 1.928 1.00
14_H 164_D 1.912 1.00
201_V 246_K 1.878 1.00
186_S 200_S 1.858 1.00
193_K 198_L 1.855 1.00
190_K 245_D 1.805 1.00
290_F 293_K 1.796 1.00
154_E 187_R 1.774 1.00
158_G 188_Y 1.768 1.00
170_D 293_K 1.768 1.00
54_E 84_R 1.713 1.00
38_S 79_Y 1.712 1.00
138_Y 141_L 1.712 1.00
69_T 74_G 1.708 1.00
47_A 51_W 1.695 1.00
258_T 279_A 1.691 1.00
142_Q 145_S 1.688 1.00
52_D 148_A 1.649 1.00
246_K 287_D 1.648 1.00
262_L 270_A 1.64 1.00
170_D 294_N 1.589 1.00
187_R 240_D 1.546 1.00
95_T 116_G 1.542 1.00
29_L 165_T 1.538 1.00
30_A 299_L 1.526 1.00
209_P 213_Q 1.525 1.00
253_E 257_S 1.523 1.00
158_G 189_I 1.5 1.00
158_G 185_V 1.486 1.00
105_K 110_N 1.485 1.00
19_R 24_G 1.478 1.00
262_L 278_V 1.475 1.00
102_K 105_K 1.46 1.00
261_R 282_L 1.458 1.00
182_L 244_V 1.445 1.00
254_E 279_A 1.433 1.00
131_V 140_L 1.423 1.00
169_V 296_V 1.423 1.00
6_E 10_L 1.405 0.99
206_T 249_G 1.404 0.99
130_I 134_N 1.399 0.99
51_W 55_K 1.385 0.99
279_A 283_K 1.379 0.99
171_V 199_I 1.359 0.99
101_R 113_L 1.353 0.99
171_V 290_F 1.349 0.99
283_K 286_E 1.349 0.99
115_E 118_K 1.345 0.99
257_S 261_R 1.331 0.99
52_D 55_K 1.329 0.99
258_T 278_V 1.323 0.99
74_G 104_L 1.312 0.99
171_V 293_K 1.311 0.99
59_L 63_V 1.303 0.99
48_N 155_K 1.286 0.99
64_E 87_K 1.277 0.99
65_L 81_A 1.273 0.99
189_I 198_L 1.273 0.99
112_V 126_K 1.27 0.99
7_D 10_L 1.267 0.99
91_T 126_K 1.263 0.99
21_N 25_N 1.255 0.99
258_T 282_L 1.247 0.99
182_L 200_S 1.241 0.98
173_I 203_V 1.24 0.98
92_M 113_L 1.24 0.98
230_I 276_A 1.227 0.98
22_R 266_E 1.224 0.98
101_R 111_L 1.212 0.98
165_T 296_V 1.205 0.98
6_E 19_R 1.204 0.98
173_I 284_L 1.195 0.98
270_A 299_L 1.179 0.98
104_L 109_A 1.178 0.98
248_I 283_K 1.178 0.98
250_I 279_A 1.168 0.97
18_V 32_V 1.165 0.97
183_T 238_N 1.163 0.97
212_A 249_G 1.153 0.97
50_I 84_R 1.141 0.97
254_E 257_S 1.14 0.97
201_V 248_I 1.137 0.97
274_S 299_L 1.133 0.97
17_L 165_T 1.126 0.97
60_K 63_V 1.124 0.97
248_I 280_A 1.123 0.97
125_Q 128_E 1.122 0.97
28_I 281_A 1.118 0.96
98_I 101_R 1.118 0.96
188_Y 192_T 1.118 0.96
185_V 298_I 1.115 0.96
171_V 295_I 1.114 0.96
22_R 265_E 1.109 0.96
66_V 130_I 1.108 0.96
155_K 159_P 1.103 0.96
122_G 125_Q 1.101 0.96
20_L 30_A 1.098 0.96
4_I 29_L 1.094 0.96
59_L 65_L 1.094 0.96
49_M 146_N 1.089 0.96
79_Y 107_L 1.081 0.95
101_R 105_K 1.079 0.95
162_W 192_T 1.077 0.95
167_G 294_N 1.056 0.95
22_R 25_N 1.052 0.95
92_M 104_L 1.052 0.95
284_L 287_D 1.046 0.94
15_T 36_N 1.043 0.94
124_I 128_E 1.039 0.94
165_T 169_V 1.034 0.94
176_V 182_L 1.031 0.94
50_I 65_L 1.03 0.94
27_R 292_N 1.023 0.93
162_W 188_Y 1.021 0.93
126_K 130_I 1.02 0.93
120_M 123_A 1.017 0.93
161_I 169_V 1.017 0.93
173_I 201_V 1.014 0.93
165_T 294_N 1.012 0.93
16_P 35_R 1.01 0.93
162_W 193_K 1.01 0.93
173_I 281_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1y7lA10.97521000.112Contact Map0.821
2pqmA20.9691000.129Contact Map0.851
1z7wA10.9691000.132Contact Map0.834
3tbhA10.9691000.133Contact Map0.776
3vc3A60.97211000.136Contact Map0.91
2q3bA10.95361000.138Contact Map0.807
4aecA20.97211000.141Contact Map0.888
3pc3A10.98451000.143Contact Map0.803
2eguA10.94431000.144Contact Map0.783
1jbqA60.98451000.145Contact Map0.85
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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