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OPENSEQ.org
TDCB - L-threonine dehydratase catabolic TdcB
UniProt: P0AGF6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10990
Length: 329 (316)
Sequences: 10400
Seq/Len: 32.91
TDCB
Paralog alert: 0.92 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_C 101_G 4.778 1.00
137_K 140_E 3.769 1.00
43_E 305_K 3.546 1.00
32_R 43_E 3.177 1.00
272_A 276_R 3.176 1.00
265_E 294_S 3.155 1.00
204_R 257_D 3.1 1.00
169_I 307_V 2.997 1.00
100_D 123_E 2.979 1.00
111_K 115_A 2.77 1.00
68_S 72_A 2.703 1.00
27_K 171_E 2.672 1.00
178_N 206_I 2.671 1.00
70_T 99_I 2.517 1.00
211_E 262_S 2.51 1.00
140_E 144_M 2.453 1.00
102_K 123_E 2.39 1.00
45_F 305_K 2.341 1.00
193_A 254_L 2.327 1.00
77_G 102_K 2.321 1.00
67_S 97_L 2.309 1.00
288_A 308_S 2.27 1.00
212_N 263_E 2.253 1.00
30_M 307_V 2.244 1.00
107_K 128_G 2.215 1.00
160_A 163_G 2.185 1.00
262_S 265_E 2.178 1.00
208_V 291_A 2.122 1.00
68_S 157_K 2.114 1.00
167_L 195_A 2.043 1.00
139_S 143_E 2.031 1.00
179_V 196_I 2.012 1.00
104_V 141_I 1.953 1.00
206_I 257_D 1.936 1.00
179_V 192_I 1.918 1.00
197_K 256_D 1.917 1.00
102_K 125_V 1.907 1.00
27_K 172_D 1.896 1.00
183_I 207_G 1.878 1.00
193_A 205_V 1.854 1.00
162_Q 198_S 1.787 1.00
200_N 203_I 1.783 1.00
166_G 195_A 1.757 1.00
151_P 154_D 1.753 1.00
301_I 304_R 1.742 1.00
269_S 290_A 1.732 1.00
32_R 45_F 1.712 1.00
177_D 304_R 1.708 1.00
257_D 298_D 1.685 1.00
63_F 67_S 1.671 1.00
54_T 92_L 1.659 1.00
154_D 245_N 1.651 1.00
70_T 73_E 1.647 1.00
273_L 281_T 1.635 1.00
82_S 87_A 1.616 1.00
107_K 129_D 1.593 1.00
217_A 221_H 1.574 1.00
77_G 100_D 1.566 1.00
214_H 218_A 1.544 1.00
108_G 129_D 1.539 1.00
46_L 310_I 1.536 1.00
142_V 149_F 1.534 1.00
249_E 253_E 1.506 1.00
273_L 289_C 1.504 1.00
264_D 268_N 1.504 1.00
70_T 97_L 1.502 1.00
41_K 302_Q 1.489 1.00
115_A 118_C 1.479 1.00
177_D 305_K 1.474 1.00
45_F 173_L 1.462 1.00
166_G 192_I 1.457 1.00
272_A 293_L 1.456 1.00
189_I 255_V 1.44 1.00
118_C 123_E 1.431 1.00
265_E 290_A 1.428 1.00
67_S 71_D 1.413 1.00
211_E 260_L 1.405 0.99
238_C 287_L 1.395 0.99
176_V 307_V 1.395 0.99
166_G 196_I 1.384 0.99
269_S 289_C 1.374 0.99
39_R 272_A 1.359 0.99
32_R 37_S 1.347 0.99
178_N 204_R 1.345 0.99
162_Q 194_V 1.343 0.99
290_A 294_S 1.334 0.99
178_N 301_I 1.33 0.99
78_V 94_C 1.328 0.99
294_S 297_L 1.303 0.99
268_N 272_A 1.293 0.99
114_V 126_L 1.29 0.99
35_Y 38_E 1.288 0.99
104_V 137_K 1.282 0.99
64_N 163_G 1.275 0.99
189_I 205_V 1.275 0.99
114_V 124_V 1.273 0.99
178_N 304_R 1.271 0.99
180_I 208_V 1.266 0.99
281_T 310_I 1.253 0.99
66_L 78_V 1.251 0.99
34_N 38_E 1.228 0.98
269_S 293_L 1.226 0.98
105_M 126_L 1.22 0.98
196_I 203_I 1.219 0.98
111_K 114_V 1.215 0.98
87_A 117_T 1.215 0.98
125_V 137_K 1.205 0.98
35_Y 277_N 1.201 0.98
261_V 290_A 1.2 0.98
31_P 48_F 1.187 0.98
259_V 294_S 1.183 0.98
300_Y 304_R 1.174 0.98
33_S 46_L 1.171 0.98
19_Q 23_G 1.171 0.98
180_I 295_G 1.161 0.97
117_T 122_A 1.152 0.97
44_I 292_L 1.136 0.97
137_K 141_I 1.132 0.97
206_I 259_V 1.127 0.97
178_N 306_T 1.125 0.97
259_V 291_A 1.125 0.97
39_R 276_R 1.123 0.97
65_K 155_D 1.12 0.96
295_G 298_D 1.118 0.96
66_L 97_L 1.115 0.96
218_A 222_S 1.109 0.96
195_A 199_I 1.106 0.96
217_A 260_L 1.106 0.96
192_I 309_I 1.103 0.96
222_S 226_T 1.102 0.96
35_Y 276_R 1.097 0.96
92_L 120_Y 1.095 0.96
114_V 118_C 1.094 0.96
20_R 23_G 1.092 0.96
265_E 268_N 1.084 0.96
18_K 160_A 1.08 0.95
12_D 15_I 1.072 0.95
30_M 173_L 1.071 0.95
79_V 141_I 1.067 0.95
285_G 310_I 1.064 0.95
173_L 307_V 1.064 0.95
141_I 145_E 1.061 0.95
135_I 139_S 1.059 0.95
180_I 292_L 1.058 0.95
163_G 167_L 1.054 0.95
136_A 139_S 1.051 0.94
170_M 199_I 1.049 0.94
139_S 142_V 1.047 0.94
170_M 195_A 1.047 0.94
227_T 242_R 1.041 0.94
169_I 176_V 1.037 0.94
105_M 117_T 1.037 0.94
170_M 200_N 1.021 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gn0A40.98481000.106Contact Map0.804
1v71A10.96661000.128Contact Map0.727
1tdjA10.98781000.131Contact Map0.733
3l6bA10.96961000.153Contact Map0.776
1ve5A40.9211000.155Contact Map0.729
4h27A10.93011000.177Contact Map0.707
3iauA20.9971000.186Contact Map0.737
2rkbA50.93621000.187Contact Map0.758
3ss7X10.9971000.197Contact Map0.628
4d9iA20.98481000.203Contact Map0.762
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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