| UniProt: | P0AEP7 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11583 | ||
| Length: | 593 (566) | ||
| Sequences: | 6491 | ||
| Seq/Len: | 11.47 |
| GCL
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 513_K | 516_E | 5.245 | 1.00 | |
| 55_S | 86_A | 4.423 | 1.00 | |
| 228_E | 248_H | 4.057 | 1.00 | |
| 472_N | 552_E | 3.785 | 1.00 | |
| 378_E | 532_A | 3.433 | 1.00 | |
| 222_L | 323_K | 3.415 | 1.00 | |
| 523_I | 537_Q | 3.407 | 1.00 | |
| 20_T | 68_N | 3.204 | 1.00 | |
| 527_K | 530_D | 3.084 | 1.00 | |
| 200_L | 275_F | 3.001 | 1.00 | |
| 222_L | 327_T | 2.965 | 1.00 | |
| 196_A | 299_V | 2.937 | 1.00 | |
| 210_A | 223_L | 2.921 | 1.00 | |
| 320_S | 325_A | 2.885 | 1.00 | |
| 524_R | 554_I | 2.825 | 1.00 | |
| 64_A | 435_D | 2.804 | 1.00 | |
| 301_I | 325_A | 2.724 | 1.00 | |
| 526_F | 530_D | 2.694 | 1.00 | |
| 271_S | 274_V | 2.653 | 1.00 | |
| 277_I | 322_A | 2.617 | 1.00 | |
| 378_E | 381_K | 2.614 | 1.00 | |
| 523_I | 549_V | 2.585 | 1.00 | |
| 450_Q | 518_L | 2.551 | 1.00 | |
| 525_V | 534_A | 2.541 | 1.00 | |
| 382_A | 536_E | 2.54 | 1.00 | |
| 21_T | 44_R | 2.506 | 1.00 | |
| 98_L | 147_F | 2.467 | 1.00 | |
| 69_I | 151_R | 2.411 | 1.00 | |
| 74_G | 83_M | 2.393 | 1.00 | |
| 194_E | 332_V | 2.385 | 1.00 | |
| 523_I | 534_A | 2.368 | 1.00 | |
| 521_K | 537_Q | 2.329 | 1.00 | |
| 428_A | 442_A | 2.285 | 1.00 | |
| 87_L | 99_C | 2.205 | 1.00 | |
| 142_V | 160_V | 2.204 | 1.00 | |
| 449_F | 453_I | 2.176 | 1.00 | |
| 59_E | 63_R | 2.17 | 1.00 | |
| 514_V | 517_G | 2.14 | 1.00 | |
| 521_K | 547_V | 2.131 | 1.00 | |
| 388_C | 431_V | 2.122 | 1.00 | |
| 381_K | 532_A | 2.104 | 1.00 | |
| 247_D | 407_F | 2.092 | 1.00 | |
| 199_M | 316_L | 2.084 | 1.00 | |
| 524_R | 552_E | 2.082 | 1.00 | |
| 81_T | 85_T | 2.08 | 1.00 | |
| 510_D | 513_K | 2.065 | 1.00 | |
| 69_I | 98_L | 2.059 | 1.00 | |
| 227_A | 234_V | 2.046 | 1.00 | |
| 208_I | 227_A | 2.011 | 1.00 | |
| 392_T | 444_S | 2.009 | 1.00 | |
| 460_A | 520_C | 2.006 | 1.00 | |
| 101_T | 159_L | 2.002 | 1.00 | |
| 277_I | 301_I | 2 | 1.00 | |
| 198_E | 202_Q | 1.992 | 1.00 | |
| 208_I | 232_V | 1.986 | 1.00 | |
| 65_T | 434_A | 1.965 | 1.00 | |
| 423_W | 427_A | 1.965 | 1.00 | |
| 200_L | 273_M | 1.959 | 1.00 | |
| 208_I | 275_F | 1.953 | 1.00 | |
| 512_V | 522_A | 1.935 | 1.00 | |
| 432_C | 465_P | 1.934 | 1.00 | |
| 199_M | 273_M | 1.929 | 1.00 | |
| 276_G | 279_N | 1.922 | 1.00 | |
| 435_D | 438_R | 1.92 | 1.00 | |
| 234_V | 244_I | 1.915 | 1.00 | |
| 15_E | 42_G | 1.907 | 1.00 | |
| 470_L | 550_V | 1.894 | 1.00 | |
| 538_A | 551_V | 1.891 | 1.00 | |
| 8_D | 36_A | 1.871 | 1.00 | |
| 118_D | 121_A | 1.871 | 1.00 | |
| 199_M | 297_K | 1.868 | 1.00 | |
| 48_A | 54_A | 1.867 | 1.00 | |
| 121_A | 124_K | 1.821 | 1.00 | |
| 459_G | 520_C | 1.796 | 1.00 | |
| 10_A | 143_L | 1.786 | 1.00 | |
| 308_I | 319_V | 1.779 | 1.00 | |
| 379_M | 443_I | 1.759 | 1.00 | |
| 34_Y | 45_H | 1.756 | 1.00 | |
| 100_I | 162_L | 1.749 | 1.00 | |
| 392_T | 448_D | 1.744 | 1.00 | |
| 87_L | 97_I | 1.74 | 1.00 | |
| 532_A | 536_E | 1.738 | 1.00 | |
| 12_Y | 16_K | 1.706 | 1.00 | |
| 59_E | 89_S | 1.695 | 1.00 | |
| 231_S | 250_L | 1.689 | 1.00 | |
| 12_Y | 15_E | 1.687 | 1.00 | |
| 83_M | 99_C | 1.683 | 1.00 | |
| 224_Q | 228_E | 1.682 | 1.00 | |
| 203_A | 206_P | 1.668 | 1.00 | |
| 197_V | 329_L | 1.665 | 1.00 | |
| 226_F | 230_T | 1.661 | 1.00 | |
| 135_E | 138_L | 1.656 | 1.00 | |
| 413_I | 431_V | 1.655 | 1.00 | |
| 141_R | 145_Q | 1.655 | 1.00 | |
| 8_D | 39_K | 1.639 | 1.00 | |
| 469_V | 551_V | 1.638 | 1.00 | |
| 429_L | 459_G | 1.634 | 1.00 | |
| 469_V | 535_F | 1.624 | 1.00 | |
| 456_L | 520_C | 1.613 | 1.00 | |
| 221_A | 225_Q | 1.608 | 1.00 | |
| 421_L | 451_F | 1.599 | 1.00 | |
| 189_S | 192_Q | 1.595 | 1.00 | |
| 24_G | 45_H | 1.594 | 1.00 | |
| 133_V | 139_V | 1.59 | 1.00 | |
| 15_E | 40_H | 1.564 | 1.00 | |
| 384_G | 387_V | 1.563 | 1.00 | |
| 127_S | 159_L | 1.557 | 1.00 | |
| 203_A | 273_M | 1.543 | 1.00 | |
| 46_I | 433_A | 1.542 | 1.00 | |
| 207_V | 271_S | 1.54 | 1.00 | |
| 48_A | 57_M | 1.534 | 1.00 | |
| 432_C | 464_I | 1.533 | 1.00 | |
| 23_F | 61_Y | 1.525 | 1.00 | |
| 53_G | 455_E | 1.521 | 1.00 | |
| 521_K | 549_V | 1.519 | 1.00 | |
| 432_C | 439_N | 1.518 | 1.00 | |
| 8_D | 12_Y | 1.508 | 1.00 | |
| 380_N | 405_H | 1.504 | 1.00 | |
| 60_G | 64_A | 1.503 | 1.00 | |
| 377_E | 381_K | 1.502 | 1.00 | |
| 131_V | 160_V | 1.497 | 1.00 | |
| 530_D | 533_P | 1.495 | 1.00 | |
| 229_L | 330_V | 1.492 | 1.00 | |
| 512_V | 524_R | 1.491 | 1.00 | |
| 383_F | 441_V | 1.485 | 1.00 | |
| 252_A | 267_T | 1.483 | 1.00 | |
| 453_I | 514_V | 1.478 | 1.00 | |
| 441_V | 539_K | 1.473 | 1.00 | |
| 459_G | 466_Y | 1.472 | 1.00 | |
| 411_H | 438_R | 1.471 | 1.00 | |
| 273_M | 299_V | 1.469 | 1.00 | |
| 227_A | 244_I | 1.46 | 1.00 | |
| 225_Q | 330_V | 1.456 | 1.00 | |
| 516_E | 521_K | 1.455 | 1.00 | |
| 17_E | 147_F | 1.436 | 1.00 | |
| 74_G | 99_C | 1.435 | 1.00 | |
| 375_V | 553_V | 1.43 | 1.00 | |
| 128_K | 156_G | 1.419 | 1.00 | |
| 138_L | 141_R | 1.406 | 0.99 | |
| 374_R | 378_E | 1.396 | 0.99 | |
| 378_E | 382_A | 1.394 | 0.99 | |
| 531_I | 553_V | 1.392 | 0.99 | |
| 467_I | 538_A | 1.39 | 0.99 | |
| 136_A | 169_A | 1.381 | 0.99 | |
| 309_G | 314_P | 1.373 | 0.99 | |
| 106_R | 165_D | 1.372 | 0.99 | |
| 10_A | 162_L | 1.371 | 0.99 | |
| 370_V | 375_V | 1.37 | 0.99 | |
| 17_E | 144_Q | 1.37 | 0.99 | |
| 374_R | 528_P | 1.37 | 0.99 | |
| 44_R | 462_F | 1.367 | 0.99 | |
| 520_C | 550_V | 1.362 | 0.99 | |
| 206_P | 272_D | 1.358 | 0.99 | |
| 469_V | 553_V | 1.352 | 0.99 | |
| 533_P | 536_E | 1.348 | 0.99 | |
| 439_N | 539_K | 1.347 | 0.99 | |
| 143_L | 160_V | 1.347 | 0.99 | |
| 55_S | 83_M | 1.346 | 0.99 | |
| 526_F | 554_I | 1.346 | 0.99 | |
| 241_W | 246_D | 1.344 | 0.99 | |
| 533_P | 537_Q | 1.343 | 0.99 | |
| 80_G | 101_T | 1.336 | 0.99 | |
| 21_T | 433_A | 1.336 | 0.99 | |
| 225_Q | 229_L | 1.335 | 0.99 | |
| 46_I | 462_F | 1.327 | 0.99 | |
| 536_E | 540_A | 1.323 | 0.99 | |
| 195_K | 198_E | 1.318 | 0.99 | |
| 534_A | 551_V | 1.317 | 0.99 | |
| 72_C | 83_M | 1.314 | 0.99 | |
| 91_S | 157_P | 1.307 | 0.99 | |
| 190_R | 328_L | 1.293 | 0.99 | |
| 531_I | 535_F | 1.29 | 0.99 | |
| 208_I | 226_F | 1.285 | 0.99 | |
| 226_F | 330_V | 1.283 | 0.99 | |
| 388_C | 435_D | 1.282 | 0.99 | |
| 384_G | 439_N | 1.271 | 0.99 | |
| 382_A | 532_A | 1.271 | 0.99 | |
| 214_V | 223_L | 1.266 | 0.99 | |
| 210_A | 214_V | 1.265 | 0.99 | |
| 270_A | 351_D | 1.259 | 0.99 | |
| 20_T | 44_R | 1.259 | 0.99 | |
| 84_I | 122_I | 1.258 | 0.99 | |
| 236_P | 251_M | 1.256 | 0.99 | |
| 457_A | 461_Q | 1.253 | 0.99 | |
| 7_V | 36_A | 1.253 | 0.99 | |
| 374_R | 531_I | 1.253 | 0.99 | |
| 223_L | 326_L | 1.24 | 0.98 | |
| 149_L | 158_V | 1.237 | 0.98 | |
| 523_I | 551_V | 1.235 | 0.98 | |
| 522_A | 550_V | 1.235 | 0.98 | |
| 442_A | 468_H | 1.225 | 0.98 | |
| 193_I | 332_V | 1.224 | 0.98 | |
| 208_I | 223_L | 1.223 | 0.98 | |
| 301_I | 318_I | 1.223 | 0.98 | |
| 197_V | 201_I | 1.223 | 0.98 | |
| 192_Q | 195_K | 1.221 | 0.98 | |
| 9_A | 171_I | 1.218 | 0.98 | |
| 449_F | 550_V | 1.218 | 0.98 | |
| 196_A | 318_I | 1.218 | 0.98 | |
| 515_A | 522_A | 1.216 | 0.98 | |
| 222_L | 330_V | 1.215 | 0.98 | |
| 13_V | 144_Q | 1.214 | 0.98 | |
| 229_L | 334_Q | 1.213 | 0.98 | |
| 9_A | 140_P | 1.213 | 0.98 | |
| 525_V | 530_D | 1.211 | 0.98 | |
| 351_D | 355_R | 1.208 | 0.98 | |
| 225_Q | 327_T | 1.207 | 0.98 | |
| 53_G | 452_L | 1.207 | 0.98 | |
| 87_L | 126_V | 1.202 | 0.98 | |
| 127_S | 130_A | 1.2 | 0.98 | |
| 228_E | 250_L | 1.198 | 0.98 | |
| 387_V | 439_N | 1.196 | 0.98 | |
| 30_I | 33_F | 1.194 | 0.98 | |
| 69_I | 147_F | 1.189 | 0.98 | |
| 277_I | 326_L | 1.179 | 0.98 | |
| 222_L | 326_L | 1.176 | 0.98 | |
| 465_P | 547_V | 1.168 | 0.97 | |
| 318_I | 325_A | 1.167 | 0.97 | |
| 447_F | 476_L | 1.163 | 0.97 | |
| 13_V | 143_L | 1.162 | 0.97 | |
| 88_Y | 418_A | 1.149 | 0.97 | |
| 61_Y | 434_A | 1.147 | 0.97 | |
| 64_A | 431_V | 1.144 | 0.97 | |
| 62_T | 96_P | 1.137 | 0.97 | |
| 19_I | 71_V | 1.134 | 0.97 | |
| 424_T | 442_A | 1.131 | 0.97 | |
| 370_V | 553_V | 1.129 | 0.97 | |
| 84_I | 126_V | 1.129 | 0.97 | |
| 432_C | 436_P | 1.127 | 0.97 | |
| 207_V | 274_V | 1.125 | 0.97 | |
| 131_V | 145_Q | 1.122 | 0.97 | |
| 224_Q | 248_H | 1.118 | 0.96 | |
| 203_A | 272_D | 1.109 | 0.96 | |
| 202_Q | 273_M | 1.108 | 0.96 | |
| 227_A | 250_L | 1.108 | 0.96 | |
| 432_C | 437_K | 1.106 | 0.96 | |
| 163_P | 166_V | 1.104 | 0.96 | |
| 286_T | 289_V | 1.103 | 0.96 | |
| 538_A | 549_V | 1.1 | 0.96 | |
| 433_A | 464_I | 1.1 | 0.96 | |
| 131_V | 142_V | 1.096 | 0.96 | |
| 5_R | 8_D | 1.09 | 0.96 | |
| 224_Q | 245_P | 1.089 | 0.96 | |
| 55_S | 72_C | 1.088 | 0.96 | |
| 98_L | 150_M | 1.086 | 0.96 | |
| 525_V | 531_I | 1.085 | 0.96 | |
| 512_V | 552_E | 1.083 | 0.96 | |
| 323_K | 327_T | 1.082 | 0.96 | |
| 225_Q | 334_Q | 1.08 | 0.95 | |
| 515_A | 520_C | 1.078 | 0.95 | |
| 245_P | 248_H | 1.071 | 0.95 | |
| 6_A | 136_A | 1.07 | 0.95 | |
| 515_A | 550_V | 1.07 | 0.95 | |
| 33_F | 162_L | 1.068 | 0.95 | |
| 425_I | 468_H | 1.066 | 0.95 | |
| 225_Q | 228_E | 1.064 | 0.95 | |
| 6_A | 139_V | 1.063 | 0.95 | |
| 453_I | 518_L | 1.059 | 0.95 | |
| 456_L | 550_V | 1.058 | 0.95 | |
| 246_D | 251_M | 1.058 | 0.95 | |
| 534_A | 538_A | 1.058 | 0.95 | |
| 512_V | 516_E | 1.053 | 0.95 | |
| 122_I | 126_V | 1.053 | 0.95 | |
| 391_T | 414_N | 1.05 | 0.94 | |
| 244_I | 251_M | 1.049 | 0.94 | |
| 390_V | 442_A | 1.042 | 0.94 | |
| 57_M | 459_G | 1.033 | 0.94 | |
| 87_L | 123_A | 1.031 | 0.94 | |
| 196_A | 316_L | 1.03 | 0.94 | |
| 37_M | 43_I | 1.028 | 0.94 | |
| 20_T | 61_Y | 1.027 | 0.94 | |
| 266_A | 270_A | 1.021 | 0.93 | |
| 244_I | 248_H | 1.018 | 0.93 | |
| 196_A | 273_M | 1.018 | 0.93 | |
| 432_C | 440_V | 1.017 | 0.93 | |
| 388_C | 440_V | 1.016 | 0.93 | |
| 205_R | 270_A | 1.014 | 0.93 | |
| 64_A | 413_I | 1.012 | 0.93 | |
| 314_P | 317_G | 1.012 | 0.93 | |
| 222_L | 225_Q | 1.01 | 0.93 | |
| 120_E | 130_A | 1.009 | 0.93 | |
| 324_A | 327_T | 1.009 | 0.93 | |
| 432_C | 547_V | 1.001 | 0.92 | |
| 22_A | 37_M | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2panA | 6 | 0.9916 | 100 | 0.152 | Contact Map | 0.743 |
| 1ybhA | 1 | 0.968 | 100 | 0.181 | Contact Map | 0.821 |
| 2ihtA | 4 | 0.914 | 100 | 0.186 | Contact Map | 0.816 |
| 1ozhA | 4 | 0.9359 | 100 | 0.186 | Contact Map | 0.8 |
| 2uz1A | 2 | 0.9325 | 100 | 0.19 | Contact Map | 0.749 |
| 1t9bA | 2 | 0.9595 | 100 | 0.19 | Contact Map | 0.845 |
| 2pgnA | 2 | 0.9477 | 100 | 0.2 | Contact Map | 0.779 |
| 3eyaA | 12 | 0.9157 | 100 | 0.202 | Contact Map | 0.797 |
| 1q6zA | 1 | 0.8836 | 100 | 0.206 | Contact Map | 0.797 |
| 3lq1A | 2 | 0.9292 | 100 | 0.214 | Contact Map | 0.705 |
Sequence Conservation (Image Generated using WebLogo v3)