| UniProt: | P07003 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10754 | ||
| Length: | 572 (533) | ||
| Sequences: | 6543 | ||
| Seq/Len: | 12.28 |
| POXB
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 489_R | 492_E | 5.022 | 1.00 | |
| 54_A | 84_G | 4.29 | 1.00 | |
| 224_G | 244_N | 3.88 | 1.00 | |
| 459_N | 524_D | 3.672 | 1.00 | |
| 365_Q | 508_D | 3.418 | 1.00 | |
| 19_K | 66_E | 3.337 | 1.00 | |
| 499_I | 513_R | 3.298 | 1.00 | |
| 218_E | 313_K | 3.251 | 1.00 | |
| 503_K | 506_E | 3.031 | 1.00 | |
| 218_E | 317_R | 2.96 | 1.00 | |
| 194_L | 289_I | 2.908 | 1.00 | |
| 500_R | 526_V | 2.836 | 1.00 | |
| 310_G | 315_T | 2.823 | 1.00 | |
| 208_C | 219_L | 2.812 | 1.00 | |
| 198_L | 270_V | 2.742 | 1.00 | |
| 63_L | 422_E | 2.734 | 1.00 | |
| 502_E | 506_E | 2.648 | 1.00 | |
| 291_I | 315_T | 2.601 | 1.00 | |
| 499_I | 521_V | 2.564 | 1.00 | |
| 272_L | 312_I | 2.552 | 1.00 | |
| 266_A | 269_L | 2.527 | 1.00 | |
| 365_Q | 368_H | 2.523 | 1.00 | |
| 67_L | 149_V | 2.506 | 1.00 | |
| 369_F | 512_Q | 2.488 | 1.00 | |
| 437_S | 494_C | 2.472 | 1.00 | |
| 501_V | 510_A | 2.432 | 1.00 | |
| 72_G | 81_L | 2.416 | 1.00 | |
| 96_L | 145_M | 2.41 | 1.00 | |
| 20_R | 43_E | 2.405 | 1.00 | |
| 192_R | 322_L | 2.39 | 1.00 | |
| 499_I | 510_A | 2.252 | 1.00 | |
| 140_V | 157_V | 2.211 | 1.00 | |
| 497_T | 513_R | 2.208 | 1.00 | |
| 415_A | 429_A | 2.195 | 1.00 | |
| 497_T | 519_G | 2.137 | 1.00 | |
| 85_L | 97_A | 2.125 | 1.00 | |
| 500_R | 524_D | 2.093 | 1.00 | |
| 436_F | 440_M | 2.091 | 1.00 | |
| 490_I | 493_A | 2.073 | 1.00 | |
| 197_L | 306_M | 2.055 | 1.00 | |
| 79_L | 83_N | 2.039 | 1.00 | |
| 58_G | 62_Q | 2.031 | 1.00 | |
| 67_L | 96_L | 2.002 | 1.00 | |
| 368_H | 508_D | 1.977 | 1.00 | |
| 375_I | 418_A | 1.972 | 1.00 | |
| 64_S | 421_T | 1.971 | 1.00 | |
| 447_V | 496_I | 1.967 | 1.00 | |
| 14_E | 41_T | 1.961 | 1.00 | |
| 379_D | 431_C | 1.954 | 1.00 | |
| 243_D | 394_N | 1.952 | 1.00 | |
| 7_A | 35_S | 1.941 | 1.00 | |
| 486_N | 489_R | 1.937 | 1.00 | |
| 206_L | 223_A | 1.913 | 1.00 | |
| 419_Q | 452_P | 1.905 | 1.00 | |
| 223_A | 230_I | 1.894 | 1.00 | |
| 198_L | 268_T | 1.891 | 1.00 | |
| 422_E | 425_R | 1.889 | 1.00 | |
| 272_L | 291_I | 1.882 | 1.00 | |
| 196_Q | 200_Y | 1.882 | 1.00 | |
| 99_A | 156_V | 1.881 | 1.00 | |
| 206_L | 270_V | 1.87 | 1.00 | |
| 197_L | 268_T | 1.867 | 1.00 | |
| 271_L | 274_T | 1.867 | 1.00 | |
| 206_L | 228_A | 1.866 | 1.00 | |
| 457_V | 522_L | 1.85 | 1.00 | |
| 47_T | 53_A | 1.844 | 1.00 | |
| 379_D | 435_G | 1.825 | 1.00 | |
| 119_E | 122_R | 1.814 | 1.00 | |
| 514_A | 523_V | 1.809 | 1.00 | |
| 230_I | 240_V | 1.798 | 1.00 | |
| 116_H | 119_E | 1.792 | 1.00 | |
| 197_L | 287_K | 1.791 | 1.00 | |
| 488_A | 498_G | 1.79 | 1.00 | |
| 410_N | 414_Q | 1.785 | 1.00 | |
| 9_I | 141_L | 1.777 | 1.00 | |
| 366_I | 430_M | 1.761 | 1.00 | |
| 298_I | 309_V | 1.759 | 1.00 | |
| 11_K | 15_S | 1.73 | 1.00 | |
| 98_I | 159_L | 1.728 | 1.00 | |
| 133_S | 136_Q | 1.716 | 1.00 | |
| 446_V | 496_I | 1.711 | 1.00 | |
| 508_D | 512_Q | 1.699 | 1.00 | |
| 11_K | 14_E | 1.698 | 1.00 | |
| 195_A | 319_L | 1.683 | 1.00 | |
| 23_G | 44_W | 1.667 | 1.00 | |
| 7_A | 38_R | 1.664 | 1.00 | |
| 33_S | 44_W | 1.662 | 1.00 | |
| 81_L | 97_A | 1.651 | 1.00 | |
| 220_V | 224_G | 1.645 | 1.00 | |
| 85_L | 95_V | 1.637 | 1.00 | |
| 187_E | 190_E | 1.604 | 1.00 | |
| 227_K | 246_Y | 1.602 | 1.00 | |
| 400_L | 418_A | 1.601 | 1.00 | |
| 456_V | 511_L | 1.601 | 1.00 | |
| 443_F | 496_I | 1.599 | 1.00 | |
| 58_G | 87_D | 1.594 | 1.00 | |
| 456_V | 523_V | 1.593 | 1.00 | |
| 201_S | 204_I | 1.586 | 1.00 | |
| 222_F | 226_I | 1.58 | 1.00 | |
| 419_Q | 426_Q | 1.566 | 1.00 | |
| 205_A | 266_A | 1.548 | 1.00 | |
| 416_L | 446_V | 1.548 | 1.00 | |
| 131_V | 137_I | 1.539 | 1.00 | |
| 125_S | 156_V | 1.533 | 1.00 | |
| 45_M | 420_A | 1.525 | 1.00 | |
| 497_T | 521_V | 1.523 | 1.00 | |
| 371_A | 374_A | 1.519 | 1.00 | |
| 201_S | 268_T | 1.516 | 1.00 | |
| 14_E | 39_M | 1.514 | 1.00 | |
| 217_K | 221_E | 1.508 | 1.00 | |
| 408_M | 438_M | 1.498 | 1.00 | |
| 225_K | 320_L | 1.498 | 1.00 | |
| 139_Q | 143_I | 1.49 | 1.00 | |
| 129_E | 157_V | 1.478 | 1.00 | |
| 367_S | 392_K | 1.478 | 1.00 | |
| 419_Q | 451_L | 1.473 | 1.00 | |
| 52_V | 442_D | 1.47 | 1.00 | |
| 488_A | 500_R | 1.469 | 1.00 | |
| 47_T | 56_A | 1.467 | 1.00 | |
| 492_E | 497_T | 1.446 | 1.00 | |
| 506_E | 509_E | 1.446 | 1.00 | |
| 364_Q | 368_H | 1.438 | 1.00 | |
| 362_L | 525_V | 1.436 | 1.00 | |
| 428_V | 515_F | 1.429 | 1.00 | |
| 22_W | 60_E | 1.424 | 1.00 | |
| 299_G | 304_V | 1.42 | 1.00 | |
| 440_M | 490_I | 1.415 | 1.00 | |
| 126_H | 153_G | 1.414 | 1.00 | |
| 507_V | 525_V | 1.412 | 1.00 | |
| 59_A | 63_L | 1.409 | 1.00 | |
| 221_E | 320_L | 1.401 | 0.99 | |
| 12_T | 142_A | 1.398 | 0.99 | |
| 9_I | 159_L | 1.395 | 0.99 | |
| 370_A | 428_V | 1.394 | 0.99 | |
| 221_E | 225_K | 1.392 | 0.99 | |
| 223_A | 240_V | 1.391 | 0.99 | |
| 70_C | 81_L | 1.388 | 0.99 | |
| 16_A | 142_A | 1.388 | 0.99 | |
| 248_V | 262_T | 1.388 | 0.99 | |
| 446_V | 453_V | 1.386 | 0.99 | |
| 365_Q | 369_F | 1.381 | 0.99 | |
| 72_G | 97_A | 1.369 | 0.99 | |
| 454_K | 514_A | 1.366 | 0.99 | |
| 268_T | 289_I | 1.365 | 0.99 | |
| 43_E | 449_M | 1.363 | 0.99 | |
| 16_A | 145_M | 1.358 | 0.99 | |
| 361_Y | 365_Q | 1.358 | 0.99 | |
| 357_I | 362_L | 1.356 | 0.99 | |
| 19_K | 43_E | 1.355 | 0.99 | |
| 225_K | 324_E | 1.348 | 0.99 | |
| 193_K | 196_Q | 1.348 | 0.99 | |
| 20_R | 420_A | 1.344 | 0.99 | |
| 456_V | 525_V | 1.341 | 0.99 | |
| 191_L | 322_L | 1.336 | 0.99 | |
| 426_Q | 515_F | 1.336 | 0.99 | |
| 7_A | 11_K | 1.33 | 0.99 | |
| 78_N | 99_A | 1.327 | 0.99 | |
| 502_E | 526_V | 1.326 | 0.99 | |
| 45_M | 449_M | 1.326 | 0.99 | |
| 54_A | 81_L | 1.314 | 0.99 | |
| 134_P | 166_K | 1.312 | 0.99 | |
| 496_I | 522_L | 1.309 | 0.99 | |
| 375_I | 422_E | 1.309 | 0.99 | |
| 509_E | 513_R | 1.309 | 0.99 | |
| 509_E | 512_Q | 1.302 | 0.99 | |
| 237_K | 242_Y | 1.301 | 0.99 | |
| 96_L | 148_A | 1.293 | 0.99 | |
| 89_H | 154_V | 1.293 | 0.99 | |
| 361_Y | 504_A | 1.291 | 0.99 | |
| 141_L | 157_V | 1.29 | 0.99 | |
| 339_Y | 343_R | 1.288 | 0.99 | |
| 104_S | 162_D | 1.282 | 0.99 | |
| 204_I | 267_D | 1.277 | 0.99 | |
| 369_F | 508_D | 1.276 | 0.99 | |
| 206_L | 222_F | 1.271 | 0.99 | |
| 510_A | 523_V | 1.271 | 0.99 | |
| 186_P | 315_T | 1.266 | 0.99 | |
| 507_V | 511_L | 1.264 | 0.99 | |
| 232_H | 247_D | 1.262 | 0.99 | |
| 219_L | 316_L | 1.258 | 0.99 | |
| 498_G | 522_L | 1.258 | 0.99 | |
| 136_Q | 139_Q | 1.257 | 0.99 | |
| 195_A | 199_R | 1.24 | 0.98 | |
| 194_L | 308_L | 1.233 | 0.98 | |
| 3_Q | 11_K | 1.231 | 0.98 | |
| 29_L | 32_L | 1.227 | 0.98 | |
| 82_I | 120_L | 1.223 | 0.98 | |
| 512_Q | 516_S | 1.221 | 0.98 | |
| 361_Y | 507_V | 1.221 | 0.98 | |
| 499_I | 523_V | 1.219 | 0.98 | |
| 222_F | 320_L | 1.215 | 0.98 | |
| 6_A | 35_S | 1.212 | 0.98 | |
| 52_V | 439_L | 1.211 | 0.98 | |
| 206_L | 219_L | 1.201 | 0.98 | |
| 452_P | 519_G | 1.198 | 0.98 | |
| 188_E | 318_A | 1.197 | 0.98 | |
| 67_L | 145_M | 1.189 | 0.98 | |
| 501_V | 506_E | 1.188 | 0.98 | |
| 374_A | 426_Q | 1.188 | 0.98 | |
| 86_F | 405_H | 1.186 | 0.98 | |
| 125_S | 128_C | 1.186 | 0.98 | |
| 8_Y | 168_A | 1.185 | 0.98 | |
| 444_L | 448_Q | 1.185 | 0.98 | |
| 357_I | 525_V | 1.183 | 0.98 | |
| 4_T | 7_A | 1.183 | 0.98 | |
| 371_A | 426_Q | 1.183 | 0.98 | |
| 8_Y | 138_P | 1.178 | 0.98 | |
| 429_A | 455_I | 1.177 | 0.98 | |
| 85_L | 124_C | 1.172 | 0.98 | |
| 54_A | 70_C | 1.169 | 0.97 | |
| 147_K | 155_S | 1.167 | 0.97 | |
| 491_A | 498_G | 1.164 | 0.97 | |
| 129_E | 140_V | 1.16 | 0.97 | |
| 4_T | 167_P | 1.158 | 0.97 | |
| 221_E | 317_R | 1.153 | 0.97 | |
| 434_G | 463_L | 1.152 | 0.97 | |
| 224_G | 246_Y | 1.147 | 0.97 | |
| 398_R | 425_R | 1.145 | 0.97 | |
| 18_V | 69_V | 1.145 | 0.97 | |
| 218_E | 320_L | 1.142 | 0.97 | |
| 60_E | 421_T | 1.142 | 0.97 | |
| 411_A | 429_A | 1.135 | 0.97 | |
| 12_T | 141_L | 1.135 | 0.97 | |
| 272_L | 316_L | 1.132 | 0.97 | |
| 129_E | 143_I | 1.128 | 0.97 | |
| 291_I | 308_L | 1.126 | 0.97 | |
| 308_L | 315_T | 1.123 | 0.97 | |
| 436_F | 522_L | 1.122 | 0.97 | |
| 218_E | 316_L | 1.121 | 0.97 | |
| 240_V | 244_N | 1.111 | 0.96 | |
| 205_A | 269_L | 1.11 | 0.96 | |
| 221_E | 224_G | 1.104 | 0.96 | |
| 443_F | 522_L | 1.101 | 0.96 | |
| 5_V | 134_P | 1.098 | 0.96 | |
| 190_E | 193_K | 1.094 | 0.96 | |
| 514_A | 521_V | 1.092 | 0.96 | |
| 63_L | 400_L | 1.079 | 0.95 | |
| 61_A | 94_P | 1.073 | 0.95 | |
| 420_A | 451_L | 1.072 | 0.95 | |
| 241_E | 244_N | 1.07 | 0.95 | |
| 220_V | 244_N | 1.069 | 0.95 | |
| 265_N | 334_K | 1.068 | 0.95 | |
| 440_M | 494_C | 1.068 | 0.95 | |
| 160_P | 163_V | 1.063 | 0.95 | |
| 419_Q | 423_P | 1.062 | 0.95 | |
| 201_S | 267_D | 1.061 | 0.95 | |
| 194_L | 306_M | 1.061 | 0.95 | |
| 82_I | 124_C | 1.059 | 0.95 | |
| 488_A | 524_D | 1.058 | 0.95 | |
| 491_A | 522_L | 1.054 | 0.95 | |
| 242_Y | 247_D | 1.052 | 0.95 | |
| 491_A | 496_I | 1.052 | 0.95 | |
| 5_V | 137_I | 1.045 | 0.94 | |
| 63_L | 418_A | 1.045 | 0.94 | |
| 70_C | 97_A | 1.045 | 0.94 | |
| 501_V | 507_V | 1.041 | 0.94 | |
| 223_A | 246_Y | 1.04 | 0.94 | |
| 56_A | 446_V | 1.039 | 0.94 | |
| 313_K | 317_R | 1.034 | 0.94 | |
| 497_T | 517_I | 1.031 | 0.94 | |
| 203_N | 265_N | 1.03 | 0.94 | |
| 314_S | 317_R | 1.027 | 0.94 | |
| 200_Y | 268_T | 1.026 | 0.94 | |
| 419_Q | 519_G | 1.023 | 0.93 | |
| 510_A | 514_A | 1.021 | 0.93 | |
| 220_V | 241_E | 1.019 | 0.93 | |
| 461_S | 484_D | 1.018 | 0.93 | |
| 218_E | 221_E | 1.018 | 0.93 | |
| 261_H | 265_N | 1.018 | 0.93 | |
| 517_I | 521_V | 1.018 | 0.93 | |
| 120_L | 124_C | 1.015 | 0.93 | |
| 488_A | 492_E | 1.01 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3eyaA | 12 | 0.9598 | 100 | 0.164 | Contact Map | 0.801 |
| 1v5eA | 1 | 0.9983 | 100 | 0.192 | Contact Map | 0.791 |
| 1ozhA | 4 | 0.951 | 100 | 0.195 | Contact Map | 0.803 |
| 2ihtA | 4 | 0.9301 | 100 | 0.198 | Contact Map | 0.82 |
| 1ybhA | 1 | 0.9738 | 100 | 0.201 | Contact Map | 0.825 |
| 1t9bA | 2 | 0.979 | 100 | 0.203 | Contact Map | 0.845 |
| 4kgdA | 2 | 0.9983 | 100 | 0.204 | Contact Map | 0.814 |
| 2panA | 6 | 0.986 | 100 | 0.208 | Contact Map | 0.73 |
| 2uz1A | 2 | 0.9476 | 100 | 0.213 | Contact Map | 0.75 |
| 2pgnA | 2 | 0.979 | 100 | 0.217 | Contact Map | 0.782 |
Sequence Conservation (Image Generated using WebLogo v3)