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OPENSEQ.org
ILVI - Acetolactate synthase isozyme 3 large subunit
UniProt: P00893 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10500
Length: 574 (559)
Sequences: 6479
Seq/Len: 11.59
ILVI
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
506_R 509_E 5.316 1.00
55_V 85_G 4.35 1.00
231_E 251_H 3.864 1.00
380_T 525_E 3.647 1.00
474_N 544_D 3.553 1.00
225_Q 325_R 3.455 1.00
516_I 530_E 3.437 1.00
20_K 67_E 3.422 1.00
520_H 523_E 3.317 1.00
225_Q 329_E 3.262 1.00
517_Q 546_T 2.911 1.00
64_A 437_L 2.872 1.00
199_A 301_L 2.847 1.00
213_V 226_L 2.82 1.00
322_G 327_V 2.803 1.00
380_T 383_R 2.801 1.00
68_V 150_A 2.714 1.00
197_K 334_L 2.714 1.00
203_L 277_F 2.7 1.00
519_S 523_E 2.696 1.00
384_L 529_S 2.669 1.00
279_V 324_A 2.655 1.00
516_I 541_V 2.644 1.00
273_A 276_I 2.57 1.00
303_I 327_V 2.549 1.00
250_T 409_D 2.526 1.00
97_V 146_F 2.524 1.00
452_Q 511_Y 2.432 1.00
518_I 527_K 2.428 1.00
516_I 527_K 2.423 1.00
21_Q 44_D 2.416 1.00
514_V 530_E 2.413 1.00
430_A 444_C 2.395 1.00
514_V 539_R 2.395 1.00
73_V 82_A 2.246 1.00
383_R 525_E 2.178 1.00
451_I 455_I 2.162 1.00
201_Q 205_A 2.156 1.00
141_V 159_V 2.152 1.00
202_T 318_I 2.125 1.00
503_D 506_R 2.109 1.00
437_L 440_E 2.09 1.00
86_I 98_V 2.079 1.00
8_E 36_A 2.078 1.00
462_L 513_H 2.058 1.00
59_D 63_R 2.053 1.00
507_L 510_A 2.045 1.00
68_V 97_V 2.038 1.00
211_V 230_V 2.024 1.00
80_T 84_T 2.019 1.00
525_E 529_S 2.004 1.00
390_Y 433_V 1.984 1.00
517_Q 544_D 1.97 1.00
230_V 237_V 1.956 1.00
202_T 275_V 1.948 1.00
65_T 436_A 1.947 1.00
434_K 467_P 1.937 1.00
211_V 235_L 1.937 1.00
48_V 54_A 1.931 1.00
15_I 42_G 1.913 1.00
120_G 123_R 1.896 1.00
531_A 543_V 1.871 1.00
394_D 446_T 1.867 1.00
134_Q 137_D 1.862 1.00
472_N 542_F 1.857 1.00
279_V 303_I 1.843 1.00
278_A 281_V 1.841 1.00
8_E 39_T 1.838 1.00
117_D 120_G 1.83 1.00
202_T 299_T 1.819 1.00
505_V 515_G 1.798 1.00
237_V 247_F 1.798 1.00
211_V 277_F 1.783 1.00
203_L 275_V 1.782 1.00
415_I 433_V 1.78 1.00
10_V 142_L 1.78 1.00
100_S 158_V 1.778 1.00
12_R 16_D 1.778 1.00
394_D 450_S 1.765 1.00
99_L 161_L 1.739 1.00
310_I 321_V 1.738 1.00
425_F 429_A 1.735 1.00
381_L 445_V 1.732 1.00
224_Q 228_E 1.731 1.00
12_R 15_I 1.728 1.00
227_K 231_E 1.714 1.00
529_S 533_E 1.705 1.00
234_N 253_Q 1.685 1.00
379_E 383_R 1.678 1.00
192_H 195_Q 1.678 1.00
86_I 96_L 1.677 1.00
434_K 441_T 1.654 1.00
200_L 331_M 1.634 1.00
34_Y 45_H 1.61 1.00
232_A 332_L 1.609 1.00
126_V 158_V 1.608 1.00
228_E 232_A 1.597 1.00
509_E 514_V 1.595 1.00
59_D 88_T 1.594 1.00
382_W 407_P 1.594 1.00
380_T 384_L 1.59 1.00
461_A 513_H 1.583 1.00
232_A 336_S 1.578 1.00
82_A 98_V 1.574 1.00
458_L 513_H 1.573 1.00
132_V 138_I 1.569 1.00
431_L 461_A 1.568 1.00
471_V 528_L 1.564 1.00
46_V 435_M 1.558 1.00
523_E 526_S 1.555 1.00
505_V 517_Q 1.543 1.00
471_V 543_V 1.536 1.00
311_S 316_A 1.532 1.00
524_L 545_V 1.529 1.00
228_E 332_L 1.528 1.00
142_L 159_V 1.519 1.00
514_V 541_V 1.518 1.00
434_K 466_L 1.513 1.00
386_K 389_A 1.502 1.00
206_A 209_P 1.502 1.00
229_T 233_L 1.501 1.00
24_G 45_H 1.478 1.00
526_S 530_E 1.477 1.00
526_S 529_S 1.469 1.00
443_V 532_L 1.462 1.00
230_V 247_F 1.459 1.00
198_R 201_Q 1.458 1.00
20_K 44_D 1.456 1.00
255_L 269_T 1.442 1.00
519_S 546_T 1.432 1.00
140_Q 144_K 1.428 1.00
206_A 275_V 1.427 1.00
423_M 453_M 1.425 1.00
441_T 532_L 1.424 1.00
10_V 161_L 1.423 1.00
23_F 61_L 1.419 1.00
60_G 64_A 1.418 1.00
376_A 380_T 1.415 1.00
53_A 457_E 1.414 1.00
130_F 159_V 1.414 1.00
193_K 330_Q 1.403 0.99
21_Q 435_M 1.399 0.99
17_Q 143_K 1.396 0.99
127_K 155_G 1.386 0.99
210_V 273_A 1.383 0.99
48_V 57_M 1.383 0.99
377_V 545_V 1.382 0.99
471_V 545_V 1.38 0.99
376_A 521_P 1.375 0.99
44_D 464_Y 1.375 0.99
73_V 98_V 1.373 0.99
413_R 440_E 1.37 0.99
137_D 140_Q 1.365 0.99
384_L 525_E 1.364 0.99
272_N 353_Q 1.36 0.99
196_I 334_L 1.357 0.99
385_T 443_V 1.357 0.99
13_S 143_K 1.352 0.99
55_V 82_A 1.348 0.99
275_V 301_L 1.341 0.99
461_A 468_V 1.341 0.99
191_G 327_V 1.336 0.99
5_S 8_E 1.333 0.99
390_Y 437_L 1.324 0.99
105_T 164_D 1.324 0.99
455_I 507_L 1.323 0.99
217_A 226_L 1.32 0.99
213_V 217_A 1.314 0.99
135_T 168_P 1.307 0.99
372_I 377_V 1.301 0.99
17_Q 146_F 1.292 0.99
79_A 100_S 1.288 0.99
15_I 40_V 1.287 0.99
513_H 542_F 1.283 0.99
469_L 531_A 1.275 0.99
211_V 229_T 1.274 0.99
244_L 249_A 1.265 0.99
508_A 515_G 1.262 0.99
516_I 543_V 1.259 0.99
4_L 12_R 1.259 0.99
228_E 336_S 1.256 0.99
97_V 149_A 1.253 0.99
90_Y 156_P 1.246 0.98
372_I 545_V 1.245 0.98
527_K 543_V 1.241 0.98
200_L 204_V 1.239 0.98
239_C 254_A 1.238 0.98
389_A 441_T 1.231 0.98
199_A 320_I 1.23 0.98
9_M 170_N 1.224 0.98
386_K 441_T 1.215 0.98
71_V 82_A 1.214 0.98
231_E 253_Q 1.213 0.98
229_T 332_L 1.213 0.98
46_V 464_Y 1.211 0.98
376_A 524_L 1.211 0.98
30_V 33_I 1.202 0.98
8_E 12_R 1.201 0.98
68_V 146_F 1.2 0.98
518_I 523_E 1.199 0.98
279_V 328_L 1.197 0.98
209_P 274_D 1.197 0.98
451_I 542_F 1.196 0.98
524_L 528_L 1.195 0.98
326_Q 329_E 1.193 0.98
162_P 165_I 1.184 0.98
228_E 329_E 1.184 0.98
53_A 454_N 1.184 0.98
7_A 36_A 1.18 0.98
320_I 327_V 1.176 0.98
228_E 231_E 1.174 0.98
230_V 253_Q 1.174 0.98
435_M 466_L 1.174 0.98
13_S 142_L 1.173 0.98
458_L 542_F 1.173 0.98
515_G 542_F 1.162 0.97
83_I 121_I 1.16 0.97
444_C 470_V 1.16 0.97
211_V 226_L 1.155 0.97
561_G 565_E 1.153 0.97
325_R 329_E 1.153 0.97
226_L 328_L 1.152 0.97
352_Q 355_E 1.15 0.97
247_F 251_H 1.15 0.97
87_A 420_L 1.148 0.97
467_P 539_R 1.143 0.97
348_R 352_Q 1.139 0.97
15_I 41_G 1.119 0.96
459_S 463_Q 1.118 0.96
126_V 129_S 1.116 0.96
55_V 71_V 1.115 0.96
195_Q 198_R 1.114 0.96
210_V 276_I 1.111 0.96
9_M 139_P 1.106 0.96
19_V 70_V 1.105 0.96
449_G 478_L 1.105 0.96
227_K 251_H 1.105 0.96
392_T 442_V 1.102 0.96
130_F 141_V 1.1 0.96
83_I 125_V 1.1 0.96
508_A 513_H 1.097 0.96
208_K 272_N 1.097 0.96
86_I 125_V 1.097 0.96
225_Q 228_E 1.096 0.96
288_T 291_L 1.094 0.96
514_V 537_N 1.089 0.96
148_L 157_V 1.087 0.96
211_V 279_V 1.085 0.96
356_Q 360_R 1.083 0.96
531_A 541_V 1.082 0.96
225_Q 328_L 1.079 0.95
225_Q 332_L 1.075 0.95
268_M 272_N 1.072 0.95
227_K 248_P 1.072 0.95
5_S 169_A 1.07 0.95
508_A 542_F 1.066 0.95
206_A 274_D 1.064 0.95
505_V 544_D 1.062 0.95
61_L 436_A 1.06 0.95
426_G 444_C 1.056 0.95
455_I 511_Y 1.052 0.95
55_V 96_L 1.047 0.94
248_P 251_H 1.047 0.94
390_Y 442_V 1.046 0.94
505_V 509_E 1.042 0.94
392_T 444_C 1.038 0.94
130_F 144_K 1.032 0.94
128_H 141_V 1.031 0.94
434_K 438_P 1.03 0.94
205_A 275_V 1.028 0.94
199_A 318_I 1.028 0.94
518_I 524_L 1.027 0.94
523_E 527_K 1.022 0.93
61_L 67_E 1.022 0.93
64_A 433_V 1.02 0.93
434_K 442_V 1.019 0.93
57_M 461_A 1.018 0.93
62_A 95_P 1.014 0.93
316_A 319_P 1.013 0.93
355_E 358_R 1.008 0.93
378_I 406_Y 1.006 0.93
198_R 202_T 1.006 0.93
6_G 138_I 1.005 0.93
97_V 150_A 1.003 0.93
303_I 320_I 1.001 0.92
434_K 439_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ybhA10.98611000.14Contact Map0.817
2panA60.98781000.15Contact Map0.733
1t9bA20.97911000.151Contact Map0.836
2ihtA40.94951000.152Contact Map0.805
1ozhA40.96861000.152Contact Map0.798
2uz1A20.96521000.154Contact Map0.744
2pgnA20.96341000.167Contact Map0.777
1q6zA10.91461000.174Contact Map0.793
3eyaA120.94951000.178Contact Map0.791
1v5eA10.96691000.187Contact Map0.789
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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