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OPENSEQ.org

USPA - Universal stress protein A
UniProt: P0AED0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11390
Length: 144 (139)
Sequences: 6454
Seq/Len: 46.43

USPA
Paralog alert: 0.77 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: USPA USPC USPD USPF USPG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_K 83_E 2.651 1.00
5_H 35_S 2.628 1.00
5_H 33_K 2.561 1.00
124_R 128_N 2.431 1.00
92_G 125_Q 2.419 1.00
9_A 109_C 2.391 1.00
106_L 135_L 2.387 1.00
35_S 85_L 2.266 1.00
7_L 104_M 2.261 1.00
99_I 107_V 2.077 1.00
98_A 102_Y 2.046 1.00
109_C 126_L 2.043 1.00
89_G 94_V 1.922 1.00
111_H 138_P 1.912 1.00
85_L 98_A 1.849 1.00
22_K 135_L 1.846 1.00
35_S 102_Y 1.83 1.00
107_V 130_V 1.692 1.00
35_S 104_M 1.689 1.00
100_K 131_H 1.687 1.00
94_V 97_D 1.683 1.00
127_I 136_I 1.683 1.00
8_I 23_A 1.672 1.00
111_H 136_I 1.662 1.00
3_Y 22_K 1.648 1.00
87_G 94_V 1.647 1.00
67_H 71_T 1.624 1.00
21_E 76_N 1.563 1.00
35_S 98_A 1.543 1.00
74_S 84_T 1.502 1.00
38_H 66_T 1.496 1.00
9_A 95_L 1.467 1.00
23_A 27_A 1.451 1.00
39_V 94_V 1.4 0.99
33_K 81_I 1.361 0.99
107_V 132_V 1.342 0.99
35_S 83_E 1.316 0.99
26_M 30_Y 1.309 0.99
37_I 98_A 1.308 0.99
20_V 73_L 1.299 0.99
96_V 129_T 1.297 0.99
96_V 126_L 1.295 0.99
63_S 67_H 1.28 0.99
37_I 95_L 1.279 0.99
130_V 134_M 1.276 0.99
17_K 76_N 1.267 0.99
22_K 25_S 1.252 0.99
125_Q 129_T 1.249 0.99
22_K 133_D 1.233 0.98
74_S 78_G 1.221 0.98
25_S 29_P 1.21 0.98
8_I 20_V 1.207 0.98
3_Y 133_D 1.203 0.98
91_L 122_S 1.202 0.98
13_S 113_Q 1.202 0.98
123_A 136_I 1.193 0.98
96_V 99_I 1.18 0.98
13_S 16_S 1.176 0.98
6_I 106_L 1.168 0.97
87_G 98_A 1.168 0.97
24_V 77_A 1.166 0.97
85_L 102_Y 1.149 0.97
99_I 131_H 1.144 0.97
107_V 126_L 1.094 0.96
97_D 101_K 1.09 0.96
5_H 104_M 1.089 0.96
16_S 19_L 1.088 0.96
95_L 126_L 1.077 0.95
23_A 34_V 1.075 0.95
59_Q 63_S 1.058 0.95
99_I 104_M 1.033 0.94
26_M 108_V 1.03 0.94
69_A 73_L 1.02 0.93
5_H 105_D 1.004 0.93
27_A 32_A 1.004 0.93
10_V 73_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tnjA10.979299.90.138Contact Map0.77
2dumA4199.90.149Contact Map0.792
1mjhA20.986199.90.157Contact Map0.892
3s3tA80.951499.90.16Contact Map0.724
1jmvA40.972299.90.165Contact Map0.791
3olqA1199.90.166Contact Map0.772
3fg9A60.937599.90.177Contact Map0.708
2gm3A6199.90.18Contact Map0.824
3hgmA40.937599.90.191Contact Map0.891
1tq8A60.993199.90.192Contact Map0.721

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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