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OPENSEQ.org

USPD - Universal stress protein D
UniProt: P0AAB8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11877
Length: 142 (139)
Sequences: 6493
Seq/Len: 46.71

USPD
Paralog alert: 0.77 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: USPA USPC USPD USPF USPG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_H 83_K 2.724 1.00
5_H 35_T 2.616 1.00
5_H 33_H 2.576 1.00
92_P 125_G 2.443 1.00
124_R 128_N 2.418 1.00
106_L 135_L 2.404 1.00
9_A 109_C 2.376 1.00
35_T 85_R 2.257 1.00
7_G 104_C 2.253 1.00
99_M 107_L 2.084 1.00
98_I 102_E 2.045 1.00
109_C 126_M 2.038 1.00
111_H 138_P 1.923 1.00
89_G 94_T 1.909 1.00
85_R 98_I 1.881 1.00
22_K 135_L 1.848 1.00
35_T 102_E 1.844 1.00
35_T 104_C 1.7 1.00
107_L 130_M 1.69 1.00
8_V 23_A 1.678 1.00
111_H 136_I 1.667 1.00
100_Q 131_S 1.663 1.00
94_T 97_E 1.659 1.00
87_E 94_T 1.654 1.00
67_D 71_Y 1.646 1.00
127_I 136_I 1.646 1.00
3_Y 22_K 1.627 1.00
21_N 76_N 1.612 1.00
35_T 98_I 1.546 1.00
74_T 84_L 1.493 1.00
38_H 66_S 1.489 1.00
9_A 95_L 1.464 1.00
23_A 27_A 1.452 1.00
33_H 81_K 1.388 0.99
39_I 94_T 1.38 0.99
35_T 83_K 1.33 0.99
26_L 30_N 1.32 0.99
107_L 132_A 1.317 0.99
96_L 129_K 1.314 0.99
17_A 76_N 1.304 0.99
37_I 98_I 1.297 0.99
130_M 134_L 1.284 0.99
63_K 67_D 1.273 0.99
20_V 73_L 1.269 0.99
74_T 78_Q 1.267 0.99
96_L 126_M 1.267 0.99
37_I 95_L 1.266 0.99
22_K 25_E 1.249 0.99
125_G 129_K 1.234 0.98
8_V 20_V 1.229 0.98
91_M 122_A 1.211 0.98
22_K 133_D 1.199 0.98
99_M 131_S 1.191 0.98
3_Y 133_D 1.191 0.98
87_E 98_I 1.191 0.98
13_N 16_D 1.185 0.98
13_N 113_H 1.171 0.98
25_E 29_H 1.17 0.97
123_Y 136_I 1.169 0.97
6_I 106_L 1.165 0.97
85_R 102_E 1.165 0.97
96_L 99_M 1.163 0.97
24_L 77_I 1.162 0.97
5_H 104_C 1.116 0.96
16_D 19_L 1.114 0.96
23_A 34_L 1.109 0.96
107_L 126_M 1.09 0.96
97_E 101_K 1.086 0.96
95_L 126_M 1.07 0.95
69_K 73_L 1.051 0.94
5_H 105_D 1.038 0.94
99_M 104_C 1.036 0.94
26_L 108_V 1.032 0.94
59_L 63_K 1.025 0.93
27_A 32_A 1.018 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tnjA10.99399.90.13Contact Map0.765
1jmvA40.985999.90.14Contact Map0.784
2dumA4199.90.145Contact Map0.797
3s3tA80.964899.90.156Contact Map0.722
3olqA1199.90.156Contact Map0.776
1mjhA2199.90.16Contact Map0.891
2gm3A6199.90.174Contact Map0.821
3fg9A60.950799.90.178Contact Map0.705
1tq8A60.99399.90.185Contact Map0.72
3hgmA40.957799.90.185Contact Map0.891

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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