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OPENSEQ.org

MENB - 1,4-Dihydroxy-2-naphthoyl-CoA synthase
UniProt: P0ABU0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11368
Length: 285 (259)
Sequences: 11411
Seq/Len: 44.06

MENB
Paralog alert: 0.65 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: CAID MENB PAAF PAAG SCPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
203_T 213_E 3.32 1.00
148_D 206_P 3.216 1.00
151_I 189_Q 3.091 1.00
213_E 216_R 3.077 1.00
146_A 201_V 2.886 1.00
36_K 215_V 2.675 1.00
64_R 119_P 2.66 1.00
188_R 220_E 2.651 1.00
149_N 207_L 2.639 1.00
124_A 141_C 2.443 1.00
26_R 40_N 2.396 1.00
191_D 194_Q 2.389 1.00
194_Q 197_D 2.318 1.00
158_K 224_N 2.299 1.00
268_N 272_Q 2.226 1.00
179_K 198_M 2.203 1.00
125_M 214_T 2.156 1.00
182_E 188_R 2.146 1.00
45_R 80_K 2.09 1.00
209_D 212_K 2.077 1.00
148_D 193_K 2.048 1.00
61_A 114_Q 1.991 1.00
125_M 211_E 1.981 1.00
45_R 81_A 1.938 1.00
145_I 205_V 1.928 1.00
184_W 232_L 1.921 1.00
75_T 127_A 1.895 1.00
35_A 63_A 1.877 1.00
182_E 202_N 1.872 1.00
131_I 153_G 1.842 1.00
182_E 203_T 1.83 1.00
193_K 197_D 1.804 1.00
38_T 77_A 1.796 1.00
194_Q 198_M 1.792 1.00
72_I 118_C 1.791 1.00
148_D 207_L 1.79 1.00
29_K 66_D 1.782 1.00
51_L 55_E 1.778 1.00
40_N 77_A 1.748 1.00
33_G 70_G 1.746 1.00
265_E 274_R 1.735 1.00
145_I 217_W 1.726 1.00
181_R 237_N 1.721 1.00
29_K 35_A 1.71 1.00
177_Q 181_R 1.687 1.00
36_K 75_T 1.679 1.00
181_R 236_L 1.675 1.00
138_H 144_T 1.674 1.00
188_R 194_Q 1.65 1.00
181_R 185_F 1.622 1.00
63_A 72_I 1.603 1.00
27_Y 35_A 1.599 1.00
31_T 219_R 1.588 1.00
146_A 152_F 1.573 1.00
144_T 178_K 1.552 1.00
209_D 213_E 1.551 1.00
215_V 219_R 1.53 1.00
142_D 233_K 1.53 1.00
39_I 52_T 1.511 1.00
35_A 69_I 1.51 1.00
157_P 187_C 1.485 1.00
38_T 75_T 1.48 1.00
57_I 114_Q 1.475 1.00
261_E 279_S 1.474 1.00
147_A 207_L 1.462 1.00
196_L 204_V 1.436 1.00
62_D 66_D 1.433 1.00
37_I 59_A 1.424 1.00
27_Y 63_A 1.409 1.00
44_V 89_K 1.398 0.99
115_I 122_V 1.389 0.99
49_R 52_T 1.388 0.99
127_A 149_N 1.361 0.99
205_V 213_E 1.354 0.99
127_A 147_A 1.347 0.99
135_H 154_Q 1.342 0.99
234_A 238_A 1.323 0.99
210_L 214_T 1.321 0.99
144_T 174_I 1.319 0.99
192_A 204_V 1.317 0.99
183_I 190_Y 1.312 0.99
218_C 222_L 1.282 0.99
73_I 214_T 1.273 0.99
60_L 118_C 1.269 0.99
147_A 210_L 1.263 0.99
178_K 202_N 1.253 0.99
30_S 215_V 1.247 0.99
211_E 215_V 1.246 0.98
153_G 189_Q 1.245 0.98
30_S 36_K 1.243 0.98
179_K 182_E 1.237 0.98
211_E 214_T 1.235 0.98
71_V 218_C 1.22 0.98
126_V 130_S 1.213 0.98
129_Y 151_I 1.207 0.98
36_K 211_E 1.201 0.98
221_M 229_L 1.2 0.98
30_S 219_R 1.195 0.98
41_R 44_V 1.189 0.98
64_R 114_Q 1.183 0.98
75_T 211_E 1.183 0.98
224_N 229_L 1.177 0.98
126_V 152_F 1.173 0.98
179_K 194_Q 1.161 0.97
41_R 87_D 1.156 0.97
55_E 59_A 1.151 0.97
176_G 179_K 1.148 0.97
89_K 271_N 1.143 0.97
242_G 245_G 1.139 0.97
190_Y 198_M 1.133 0.97
39_I 83_C 1.117 0.96
143_L 217_W 1.114 0.96
26_R 77_A 1.094 0.96
57_I 61_A 1.09 0.96
206_P 209_D 1.089 0.96
193_K 196_L 1.081 0.95
116_R 170_Y 1.073 0.95
72_I 120_K 1.072 0.95
50_P 90_V 1.067 0.95
83_C 134_G 1.048 0.94
113_R 117_T 1.042 0.94
29_K 62_D 1.041 0.94
28_E 38_T 1.038 0.94
67_D 120_K 1.037 0.94
264_Q 268_N 1.028 0.94
64_R 118_C 1.026 0.94
127_A 210_L 1.012 0.93
227_M 262_E 1.01 0.93
214_T 218_C 1.009 0.93
171_M 175_V 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i42A120.99651000.102Contact Map0.866
4jcsA10.94391000.168Contact Map0.622
4lk5A30.97891000.175Contact Map0.704
2uzfA20.95791000.176Contact Map0.749
4jfcA10.92281000.177Contact Map0.701
4jwvA20.91931000.177Contact Map0.677
1nzyA20.92281000.178Contact Map0.723
3qxzA30.91581000.178Contact Map0.757
4fzwC20.95091000.178Contact Map0.659
3t8bA20.99651000.178Contact Map0.735

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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