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OPENSEQ.org
GARR - 2-hydroxy-3-oxopropionate reductase
UniProt: P0ABQ2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11176
Length: 294 (286)
Sequences: 4643
Seq/Len: 16.23
GARR
Paralog alert: 0.77 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GARR GLXR YGBJ YIHU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
140_K 144_D 3.932 1.00
147_Y 151_K 3.518 1.00
71_K 103_E 3.517 1.00
27_V 47_A 2.809 1.00
48_S 52_A 2.719 1.00
114_D 145_K 2.715 1.00
4_G 53_I 2.601 1.00
2_K 25_S 2.575 1.00
37_A 41_A 2.548 1.00
114_D 142_I 2.48 1.00
144_D 147_Y 2.39 1.00
40_I 46_T 2.386 1.00
17_K 42_A 2.375 1.00
89_V 146_Y 2.338 1.00
20_L 44_A 2.293 1.00
36_I 46_T 2.163 1.00
234_D 274_T 2.144 1.00
108_L 113_I 2.12 1.00
81_I 108_L 2.025 1.00
140_K 159_H 1.942 1.00
106_E 110_A 1.941 1.00
107_A 110_A 1.926 1.00
192_T 285_E 1.906 1.00
62_T 90_L 1.876 1.00
63_M 93_M 1.846 1.00
116_L 138_G 1.815 1.00
49_T 52_A 1.814 1.00
34_E 37_A 1.813 1.00
51_K 55_E 1.767 1.00
28_V 44_A 1.749 1.00
134_V 153_M 1.744 1.00
99_L 249_G 1.741 1.00
211_G 216_D 1.734 1.00
197_N 200_L 1.733 1.00
58_D 85_K 1.722 1.00
246_T 249_G 1.698 1.00
116_L 143_F 1.695 1.00
109_K 139_D 1.694 1.00
89_V 142_I 1.682 1.00
25_S 45_E 1.676 1.00
143_F 147_Y 1.673 1.00
18_N 21_K 1.646 1.00
114_D 139_D 1.623 1.00
32_N 35_A 1.619 1.00
199_D 203_Q 1.605 1.00
53_I 57_C 1.59 1.00
13_K 38_D 1.588 1.00
171_L 242_N 1.586 1.00
54_A 83_G 1.575 1.00
74_A 90_L 1.574 1.00
191_A 201_V 1.554 1.00
61_I 93_M 1.547 1.00
272_L 275_A 1.546 1.00
234_D 273_G 1.542 1.00
24_Y 152_A 1.536 1.00
234_D 268_R 1.532 1.00
91_I 146_Y 1.529 1.00
84_A 88_T 1.529 1.00
139_D 142_I 1.509 1.00
85_K 88_T 1.509 1.00
63_M 120_V 1.499 1.00
22_A 152_A 1.497 1.00
4_G 57_C 1.49 1.00
105_S 163_I 1.488 1.00
258_A 262_E 1.485 1.00
134_V 154_A 1.453 1.00
18_N 130_G 1.448 1.00
33_P 37_A 1.442 1.00
116_L 136_V 1.422 1.00
37_A 40_I 1.41 1.00
105_S 109_K 1.402 0.99
103_E 107_A 1.35 0.99
50_A 83_G 1.34 0.99
89_V 145_K 1.334 0.99
27_V 56_Q 1.331 0.99
66_N 69_H 1.331 0.99
146_Y 150_M 1.324 0.99
30_D 35_A 1.322 0.99
179_L 183_A 1.32 0.99
233_I 267_L 1.32 0.99
206_R 216_D 1.316 0.99
51_K 83_G 1.316 0.99
75_L 107_A 1.306 0.99
194_A 250_V 1.295 0.99
116_L 146_Y 1.294 0.99
160_T 169_T 1.275 0.99
5_F 15_M 1.271 0.99
82_E 111_K 1.267 0.99
248_H 258_A 1.26 0.99
143_F 159_H 1.256 0.99
21_K 42_A 1.242 0.98
27_V 45_E 1.229 0.98
247_S 254_L 1.229 0.98
52_A 55_E 1.218 0.98
162_E 165_A 1.215 0.98
68_P 72_E 1.191 0.98
76_G 79_G 1.19 0.98
6_I 50_A 1.188 0.98
33_P 48_S 1.187 0.98
101_S 115_M 1.181 0.98
220_P 224_D 1.18 0.98
118_A 134_V 1.175 0.98
261_M 265_Q 1.163 0.97
20_L 43_G 1.159 0.97
108_L 115_M 1.158 0.97
253_Q 258_A 1.152 0.97
16_S 26_L 1.151 0.97
56_Q 85_K 1.151 0.97
93_M 134_V 1.149 0.97
117_D 164_G 1.149 0.97
61_I 91_I 1.147 0.97
124_E 128_I 1.141 0.97
14_P 128_I 1.139 0.97
106_E 109_K 1.139 0.97
84_A 113_I 1.136 0.97
178_A 240_L 1.131 0.97
5_F 16_S 1.131 0.97
259_A 262_E 1.129 0.97
178_A 236_H 1.124 0.97
67_S 100_A 1.123 0.97
84_A 90_L 1.123 0.97
121_S 135_M 1.105 0.96
127_A 132_L 1.099 0.96
67_S 97_A 1.097 0.96
93_M 153_M 1.091 0.96
275_A 282_C 1.089 0.96
131_T 155_G 1.085 0.96
5_F 61_I 1.085 0.96
38_D 41_A 1.077 0.95
188_L 202_Y 1.075 0.95
61_I 149_L 1.075 0.95
59_V 89_V 1.073 0.95
136_V 143_F 1.07 0.95
237_I 268_R 1.065 0.95
2_K 27_V 1.065 0.95
59_V 149_L 1.058 0.95
88_T 113_I 1.057 0.95
31_R 35_A 1.054 0.95
101_S 167_N 1.053 0.95
268_R 273_G 1.053 0.95
97_A 100_A 1.044 0.94
15_M 153_M 1.043 0.94
142_I 146_Y 1.038 0.94
139_D 162_E 1.038 0.94
137_G 166_G 1.037 0.94
18_N 153_M 1.03 0.94
206_R 215_L 1.024 0.93
179_L 256_L 1.022 0.93
47_A 52_A 1.017 0.93
121_S 173_N 1.014 0.93
28_V 36_I 1.014 0.93
123_G 126_K 1.01 0.93
189_T 193_K 1.007 0.93
202_Y 219_A 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ckyA411000.351Contact Map0.801
3pefA80.97281000.352Contact Map0.823
1vpdA111000.354Contact Map0.762
3pduA80.97281000.361Contact Map0.754
3dojA10.9831000.363Contact Map0.802
1yb4A20.99321000.37Contact Map0.781
2h78A10.99321000.371Contact Map0.729
2uyyA40.97281000.372Contact Map0.805
4dllA20.9831000.372Contact Map0.757
2gf2A40.9831000.374Contact Map0.762
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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