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OPENSEQ.org
YGBJ - Uncharacterized oxidoreductase YgbJ
UniProt: Q46888 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13104
Length: 302 (287)
Sequences: 4719
Seq/Len: 16.44
YGBJ
Paralog alert: 0.77 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: GARR GLXR YGBJ YIHU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
147_D 151_E 3.96 1.00
154_A 158_E 3.535 1.00
78_K 110_E 3.485 1.00
33_W 54_S 2.823 1.00
121_E 152_R 2.72 1.00
55_D 59_T 2.714 1.00
10_G 60_F 2.691 1.00
8_H 31_S 2.686 1.00
43_A 47_E 2.596 1.00
121_E 149_A 2.489 1.00
23_L 48_A 2.375 1.00
151_E 154_A 2.363 1.00
96_A 153_L 2.329 1.00
46_K 52_G 2.302 1.00
26_V 50_A 2.234 1.00
115_L 120_L 2.133 1.00
242_D 282_K 2.097 1.00
88_A 115_L 1.95 1.00
113_T 117_G 1.944 1.00
42_C 52_G 1.92 1.00
69_V 97_V 1.904 1.00
114_A 117_G 1.903 1.00
200_A 293_S 1.9 1.00
147_D 166_R 1.894 1.00
82_F 114_A 1.848 1.00
70_L 100_S 1.833 1.00
123_L 145_G 1.813 1.00
40_N 43_A 1.802 1.00
56_N 59_T 1.79 1.00
58_A 62_E 1.781 1.00
106_A 257_A 1.767 1.00
205_P 208_V 1.75 1.00
141_V 160_V 1.741 1.00
34_G 50_A 1.719 1.00
254_T 257_A 1.71 1.00
219_N 224_E 1.708 1.00
123_L 150_F 1.694 1.00
116_A 146_S 1.687 1.00
65_D 92_K 1.685 1.00
31_S 51_C 1.685 1.00
24_S 27_R 1.68 1.00
207_D 211_D 1.655 1.00
150_F 154_A 1.646 1.00
179_I 250_L 1.638 1.00
96_A 149_A 1.633 1.00
38_N 41_A 1.627 1.00
60_F 64_L 1.597 1.00
81_L 97_V 1.571 1.00
10_G 64_L 1.567 1.00
19_M 44_T 1.563 1.00
121_E 146_S 1.562 1.00
199_A 209_M 1.556 1.00
61_A 90_H 1.541 1.00
43_A 46_K 1.514 1.00
68_L 100_S 1.512 1.00
280_Y 283_E 1.509 1.00
70_L 127_V 1.497 1.00
39_S 43_A 1.495 1.00
98_M 153_L 1.483 1.00
242_D 281_G 1.477 1.00
91_L 95_T 1.475 1.00
146_S 149_A 1.474 1.00
30_L 159_A 1.474 1.00
242_D 276_S 1.471 1.00
123_L 143_A 1.467 1.00
28_A 159_A 1.453 1.00
266_S 270_N 1.448 1.00
24_S 137_G 1.444 1.00
112_A 116_A 1.438 1.00
141_V 161_A 1.427 1.00
92_K 95_T 1.414 1.00
214_T 224_E 1.377 0.99
36_D 41_A 1.353 0.99
241_V 275_A 1.349 0.99
57_A 90_H 1.347 0.99
112_A 171_P 1.347 0.99
187_V 191_A 1.344 0.99
110_E 114_A 1.338 0.99
228_R 232_D 1.33 0.99
73_N 76_Q 1.315 0.99
96_A 152_R 1.301 0.99
33_W 63_K 1.285 0.99
202_A 258_L 1.282 0.99
27_R 48_A 1.273 0.99
123_L 153_L 1.271 0.99
167_I 177_V 1.266 0.99
59_T 62_E 1.264 0.99
153_L 157_L 1.263 0.99
11_I 21_A 1.259 0.99
150_F 166_R 1.244 0.98
33_W 51_C 1.244 0.98
58_A 90_H 1.239 0.98
89_Q 118_F 1.234 0.98
256_K 266_S 1.227 0.98
255_A 262_L 1.212 0.98
83_G 86_G 1.211 0.98
113_T 116_A 1.206 0.98
269_L 273_T 1.205 0.98
91_L 120_L 1.19 0.98
100_S 141_V 1.178 0.98
125_A 141_V 1.172 0.98
131_A 135_A 1.172 0.98
11_I 22_A 1.171 0.98
124_D 172_G 1.169 0.97
63_K 92_K 1.168 0.97
68_L 98_M 1.165 0.97
20_G 135_A 1.162 0.97
39_S 55_D 1.158 0.97
26_V 49_G 1.157 0.97
108_A 122_M 1.151 0.97
75_A 79_Q 1.126 0.97
100_S 160_V 1.125 0.97
115_L 122_M 1.119 0.96
186_G 248_L 1.115 0.96
11_I 68_L 1.115 0.96
128_S 142_M 1.114 0.96
267_T 270_N 1.11 0.96
95_T 120_L 1.104 0.96
186_G 244_F 1.103 0.96
134_A 139_M 1.102 0.96
74_A 107_D 1.098 0.96
12_V 57_A 1.098 0.96
22_A 32_T 1.091 0.96
74_A 104_A 1.089 0.96
68_L 156_V 1.086 0.96
45_L 50_A 1.085 0.96
8_H 33_W 1.078 0.95
196_M 210_Y 1.073 0.95
91_L 97_V 1.07 0.95
66_A 96_A 1.063 0.95
239_S 243_I 1.06 0.95
143_A 150_F 1.059 0.95
283_E 290_K 1.057 0.95
261_P 266_S 1.049 0.94
37_L 41_A 1.048 0.94
138_E 162_G 1.045 0.94
44_T 47_E 1.043 0.94
108_A 175_S 1.037 0.94
187_V 264_L 1.037 0.94
24_S 160_V 1.036 0.94
21_A 160_V 1.031 0.94
109_Q 176_T 1.022 0.93
245_V 276_S 1.021 0.93
66_A 156_V 1.02 0.93
197_A 201_R 1.019 0.93
128_S 181_H 1.019 0.93
276_S 281_G 1.017 0.93
169_A 173_L 1.009 0.93
59_T 63_K 1.009 0.93
144_S 174_G 1.007 0.93
104_A 107_D 1.006 0.93
34_G 42_C 1.004 0.93
180_I 199_A 1.004 0.93
54_S 59_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pefA80.95031000.352Contact Map0.823
3ckyA40.98681000.356Contact Map0.799
3pduA80.95031000.357Contact Map0.757
3dojA10.97681000.36Contact Map0.793
1vpdA10.98341000.363Contact Map0.763
2h78A10.97681000.364Contact Map0.729
2uyyA40.96691000.368Contact Map0.809
4dllA20.97681000.372Contact Map0.75
3zgyA40.97351000.373Contact Map0.654
2gf2A40.9571000.374Contact Map0.765
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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