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OPENSEQ.org
YIHU - Uncharacterized oxidoreductase YihU
UniProt: P0A9V8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11847
Length: 298 (289)
Sequences: 4458
Seq/Len: 15.43
YIHU
Paralog alert: 0.70 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GARR GLXR YGBJ YIHU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
141_A 145_E 3.895 1.00
72_R 104_K 3.551 1.00
148_T 152_M 3.426 1.00
5_A 54_A 2.79 1.00
38_R 42_D 2.753 1.00
28_R 48_A 2.712 1.00
115_S 146_R 2.689 1.00
49_A 53_Q 2.677 1.00
115_S 143_Q 2.526 1.00
145_E 148_T 2.422 1.00
90_L 147_A 2.418 1.00
41_V 47_P 2.417 1.00
18_S 43_K 2.392 1.00
21_L 45_A 2.289 1.00
109_M 114_F 2.25 1.00
236_D 276_R 2.195 1.00
3_A 26_Q 2.067 1.00
37_V 47_P 2.058 1.00
82_C 109_M 1.965 1.00
63_T 91_V 1.943 1.00
108_D 111_A 1.917 1.00
107_A 111_A 1.879 1.00
64_M 94_M 1.873 1.00
29_V 45_A 1.861 1.00
117_M 139_G 1.855 1.00
135_L 154_M 1.837 1.00
35_E 38_R 1.831 1.00
141_A 160_N 1.805 1.00
100_L 251_Q 1.804 1.00
144_V 148_T 1.786 1.00
19_N 22_Q 1.753 1.00
50_N 53_Q 1.749 1.00
117_M 144_V 1.748 1.00
110_Q 140_T 1.71 1.00
172_L 244_I 1.709 1.00
26_Q 46_T 1.694 1.00
14_S 39_H 1.682 1.00
52_A 56_K 1.681 1.00
54_A 58_A 1.672 1.00
5_A 58_A 1.656 1.00
193_E 287_R 1.649 1.00
59_E 86_S 1.648 1.00
90_L 143_Q 1.644 1.00
76_F 108_D 1.642 1.00
200_D 204_K 1.623 1.00
64_M 121_V 1.62 1.00
260_A 264_E 1.591 1.00
38_R 41_V 1.57 1.00
115_S 140_T 1.563 1.00
75_L 91_V 1.56 1.00
198_P 201_V 1.559 1.00
248_V 251_Q 1.553 1.00
117_M 137_A 1.552 1.00
85_L 89_A 1.538 1.00
236_D 270_R 1.536 1.00
33_N 36_A 1.52 1.00
19_N 131_G 1.52 1.00
192_C 202_A 1.519 1.00
140_T 143_Q 1.516 1.00
92_I 147_A 1.516 1.00
23_Q 153_A 1.514 1.00
106_I 164_P 1.514 1.00
212_G 217_T 1.514 1.00
62_I 94_M 1.513 1.00
236_D 275_G 1.503 1.00
274_R 277_Q 1.501 1.00
25_H 153_A 1.491 1.00
135_L 155_G 1.491 1.00
86_S 89_A 1.477 1.00
34_A 38_R 1.47 1.00
55_A 84_G 1.425 1.00
22_Q 43_K 1.418 1.00
147_A 151_L 1.396 0.99
67_N 70_L 1.393 0.99
106_I 110_Q 1.386 0.99
28_R 57_D 1.374 0.99
180_A 184_L 1.37 0.99
31_D 36_A 1.369 0.99
235_I 269_A 1.367 0.99
195_L 252_L 1.366 0.99
77_G 80_G 1.324 0.99
144_V 160_N 1.317 0.99
7_I 51_P 1.307 0.99
6_F 16_M 1.302 0.99
28_R 46_T 1.301 0.99
161_A 170_V 1.275 0.99
250_N 260_A 1.265 0.99
90_L 146_R 1.253 0.99
163_G 166_M 1.252 0.99
53_Q 56_K 1.238 0.98
117_M 147_A 1.235 0.98
119_V 135_L 1.23 0.98
62_I 92_I 1.23 0.98
107_A 110_Q 1.23 0.98
83_E 112_K 1.228 0.98
249_A 256_M 1.225 0.98
207_S 217_T 1.223 0.98
94_M 135_L 1.215 0.98
104_K 108_D 1.207 0.98
6_F 17_A 1.205 0.98
118_D 165_G 1.204 0.98
125_S 129_I 1.195 0.98
85_L 114_F 1.194 0.98
263_R 267_S 1.194 0.98
51_P 84_G 1.189 0.98
261_A 264_E 1.176 0.98
15_P 129_I 1.175 0.98
17_A 27_L 1.168 0.97
52_A 84_G 1.161 0.97
102_T 116_M 1.159 0.97
94_M 154_M 1.153 0.97
109_M 116_M 1.152 0.97
137_A 144_V 1.147 0.97
21_L 44_G 1.144 0.97
239_H 270_R 1.144 0.97
68_G 98_H 1.143 0.97
68_G 101_Q 1.141 0.97
89_A 114_F 1.141 0.97
122_G 136_L 1.133 0.97
57_D 86_S 1.131 0.97
60_F 150_I 1.126 0.97
128_A 133_L 1.119 0.96
140_T 163_G 1.113 0.96
255_P 260_A 1.111 0.96
138_G 167_G 1.109 0.96
85_L 91_V 1.107 0.96
62_I 150_I 1.1 0.96
60_F 90_L 1.1 0.96
270_R 275_G 1.098 0.96
40_L 45_A 1.094 0.96
132_T 156_S 1.084 0.96
179_I 242_L 1.079 0.95
103_D 169_R 1.077 0.95
19_N 154_M 1.074 0.95
34_A 49_A 1.067 0.95
6_F 62_I 1.067 0.95
169_R 195_L 1.06 0.95
189_A 203_V 1.059 0.95
122_G 174_N 1.057 0.95
277_Q 284_E 1.056 0.95
102_T 168_I 1.054 0.95
179_I 238_A 1.047 0.94
233_F 237_L 1.037 0.94
173_I 192_C 1.035 0.94
98_H 101_Q 1.035 0.94
152_M 158_L 1.028 0.94
143_Q 147_A 1.024 0.93
37_V 41_V 1.019 0.93
39_H 42_D 1.014 0.93
4_I 150_I 1.007 0.93
235_I 270_R 1.007 0.93
16_M 154_M 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pefA80.96311000.355Contact Map0.838
3ckyA40.99661000.358Contact Map0.822
3pduA80.96311000.36Contact Map0.773
1vpdA10.98991000.361Contact Map0.765
3dojA10.97321000.366Contact Map0.795
2h78A10.98661000.369Contact Map0.74
4dllA20.97321000.373Contact Map0.762
2uyyA40.96311000.375Contact Map0.823
1yb4A20.98321000.377Contact Map0.792
2gf2A40.97321000.384Contact Map0.768
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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