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OPENSEQ.org
DAPA - 4-hydroxy-tetrahydrodipicolinate synthase
UniProt: P0A6L2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10205
Length: 292 (290)
Sequences: 4543
Seq/Len: 15.67
DAPA
Paralog alert: 0.62 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DAPA NANA YAGE YJHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
225_H 228_E 4.437 1.00
14_D 18_N 3.456 1.00
29_D 66_L 3.326 1.00
116_Y 150_R 3.144 1.00
93_N 127_D 2.988 1.00
21_R 58_D 2.874 1.00
77_T 89_T 2.829 1.00
258_E 283_R 2.775 1.00
25_K 66_L 2.676 1.00
21_R 62_M 2.643 1.00
220_L 228_E 2.635 1.00
194_F 199_G 2.544 1.00
25_K 62_M 2.458 1.00
29_D 70_R 2.298 1.00
228_E 231_V 2.274 1.00
89_T 100_C 2.219 1.00
57_A 91_R 2.18 1.00
220_L 225_H 2.175 1.00
112_Q 147_T 2.166 1.00
25_K 65_D 2.125 1.00
219_K 223_E 2.102 1.00
6_I 38_A 2.072 1.00
37_S 219_K 2.062 1.00
113_E 117_Q 2.062 1.00
29_D 33_A 2.053 1.00
7_V 207_A 2.034 1.00
142_D 169_R 2.016 1.00
58_D 61_M 1.995 1.00
124_E 154_V 1.99 1.00
61_M 65_D 1.968 1.00
28_I 63_T 1.918 1.00
116_Y 120_K 1.912 1.00
113_E 150_R 1.903 1.00
82_T 118_H 1.872 1.00
120_K 124_E 1.869 1.00
148_V 160_I 1.867 1.00
30_Y 34_S 1.866 1.00
120_K 154_V 1.86 1.00
195_M 221_A 1.846 1.00
131_I 159_G 1.83 1.00
20_C 23_S 1.723 1.00
231_V 235_R 1.717 1.00
123_A 154_V 1.712 1.00
58_D 62_M 1.709 1.00
64_L 73_V 1.702 1.00
131_I 203_I 1.7 1.00
215_A 219_K 1.693 1.00
55_E 268_R 1.692 1.00
149_G 176_L 1.691 1.00
34_S 212_R 1.688 1.00
53_H 84_E 1.661 1.00
283_R 287_K 1.654 1.00
280_E 283_R 1.653 1.00
23_S 26_K 1.652 1.00
144_L 147_T 1.64 1.00
213_D 235_R 1.632 1.00
86_I 121_A 1.606 1.00
117_Q 120_K 1.569 1.00
102_T 122_I 1.566 1.00
24_L 59_V 1.558 1.00
24_L 63_T 1.556 1.00
112_Q 144_L 1.552 1.00
151_L 157_I 1.501 1.00
254_W 279_R 1.488 1.00
32_V 70_R 1.486 1.00
12_P 24_L 1.465 1.00
60_V 75_A 1.464 1.00
10_V 256_C 1.461 1.00
90_Q 94_D 1.453 1.00
85_A 122_I 1.445 1.00
100_C 126_T 1.434 1.00
280_E 284_A 1.425 1.00
6_I 40_V 1.41 1.00
216_Q 220_L 1.406 0.99
89_T 126_T 1.391 0.99
93_N 126_T 1.381 0.99
117_Q 121_A 1.375 0.99
28_I 67_A 1.359 0.99
28_I 66_L 1.349 0.99
62_M 66_L 1.339 0.99
62_M 65_D 1.331 0.99
41_S 63_T 1.326 0.99
32_V 71_I 1.32 0.99
276_D 279_R 1.311 0.99
79_A 85_A 1.296 0.99
57_A 87_S 1.29 0.99
37_S 215_A 1.278 0.99
216_Q 219_K 1.263 0.99
5_S 36_T 1.257 0.99
192_L 229_A 1.25 0.99
47_E 253_K 1.249 0.99
74_I 131_I 1.239 0.98
254_W 258_E 1.222 0.98
53_H 91_R 1.219 0.98
174_K 183_L 1.217 0.98
257_K 262_V 1.217 0.98
284_A 288_H 1.216 0.98
54_D 58_D 1.202 0.98
121_A 269_L 1.195 0.98
221_A 226_F 1.194 0.98
226_F 230_R 1.191 0.98
276_D 280_E 1.191 0.98
74_I 99_G 1.188 0.98
257_K 264_T 1.175 0.98
67_A 73_V 1.173 0.98
227_A 230_R 1.158 0.97
3_T 222_A 1.153 0.97
57_A 61_M 1.151 0.97
275_T 278_G 1.147 0.97
18_N 83_A 1.144 0.97
86_I 90_Q 1.139 0.97
40_V 101_L 1.12 0.96
60_V 92_F 1.119 0.96
64_L 98_V 1.113 0.96
91_R 94_D 1.112 0.96
53_H 87_S 1.109 0.96
281_T 284_A 1.104 0.96
25_K 29_D 1.101 0.96
150_R 153_K 1.098 0.96
100_C 130_Q 1.096 0.96
81_A 84_E 1.082 0.96
57_A 94_D 1.079 0.95
172_Q 176_L 1.075 0.95
121_A 125_H 1.072 0.95
77_T 92_F 1.061 0.95
216_Q 228_E 1.058 0.95
30_Y 261_L 1.057 0.95
113_E 116_Y 1.051 0.94
42_V 59_V 1.05 0.94
53_H 88_L 1.042 0.94
104_T 143_L 1.038 0.94
254_W 283_R 1.031 0.94
23_S 263_A 1.03 0.94
93_N 128_L 1.028 0.94
7_V 36_T 1.027 0.94
170_V 194_F 1.026 0.94
21_R 25_K 1.022 0.93
27_L 256_C 1.02 0.93
77_T 100_C 1.015 0.93
132_L 148_V 1.013 0.93
212_R 216_Q 1.01 0.93
54_D 87_S 1.008 0.93
100_C 128_L 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ojpA211000.027Contact Map0.772
3si9A40.99661000.029Contact Map0.825
3qzeA40.99661000.031Contact Map0.832
3takA20.99661000.031Contact Map0.829
3fluA40.99661000.032Contact Map0.838
3a5fA20.99321000.033Contact Map0.833
2ehhA40.99321000.034Contact Map0.845
1o5kA20.99321000.034Contact Map0.798
3na8A40.99661000.036Contact Map0.791
2rfgA40.99321000.036Contact Map0.831
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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