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YJHH - Uncharacterized lyase YjhH
UniProt: P39359 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12550
Length: 301 (295)
Sequences: 4546
Seq/Len: 15.41
YJHH
Paralog alert: 0.62 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DAPA NANA YAGE YJHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
231_D 234_T 4.465 1.00
16_H 20_T 3.517 1.00
31_D 68_I 3.355 1.00
118_D 152_R 3.145 1.00
95_Q 129_T 3.033 1.00
23_K 60_A 2.895 1.00
79_V 91_A 2.886 1.00
265_C 290_H 2.749 1.00
226_A 234_T 2.713 1.00
27_R 68_I 2.71 1.00
23_K 64_E 2.641 1.00
200_T 205_G 2.585 1.00
27_R 64_E 2.49 1.00
31_D 72_R 2.366 1.00
234_T 237_T 2.284 1.00
91_A 102_I 2.247 1.00
59_M 93_H 2.21 1.00
226_A 231_D 2.185 1.00
114_P 149_T 2.162 1.00
27_R 67_T 2.14 1.00
115_R 119_D 2.108 1.00
225_R 229_E 2.093 1.00
8_I 40_G 2.077 1.00
39_D 225_R 2.068 1.00
9_P 213_A 2.065 1.00
144_D 172_H 2.031 1.00
31_D 35_N 2.021 1.00
60_A 63_E 1.98 1.00
118_D 122_Q 1.947 1.00
115_R 152_R 1.944 1.00
126_R 157_N 1.939 1.00
32_F 36_K 1.936 1.00
30_A 65_A 1.933 1.00
150_V 163_I 1.924 1.00
122_Q 126_R 1.91 1.00
84_T 120_Y 1.9 1.00
63_E 67_T 1.891 1.00
201_M 227_W 1.87 1.00
133_I 162_G 1.856 1.00
122_Q 157_N 1.854 1.00
60_A 64_E 1.774 1.00
66_V 75_V 1.756 1.00
133_I 209_I 1.739 1.00
125_A 157_N 1.728 1.00
237_T 241_K 1.718 1.00
22_D 25_A 1.716 1.00
290_H 294_T 1.706 1.00
25_A 28_E 1.702 1.00
36_K 218_E 1.7 1.00
219_L 241_K 1.699 1.00
57_Q 275_L 1.688 1.00
287_D 290_H 1.685 1.00
221_V 225_R 1.679 1.00
55_T 86_E 1.674 1.00
146_T 149_T 1.668 1.00
88_V 123_Q 1.665 1.00
104_A 124_I 1.602 1.00
26_M 61_L 1.581 1.00
26_M 65_A 1.576 1.00
119_D 122_Q 1.554 1.00
114_P 146_T 1.535 1.00
153_L 160_I 1.511 1.00
261_Y 286_K 1.51 1.00
34_I 72_R 1.495 1.00
287_D 291_V 1.477 1.00
12_S 263_M 1.473 1.00
14_T 26_M 1.454 1.00
102_I 128_V 1.449 1.00
62_A 77_I 1.441 1.00
87_A 124_I 1.431 1.00
8_I 42_F 1.425 1.00
95_Q 128_V 1.416 1.00
91_A 128_V 1.407 0.99
222_G 226_A 1.397 0.99
43_Y 65_A 1.38 0.99
177_I 189_V 1.379 0.99
92_Q 96_A 1.373 0.99
30_A 69_V 1.373 0.99
64_E 67_T 1.361 0.99
34_I 73_V 1.358 0.99
64_E 68_I 1.356 0.99
119_D 123_Q 1.355 0.99
30_A 68_I 1.331 0.99
264_Q 272_T 1.33 0.99
283_E 286_K 1.312 0.99
81_S 87_A 1.302 0.99
59_M 89_K 1.296 0.99
222_G 225_R 1.285 0.99
39_D 221_V 1.282 0.99
7_I 38_V 1.276 0.99
49_E 260_K 1.257 0.99
283_E 287_D 1.252 0.99
227_W 232_L 1.25 0.99
76_L 133_I 1.238 0.98
56_A 60_A 1.231 0.98
233_A 236_A 1.23 0.98
55_T 93_H 1.223 0.98
76_L 101_G 1.203 0.98
123_Q 276_P 1.198 0.98
198_L 235_A 1.193 0.98
69_V 75_V 1.191 0.98
261_Y 265_C 1.189 0.98
291_V 295_A 1.184 0.98
25_A 271_E 1.177 0.98
264_Q 269_P 1.171 0.98
102_I 132_V 1.165 0.97
59_M 63_E 1.161 0.97
282_S 285_A 1.16 0.97
5_S 228_R 1.159 0.97
232_L 236_A 1.159 0.97
93_H 96_A 1.151 0.97
88_V 92_Q 1.149 0.97
20_T 85_D 1.146 0.97
66_V 100_D 1.141 0.97
42_F 103_V 1.13 0.97
222_G 234_T 1.127 0.97
62_A 94_A 1.116 0.96
152_R 155_L 1.113 0.96
55_T 89_K 1.11 0.96
59_M 96_A 1.109 0.96
79_V 94_A 1.102 0.96
83_S 86_E 1.096 0.96
32_F 268_L 1.096 0.96
269_P 272_T 1.094 0.96
27_R 31_D 1.093 0.96
123_Q 127_S 1.076 0.95
151_T 179_T 1.068 0.95
288_K 291_V 1.057 0.95
95_Q 130_L 1.057 0.95
66_V 97_Y 1.054 0.95
106_N 145_L 1.05 0.94
173_L 200_T 1.047 0.94
233_A 237_T 1.045 0.94
44_L 61_L 1.045 0.94
9_P 38_V 1.04 0.94
55_T 90_L 1.039 0.94
102_I 130_L 1.036 0.94
29_V 263_M 1.036 0.94
79_V 102_I 1.035 0.94
281_A 289_V 1.034 0.94
7_I 224_Y 1.032 0.94
115_R 118_D 1.03 0.94
77_I 99_A 1.025 0.93
125_A 160_I 1.024 0.93
261_Y 290_H 1.023 0.93
134_L 150_V 1.022 0.93
218_E 222_G 1.02 0.93
119_D 279_L 1.014 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v9dA411000.042Contact Map0.765
3si9A40.98341000.044Contact Map0.824
3qzeA40.97671000.045Contact Map0.828
3fluA40.97341000.047Contact Map0.835
3na8A40.97341000.049Contact Map0.795
1xkyA40.97011000.049Contact Map0.845
2ojpA20.96681000.05Contact Map0.784
3cprA20.96681000.05Contact Map0.727
3a5fA20.96681000.053Contact Map0.84
3l21A60.97011000.053Contact Map0.792
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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