| UniProt: | Q46855 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13013 | ||
| Length: | 318 (282) | ||
| Sequences: | 5352 | ||
| Seq/Len: | 18.98 |
| YQHC
Paralog alert: 0.75 [within 20: 0.10] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 264_L | 301_F | 4.272 | 1.00 | |
| 222_K | 225_E | 4.01 | 1.00 | |
| 218_R | 222_K | 3.765 | 1.00 | |
| 276_M | 284_R | 3.499 | 1.00 | |
| 266_K | 269_M | 3.27 | 1.00 | |
| 253_T | 261_N | 2.871 | 1.00 | |
| 220_E | 262_Y | 2.853 | 1.00 | |
| 268_R | 301_F | 2.843 | 1.00 | |
| 230_E | 240_V | 2.76 | 1.00 | |
| 247_F | 258_Y | 2.612 | 1.00 | |
| 271_I | 278_A | 2.569 | 1.00 | |
| 219_I | 259_L | 2.389 | 1.00 | |
| 274_D | 309_A | 2.387 | 1.00 | |
| 267_A | 293_F | 2.369 | 1.00 | |
| 75_S | 116_A | 2.274 | 1.00 | |
| 261_N | 300_Y | 2.248 | 1.00 | |
| 264_L | 300_Y | 2.237 | 1.00 | |
| 217_K | 221_N | 2.204 | 1.00 | |
| 79_I | 88_R | 2.194 | 1.00 | |
| 270_M | 284_R | 2.188 | 1.00 | |
| 79_I | 86_V | 2.177 | 1.00 | |
| 297_F | 308_D | 2.146 | 1.00 | |
| 270_M | 276_M | 2.082 | 1.00 | |
| 218_R | 227_L | 2.058 | 1.00 | |
| 306_G | 310_A | 2.044 | 1.00 | |
| 182_I | 185_E | 1.959 | 1.00 | |
| 228_S | 231_Q | 1.931 | 1.00 | |
| 232_L | 255_P | 1.906 | 1.00 | |
| 303_V | 311_R | 1.899 | 1.00 | |
| 218_R | 235_E | 1.894 | 1.00 | |
| 77_H | 88_R | 1.837 | 1.00 | |
| 276_M | 280_A | 1.812 | 1.00 | |
| 219_I | 227_L | 1.812 | 1.00 | |
| 219_I | 262_Y | 1.771 | 1.00 | |
| 220_E | 258_Y | 1.761 | 1.00 | |
| 256_L | 260_K | 1.758 | 1.00 | |
| 229_V | 244_H | 1.746 | 1.00 | |
| 266_K | 270_M | 1.733 | 1.00 | |
| 216_L | 251_T | 1.732 | 1.00 | |
| 74_F | 118_L | 1.716 | 1.00 | |
| 243_F | 255_P | 1.701 | 1.00 | |
| 215_V | 243_F | 1.694 | 1.00 | |
| 212_I | 251_T | 1.692 | 1.00 | |
| 225_E | 231_Q | 1.684 | 1.00 | |
| 215_V | 236_A | 1.672 | 1.00 | |
| 238_M | 243_F | 1.663 | 1.00 | |
| 277_K | 280_A | 1.659 | 1.00 | |
| 274_D | 281_A | 1.65 | 1.00 | |
| 223_Y | 262_Y | 1.626 | 1.00 | |
| 230_E | 234_A | 1.623 | 1.00 | |
| 280_A | 283_M | 1.598 | 1.00 | |
| 188_Y | 192_T | 1.551 | 1.00 | |
| 270_M | 285_V | 1.547 | 1.00 | |
| 232_L | 235_E | 1.53 | 1.00 | |
| 271_I | 281_A | 1.515 | 1.00 | |
| 223_Y | 266_K | 1.512 | 1.00 | |
| 278_A | 281_A | 1.51 | 1.00 | |
| 271_I | 309_A | 1.501 | 1.00 | |
| 75_S | 91_A | 1.463 | 1.00 | |
| 168_V | 192_T | 1.461 | 1.00 | |
| 215_V | 235_E | 1.446 | 1.00 | |
| 255_P | 259_L | 1.423 | 1.00 | |
| 215_V | 232_L | 1.42 | 1.00 | |
| 290_A | 294_S | 1.416 | 1.00 | |
| 267_A | 285_V | 1.39 | 0.99 | |
| 281_A | 285_V | 1.381 | 0.99 | |
| 211_L | 236_A | 1.377 | 0.99 | |
| 67_E | 121_N | 1.358 | 0.99 | |
| 281_A | 309_A | 1.354 | 0.99 | |
| 295_R | 299_R | 1.351 | 0.99 | |
| 65_M | 69_G | 1.34 | 0.99 | |
| 265_H | 268_R | 1.339 | 0.99 | |
| 263_R | 285_V | 1.338 | 0.99 | |
| 280_A | 284_R | 1.332 | 0.99 | |
| 244_H | 254_S | 1.33 | 0.99 | |
| 292_Q | 296_E | 1.319 | 0.99 | |
| 276_M | 281_A | 1.316 | 0.99 | |
| 266_K | 285_V | 1.303 | 0.99 | |
| 253_T | 257_Q | 1.303 | 0.99 | |
| 231_Q | 235_E | 1.293 | 0.99 | |
| 240_V | 244_H | 1.291 | 0.99 | |
| 262_Y | 266_K | 1.291 | 0.99 | |
| 294_S | 304_T | 1.281 | 0.99 | |
| 77_H | 90_D | 1.281 | 0.99 | |
| 242_A | 246_N | 1.28 | 0.99 | |
| 90_D | 93_E | 1.28 | 0.99 | |
| 269_M | 273_H | 1.277 | 0.99 | |
| 238_M | 242_A | 1.275 | 0.99 | |
| 241_S | 245_H | 1.265 | 0.99 | |
| 303_V | 307_E | 1.263 | 0.99 | |
| 279_S | 283_M | 1.254 | 0.99 | |
| 229_V | 255_P | 1.247 | 0.99 | |
| 256_L | 292_Q | 1.229 | 0.98 | |
| 214_R | 235_E | 1.229 | 0.98 | |
| 294_S | 306_G | 1.221 | 0.98 | |
| 304_T | 307_E | 1.218 | 0.98 | |
| 236_A | 243_F | 1.216 | 0.98 | |
| 40_E | 56_E | 1.215 | 0.98 | |
| 268_R | 308_D | 1.212 | 0.98 | |
| 72_I | 94_Y | 1.212 | 0.98 | |
| 65_M | 103_F | 1.205 | 0.98 | |
| 264_L | 296_E | 1.205 | 0.98 | |
| 185_E | 189_Y | 1.203 | 0.98 | |
| 289_S | 292_Q | 1.199 | 0.98 | |
| 264_L | 287_Y | 1.194 | 0.98 | |
| 181_Q | 188_Y | 1.191 | 0.98 | |
| 216_L | 220_E | 1.185 | 0.98 | |
| 224_T | 266_K | 1.183 | 0.98 | |
| 218_R | 232_L | 1.163 | 0.97 | |
| 254_S | 257_Q | 1.155 | 0.97 | |
| 263_R | 286_G | 1.152 | 0.97 | |
| 211_L | 238_M | 1.151 | 0.97 | |
| 242_A | 245_H | 1.151 | 0.97 | |
| 279_S | 290_A | 1.137 | 0.97 | |
| 289_S | 295_R | 1.137 | 0.97 | |
| 71_I | 119_R | 1.132 | 0.97 | |
| 293_F | 305_P | 1.126 | 0.97 | |
| 275_G | 281_A | 1.117 | 0.96 | |
| 261_N | 265_H | 1.109 | 0.96 | |
| 231_Q | 234_A | 1.107 | 0.96 | |
| 78_K | 89_Y | 1.103 | 0.96 | |
| 248_K | 251_T | 1.099 | 0.96 | |
| 75_S | 114_P | 1.096 | 0.96 | |
| 214_R | 236_A | 1.094 | 0.96 | |
| 239_S | 242_A | 1.09 | 0.96 | |
| 81_Y | 86_V | 1.088 | 0.96 | |
| 238_M | 246_N | 1.087 | 0.96 | |
| 34_N | 37_K | 1.078 | 0.95 | |
| 73_L | 76_G | 1.078 | 0.95 | |
| 34_N | 38_N | 1.067 | 0.95 | |
| 181_Q | 184_R | 1.066 | 0.95 | |
| 69_G | 119_R | 1.063 | 0.95 | |
| 63_P | 103_F | 1.061 | 0.95 | |
| 216_L | 258_Y | 1.052 | 0.95 | |
| 68_P | 99_V | 1.019 | 0.93 | |
| 296_E | 300_Y | 1.018 | 0.93 | |
| 181_Q | 185_E | 1.011 | 0.93 | |
| 257_Q | 260_K | 1.011 | 0.93 | |
| 270_M | 281_A | 1.005 | 0.93 | |
| 272_I | 308_D | 1.001 | 0.92 | |
| 212_I | 215_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.8428 | 100 | 0.42 | Contact Map | 0.649 |
| 3w6vA | 1 | 0.4528 | 100 | 0.595 | Contact Map | 0.747 |
| 1bl0A | 1 | 0.3742 | 100 | 0.596 | Contact Map | 0.705 |
| 3oouA | 1 | 0.3396 | 100 | 0.596 | Contact Map | 0.766 |
| 3oioA | 1 | 0.3553 | 100 | 0.597 | Contact Map | 0.749 |
| 3mn2A | 2 | 0.3333 | 100 | 0.599 | Contact Map | 0.744 |
| 3mklA | 2 | 0.3585 | 100 | 0.603 | Contact Map | 0.775 |
| 2k9sA | 1 | 0.3333 | 100 | 0.605 | Contact Map | 0.538 |
| 3lsgA | 5 | 0.3208 | 100 | 0.611 | Contact Map | 0.85 |
| 1d5yA | 4 | 0.3491 | 99.9 | 0.616 | Contact Map | 0.676 |
Sequence Conservation (Image Generated using WebLogo v3)