| UniProt: | P77402 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13975 | ||
| Length: | 303 (254) | ||
| Sequences: | 8848 | ||
| Seq/Len: | 34.83 |
| YDIP
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 234_M | 271_V | 3.839 | 1.00 | |
| 192_N | 195_E | 3.731 | 1.00 | |
| 246_L | 254_R | 3.412 | 1.00 | |
| 223_I | 231_Q | 3.199 | 1.00 | |
| 200_E | 210_V | 2.992 | 1.00 | |
| 188_Y | 192_N | 2.989 | 1.00 | |
| 236_E | 239_W | 2.86 | 1.00 | |
| 190_N | 232_R | 2.796 | 1.00 | |
| 238_K | 271_V | 2.792 | 1.00 | |
| 267_F | 278_Y | 2.738 | 1.00 | |
| 237_A | 263_F | 2.602 | 1.00 | |
| 189_L | 229_V | 2.558 | 1.00 | |
| 240_S | 254_R | 2.365 | 1.00 | |
| 273_C | 281_Q | 2.252 | 1.00 | |
| 189_L | 232_R | 2.229 | 1.00 | |
| 53_V | 64_V | 2.209 | 1.00 | |
| 241_L | 248_Q | 2.206 | 1.00 | |
| 217_F | 228_Y | 2.191 | 1.00 | |
| 55_R | 62_L | 2.186 | 1.00 | |
| 231_Q | 270_H | 2.133 | 1.00 | |
| 198_T | 201_Q | 2.124 | 1.00 | |
| 240_S | 246_L | 2.048 | 1.00 | |
| 44_T | 75_R | 2.024 | 1.00 | |
| 234_M | 270_H | 2.019 | 1.00 | |
| 246_L | 250_E | 1.992 | 1.00 | |
| 276_S | 280_R | 1.953 | 1.00 | |
| 185_I | 213_I | 1.938 | 1.00 | |
| 247_S | 250_E | 1.882 | 1.00 | |
| 40_H | 79_H | 1.873 | 1.00 | |
| 208_A | 213_I | 1.871 | 1.00 | |
| 187_F | 191_N | 1.862 | 1.00 | |
| 226_I | 230_I | 1.859 | 1.00 | |
| 55_R | 64_V | 1.842 | 1.00 | |
| 53_V | 66_H | 1.836 | 1.00 | |
| 137_I | 162_Y | 1.831 | 1.00 | |
| 236_E | 240_S | 1.808 | 1.00 | |
| 182_I | 221_Y | 1.804 | 1.00 | |
| 188_Y | 197_I | 1.771 | 1.00 | |
| 202_L | 225_P | 1.758 | 1.00 | |
| 240_S | 255_V | 1.735 | 1.00 | |
| 59_D | 77_R | 1.734 | 1.00 | |
| 193_Y | 232_R | 1.732 | 1.00 | |
| 244_T | 279_R | 1.729 | 1.00 | |
| 57_T | 62_L | 1.713 | 1.00 | |
| 190_N | 228_Y | 1.708 | 1.00 | |
| 199_L | 214_C | 1.692 | 1.00 | |
| 188_Y | 205_K | 1.684 | 1.00 | |
| 185_I | 206_F | 1.663 | 1.00 | |
| 212_Y | 216_E | 1.657 | 1.00 | |
| 38_H | 79_H | 1.627 | 1.00 | |
| 45_E | 79_H | 1.6 | 1.00 | |
| 55_R | 82_A | 1.573 | 1.00 | |
| 250_E | 253_W | 1.555 | 1.00 | |
| 186_L | 221_Y | 1.553 | 1.00 | |
| 66_H | 69_D | 1.551 | 1.00 | |
| 208_A | 212_Y | 1.504 | 1.00 | |
| 249_A | 253_W | 1.5 | 1.00 | |
| 195_E | 201_Q | 1.489 | 1.00 | |
| 213_I | 225_P | 1.488 | 1.00 | |
| 193_Y | 236_E | 1.486 | 1.00 | |
| 264_A | 276_S | 1.465 | 1.00 | |
| 237_A | 255_V | 1.459 | 1.00 | |
| 200_E | 204_K | 1.431 | 1.00 | |
| 223_I | 227_N | 1.423 | 1.00 | |
| 57_T | 80_A | 1.422 | 1.00 | |
| 249_A | 260_V | 1.42 | 1.00 | |
| 264_A | 274_S | 1.406 | 0.99 | |
| 273_C | 277_D | 1.403 | 0.99 | |
| 212_Y | 215_H | 1.391 | 0.99 | |
| 224_S | 227_N | 1.388 | 0.99 | |
| 69_D | 119_A | 1.385 | 0.99 | |
| 250_E | 254_R | 1.383 | 0.99 | |
| 181_L | 208_A | 1.373 | 0.99 | |
| 246_L | 251_I | 1.37 | 0.99 | |
| 233_R | 255_V | 1.369 | 0.99 | |
| 251_I | 255_V | 1.365 | 0.99 | |
| 51_K | 67_A | 1.36 | 0.99 | |
| 185_I | 202_L | 1.357 | 0.99 | |
| 48_Y | 131_F | 1.353 | 0.99 | |
| 201_Q | 205_K | 1.352 | 0.99 | |
| 239_W | 243_N | 1.351 | 0.99 | |
| 225_P | 229_V | 1.346 | 0.99 | |
| 266_L | 269_R | 1.325 | 0.99 | |
| 232_R | 236_E | 1.31 | 0.99 | |
| 74_E | 77_R | 1.307 | 0.99 | |
| 181_L | 206_F | 1.295 | 0.99 | |
| 211_S | 215_H | 1.294 | 0.99 | |
| 210_V | 214_C | 1.252 | 0.99 | |
| 54_A | 65_A | 1.245 | 0.98 | |
| 185_I | 205_K | 1.236 | 0.98 | |
| 248_Q | 251_I | 1.229 | 0.98 | |
| 202_L | 205_K | 1.229 | 0.98 | |
| 262_H | 266_L | 1.228 | 0.98 | |
| 40_H | 45_E | 1.226 | 0.98 | |
| 244_T | 251_I | 1.217 | 0.98 | |
| 274_S | 277_D | 1.209 | 0.98 | |
| 37_H | 78_L | 1.204 | 0.98 | |
| 238_K | 278_Y | 1.203 | 0.98 | |
| 260_V | 264_A | 1.2 | 0.98 | |
| 51_K | 91_T | 1.196 | 0.98 | |
| 129_T | 132_N | 1.195 | 0.98 | |
| 261_D | 264_A | 1.195 | 0.98 | |
| 53_V | 84_D | 1.187 | 0.98 | |
| 257_Y | 266_L | 1.179 | 0.98 | |
| 199_L | 225_P | 1.179 | 0.98 | |
| 148_S | 155_Y | 1.169 | 0.97 | |
| 188_Y | 202_L | 1.161 | 0.97 | |
| 209_S | 212_Y | 1.145 | 0.97 | |
| 251_I | 279_R | 1.131 | 0.97 | |
| 265_K | 269_R | 1.131 | 0.97 | |
| 56_F | 71_V | 1.126 | 0.97 | |
| 236_E | 255_V | 1.121 | 0.97 | |
| 234_M | 266_L | 1.104 | 0.96 | |
| 128_K | 132_N | 1.102 | 0.96 | |
| 214_C | 225_P | 1.102 | 0.96 | |
| 194_R | 254_R | 1.091 | 0.96 | |
| 214_C | 224_S | 1.078 | 0.95 | |
| 208_A | 216_E | 1.078 | 0.95 | |
| 148_S | 151_D | 1.064 | 0.95 | |
| 271_V | 278_Y | 1.061 | 0.95 | |
| 206_F | 213_I | 1.059 | 0.95 | |
| 49_V | 54_A | 1.05 | 0.94 | |
| 186_L | 190_N | 1.044 | 0.94 | |
| 259_N | 265_K | 1.04 | 0.94 | |
| 49_V | 52_G | 1.036 | 0.94 | |
| 57_T | 82_A | 1.033 | 0.94 | |
| 184_D | 205_K | 1.03 | 0.94 | |
| 201_Q | 204_K | 1.027 | 0.94 | |
| 46_L | 72_V | 1.024 | 0.93 | |
| 99_F | 102_Q | 1.023 | 0.93 | |
| 179_D | 220_E | 1.022 | 0.93 | |
| 129_T | 133_E | 1.022 | 0.93 | |
| 264_A | 268_L | 1.021 | 0.93 | |
| 188_Y | 206_F | 1.016 | 0.93 | |
| 232_R | 235_T | 1.011 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.8713 | 100 | 0.369 | Contact Map | 0.645 |
| 1bl0A | 1 | 0.4257 | 100 | 0.56 | Contact Map | 0.721 |
| 3oouA | 1 | 0.3564 | 100 | 0.563 | Contact Map | 0.757 |
| 3oioA | 1 | 0.3729 | 100 | 0.563 | Contact Map | 0.775 |
| 3mn2A | 2 | 0.3498 | 100 | 0.568 | Contact Map | 0.739 |
| 3w6vA | 1 | 0.4851 | 100 | 0.572 | Contact Map | 0.736 |
| 2k9sA | 1 | 0.3498 | 100 | 0.573 | Contact Map | 0.535 |
| 3mklA | 2 | 0.396 | 100 | 0.573 | Contact Map | 0.782 |
| 3lsgA | 5 | 0.3366 | 100 | 0.58 | Contact Map | 0.853 |
| 1d5yA | 4 | 0.4125 | 99.9 | 0.589 | Contact Map | 0.687 |
Sequence Conservation (Image Generated using WebLogo v3)