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OPENSEQ.org

SOXS - Regulatory protein SoxS
UniProt: P0A9E2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10958
Length: 107 (103)
Sequences: 21949
Seq/Len: 213.10

SOXS
Paralog alert: 0.87 [within 20: 0.44] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
48_Q 56_Q 2.435 1.00
63_A 96_F 2.409 1.00
71_R 79_D 2.326 1.00
25_D 35_K 2.273 1.00
92_F 103_Y 2.119 1.00
13_W 17_H 2.106 1.00
15_D 57_R 2.083 1.00
65_E 79_D 1.91 1.00
62_A 88_F 1.894 1.00
61_L 64_V 1.874 1.00
59_L 96_F 1.869 1.00
56_Q 95_Q 1.861 1.00
23_N 26_V 1.747 1.00
10_L 38_L 1.734 1.00
17_H 20_Q 1.687 1.00
65_E 80_L 1.662 1.00
13_W 30_K 1.636 1.00
42_F 53_Y 1.576 1.00
71_R 75_D 1.533 1.00
37_Y 41_M 1.511 1.00
65_E 71_R 1.509 1.00
72_P 75_D 1.464 1.00
35_K 39_Q 1.439 1.00
85_Q 89_S 1.396 0.99
51_G 55_R 1.366 0.99
98_R 106_R 1.361 0.99
14_I 54_I 1.317 0.99
11_I 46_T 1.309 0.99
74_F 85_Q 1.301 0.99
64_V 68_T 1.278 0.99
27_V 50_L 1.274 0.99
66_L 73_I 1.257 0.99
59_L 95_Q 1.257 0.99
74_F 78_M 1.241 0.98
36_W 40_R 1.229 0.98
61_L 65_E 1.212 0.98
48_Q 52_D 1.206 0.98
87_T 91_V 1.196 0.98
75_D 78_M 1.196 0.98
101_S 105_H 1.188 0.98
37_Y 40_R 1.186 0.98
18_I 57_R 1.175 0.98
12_A 16_E 1.166 0.97
55_R 91_V 1.148 0.97
11_I 15_D 1.147 0.97
33_Y 37_Y 1.144 0.97
91_V 94_R 1.143 0.97
63_A 103_Y 1.13 0.97
86_Q 89_S 1.129 0.97
57_R 60_L 1.118 0.96
10_L 31_S 1.115 0.96
75_D 79_D 1.105 0.96
24_I 39_Q 1.08 0.95
57_R 61_L 1.077 0.95
98_R 102_D 1.076 0.95
55_R 94_R 1.059 0.95
82_Y 91_V 1.036 0.94
7_I 46_T 1.025 0.93
13_W 22_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.990799.90.001Contact Map0.664
4fe7A1199.90.012Contact Map0.768
1bl0A1199.90.041Contact Map0.784
3w6vA1199.90.044Contact Map0.806
3oioA1199.90.044Contact Map0.795
3oouA1199.90.047Contact Map0.813
3mn2A20.97299.90.052Contact Map0.802
2k9sA10.981399.90.062Contact Map0.57
3mklA20.990799.90.067Contact Map0.841
3lsgA50.953399.90.073Contact Map0.916

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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