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OPENSEQ.org

YFCG - Disulfide-bond oxidoreductase YfcG
UniProt: P77526 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14110
Length: 215 (202)
Sequences: 11052
Seq/Len: 54.71

YFCG
Paralog alert: 0.77 [within 20: 0.32] - ratio of genomes with paralogs
Cluster includes: GSTA GSTB SSPA YFCF YFCG YIBF YNCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_D 29_I 3.42 1.00
188_N 192_R 3.3 1.00
21_E 196_R 3.265 1.00
77_L 98_L 3.263 1.00
81_E 94_R 2.919 1.00
3_D 27_R 2.793 1.00
20_E 201_Q 2.621 1.00
145_N 185_A 2.584 1.00
19_L 26_Y 2.539 1.00
6_F 12_G 2.532 1.00
44_L 50_N 2.511 1.00
20_E 26_Y 2.467 1.00
62_D 66_P 2.457 1.00
152_P 192_R 2.454 1.00
67_L 92_R 2.183 1.00
149_E 185_A 2.166 1.00
142_H 183_Y 2.134 1.00
90_E 93_E 2.049 1.00
56_V 68_S 1.946 1.00
152_P 157_E 1.875 1.00
3_D 56_V 1.863 1.00
46_I 54_A 1.856 1.00
127_P 131_E 1.815 1.00
187_K 191_E 1.797 1.00
32_D 35_K 1.762 1.00
5_Y 56_V 1.725 1.00
41_P 45_R 1.723 1.00
81_E 98_L 1.721 1.00
21_E 198_A 1.666 1.00
138_Q 182_M 1.666 1.00
43_F 54_A 1.664 1.00
6_F 28_L 1.654 1.00
17_L 199_T 1.651 1.00
22_A 80_A 1.577 1.00
185_A 188_N 1.573 1.00
145_N 184_P 1.557 1.00
5_Y 31_V 1.554 1.00
96_A 99_Q 1.553 1.00
191_E 195_S 1.551 1.00
18_F 76_L 1.54 1.00
159_Y 164_I 1.537 1.00
154_L 166_C 1.526 1.00
142_H 146_K 1.509 1.00
56_V 66_P 1.505 1.00
100_W 147_R 1.482 1.00
46_I 56_V 1.458 1.00
88_S 97_T 1.451 1.00
42_E 45_R 1.428 1.00
131_E 135_V 1.416 1.00
195_S 200_G 1.411 1.00
57_D 78_Y 1.403 0.99
155_G 160_S 1.391 0.99
167_W 193_I 1.348 0.99
147_R 151_S 1.331 0.99
69_L 95_A 1.318 0.99
15_I 76_L 1.304 0.99
4_L 19_L 1.287 0.99
57_D 82_K 1.285 0.99
153_W 193_I 1.282 0.99
2_I 24_L 1.281 0.99
18_F 86_F 1.273 0.99
37_G 40_R 1.261 0.99
2_I 55_I 1.259 0.99
43_F 46_I 1.256 0.99
24_L 83_T 1.256 0.99
86_F 164_I 1.232 0.98
57_D 62_D 1.228 0.98
200_G 204_L 1.219 0.98
51_K 71_E 1.217 0.98
159_Y 196_R 1.212 0.98
18_F 22_A 1.198 0.98
102_F 105_V 1.184 0.98
145_N 149_E 1.183 0.98
63_G 66_P 1.182 0.98
70_F 99_Q 1.178 0.98
134_Q 138_Q 1.175 0.98
77_L 102_F 1.159 0.97
93_E 158_N 1.154 0.97
132_R 136_E 1.147 0.97
142_H 182_M 1.142 0.97
21_E 164_I 1.14 0.97
92_R 96_A 1.138 0.97
197_P 201_Q 1.135 0.97
57_D 83_T 1.125 0.97
131_E 134_Q 1.121 0.97
190_H 194_R 1.113 0.96
104_Q 166_C 1.106 0.96
21_E 159_Y 1.095 0.96
76_L 161_I 1.093 0.96
91_T 95_A 1.088 0.96
14_K 165_A 1.085 0.96
57_D 63_G 1.082 0.96
39_F 50_N 1.069 0.95
191_E 194_R 1.066 0.95
136_E 139_R 1.063 0.95
159_Y 193_I 1.061 0.95
14_K 72_S 1.046 0.94
153_W 192_R 1.043 0.94
135_V 139_R 1.043 0.94
82_K 91_T 1.04 0.94
147_R 150_N 1.04 0.94
146_K 149_E 1.017 0.93
57_D 67_L 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gx0A10.97211000.157Contact Map0.772
4l8eA10.94881000.173Contact Map0.774
4ecjA20.96741000.186Contact Map0.814
1k0dA40.93951000.192Contact Map0.849
4hz2A20.95351000.194Contact Map0.702
4ielA20.93491000.199Contact Map0.756
4kdxA20.93491000.201Contact Map0.774
4kh7A20.94421000.204Contact Map0.775
2x64A60.93021000.205Contact Map0.807
2v6kA20.94881000.207Contact Map0.719

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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