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YNCG - Uncharacterized GST-like protein YncG
UniProt: P76117 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13777
Length: 205 (201)
Sequences: 11255
Seq/Len: 56.00

YNCG
Paralog alert: 0.77 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: GSTA GSTB SSPA YFCF YFCG YIBF YNCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
184_A 188_A 3.375 1.00
72_L 94_Q 3.318 1.00
3_K 29_V 3.301 1.00
21_L 192_L 3.284 1.00
76_D 90_R 2.952 1.00
3_K 27_Q 2.803 1.00
20_T 197_E 2.673 1.00
141_N 181_N 2.635 1.00
20_T 26_Y 2.606 1.00
19_L 26_Y 2.589 1.00
148_P 188_A 2.468 1.00
6_G 12_S 2.456 1.00
45_K 51_C 2.429 1.00
62_E 88_A 2.412 1.00
145_T 181_N 2.177 1.00
138_I 179_A 2.172 1.00
86_G 89_E 2.122 1.00
148_P 153_E 1.996 1.00
57_A 63_I 1.969 1.00
47_L 55_T 1.911 1.00
3_K 57_A 1.88 1.00
183_S 187_D 1.85 1.00
76_D 94_Q 1.781 1.00
32_S 35_D 1.767 1.00
22_A 75_L 1.723 1.00
42_E 46_T 1.705 1.00
21_L 194_K 1.694 1.00
5_Y 57_A 1.692 1.00
17_L 195_L 1.684 1.00
44_L 55_T 1.656 1.00
57_A 61_D 1.636 1.00
181_N 184_A 1.626 1.00
150_A 162_L 1.625 1.00
18_M 71_A 1.623 1.00
187_D 191_Q 1.613 1.00
134_K 178_N 1.611 1.00
47_L 57_A 1.581 1.00
138_I 142_S 1.563 1.00
92_L 95_R 1.553 1.00
155_L 160_C 1.546 1.00
5_Y 31_V 1.528 1.00
96_L 143_Q 1.518 1.00
6_G 28_F 1.511 1.00
141_N 180_T 1.492 1.00
123_E 127_K 1.482 1.00
191_Q 196_Q 1.457 1.00
151_F 156_T 1.45 1.00
24_I 78_R 1.421 1.00
163_C 189_V 1.419 1.00
64_M 91_Q 1.411 1.00
83_P 93_F 1.399 0.99
2_I 56_L 1.373 0.99
15_S 71_A 1.36 0.99
143_Q 147_E 1.359 0.99
18_M 81_L 1.32 0.99
155_L 192_L 1.277 0.99
18_M 22_A 1.271 0.99
4_V 19_L 1.252 0.99
52_Q 66_E 1.231 0.98
149_Y 189_V 1.225 0.98
127_K 131_E 1.213 0.98
81_L 160_C 1.21 0.98
141_N 145_T 1.209 0.98
72_L 98_V 1.203 0.98
65_T 95_R 1.189 0.98
43_L 46_T 1.185 0.98
71_A 157_L 1.176 0.98
89_E 154_Q 1.166 0.97
193_P 197_E 1.156 0.97
177_D 183_S 1.152 0.97
130_I 134_K 1.151 0.97
21_L 160_C 1.145 0.97
77_R 87_R 1.143 0.97
21_L 155_L 1.137 0.97
196_Q 200_K 1.132 0.97
187_D 190_C 1.126 0.97
82_A 93_F 1.126 0.97
138_I 178_N 1.123 0.97
100_L 162_L 1.122 0.97
83_P 86_G 1.106 0.96
88_A 92_L 1.1 0.96
14_I 67_T 1.099 0.96
132_Y 135_S 1.097 0.96
98_V 101_V 1.096 0.96
87_R 91_Q 1.092 0.96
14_I 161_Y 1.088 0.96
39_A 51_C 1.077 0.95
123_E 126_K 1.072 0.95
131_E 135_S 1.065 0.95
155_L 189_V 1.063 0.95
186_A 190_C 1.061 0.95
175_F 178_N 1.061 0.95
124_Q 127_K 1.059 0.95
143_Q 146_A 1.059 0.95
44_L 47_L 1.054 0.95
163_C 190_C 1.045 0.94
15_S 70_I 1.041 0.94
93_F 156_T 1.032 0.94
142_S 145_T 1.028 0.94
16_E 20_T 1.025 0.93
149_Y 188_A 1.021 0.93
148_P 184_A 1.017 0.93
92_L 143_Q 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l8eA10.98541000.112Contact Map0.777
3gx0A10.99021000.125Contact Map0.777
4kgiA40.97561000.131Contact Map0.768
4hz2A20.98541000.133Contact Map0.704
2x64A60.97561000.134Contact Map0.794
4ecjA20.98541000.135Contact Map0.817
4gf0A20.98541000.135Contact Map0.736
2dsaA40.97071000.137Contact Map0.808
1k0dA40.97561000.139Contact Map0.841
4gciA20.97071000.141Contact Map0.739

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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