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OPENSEQ.org
DXS - 1-deoxy-D-xylulose-5-phosphate synthase
UniProt: P77488 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13612
Length: 620 (611)
Sequences: 4026
Seq/Len: 6.59
DXS
Paralog alert: 0.76 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DXS TKT1 TKT2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
258_D 261_G 3.496 1.00
467_Y 470_G 3.309 1.00
386_K 413_P 3.202 1.00
377_A 389_V 3.201 1.00
607_D 610_G 3.027 1.00
506_L 615_I 2.967 1.00
241_T 244_E 2.922 1.00
39_L 84_P 2.898 1.00
524_S 612_E 2.891 1.00
334_A 358_K 2.889 1.00
518_A 556_V 2.797 1.00
519_A 529_L 2.717 1.00
608_A 612_E 2.638 1.00
602_A 607_D 2.567 1.00
449_M 460_M 2.565 1.00
251_I 276_Q 2.502 1.00
438_S 559_N 2.474 1.00
101_K 599_E 2.437 1.00
249_N 276_Q 2.424 1.00
69_T 115_Y 2.418 1.00
52_S 81_Q 2.386 1.00
506_L 527_A 2.35 1.00
501_R 523_E 2.296 1.00
101_K 595_G 2.288 1.00
561_I 586_G 2.274 1.00
524_S 608_A 2.271 1.00
510_N 515_M 2.259 1.00
539_D 572_V 2.244 1.00
91_R 94_K 2.14 1.00
411_K 445_E 2.136 1.00
505_K 526_N 2.133 1.00
415_L 464_G 2.127 1.00
164_M 243_F 2.101 1.00
332_T 339_L 2.073 1.00
440_L 473_A 2.072 1.00
145_R 175_L 2.064 1.00
380_L 385_Y 2.052 1.00
509_L 532_M 2.05 1.00
126_S 150_I 2.049 1.00
505_K 551_E 2.036 1.00
32_C 61_V 2.036 1.00
583_L 614_K 2.024 1.00
446_M 473_A 1.996 1.00
441_R 568_G 1.985 1.00
59_L 177_I 1.983 1.00
497_G 542_L 1.974 1.00
501_R 522_A 1.972 1.00
176_V 248_F 1.967 1.00
528_T 550_H 1.955 1.00
524_S 609_A 1.947 1.00
544_L 572_V 1.941 1.00
374_V 416_F 1.929 1.00
496_K 532_M 1.917 1.00
441_R 571_E 1.897 1.00
555_T 584_N 1.884 1.00
394_T 436_D 1.884 1.00
452_S 531_D 1.882 1.00
256_G 282_T 1.882 1.00
150_I 176_V 1.873 1.00
520_K 523_E 1.872 1.00
128_S 372_H 1.857 1.00
286_R 292_E 1.856 1.00
151_G 154_A 1.852 1.00
108_P 120_V 1.822 1.00
177_I 266_L 1.821 1.00
145_R 270_R 1.814 1.00
130_G 148_C 1.797 1.00
522_A 529_L 1.791 1.00
602_A 609_A 1.779 1.00
597_Q 601_R 1.774 1.00
374_V 407_V 1.763 1.00
161_F 246_L 1.75 1.00
145_R 173_D 1.744 1.00
135_V 376_F 1.728 1.00
599_E 602_A 1.726 1.00
378_A 407_V 1.72 1.00
407_V 416_F 1.717 1.00
118_L 129_A 1.708 1.00
498_I 531_D 1.705 1.00
437_L 559_N 1.698 1.00
447_V 534_F 1.697 1.00
521_V 556_V 1.692 1.00
521_V 612_E 1.677 1.00
508_I 518_A 1.674 1.00
377_A 414_V 1.671 1.00
101_K 603_E 1.666 1.00
447_V 470_G 1.661 1.00
344_P 350_S 1.654 1.00
180_D 279_H 1.648 1.00
269_M 278_L 1.635 1.00
554_V 615_I 1.611 1.00
113_S 116_D 1.608 1.00
508_I 556_V 1.606 1.00
377_A 390_A 1.599 1.00
596_T 599_E 1.581 1.00
403_V 446_M 1.578 1.00
74_L 149_V 1.563 0.99
75_I 130_G 1.562 0.99
130_G 176_V 1.554 0.99
520_K 608_A 1.552 0.99
612_E 616_K 1.55 0.99
554_V 583_L 1.549 0.99
75_I 133_I 1.548 0.99
595_G 600_M 1.541 0.99
554_V 618_W 1.533 0.99
137_A 146_T 1.532 0.99
570_N 584_N 1.532 0.99
53_G 84_P 1.523 0.99
334_A 359_F 1.523 0.99
105_H 113_S 1.523 0.99
449_M 534_F 1.513 0.99
381_A 412_L 1.501 0.99
517_E 608_A 1.5 0.99
532_M 565_A 1.494 0.99
583_L 618_W 1.489 0.99
610_G 613_A 1.487 0.99
167_A 174_M 1.48 0.99
600_M 604_L 1.478 0.99
24_P 27_S 1.47 0.99
144_R 383_G 1.467 0.99
56_T 59_L 1.467 0.99
540_E 572_V 1.46 0.99
110_R 382_I 1.452 0.99
477_P 481_A 1.452 0.99
516_P 520_K 1.443 0.99
561_I 589_D 1.441 0.99
381_A 387_P 1.437 0.99
39_L 53_G 1.437 0.99
263_I 267_K 1.436 0.99
127_I 164_M 1.431 0.99
585_I 614_K 1.426 0.99
283_K 286_R 1.426 0.99
376_F 380_L 1.421 0.99
583_L 615_I 1.406 0.99
452_S 515_M 1.404 0.99
418_I 473_A 1.403 0.99
510_N 518_A 1.394 0.99
610_G 614_K 1.387 0.98
504_E 526_N 1.386 0.98
567_S 571_E 1.384 0.98
140_E 385_Y 1.383 0.98
289_E 293_K 1.383 0.98
70_P 114_E 1.381 0.98
452_S 498_I 1.38 0.98
396_L 418_I 1.375 0.98
184_S 368_I 1.374 0.98
507_A 550_H 1.374 0.98
506_L 554_V 1.372 0.98
37_R 40_L 1.369 0.98
68_N 71_F 1.368 0.98
42_S 95_I 1.367 0.98
408_A 591_F 1.366 0.98
573_L 584_N 1.362 0.98
601_R 606_L 1.359 0.98
127_I 167_A 1.357 0.98
505_K 527_A 1.353 0.98
267_K 271_D 1.349 0.98
554_V 585_I 1.345 0.98
602_A 610_G 1.342 0.98
527_A 615_I 1.341 0.98
186_S 347_R 1.338 0.98
521_V 615_I 1.338 0.98
613_A 617_A 1.337 0.98
411_K 470_G 1.331 0.98
164_M 246_L 1.328 0.98
449_M 472_S 1.326 0.98
350_S 390_A 1.323 0.98
615_I 618_W 1.319 0.98
86_K 115_Y 1.318 0.98
497_G 530_V 1.315 0.98
137_A 173_D 1.314 0.98
267_K 270_R 1.313 0.98
413_P 470_G 1.31 0.98
139_K 385_Y 1.31 0.98
499_V 528_T 1.308 0.97
137_A 144_R 1.308 0.97
283_K 293_K 1.305 0.97
456_E 531_D 1.304 0.97
508_I 615_I 1.298 0.97
393_S 475_R 1.288 0.97
124_S 157_A 1.282 0.97
251_I 268_N 1.281 0.97
146_T 173_D 1.281 0.97
457_C 476_Y 1.279 0.97
590_F 603_E 1.278 0.97
323_K 480_N 1.275 0.97
133_I 383_G 1.274 0.97
259_V 263_I 1.274 0.97
226_L 279_H 1.265 0.97
110_R 119_S 1.26 0.97
166_H 376_F 1.259 0.97
50_F 300_A 1.258 0.97
93_D 96_G 1.257 0.97
371_Q 402_Q 1.256 0.97
135_V 170_I 1.253 0.97
264_T 268_N 1.252 0.96
175_L 269_M 1.25 0.96
561_I 584_N 1.249 0.96
79_G 108_P 1.249 0.96
556_V 611_M 1.247 0.96
406_D 416_F 1.247 0.96
62_A 262_L 1.243 0.96
251_I 269_M 1.238 0.96
58_E 257_H 1.235 0.96
329_L 388_I 1.226 0.96
175_L 278_L 1.224 0.96
323_K 327_D 1.223 0.96
156_T 184_S 1.218 0.96
250_Y 279_H 1.211 0.96
606_L 610_G 1.206 0.95
426_A 596_T 1.205 0.95
166_H 170_I 1.198 0.95
182_E 281_M 1.196 0.95
139_K 340_M 1.194 0.95
380_L 387_P 1.193 0.95
393_S 440_L 1.191 0.95
437_L 448_I 1.189 0.95
507_A 530_V 1.187 0.95
515_M 529_L 1.187 0.95
323_K 351_G 1.186 0.95
429_Q 432_Q 1.185 0.95
249_N 272_L 1.183 0.95
63_L 74_L 1.183 0.95
94_K 97_T 1.18 0.95
434_A 587_L 1.177 0.95
61_V 88_L 1.175 0.94
508_I 527_A 1.172 0.94
520_K 609_A 1.166 0.94
447_V 472_S 1.163 0.94
52_S 56_T 1.163 0.94
570_N 582_V 1.163 0.94
38_Y 42_S 1.156 0.94
408_A 443_I 1.154 0.94
342_I 377_A 1.153 0.94
517_E 520_K 1.151 0.94
319_P 327_D 1.151 0.94
118_L 382_I 1.148 0.94
521_V 585_I 1.148 0.94
324_I 454_E 1.147 0.94
447_V 537_P 1.146 0.93
340_M 385_Y 1.144 0.93
575_A 584_N 1.143 0.93
511_F 535_V 1.143 0.93
587_L 590_F 1.143 0.93
381_A 414_V 1.14 0.93
336_D 386_K 1.138 0.93
379_G 412_L 1.134 0.93
462_Y 466_H 1.133 0.93
583_L 617_A 1.126 0.93
447_V 467_Y 1.125 0.93
137_A 383_G 1.12 0.92
65_Y 263_I 1.119 0.92
398_R 439_Y 1.115 0.92
518_A 529_L 1.114 0.92
551_E 576_H 1.111 0.92
243_F 277_F 1.11 0.92
558_E 601_R 1.098 0.91
35_L 84_P 1.097 0.91
127_I 176_V 1.097 0.91
87_I 92_R 1.094 0.91
15_D 92_R 1.092 0.91
568_G 571_E 1.091 0.91
56_T 81_Q 1.091 0.91
136_A 383_G 1.089 0.91
443_I 446_M 1.088 0.91
262_L 266_L 1.087 0.91
547_A 573_L 1.086 0.91
333_A 355_F 1.086 0.91
450_T 513_T 1.085 0.91
539_D 571_E 1.08 0.91
145_R 266_L 1.08 0.91
319_P 324_I 1.08 0.91
135_V 364_F 1.08 0.91
52_S 78_V 1.079 0.90
511_F 532_M 1.079 0.90
168_G 191_A 1.078 0.90
521_V 611_M 1.077 0.90
171_R 357_R 1.077 0.90
66_V 263_I 1.076 0.90
32_C 58_E 1.075 0.90
403_V 416_F 1.075 0.90
386_K 415_L 1.074 0.90
544_L 576_H 1.073 0.90
10_T 27_S 1.062 0.90
78_V 151_G 1.062 0.90
325_F 390_A 1.061 0.90
27_S 30_K 1.06 0.89
59_L 280_I 1.06 0.89
387_P 413_P 1.058 0.89
64_H 85_H 1.058 0.89
540_E 576_H 1.057 0.89
159_M 163_A 1.057 0.89
147_V 175_L 1.056 0.89
131_I 167_A 1.053 0.89
298_F 301_V 1.05 0.89
101_K 600_M 1.049 0.89
14_V 23_L 1.046 0.89
13_L 27_S 1.046 0.89
269_M 276_Q 1.041 0.88
73_Q 133_I 1.039 0.88
332_T 462_Y 1.039 0.88
406_D 414_V 1.038 0.88
186_S 348_E 1.037 0.88
285_G 298_F 1.036 0.88
328_W 458_R 1.031 0.88
294_D 297_T 1.027 0.87
328_W 332_T 1.027 0.87
150_I 160_A 1.027 0.87
614_K 617_A 1.026 0.87
14_V 19_E 1.024 0.87
185_I 188_N 1.024 0.87
397_Q 400_Y 1.023 0.87
454_E 483_G 1.022 0.87
133_I 379_G 1.021 0.87
587_L 604_L 1.02 0.87
147_V 270_R 1.02 0.87
496_K 541_A 1.009 0.86
540_E 544_L 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o1xA40.99521000.249Contact Map0.766
2o1sA411000.255Contact Map0.773
2qtcA20.98061000.328Contact Map0.596
1r9jA20.86941000.353Contact Map0.746
1gpuA20.8711000.358Contact Map0.77
3komA20.87421000.365Contact Map0.773
4kxvA10.89681000.366Contact Map0.647
3mosA10.88871000.368Contact Map0.656
3rimA40.89681000.371Contact Map0.722
2r8oA20.8711000.372Contact Map0.771
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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