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OPENSEQ.org
TKT2 - Transketolase 2
UniProt: P33570 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12100
Length: 667 (660)
Sequences: 4424
Seq/Len: 6.70
TKT2
Paralog alert: 0.77 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DXS TKT1 TKT2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
573_E 659_H 4.93 1.00
551_I 658_A 3.429 1.00
219_D 222_A 3.416 1.00
569_K 655_V 3.187 1.00
543_K 568_E 3.17 1.00
417_A 430_T 3.134 1.00
202_K 205_E 3.078 1.00
369_P 398_D 3.04 1.00
14_S 72_S 3.035 1.00
50_D 303_Q 2.997 1.00
543_K 567_A 2.885 1.00
427_V 453_R 2.847 1.00
82_P 85_E 2.8 1.00
563_T 610_V 2.778 1.00
564_L 579_V 2.715 1.00
314_K 325_T 2.702 1.00
212_I 238_S 2.69 1.00
651_A 655_V 2.654 1.00
650_T 653_N 2.594 1.00
210_H 238_S 2.525 1.00
539_G 582_L 2.473 1.00
43_F 224_K 2.415 1.00
92_L 642_K 2.366 1.00
565_Q 568_E 2.328 1.00
147_F 178_I 2.314 1.00
132_L 144_V 2.299 1.00
550_D 576_N 2.294 1.00
645_P 650_T 2.287 1.00
627_A 657_K 2.258 1.00
597_E 602_S 2.232 1.00
490_W 501_G 2.232 1.00
551_I 577_V 2.224 1.00
593_E 597_E 2.214 1.00
569_K 651_A 2.199 1.00
508_R 511_G 2.171 1.00
479_A 613_G 2.17 1.00
420_I 426_F 2.159 1.00
92_L 638_A 2.133 1.00
122_A 150_V 2.103 1.00
199_D 202_K 2.085 1.00
287_K 291_H 2.072 1.00
555_A 560_M 2.034 1.00
233_V 236_K 2.021 1.00
615_A 630_G 2.019 1.00
447_A 456_M 1.997 1.00
487_F 514_A 1.984 1.00
28_A 66_A 1.982 1.00
642_K 645_P 1.979 1.00
180_F 227_I 1.964 1.00
147_F 231_Q 1.932 1.00
270_A 274_Q 1.92 1.00
568_E 572_G 1.92 1.00
569_K 572_G 1.915 1.00
645_P 652_E 1.911 1.00
42_D 224_K 1.908 1.00
45_K 55_D 1.908 1.00
228_L 232_S 1.905 1.00
367_Y 374_L 1.896 1.00
554_I 582_L 1.887 1.00
553_L 563_T 1.886 1.00
47_N 303_Q 1.881 1.00
609_A 628_I 1.865 1.00
35_I 180_F 1.863 1.00
455_I 505_A 1.862 1.00
303_Q 307_N 1.858 1.00
166_C 204_F 1.858 1.00
451_K 486_N 1.846 1.00
141_H 309_K 1.841 1.00
569_K 652_E 1.838 1.00
414_T 456_M 1.838 1.00
589_D 621_Y 1.834 1.00
7_A 37_E 1.833 1.00
550_D 605_A 1.827 1.00
608_V 658_A 1.826 1.00
435_M 477_Q 1.805 1.00
179_G 209_W 1.803 1.00
655_V 659_H 1.8 1.00
152_M 179_G 1.783 1.00
561_E 565_Q 1.776 1.00
210_H 233_V 1.775 1.00
627_A 660_K 1.757 1.00
228_L 231_Q 1.748 1.00
482_R 620_K 1.737 1.00
567_A 579_V 1.733 1.00
84_E 87_K 1.722 1.00
326_R 373_E 1.711 1.00
281_P 284_E 1.7 1.00
540_Y 581_S 1.695 1.00
518_S 522_L 1.688 1.00
481_L 514_A 1.685 1.00
565_Q 651_A 1.678 1.00
45_K 302_A 1.675 1.00
163_H 207_Y 1.672 1.00
153_G 156_C 1.67 1.00
74_L 107_G 1.654 1.00
100_P 112_T 1.639 1.00
414_T 447_A 1.629 1.00
15_M 269_V 1.628 1.00
619_Y 628_I 1.628 1.00
493_C 581_S 1.626 1.00
640_A 644_F 1.625 1.00
608_V 661_V 1.621 1.00
301_K 305_S 1.618 1.00
488_S 584_S 1.617 1.00
19_Q 266_E 1.613 1.00
541_V 578_R 1.606 1.00
549_P 576_N 1.601 1.00
225_E 229_E 1.6 1.00
118_G 152_M 1.593 1.00
224_K 228_L 1.588 1.00
175_G 210_H 1.586 1.00
105_T 108_V 1.577 1.00
566_A 655_V 1.577 1.00
444_A 487_F 1.575 1.00
19_Q 22_N 1.571 1.00
92_L 646_F 1.57 1.00
324_F 328_M 1.569 1.00
369_P 399_P 1.565 0.99
478_L 613_G 1.561 0.99
544_D 578_R 1.559 0.99
610_V 654_I 1.558 0.99
217_G 244_T 1.552 0.99
59_F 151_F 1.544 0.99
43_F 231_Q 1.537 0.99
47_N 56_R 1.532 0.99
17_A 68_M 1.531 0.99
127_I 416_I 1.53 0.99
290_Y 294_D 1.516 0.99
60_I 122_A 1.512 0.99
566_A 610_V 1.509 0.99
656_A 660_K 1.505 0.99
418_N 447_A 1.502 0.99
578_R 604_V 1.494 0.99
571_A 576_N 1.493 0.99
615_A 632_T 1.492 0.99
653_N 656_A 1.482 0.99
553_L 610_V 1.475 0.99
562_I 651_A 1.47 0.99
653_N 657_K 1.469 0.99
553_L 658_A 1.463 0.99
183_H 241_I 1.457 0.99
490_W 584_S 1.456 0.99
498_A 517_L 1.453 0.99
212_I 229_E 1.453 0.99
379_A 385_N 1.449 0.99
248_F 254_A 1.447 0.99
488_S 511_G 1.436 0.99
657_K 660_K 1.427 0.99
245_V 255_G 1.422 0.99
417_A 431_A 1.417 0.99
173_G 397_E 1.406 0.99
252_N 271_L 1.401 0.99
608_V 627_A 1.399 0.99
110_T 121_N 1.396 0.99
175_G 235_D 1.395 0.99
421_A 452_A 1.392 0.99
97_P 105_T 1.383 0.98
605_A 625_K 1.381 0.98
575_R 659_H 1.38 0.98
629_V 657_K 1.38 0.98
132_L 426_F 1.38 0.98
147_F 176_K 1.38 0.98
552_I 604_V 1.379 0.98
441_R 480_S 1.378 0.98
627_A 661_V 1.377 0.98
417_A 454_Q 1.374 0.98
458_Y 514_A 1.365 0.98
120_A 412_G 1.364 0.98
633_G 646_F 1.364 0.98
639_P 642_K 1.363 0.98
493_C 560_M 1.36 0.98
643_L 647_F 1.358 0.98
46_H 79_Y 1.355 0.98
447_A 454_Q 1.354 0.98
644_F 649_F 1.354 0.98
230_A 240_I 1.35 0.98
201_A 241_I 1.347 0.98
638_A 643_L 1.346 0.98
75_H 290_Y 1.338 0.98
358_K 362_N 1.337 0.98
185_G 243_R 1.334 0.98
119_L 166_C 1.329 0.98
138_Q 320_L 1.327 0.98
54_Y 324_F 1.323 0.98
448_A 634_Y 1.313 0.98
555_A 563_T 1.305 0.98
608_V 629_V 1.295 0.97
307_N 311_A 1.292 0.97
358_K 521_N 1.288 0.97
421_A 428_P 1.286 0.97
127_I 172_L 1.286 0.97
562_I 565_Q 1.285 0.97
490_W 513_T 1.285 0.97
649_F 653_N 1.282 0.97
358_K 386_L 1.281 0.97
142_E 145_D 1.278 0.97
253_K 258_E 1.277 0.97
493_C 540_Y 1.276 0.97
543_K 564_L 1.274 0.97
37_E 76_L 1.272 0.97
451_K 511_G 1.268 0.97
142_E 309_K 1.267 0.97
359_A 495_Q 1.267 0.97
189_D 382_A 1.264 0.97
571_A 577_V 1.264 0.97
7_A 34_D 1.257 0.97
49_T 300_E 1.256 0.97
589_D 620_K 1.256 0.97
85_E 88_N 1.256 0.97
212_I 230_A 1.25 0.97
201_A 205_E 1.249 0.97
129_E 146_H 1.249 0.97
122_A 179_G 1.248 0.97
26_P 261_G 1.248 0.97
245_V 248_F 1.246 0.96
29_P 72_S 1.246 0.96
129_E 148_T 1.245 0.96
146_H 423_H 1.244 0.96
623_G 626_G 1.241 0.96
645_P 653_N 1.237 0.96
17_A 86_L 1.229 0.96
475_V 631_M 1.229 0.96
51_P 106_P 1.227 0.96
80_D 95_K 1.224 0.96
577_V 658_A 1.219 0.96
144_V 324_F 1.217 0.96
569_K 573_E 1.215 0.96
250_S 272_A 1.212 0.96
484_T 487_F 1.212 0.96
542_L 560_M 1.196 0.95
545_S 576_N 1.195 0.95
12_A 15_M 1.189 0.95
552_I 580_V 1.189 0.95
622_V 628_I 1.175 0.95
503_K 507_E 1.172 0.95
38_V 223_V 1.171 0.95
127_I 404_I 1.17 0.95
416_I 420_I 1.169 0.94
362_N 390_K 1.168 0.94
385_N 431_A 1.162 0.94
367_Y 503_K 1.162 0.94
60_I 125_L 1.161 0.94
245_V 254_A 1.159 0.94
453_R 511_G 1.156 0.94
304_Q 308_E 1.154 0.94
590_A 621_Y 1.148 0.94
14_S 29_P 1.146 0.94
32_M 35_I 1.146 0.94
166_C 207_Y 1.142 0.94
125_L 423_H 1.139 0.93
414_T 440_A 1.132 0.93
131_T 426_F 1.131 0.93
354_I 359_A 1.13 0.93
80_D 106_P 1.129 0.93
102_I 422_H 1.129 0.93
566_A 654_I 1.128 0.93
308_E 312_A 1.121 0.93
119_L 169_A 1.119 0.93
55_D 309_K 1.119 0.93
169_A 177_L 1.115 0.92
256_K 259_A 1.115 0.92
149_Y 178_I 1.113 0.92
543_K 571_A 1.112 0.92
538_G 580_V 1.111 0.92
168_L 416_I 1.109 0.92
201_A 211_V 1.108 0.92
271_L 274_Q 1.105 0.92
305_S 308_E 1.104 0.92
542_L 564_L 1.104 0.92
364_L 429_Y 1.102 0.92
368_G 389_W 1.1 0.92
596_R 618_W 1.097 0.92
160_G 164_E 1.095 0.92
40_W 73_L 1.093 0.91
541_V 580_V 1.091 0.91
110_T 422_H 1.09 0.91
565_Q 652_E 1.09 0.91
488_S 513_T 1.088 0.91
13_L 17_A 1.088 0.91
488_S 586_D 1.086 0.91
331_G 509_H 1.086 0.91
375_L 420_I 1.084 0.91
652_E 656_A 1.082 0.91
131_T 375_L 1.081 0.91
593_E 602_S 1.079 0.91
470_P 473_Q 1.078 0.91
478_L 489_T 1.078 0.91
210_H 229_E 1.075 0.91
377_G 417_A 1.074 0.90
505_A 513_T 1.073 0.90
43_F 228_L 1.071 0.90
251_P 255_G 1.07 0.90
46_H 77_T 1.069 0.90
511_G 590_A 1.069 0.90
552_I 578_R 1.069 0.90
38_V 43_F 1.068 0.90
434_L 516_I 1.068 0.90
81_L 105_T 1.068 0.90
437_V 458_Y 1.066 0.90
356_T 522_L 1.065 0.90
658_A 661_V 1.061 0.90
467_E 639_P 1.055 0.89
434_L 481_L 1.049 0.89
566_A 629_V 1.048 0.89
541_V 544_D 1.048 0.89
30_M 268_E 1.047 0.89
205_E 213_H 1.047 0.89
627_A 658_A 1.045 0.89
562_I 644_F 1.041 0.89
28_A 32_M 1.036 0.88
178_I 240_I 1.036 0.88
556_T 582_L 1.036 0.88
488_S 587_I 1.036 0.88
252_N 268_E 1.034 0.88
546_G 571_A 1.032 0.88
204_F 239_L 1.031 0.88
15_M 272_A 1.03 0.88
247_G 259_A 1.027 0.88
75_H 83_L 1.027 0.88
633_G 647_F 1.026 0.88
497_E 581_S 1.024 0.87
375_L 426_F 1.024 0.87
129_E 423_H 1.021 0.87
119_L 179_G 1.014 0.87
187_S 408_V 1.014 0.87
274_Q 279_H 1.012 0.87
411_F 443_A 1.01 0.86
229_E 232_S 1.01 0.86
523_A 561_E 1.009 0.86
102_I 111_T 1.009 0.86
550_D 577_V 1.008 0.86
175_G 234_K 1.006 0.86
141_H 316_A 1.006 0.86
116_G 159_E 1.005 0.86
148_T 176_K 1.002 0.86
582_L 585_T 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r8oA211000.169Contact Map0.784
1r9jA20.9761000.171Contact Map0.733
3komA20.98651000.173Contact Map0.784
1gpuA20.9791000.177Contact Map0.767
3rimA40.9851000.178Contact Map0.744
1itzA30.9791000.188Contact Map0.713
3m49A20.9851000.188Contact Map0.781
3uk1A20.9881000.196Contact Map0.754
2e6kA40.96551000.203Contact Map0.786
3l84A10.93851000.232Contact Map0.771
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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