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OPENSEQ.org
TKT1 - Transketolase 1
UniProt: P27302 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11427
Length: 663 (659)
Sequences: 4290
Seq/Len: 6.51
TKT1
Paralog alert: 0.76 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DXS TKT1 TKT2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
574_E 660_K 4.796 1.00
418_A 431_T 3.433 1.00
220_D 223_S 3.302 1.00
552_L 659_A 3.294 1.00
15_S 73_S 3.289 1.00
203_M 206_E 3.21 1.00
51_N 304_E 3.128 1.00
428_L 454_R 3.117 1.00
564_A 611_V 2.867 1.00
509_R 512_G 2.824 1.00
570_K 656_V 2.793 1.00
544_K 568_Y 2.783 1.00
213_I 239_S 2.769 1.00
211_H 239_S 2.759 1.00
83_P 86_E 2.744 1.00
652_V 656_V 2.734 1.00
44_F 225_K 2.627 1.00
315_A 326_T 2.62 1.00
544_K 569_E 2.475 1.00
651_T 654_N 2.469 1.00
552_L 578_A 2.389 1.00
565_V 580_V 2.341 1.00
598_E 603_K 2.276 1.00
148_Y 179_I 2.276 1.00
590_D 622_Y 2.276 1.00
29_A 67_G 2.263 1.00
93_L 643_L 2.257 1.00
551_E 577_K 2.238 1.00
48_N 304_E 2.232 1.00
370_P 399_D 2.229 1.00
566_A 569_E 2.182 1.00
646_E 651_T 2.177 1.00
556_A 561_V 2.174 1.00
616_A 631_G 2.17 1.00
540_G 583_M 2.163 1.00
628_A 658_K 2.16 1.00
570_K 652_V 2.153 1.00
594_A 598_E 2.146 1.00
167_C 205_F 2.146 1.00
491_W 502_A 2.139 1.00
480_A 614_G 2.061 1.00
8_A 38_E 2.043 1.00
43_D 225_K 2.034 1.00
93_L 639_A 2.027 1.00
211_H 234_V 1.997 1.00
610_A 629_I 1.994 1.00
555_I 583_M 1.991 1.00
234_V 237_K 1.982 1.00
46_K 56_D 1.972 1.00
488_M 515_A 1.957 1.00
436_M 478_Q 1.956 1.00
304_E 308_N 1.95 1.00
153_M 180_A 1.948 1.00
643_L 646_E 1.946 1.00
36_I 181_F 1.946 1.00
327_R 374_E 1.927 1.00
646_E 653_D 1.918 1.00
176_G 211_H 1.913 1.00
142_H 310_K 1.903 1.00
421_I 427_F 1.901 1.00
288_S 292_A 1.89 1.00
570_K 653_D 1.861 1.00
200_D 203_M 1.843 1.00
148_Y 232_R 1.836 1.00
570_K 573_A 1.835 1.00
489_S 585_S 1.835 1.00
445_V 488_M 1.826 1.00
20_Q 267_D 1.811 1.00
16_M 270_I 1.81 1.00
482_L 515_A 1.801 1.00
123_A 151_A 1.795 1.00
181_F 228_V 1.79 1.00
519_S 523_L 1.789 1.00
246_I 256_G 1.769 1.00
291_Y 295_D 1.767 1.00
483_R 621_K 1.762 1.00
164_H 208_Y 1.75 1.00
18_A 69_M 1.74 1.00
180_A 210_W 1.73 1.00
44_F 232_R 1.729 1.00
174_K 398_E 1.727 1.00
218_G 245_T 1.726 1.00
101_P 113_T 1.725 1.00
456_V 506_G 1.722 1.00
641_A 645_F 1.719 1.00
154_G 157_C 1.695 1.00
119_G 153_M 1.69 1.00
567_A 656_V 1.69 1.00
609_V 659_A 1.687 1.00
133_L 145_V 1.671 1.00
415_T 457_M 1.67 1.00
545_D 579_R 1.66 1.00
554_F 611_V 1.642 1.00
609_V 662_L 1.636 1.00
572_T 578_A 1.634 1.00
418_A 455_Q 1.626 1.00
562_E 566_A 1.625 1.00
494_C 582_S 1.605 1.00
61_V 126_M 1.596 1.00
418_A 432_S 1.596 1.00
111_T 122_N 1.581 1.00
46_K 303_K 1.58 1.00
225_K 229_E 1.577 0.99
325_F 329_M 1.576 0.99
368_F 375_F 1.571 0.99
489_S 512_G 1.567 0.99
253_N 272_L 1.566 0.99
47_H 80_Y 1.565 0.99
442_R 481_S 1.565 0.99
148_Y 177_K 1.564 0.99
541_Y 582_S 1.563 0.99
579_R 605_V 1.562 0.99
98_P 106_T 1.558 0.99
569_E 573_A 1.555 0.99
609_V 628_A 1.553 0.99
554_F 564_A 1.553 0.99
654_N 658_K 1.552 0.99
121_A 413_G 1.533 0.99
494_C 561_V 1.532 0.99
567_A 611_V 1.529 0.99
139_R 321_E 1.525 0.99
568_Y 580_V 1.524 0.99
93_L 647_E 1.519 0.99
106_T 109_V 1.511 0.99
452_K 487_N 1.51 0.99
249_F 255_A 1.505 0.99
61_V 123_A 1.502 0.99
479_V 614_G 1.499 0.99
628_A 661_E 1.499 0.99
123_A 180_A 1.479 0.99
551_E 606_T 1.476 0.99
184_D 242_M 1.475 0.99
590_D 621_K 1.472 0.99
302_A 306_A 1.469 0.99
616_A 633_T 1.467 0.99
422_S 453_Q 1.464 0.99
271_A 275_E 1.454 0.99
76_H 291_Y 1.452 0.99
20_Q 23_K 1.451 0.99
226_R 230_E 1.449 0.99
448_A 457_M 1.443 0.99
563_L 652_V 1.44 0.99
554_F 659_A 1.44 0.99
145_V 325_F 1.437 0.99
644_L 648_F 1.436 0.99
656_V 660_K 1.43 0.99
645_F 650_F 1.429 0.99
213_I 230_E 1.428 0.99
176_G 236_D 1.412 0.99
654_N 657_A 1.412 0.99
202_A 242_M 1.411 0.99
130_E 149_T 1.41 0.99
553_I 605_V 1.401 0.99
282_A 285_E 1.401 0.99
75_L 108_G 1.399 0.99
628_A 662_L 1.398 0.99
499_S 518_L 1.396 0.98
657_A 661_E 1.396 0.98
8_A 35_D 1.395 0.98
85_E 88_K 1.391 0.98
143_D 310_K 1.388 0.98
650_F 654_N 1.386 0.98
380_A 386_N 1.385 0.98
623_V 629_I 1.38 0.98
494_C 541_Y 1.376 0.98
359_K 522_N 1.373 0.98
167_C 208_Y 1.368 0.98
422_S 429_P 1.368 0.98
254_K 259_D 1.363 0.98
251_S 273_T 1.359 0.98
147_H 424_H 1.359 0.98
639_A 644_L 1.358 0.98
611_V 655_V 1.357 0.98
143_D 146_D 1.356 0.98
459_Y 515_A 1.354 0.98
640_P 643_L 1.351 0.98
128_I 417_I 1.351 0.98
542_V 579_R 1.346 0.98
566_A 652_V 1.341 0.98
572_T 577_K 1.341 0.98
120_I 167_C 1.336 0.98
567_A 659_A 1.334 0.98
30_P 73_S 1.33 0.98
491_W 585_S 1.326 0.98
659_A 662_L 1.317 0.98
170_A 178_L 1.315 0.98
609_V 630_V 1.315 0.98
52_P 107_A 1.312 0.97
576_V 660_K 1.307 0.97
33_M 36_I 1.303 0.97
13_A 16_M 1.298 0.97
620_Y 629_I 1.297 0.97
128_I 173_L 1.292 0.97
438_V 459_Y 1.292 0.97
386_N 432_S 1.289 0.97
229_E 232_R 1.284 0.97
229_E 233_A 1.279 0.97
15_S 30_P 1.277 0.97
246_I 255_A 1.276 0.97
485_T 488_M 1.275 0.97
60_F 152_F 1.271 0.97
422_S 455_Q 1.269 0.97
624_G 627_G 1.268 0.97
359_K 387_L 1.268 0.97
628_A 659_A 1.266 0.97
476_V 632_M 1.264 0.97
130_E 177_K 1.264 0.97
556_A 564_A 1.262 0.97
81_D 96_K 1.26 0.97
435_L 482_L 1.255 0.96
16_M 273_T 1.248 0.96
415_T 441_A 1.247 0.96
120_I 170_A 1.242 0.96
186_G 244_K 1.242 0.96
578_A 659_A 1.242 0.96
598_E 622_Y 1.237 0.96
41_W 74_L 1.237 0.96
130_E 147_H 1.233 0.96
570_K 574_E 1.23 0.96
546_C 577_K 1.23 0.96
231_A 241_L 1.228 0.96
417_I 421_I 1.227 0.96
202_A 206_E 1.226 0.96
117_G 160_E 1.223 0.96
103_V 423_L 1.222 0.96
550_P 577_K 1.221 0.96
188_S 409_V 1.221 0.96
253_N 269_E 1.216 0.96
18_A 87_L 1.212 0.95
29_A 33_M 1.209 0.95
491_W 514_T 1.203 0.95
363_N 391_S 1.203 0.95
543_L 561_V 1.201 0.95
213_I 231_A 1.2 0.95
111_T 423_L 1.198 0.95
55_A 325_F 1.197 0.95
308_N 312_A 1.196 0.95
39_V 224_I 1.195 0.95
551_E 578_A 1.193 0.95
150_Y 179_I 1.192 0.95
355_I 360_A 1.191 0.95
360_A 496_Q 1.184 0.95
359_K 363_N 1.182 0.95
56_D 310_K 1.181 0.95
246_I 249_F 1.181 0.95
557_T 583_M 1.178 0.94
435_L 517_I 1.177 0.94
630_V 658_K 1.176 0.94
606_T 626_N 1.175 0.94
547_A 572_T 1.175 0.94
172_T 198_T 1.174 0.94
498_E 582_S 1.174 0.94
646_E 654_N 1.174 0.94
47_H 78_T 1.168 0.94
51_N 308_N 1.165 0.94
314_Y 318_Y 1.164 0.94
169_L 173_L 1.163 0.94
544_K 565_V 1.162 0.94
412_F 444_A 1.159 0.94
365_I 430_Y 1.155 0.94
179_I 241_L 1.155 0.94
190_D 383_A 1.153 0.94
553_I 602_P 1.151 0.94
543_L 565_V 1.145 0.93
159_M 188_S 1.141 0.93
553_I 581_V 1.137 0.93
132_T 427_F 1.136 0.93
31_M 269_E 1.136 0.93
179_I 231_A 1.136 0.93
133_L 427_F 1.135 0.93
55_A 108_G 1.135 0.93
31_M 273_T 1.134 0.93
169_L 417_I 1.132 0.93
176_G 235_T 1.125 0.93
468_E 640_P 1.123 0.92
489_S 588_A 1.121 0.92
552_L 609_V 1.119 0.92
168_S 197_F 1.114 0.92
86_E 89_N 1.112 0.92
428_L 456_V 1.111 0.92
471_P 474_Q 1.11 0.92
149_T 177_K 1.11 0.92
50_Q 301_Q 1.104 0.92
309_E 313_A 1.102 0.91
544_K 572_T 1.101 0.91
248_G 260_S 1.101 0.91
211_H 230_E 1.099 0.91
36_I 243_C 1.099 0.91
161_G 165_E 1.099 0.91
65_G 101_P 1.093 0.91
212_V 242_M 1.093 0.91
372_L 428_L 1.087 0.91
94_H 647_E 1.086 0.91
376_L 427_F 1.084 0.91
36_I 152_F 1.08 0.90
357_S 523_L 1.08 0.90
489_S 514_T 1.079 0.90
14_L 18_A 1.077 0.90
81_D 107_A 1.071 0.90
257_T 260_S 1.071 0.90
567_A 655_V 1.069 0.90
82_L 106_T 1.068 0.90
44_F 229_E 1.067 0.90
148_Y 228_V 1.062 0.89
130_E 424_H 1.055 0.89
128_I 405_I 1.054 0.89
561_V 580_V 1.053 0.89
126_M 424_H 1.053 0.89
479_V 490_T 1.051 0.89
202_A 212_V 1.049 0.89
64_N 154_G 1.049 0.89
504_K 508_E 1.045 0.88
369_G 390_W 1.044 0.88
162_I 166_V 1.043 0.88
452_K 512_G 1.04 0.88
352_P 525_Q 1.04 0.88
370_P 400_A 1.039 0.88
566_A 653_D 1.039 0.88
658_K 661_E 1.038 0.88
449_A 635_F 1.036 0.88
39_V 221_A 1.033 0.88
489_S 587_D 1.032 0.87
11_I 73_S 1.032 0.87
554_F 578_A 1.031 0.87
39_V 44_F 1.031 0.87
448_A 455_Q 1.031 0.87
27_P 262_G 1.031 0.87
251_S 272_L 1.031 0.87
465_G 645_F 1.03 0.87
571_L 576_V 1.028 0.87
33_M 67_G 1.026 0.87
205_F 240_L 1.026 0.87
213_I 241_L 1.025 0.87
512_G 591_K 1.023 0.87
421_I 429_P 1.021 0.87
376_L 421_I 1.018 0.87
567_A 630_V 1.015 0.86
132_T 376_L 1.013 0.86
563_L 566_A 1.012 0.86
616_A 629_I 1.011 0.86
35_D 219_H 1.01 0.86
142_H 317_A 1.01 0.86
103_V 112_T 1.008 0.86
546_C 549_Q 1.004 0.85
423_L 453_Q 1.001 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r8oA211000.177Contact Map0.801
1r9jA20.97591000.18Contact Map0.749
3komA20.9941000.184Contact Map0.802
1gpuA20.97891000.184Contact Map0.782
3rimA40.9911000.188Contact Map0.756
3m49A20.99251000.197Contact Map0.795
1itzA30.98641000.199Contact Map0.734
3uk1A20.9941000.206Contact Map0.776
2e6kA40.97291000.212Contact Map0.786
3l84A10.94571000.242Contact Map0.773
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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