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OPENSEQ.org
YEAX - Putative dioxygenase subunit beta YeaX
UniProt: P76254 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13510
Length: 321 (315)
Sequences: 2213
Seq/Len: 7.03
YEAX
Paralog alert: 0.58 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: HCR PAAE YEAX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
252_M 260_N 4.106 1.00
76_L 89_Q 3.622 1.00
17_L 23_R 3.594 1.00
249_P 252_M 3.295 1.00
114_K 140_D 3.209 1.00
9_V 99_I 3.115 1.00
259_E 271_R 3.033 1.00
92_K 95_D 2.839 1.00
11_V 91_V 2.771 1.00
132_A 158_E 2.736 1.00
124_I 143_L 2.628 1.00
45_V 72_I 2.628 1.00
87_L 91_V 2.591 1.00
24_F 87_L 2.544 1.00
16_P 22_K 2.463 1.00
286_E 313_K 2.444 1.00
12_S 27_V 2.436 1.00
255_L 268_C 2.422 1.00
13_Q 93_V 2.382 1.00
23_R 71_Q 2.348 1.00
236_T 247_V 2.339 1.00
280_T 307_I 2.336 1.00
76_L 85_R 2.335 1.00
296_D 300_A 2.287 1.00
119_A 145_Y 2.177 1.00
14_V 22_K 2.166 1.00
147_S 153_C 2.153 1.00
10_Q 96_R 2.088 1.00
246_F 257_V 2.085 1.00
241_R 320_D 2.084 1.00
14_V 93_V 2.049 1.00
117_F 131_M 2.041 1.00
10_Q 27_V 2.023 1.00
200_E 204_E 2.014 1.00
236_T 245_E 1.999 1.00
180_E 183_R 1.99 1.00
44_I 57_A 1.97 1.00
133_E 137_S 1.97 1.00
8_E 96_R 1.943 1.00
252_M 257_V 1.909 1.00
238_V 316_R 1.885 1.00
284_E 316_R 1.884 1.00
282_I 305_M 1.867 1.00
150_P 175_T 1.836 1.00
196_T 206_V 1.828 1.00
193_H 221_H 1.821 1.00
284_E 318_V 1.741 1.00
249_P 257_V 1.69 1.00
119_A 143_L 1.69 1.00
149_N 152_S 1.689 1.00
248_V 257_V 1.665 1.00
237_L 254_I 1.664 1.00
118_I 202_L 1.657 1.00
46_Q 98_T 1.636 1.00
146_C 202_L 1.617 1.00
23_R 155_F 1.613 1.00
43_V 99_I 1.605 1.00
156_R 160_V 1.589 1.00
13_Q 25_T 1.577 1.00
147_S 172_H 1.576 1.00
8_E 98_T 1.565 1.00
239_L 258_I 1.563 1.00
117_F 141_W 1.561 1.00
118_I 206_V 1.552 1.00
236_T 316_R 1.538 0.99
173_S 178_R 1.533 0.99
120_G 202_L 1.524 0.99
254_I 307_I 1.519 0.99
34_L 70_Y 1.512 0.99
45_V 87_L 1.509 0.99
19_E 151_E 1.506 0.99
178_R 201_A 1.495 0.99
254_I 317_L 1.487 0.99
238_V 245_E 1.481 0.99
73_A 154_A 1.475 0.99
25_T 69_C 1.474 0.99
282_I 287_A 1.461 0.99
254_I 305_M 1.447 0.99
207_R 224_Q 1.43 0.99
239_L 242_S 1.429 0.99
11_V 26_L 1.423 0.99
91_V 95_D 1.421 0.99
20_Q 152_S 1.408 0.99
119_A 127_F 1.399 0.99
61_L 73_A 1.387 0.99
21_V 154_A 1.382 0.99
256_Q 271_R 1.382 0.99
259_E 268_C 1.38 0.99
91_V 97_L 1.376 0.99
146_C 173_S 1.372 0.99
23_R 73_A 1.365 0.98
150_P 156_R 1.364 0.98
207_R 222_F 1.359 0.98
296_D 299_R 1.334 0.98
116_L 194_V 1.331 0.98
131_M 143_L 1.327 0.98
211_A 217_A 1.323 0.98
17_L 155_F 1.319 0.98
39_G 133_E 1.317 0.98
256_Q 259_E 1.312 0.98
108_L 134_L 1.303 0.98
131_M 141_W 1.291 0.98
266_V 307_I 1.284 0.97
114_K 142_Q 1.278 0.97
114_K 192_T 1.263 0.97
15_E 23_R 1.244 0.97
131_M 168_V 1.24 0.97
207_R 220_L 1.239 0.97
24_F 74_V 1.236 0.97
246_F 261_N 1.216 0.96
26_L 72_I 1.206 0.96
74_V 87_L 1.204 0.96
85_R 89_Q 1.201 0.96
279_E 306_L 1.199 0.96
21_V 122_I 1.194 0.96
287_A 310_S 1.175 0.95
173_S 201_A 1.157 0.95
14_V 92_K 1.156 0.95
9_V 26_L 1.145 0.94
37_F 60_L 1.145 0.94
194_V 215_I 1.143 0.94
153_C 172_H 1.136 0.94
253_T 256_Q 1.136 0.94
238_V 318_V 1.128 0.94
196_T 203_I 1.127 0.94
37_F 62_S 1.101 0.92
203_I 222_F 1.085 0.92
25_T 71_Q 1.084 0.92
86_F 90_Q 1.084 0.92
294_F 299_R 1.08 0.91
75_R 154_A 1.068 0.91
49_D 54_Y 1.064 0.91
24_F 91_V 1.059 0.90
9_V 34_L 1.05 0.90
45_V 97_L 1.043 0.90
41_S 104_N 1.043 0.90
117_F 127_F 1.034 0.89
241_R 244_K 1.022 0.88
37_F 129_S 1.02 0.88
196_T 207_R 1.014 0.88
15_E 25_T 1.014 0.88
9_V 29_T 1.013 0.88
56_N 130_H 1.008 0.87
258_I 266_V 1.005 0.87
146_C 179_L 1.002 0.87
142_Q 169_H 1.001 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2piaA10.97511000.264Contact Map0.873
1gvhA10.71341000.497Contact Map0.794
1cqxA20.71651000.501Contact Map0.777
4g1vA10.72271000.502Contact Map0.818
1ep3B10.78821000.533Contact Map0.689
4eh1A20.70721000.537Contact Map0.915
1krhA20.69471000.542Contact Map0.73
1tvcA10.70721000.548Contact Map0.524
2r6hA40.69471000.548Contact Map0.838
2eixA20.68851000.555Contact Map0.83
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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