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OPENSEQ.org
HCR - NADH oxidoreductase hcr
UniProt: P75824 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13691
Length: 322 (314)
Sequences: 2190
Seq/Len: 6.97
HCR
Paralog alert: 0.57 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: HCR PAAE YEAX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
256_T 264_S 4.157 1.00
20_E 26_T 3.643 1.00
75_R 87_R 3.626 1.00
253_P 256_T 3.454 1.00
113_K 141_D 3.256 1.00
12_M 97_L 3.146 1.00
263_E 274_R 2.997 1.00
90_K 93_D 2.963 1.00
14_V 89_V 2.834 1.00
131_R 159_E 2.784 1.00
123_V 144_V 2.721 1.00
85_L 89_V 2.681 1.00
45_V 71_L 2.656 1.00
27_I 85_L 2.625 1.00
240_K 251_Y 2.61 1.00
15_H 30_I 2.513 1.00
16_H 91_R 2.47 1.00
289_E 316_Q 2.465 1.00
259_L 271_A 2.463 1.00
283_T 310_A 2.416 1.00
19_Q 25_W 2.41 1.00
250_F 261_A 2.354 1.00
26_T 70_T 2.349 1.00
300_D 304_A 2.31 1.00
75_R 83_Q 2.275 1.00
17_I 25_W 2.197 1.00
17_I 91_R 2.194 1.00
148_V 154_V 2.193 1.00
183_T 186_L 2.154 1.00
13_Q 94_Y 2.088 1.00
204_A 208_D 2.054 1.00
118_A 146_Y 2.053 1.00
116_L 130_R 2.031 1.00
11_R 94_Y 2.029 1.00
44_L 56_A 1.975 1.00
13_Q 30_I 1.974 1.00
132_W 136_N 1.969 1.00
256_T 261_A 1.932 1.00
285_V 308_V 1.919 1.00
240_K 249_E 1.867 1.00
253_P 261_A 1.824 1.00
200_T 210_V 1.818 1.00
118_A 144_V 1.734 1.00
151_P 172_N 1.731 1.00
150_T 153_D 1.713 1.00
170_E 181_R 1.691 1.00
197_T 223_F 1.69 1.00
117_L 206_Y 1.68 1.00
154_V 169_A 1.666 1.00
26_T 156_F 1.649 1.00
119_A 206_Y 1.649 1.00
241_F 258_L 1.64 1.00
181_R 205_P 1.618 1.00
45_V 85_L 1.609 1.00
147_N 206_Y 1.601 1.00
243_K 246_P 1.599 1.00
116_L 142_V 1.582 1.00
46_S 96_W 1.562 1.00
16_H 28_S 1.553 1.00
117_L 210_V 1.548 0.99
258_L 308_V 1.533 0.99
258_L 310_A 1.533 0.99
11_R 96_W 1.532 0.99
157_A 161_R 1.521 0.99
22_P 152_Q 1.495 0.99
285_V 290_Y 1.492 0.99
43_A 97_L 1.491 0.99
250_F 265_N 1.489 0.99
72_T 155_I 1.482 0.99
147_N 170_E 1.481 0.99
252_A 261_A 1.481 0.99
47_V 81_G 1.473 0.99
170_E 205_P 1.469 0.99
39_A 132_W 1.465 0.99
14_V 29_L 1.463 0.99
293_S 314_H 1.46 0.99
118_A 126_I 1.451 0.99
106_C 133_L 1.45 0.99
211_E 226_K 1.45 0.99
60_S 72_T 1.45 0.99
23_D 153_D 1.444 0.99
28_S 68_Y 1.438 0.99
243_K 262_L 1.425 0.99
263_E 271_A 1.407 0.99
89_V 93_D 1.394 0.99
151_P 157_A 1.391 0.99
24_V 155_I 1.383 0.99
148_V 169_A 1.383 0.99
242_T 249_E 1.375 0.99
26_T 72_T 1.363 0.98
27_I 73_V 1.36 0.98
260_E 274_R 1.355 0.98
117_L 187_L 1.345 0.98
130_R 142_V 1.34 0.98
211_E 224_K 1.334 0.98
115_L 198_V 1.321 0.98
260_E 263_E 1.313 0.98
89_V 95_L 1.31 0.98
130_R 144_V 1.302 0.98
211_E 222_F 1.284 0.97
300_D 303_I 1.28 0.97
20_E 156_F 1.275 0.97
18_T 26_T 1.267 0.97
143_R 166_T 1.263 0.97
282_K 309_L 1.252 0.97
83_Q 87_R 1.247 0.97
269_V 310_A 1.239 0.97
245_Q 248_R 1.233 0.96
113_K 143_R 1.231 0.96
29_L 71_L 1.211 0.96
290_Y 313_C 1.209 0.96
73_V 85_L 1.194 0.96
24_V 121_C 1.189 0.95
12_M 29_L 1.189 0.95
116_L 126_I 1.188 0.95
200_T 207_M 1.176 0.95
289_E 317_G 1.152 0.94
12_M 32_H 1.137 0.94
37_Y 61_S 1.134 0.94
287_S 320_V 1.131 0.94
282_K 307_Y 1.127 0.93
84_W 88_D 1.122 0.93
37_Y 59_I 1.12 0.93
147_N 182_L 1.118 0.93
113_K 196_R 1.117 0.93
207_M 224_K 1.117 0.93
198_V 219_V 1.113 0.93
250_F 253_P 1.098 0.92
257_T 260_E 1.094 0.92
17_I 90_K 1.092 0.92
74_R 155_I 1.09 0.92
200_T 211_E 1.077 0.91
27_I 89_V 1.068 0.91
262_L 269_V 1.06 0.90
18_T 28_S 1.06 0.90
37_Y 128_S 1.053 0.90
55_R 129_M 1.039 0.89
28_S 70_T 1.036 0.89
41_Q 102_G 1.029 0.89
45_V 95_L 1.024 0.88
35_Y 69_I 1.012 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2piaA10.95651000.279Contact Map0.872
1gvhA10.71741000.498Contact Map0.79
1cqxA20.71741000.503Contact Map0.764
4g1vA10.7051000.514Contact Map0.831
1ep3B10.79191000.519Contact Map0.693
1tvcA10.72051000.531Contact Map0.523
4eh1A20.69571000.535Contact Map0.907
1krhA20.70191000.536Contact Map0.736
1qfjA40.68631000.541Contact Map0.757
2eixA20.69571000.553Contact Map0.838
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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