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OPENSEQ.org
PAAE - 1,2-phenylacetyl-CoA epoxidase, subunit E
UniProt: P76081 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13739
Length: 356 (348)
Sequences: 2189
Seq/Len: 6.29
PAAE
Paralog alert: 0.58 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: HCR PAAE YEAX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
282_E 290_R 4.345 1.00
74_A 86_E 3.757 1.00
15_E 21_T 3.732 1.00
278_N 282_E 3.47 1.00
114_R 142_Q 3.449 1.00
7_L 96_V 3.161 1.00
289_L 300_K 3.147 1.00
89_R 92_M 2.963 1.00
132_A 160_A 2.908 1.00
124_I 145_L 2.896 1.00
9_V 88_I 2.856 1.00
44_L 70_V 2.761 1.00
22_I 84_A 2.712 1.00
84_A 88_I 2.707 1.00
285_L 297_Y 2.615 1.00
275_I 287_A 2.599 1.00
10_A 25_A 2.549 1.00
14_S 20_V 2.515 1.00
315_K 342_L 2.459 1.00
326_P 330_A 2.454 1.00
11_K 90_Q 2.451 1.00
74_A 82_R 2.433 1.00
309_C 336_S 2.431 1.00
21_T 69_S 2.348 1.00
133_T 137_T 2.335 1.00
149_N 155_M 2.319 1.00
12_V 90_Q 2.245 1.00
12_V 20_V 2.242 1.00
6_S 93_T 2.204 1.00
8_T 93_T 2.201 1.00
119_A 147_Y 2.119 1.00
43_T 56_C 2.101 1.00
8_T 25_A 2.085 1.00
117_A 131_I 2.082 1.00
219_A 223_D 2.071 1.00
311_V 334_V 1.983 1.00
282_E 287_A 1.981 1.00
313_R 345_D 1.976 1.00
278_N 287_A 1.915 1.00
215_I 225_A 1.877 1.00
212_E 240_H 1.862 1.00
119_A 145_L 1.802 1.00
313_R 347_V 1.782 1.00
191_R 220_A 1.763 1.00
278_N 281_D 1.746 1.00
118_I 221_M 1.743 1.00
148_G 221_M 1.735 1.00
151_T 154_S 1.721 1.00
42_L 96_V 1.686 1.00
117_A 143_F 1.686 1.00
21_T 157_F 1.686 1.00
268_Q 271_R 1.676 1.00
6_S 95_E 1.672 1.00
266_V 269_D 1.669 1.00
149_N 176_C 1.654 1.00
44_L 84_A 1.651 1.00
120_A 221_M 1.623 1.00
284_I 336_S 1.607 1.00
118_I 225_A 1.596 1.00
158_R 162_A 1.593 0.99
11_K 23_T 1.553 0.99
284_I 334_V 1.542 0.99
284_I 346_V 1.533 0.99
193_D 196_K 1.526 0.99
275_I 291_Q 1.525 0.99
71_A 156_M 1.515 0.99
119_A 127_M 1.511 0.99
23_T 67_E 1.505 0.99
226_E 243_R 1.496 0.99
46_A 80_F 1.489 0.99
265_T 345_D 1.489 0.99
311_V 316_V 1.488 0.99
277_L 287_A 1.486 0.99
45_K 95_E 1.485 0.99
289_L 297_Y 1.484 0.99
88_I 94_L 1.473 0.99
88_I 92_M 1.465 0.99
15_E 157_F 1.461 0.99
18_D 154_S 1.46 0.99
60_C 71_A 1.457 0.99
226_E 241_L 1.447 0.99
105_Y 134_T 1.447 0.99
9_V 24_F 1.427 0.99
265_T 274_E 1.425 0.99
152_S 158_R 1.421 0.99
264_V 270_G 1.418 0.99
19_A 156_M 1.416 0.99
17_R 153_Q 1.412 0.99
38_P 133_T 1.407 0.98
266_V 271_R 1.4 0.98
131_I 143_F 1.392 0.98
33_A 68_I 1.391 0.98
286_D 289_L 1.38 0.98
155_M 178_F 1.367 0.98
308_K 335_L 1.363 0.98
114_R 144_T 1.357 0.98
22_I 72_V 1.354 0.98
286_D 300_K 1.351 0.98
26_V 30_L 1.343 0.98
21_T 71_A 1.336 0.98
131_I 145_L 1.328 0.98
326_P 329_L 1.325 0.98
226_E 239_I 1.324 0.97
13_E 21_T 1.319 0.97
179_S 191_R 1.318 0.97
230_K 236_D 1.302 0.97
24_F 70_V 1.29 0.97
148_G 179_S 1.285 0.97
263_K 276_V 1.284 0.97
295_L 336_S 1.28 0.97
179_S 220_A 1.279 0.97
44_L 94_L 1.243 0.96
36_F 61_R 1.241 0.96
72_V 84_A 1.234 0.96
319_E 340_L 1.232 0.96
82_R 86_E 1.227 0.96
83_Y 87_H 1.226 0.96
131_I 172_L 1.223 0.95
114_R 211_D 1.222 0.95
316_V 339_A 1.217 0.95
275_I 278_N 1.215 0.95
118_I 197_L 1.208 0.95
116_L 213_A 1.205 0.95
7_L 33_A 1.201 0.95
265_T 276_V 1.187 0.94
148_G 192_I 1.183 0.94
215_I 222_M 1.181 0.94
7_L 27_P 1.181 0.94
264_V 271_R 1.177 0.94
264_V 268_Q 1.171 0.94
73_K 156_M 1.162 0.94
308_K 333_Y 1.158 0.93
117_A 127_M 1.148 0.93
270_G 273_R 1.147 0.93
23_T 69_S 1.147 0.93
22_I 88_I 1.141 0.93
264_V 272_D 1.139 0.93
283_S 286_D 1.135 0.92
222_M 241_L 1.134 0.92
315_K 343_T 1.133 0.92
152_S 162_A 1.126 0.92
19_A 122_S 1.12 0.92
223_D 227_T 1.109 0.91
55_R 130_I 1.105 0.91
213_A 234_M 1.104 0.91
36_F 129_A 1.1 0.91
215_I 226_E 1.093 0.91
12_V 89_R 1.092 0.90
48_F 53_L 1.091 0.90
207_F 234_M 1.078 0.90
36_F 59_I 1.078 0.90
316_V 346_V 1.073 0.89
142_Q 171_R 1.062 0.89
267_R 345_D 1.061 0.89
12_V 92_M 1.046 0.88
224_D 228_A 1.043 0.88
317_A 342_L 1.04 0.87
155_M 176_C 1.036 0.87
13_E 23_T 1.03 0.87
324_L 329_L 1.027 0.86
288_A 295_L 1.022 0.86
288_A 336_S 1.018 0.86
40_Q 101_G 1.014 0.86
9_V 22_I 1.014 0.86
155_M 158_R 1.009 0.85
274_E 345_D 1.006 0.85
285_L 289_L 1.006 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2piaA10.88481000.331Contact Map0.846
1gvhA10.6771000.494Contact Map0.769
1cqxA20.6771000.5Contact Map0.741
4g1vA10.66851000.51Contact Map0.803
4eh1A20.66291000.54Contact Map0.897
1krhA20.65731000.54Contact Map0.704
1tvcA10.67421000.543Contact Map0.503
2eixA20.65731000.55Contact Map0.804
2cndA10.66851000.553Contact Map0.763
1qfjA40.64611000.554Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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