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UBIF - 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
UniProt: P75728 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13658
Length: 391 (381)
Sequences: 10358
Seq/Len: 27.19
UBIF
Paralog alert: 0.83 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_T 131_R 4.361 1.00
36_H 135_S 4.068 1.00
16_V 304_G 3.64 1.00
7_E 159_K 3.524 1.00
335_Q 339_M 3.469 1.00
7_E 30_A 3.425 1.00
9_A 158_A 3.346 1.00
20_L 162_I 3.329 1.00
9_A 148_L 3.079 1.00
163_G 171_V 2.758 1.00
138_A 174_M 2.732 1.00
136_L 148_L 2.671 1.00
121_A 124_A 2.643 1.00
19_A 305_Y 2.614 1.00
9_A 34_I 2.563 1.00
71_A 120_Q 2.538 1.00
134_G 152_G 2.509 1.00
135_S 151_K 2.485 1.00
147_E 157_R 2.456 1.00
116_Q 120_Q 2.455 1.00
23_G 312_I 2.411 1.00
34_I 156_I 2.389 1.00
27_H 316_V 2.374 1.00
6_T 32_T 2.371 1.00
140_H 147_E 2.351 1.00
138_A 149_E 2.33 1.00
16_V 286_V 2.31 1.00
241_N 244_Q 2.292 1.00
139_L 161_V 2.29 1.00
279_V 332_K 2.215 1.00
149_E 155_V 2.185 1.00
164_A 286_V 2.131 1.00
30_A 129_T 2.084 1.00
21_A 33_V 2.045 1.00
22_L 121_A 2.045 1.00
10_I 20_L 2.043 1.00
122_L 128_V 2.037 1.00
314_V 337_R 2.018 1.00
142_H 157_R 2.014 1.00
8_I 29_F 2.012 1.00
147_E 155_V 1.96 1.00
7_E 32_T 1.936 1.00
34_I 150_L 1.918 1.00
163_G 285_L 1.916 1.00
64_K 69_W 1.915 1.00
160_L 331_L 1.913 1.00
247_A 251_K 1.911 1.00
134_G 150_L 1.902 1.00
145_L 157_R 1.894 1.00
131_R 134_G 1.885 1.00
59_S 302_N 1.87 1.00
165_D 169_S 1.868 1.00
277_Q 280_Q 1.852 1.00
150_L 156_I 1.847 1.00
9_A 156_I 1.845 1.00
308_V 312_I 1.832 1.00
175_A 283_L 1.818 1.00
310_A 314_V 1.807 1.00
71_A 121_A 1.791 1.00
8_I 24_L 1.773 1.00
140_H 149_E 1.771 1.00
20_L 24_L 1.761 1.00
25_A 128_V 1.746 1.00
313_D 337_R 1.724 1.00
279_V 284_A 1.687 1.00
20_L 308_V 1.674 1.00
32_T 156_I 1.673 1.00
278_Y 342_N 1.661 1.00
314_V 330_V 1.658 1.00
38_E 133_P 1.656 1.00
62_L 309_D 1.645 1.00
137_I 151_K 1.633 1.00
59_S 305_Y 1.632 1.00
146_Q 161_V 1.623 1.00
170_Q 174_M 1.622 1.00
339_M 343_F 1.614 1.00
142_H 145_L 1.611 1.00
29_F 316_V 1.606 1.00
142_H 147_E 1.599 1.00
71_A 124_A 1.582 1.00
278_Y 335_Q 1.576 1.00
121_A 125_H 1.57 1.00
10_I 31_V 1.562 1.00
65_G 309_D 1.562 1.00
277_Q 335_Q 1.559 1.00
15_M 301_V 1.557 1.00
310_A 337_R 1.55 1.00
141_R 280_Q 1.542 1.00
23_G 66_L 1.515 1.00
194_Q 261_T 1.509 1.00
286_V 334_Y 1.508 1.00
148_L 161_V 1.506 1.00
131_R 154_E 1.503 1.00
306_R 341_D 1.502 1.00
314_V 333_R 1.502 1.00
243_A 247_A 1.496 1.00
177_I 275_A 1.483 1.00
20_L 286_V 1.475 1.00
307_D 338_R 1.475 1.00
158_A 161_V 1.47 1.00
134_G 154_E 1.453 1.00
11_V 161_V 1.44 1.00
169_S 172_R 1.432 1.00
9_A 32_T 1.43 1.00
71_A 75_M 1.428 1.00
22_L 122_L 1.426 1.00
162_I 284_A 1.425 1.00
291_H 307_D 1.417 1.00
22_L 66_L 1.399 0.99
19_A 23_G 1.396 0.99
284_A 311_L 1.388 0.99
136_L 171_V 1.377 0.99
146_Q 282_G 1.37 0.99
246_Q 250_A 1.37 0.99
10_I 21_A 1.365 0.99
22_L 26_Q 1.365 0.99
136_L 139_L 1.344 0.99
34_I 131_R 1.336 0.99
120_Q 123_E 1.334 0.99
11_V 136_L 1.32 0.99
76_R 113_V 1.313 0.99
13_G 18_G 1.31 0.99
13_G 35_E 1.296 0.99
162_I 286_V 1.289 0.99
167_A 292_T 1.289 0.99
119_W 132_V 1.285 0.99
279_V 328_Y 1.271 0.99
70_D 75_M 1.267 0.99
11_V 171_V 1.266 0.99
6_T 9_A 1.262 0.99
170_Q 173_Q 1.247 0.99
119_W 130_L 1.236 0.98
70_D 74_A 1.23 0.98
141_R 282_G 1.215 0.98
26_Q 121_A 1.213 0.98
148_L 158_A 1.207 0.98
31_V 128_V 1.205 0.98
242_M 265_A 1.199 0.98
19_A 66_L 1.182 0.98
7_E 29_F 1.178 0.98
131_R 156_I 1.177 0.98
285_L 289_A 1.171 0.98
248_E 251_K 1.168 0.97
72_V 117_A 1.164 0.97
53_S 301_V 1.159 0.97
82_R 202_S 1.146 0.97
22_L 125_H 1.14 0.97
284_A 334_Y 1.138 0.97
279_V 331_L 1.13 0.97
279_V 335_Q 1.126 0.97
137_I 149_E 1.119 0.96
87_E 90_T 1.118 0.96
33_V 130_L 1.116 0.96
141_R 146_Q 1.116 0.96
233_R 236_Q 1.114 0.96
310_A 313_D 1.114 0.96
293_I 346_Q 1.112 0.96
247_A 250_A 1.111 0.96
160_L 284_A 1.1 0.96
72_V 114_L 1.09 0.96
273_R 292_T 1.087 0.96
63_L 68_V 1.076 0.95
68_V 121_A 1.072 0.95
317_N 333_R 1.072 0.95
324_A 329_P 1.062 0.95
293_I 303_L 1.059 0.95
318_A 333_R 1.056 0.95
178_G 276_L 1.055 0.95
34_I 134_G 1.05 0.94
122_L 127_K 1.05 0.94
150_L 154_E 1.048 0.94
314_V 317_N 1.045 0.94
53_S 111_N 1.042 0.94
24_L 29_F 1.04 0.94
76_R 117_A 1.037 0.94
163_G 283_L 1.032 0.94
69_W 74_A 1.031 0.94
60_V 107_Y 1.028 0.94
21_A 31_V 1.026 0.94
244_Q 247_A 1.026 0.94
332_K 336_M 1.019 0.93
139_L 175_A 1.018 0.93
58_A 299_Q 1.017 0.93
171_V 283_L 1.014 0.93
140_H 155_V 1.013 0.93
362_P 366_M 1.012 0.93
18_G 33_V 1.005 0.93
333_R 336_M 1.004 0.93
25_A 129_T 1.003 0.93
5_P 159_K 1.003 0.93
162_I 311_L 1.002 0.92
58_A 306_R 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4n9xA10.99491000.216Contact Map0.7
4k22A20.92581000.265Contact Map0.748
2qa2A10.94881000.281Contact Map0.752
2x3nA10.96421000.289Contact Map0.766
2qa1A10.94881000.29Contact Map0.793
4k2xA20.95911000.292Contact Map0.797
3fmwA30.96161000.298Contact Map0.702
1k0iA10.9541000.302Contact Map0.709
4k5sA10.96161000.302Contact Map0.803
1pn0A40.95911000.322Contact Map0.768
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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