May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
FIXC - Protein FixC
UniProt: P68644 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11564
Length: 428 (367)
Sequences: 7091
Seq/Len: 19.32
FIXC
Paralog alert: 0.76 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_L 126_I 4.179 1.00
349_R 353_E 4.032 1.00
9_I 144_V 3.832 1.00
36_R 130_R 3.804 1.00
20_A 157_I 3.661 1.00
7_D 154_K 3.411 1.00
9_I 153_A 3.402 1.00
16_A 320_A 3.316 1.00
7_D 30_Q 3.245 1.00
117_Q 120_E 3.141 1.00
133_N 169_K 3.028 1.00
158_L 166_L 2.947 1.00
131_V 144_V 2.766 1.00
133_N 145_E 2.735 1.00
16_A 300_A 2.615 1.00
143_G 152_E 2.558 1.00
6_F 32_L 2.537 1.00
134_L 156_V 2.421 1.00
19_V 321_I 2.416 1.00
250_S 253_Q 2.393 1.00
145_E 150_V 2.365 1.00
23_V 328_A 2.363 1.00
9_I 34_I 2.363 1.00
27_E 332_L 2.317 1.00
159_A 300_A 2.317 1.00
140_K 152_E 2.317 1.00
135_V 143_G 2.262 1.00
34_I 146_A 2.24 1.00
21_A 33_V 2.197 1.00
293_V 298_L 2.197 1.00
34_I 151_I 2.19 1.00
130_R 147_D 2.164 1.00
329_K 351_H 2.13 1.00
112_A 116_E 2.124 1.00
293_V 346_A 2.12 1.00
157_I 298_L 2.075 1.00
10_I 20_A 2.073 1.00
157_I 300_A 2.062 1.00
190_E 272_K 2.055 1.00
129_I 146_A 2.035 1.00
291_E 294_G 1.976 1.00
137_R 140_K 1.967 1.00
137_R 152_E 1.954 1.00
20_A 300_A 1.939 1.00
22_L 117_Q 1.925 1.00
330_T 351_H 1.918 1.00
160_D 164_S 1.915 1.00
32_L 151_I 1.913 1.00
158_L 299_I 1.911 1.00
8_A 29_A 1.895 1.00
153_A 156_V 1.894 1.00
7_D 32_L 1.886 1.00
118_A 123_A 1.879 1.00
155_T 345_L 1.867 1.00
143_G 150_V 1.865 1.00
146_A 151_I 1.862 1.00
135_V 145_E 1.86 1.00
8_A 24_L 1.787 1.00
30_Q 124_Q 1.764 1.00
9_I 151_I 1.755 1.00
324_G 328_A 1.741 1.00
5_I 154_K 1.72 1.00
20_A 324_G 1.718 1.00
330_T 344_K 1.705 1.00
326_A 351_H 1.695 1.00
165_I 169_K 1.694 1.00
126_I 149_D 1.692 1.00
129_I 149_D 1.678 1.00
322_A 355_G 1.668 1.00
326_A 330_T 1.64 1.00
144_V 156_V 1.631 1.00
56_E 63_A 1.629 1.00
6_F 9_I 1.592 1.00
22_L 58_I 1.591 1.00
29_A 332_L 1.591 1.00
170_L 297_V 1.59 1.00
11_V 156_V 1.573 1.00
132_D 147_D 1.564 1.00
137_R 143_G 1.534 1.00
38_N 128_G 1.531 1.00
291_E 349_R 1.529 1.00
61_G 116_E 1.507 1.00
330_T 347_E 1.5 1.00
141_V 156_V 1.486 1.00
300_A 348_Y 1.48 1.00
126_I 151_I 1.465 1.00
10_I 21_A 1.455 1.00
353_E 357_L 1.453 1.00
25_A 123_A 1.448 1.00
126_I 129_I 1.448 1.00
5_I 152_E 1.441 1.00
13_A 18_S 1.441 1.00
292_L 356_P 1.432 1.00
333_S 347_E 1.418 1.00
15_L 317_M 1.418 1.00
22_L 118_A 1.41 1.00
252_P 256_E 1.41 1.00
13_A 40_A 1.41 1.00
298_L 327_A 1.394 0.99
34_I 144_V 1.383 0.99
305_G 323_A 1.379 0.99
157_I 331_V 1.378 0.99
142_V 152_E 1.374 0.99
136_Q 294_G 1.367 0.99
10_I 31_V 1.352 0.99
7_D 29_A 1.35 0.99
19_V 23_V 1.346 0.99
20_A 24_L 1.342 0.99
164_S 167_A 1.327 0.99
323_A 352_L 1.312 0.99
9_I 32_L 1.298 0.99
131_V 134_L 1.283 0.99
243_H 246_D 1.275 0.99
46_T 49_R 1.273 0.99
190_E 231_N 1.271 0.99
34_I 126_I 1.27 0.99
23_V 58_I 1.261 0.99
256_E 259_K 1.258 0.99
292_L 349_R 1.251 0.99
294_G 297_V 1.25 0.99
116_E 119_E 1.24 0.98
11_V 131_V 1.236 0.98
57_H 325_E 1.233 0.98
309_N 319_L 1.232 0.98
115_M 127_T 1.229 0.98
136_Q 141_V 1.206 0.98
330_T 333_S 1.195 0.98
53_H 56_E 1.188 0.98
136_Q 296_G 1.184 0.98
157_I 327_A 1.18 0.98
13_A 35_E 1.179 0.98
31_V 123_A 1.173 0.98
293_V 345_L 1.164 0.97
293_V 342_K 1.158 0.97
61_G 64_D 1.143 0.97
286_I 308_M 1.142 0.97
166_L 297_V 1.139 0.97
115_M 125_L 1.137 0.97
35_E 127_T 1.136 0.97
26_R 117_Q 1.13 0.97
131_V 166_L 1.127 0.97
346_A 350_Q 1.124 0.97
192_P 195_V 1.124 0.97
47_G 107_R 1.123 0.97
253_Q 257_D 1.123 0.97
6_F 124_Q 1.119 0.96
140_K 143_G 1.115 0.96
24_L 29_A 1.109 0.96
339_D 343_Q 1.108 0.96
46_T 50_L 1.104 0.96
117_Q 121_A 1.102 0.96
54_S 325_E 1.1 0.96
167_A 303_A 1.097 0.96
24_L 328_A 1.095 0.96
109_K 112_A 1.093 0.96
76_K 89_D 1.091 0.96
347_E 350_Q 1.084 0.96
135_V 150_V 1.084 0.96
165_I 168_E 1.08 0.95
20_A 331_V 1.076 0.95
155_T 298_L 1.074 0.95
129_I 147_D 1.067 0.95
265_A 269_A 1.063 0.95
258_F 264_V 1.057 0.95
15_L 321_I 1.054 0.95
105_V 110_F 1.054 0.95
22_L 26_R 1.05 0.94
29_A 335_M 1.05 0.94
256_E 260_Q 1.043 0.94
308_M 323_A 1.04 0.94
347_E 351_H 1.039 0.94
34_I 129_I 1.038 0.94
293_V 349_R 1.035 0.94
292_L 304_A 1.033 0.94
364_Q 368_A 1.025 0.93
299_I 304_A 1.022 0.93
334_A 347_E 1.017 0.93
309_N 363_Y 1.009 0.93
76_K 208_A 1.008 0.93
132_D 145_E 1.006 0.93
171_G 174_K 1.005 0.93
134_L 297_V 1.002 0.92
178_P 364_Q 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gmhA20.9651000.384Contact Map0.762
3atrA10.92291000.428Contact Map0.735
3cgvA10.89491000.477Contact Map0.755
2x3nA10.86921000.484Contact Map0.756
4n9xA10.89251000.492Contact Map0.7
4k22A20.80371000.493Contact Map0.755
4hb9A10.88081000.504Contact Map0.733
2qa2A10.89251000.509Contact Map0.771
3e1tA10.95561000.509Contact Map0.745
4bjzA10.92061000.514Contact Map0.735
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.4026 seconds.