| UniProt: | P25535 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11333 | ||
| Length: | 400 (388) | ||
| Sequences: | 10099 | ||
| Seq/Len: | 26.03 |
| VISC
Paralog alert: 0.82 [within 20: 0.32] - ratio of genomes with paralogs Cluster includes: CBRA FIXC UBIF UBIH VISC YDIS YGCN |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 30_A | 130_L | 4.429 | 1.00 | |
| 34_Q | 134_E | 4.034 | 1.00 | |
| 14_V | 305_G | 3.665 | 1.00 | |
| 336_E | 340_K | 3.606 | 1.00 | |
| 5_D | 158_R | 3.511 | 1.00 | |
| 7_A | 157_A | 3.386 | 1.00 | |
| 5_D | 28_R | 3.365 | 1.00 | |
| 18_V | 161_I | 3.325 | 1.00 | |
| 7_A | 147_L | 3.242 | 1.00 | |
| 162_G | 170_L | 2.759 | 1.00 | |
| 137_Q | 173_K | 2.714 | 1.00 | |
| 135_L | 147_L | 2.699 | 1.00 | |
| 120_K | 123_Q | 2.693 | 1.00 | |
| 134_E | 150_K | 2.69 | 1.00 | |
| 69_D | 119_N | 2.617 | 1.00 | |
| 17_A | 306_F | 2.581 | 1.00 | |
| 133_A | 151_D | 2.556 | 1.00 | |
| 146_F | 156_T | 2.555 | 1.00 | |
| 7_A | 32_L | 2.548 | 1.00 | |
| 115_Y | 119_N | 2.504 | 1.00 | |
| 21_G | 313_I | 2.433 | 1.00 | |
| 137_Q | 148_T | 2.424 | 1.00 | |
| 4_V | 30_A | 2.424 | 1.00 | |
| 32_L | 155_L | 2.422 | 1.00 | |
| 25_S | 317_K | 2.392 | 1.00 | |
| 14_V | 287_V | 2.378 | 1.00 | |
| 148_T | 154_M | 2.299 | 1.00 | |
| 138_V | 160_V | 2.267 | 1.00 | |
| 139_A | 146_F | 2.256 | 1.00 | |
| 241_S | 244_E | 2.235 | 1.00 | |
| 280_A | 333_R | 2.137 | 1.00 | |
| 163_A | 287_V | 2.134 | 1.00 | |
| 19_A | 31_V | 2.1 | 1.00 | |
| 6_V | 27_L | 2.092 | 1.00 | |
| 315_E | 338_S | 2.077 | 1.00 | |
| 8_I | 18_V | 2.074 | 1.00 | |
| 32_L | 149_L | 2.072 | 1.00 | |
| 121_A | 127_I | 2.049 | 1.00 | |
| 20_C | 120_K | 2.044 | 1.00 | |
| 149_L | 155_L | 2.003 | 1.00 | |
| 28_R | 128_T | 1.985 | 1.00 | |
| 62_T | 67_W | 1.977 | 1.00 | |
| 146_F | 154_M | 1.973 | 1.00 | |
| 141_G | 156_T | 1.968 | 1.00 | |
| 162_G | 286_L | 1.938 | 1.00 | |
| 133_A | 149_L | 1.923 | 1.00 | |
| 136_Q | 150_K | 1.908 | 1.00 | |
| 144_E | 156_T | 1.905 | 1.00 | |
| 164_D | 168_S | 1.901 | 1.00 | |
| 247_R | 251_I | 1.885 | 1.00 | |
| 5_D | 30_A | 1.88 | 1.00 | |
| 159_L | 332_L | 1.878 | 1.00 | |
| 57_S | 303_N | 1.873 | 1.00 | |
| 309_A | 313_I | 1.871 | 1.00 | |
| 130_L | 133_A | 1.846 | 1.00 | |
| 139_A | 148_T | 1.844 | 1.00 | |
| 7_A | 155_L | 1.834 | 1.00 | |
| 278_Q | 281_S | 1.831 | 1.00 | |
| 23_Q | 127_I | 1.805 | 1.00 | |
| 69_D | 120_K | 1.798 | 1.00 | |
| 311_E | 315_E | 1.784 | 1.00 | |
| 174_A | 284_L | 1.781 | 1.00 | |
| 18_V | 22_L | 1.778 | 1.00 | |
| 36_V | 132_P | 1.751 | 1.00 | |
| 314_A | 338_S | 1.746 | 1.00 | |
| 6_V | 22_L | 1.737 | 1.00 | |
| 130_L | 153_S | 1.726 | 1.00 | |
| 120_K | 124_S | 1.725 | 1.00 | |
| 18_V | 309_A | 1.707 | 1.00 | |
| 315_E | 331_Y | 1.686 | 1.00 | |
| 340_K | 344_A | 1.675 | 1.00 | |
| 145_T | 160_V | 1.674 | 1.00 | |
| 30_A | 155_L | 1.673 | 1.00 | |
| 279_F | 343_A | 1.668 | 1.00 | |
| 169_W | 173_K | 1.663 | 1.00 | |
| 280_A | 285_A | 1.624 | 1.00 | |
| 133_A | 153_S | 1.608 | 1.00 | |
| 140_W | 281_S | 1.602 | 1.00 | |
| 141_G | 144_E | 1.59 | 1.00 | |
| 279_F | 336_E | 1.585 | 1.00 | |
| 27_L | 317_K | 1.581 | 1.00 | |
| 57_S | 306_F | 1.58 | 1.00 | |
| 307_M | 342_S | 1.575 | 1.00 | |
| 278_Q | 336_E | 1.574 | 1.00 | |
| 311_E | 338_S | 1.574 | 1.00 | |
| 147_L | 160_V | 1.569 | 1.00 | |
| 69_D | 123_Q | 1.566 | 1.00 | |
| 63_R | 310_A | 1.555 | 1.00 | |
| 60_L | 310_A | 1.555 | 1.00 | |
| 21_G | 64_L | 1.551 | 1.00 | |
| 141_G | 146_F | 1.545 | 1.00 | |
| 287_V | 335_Y | 1.532 | 1.00 | |
| 315_E | 334_R | 1.523 | 1.00 | |
| 8_I | 29_V | 1.521 | 1.00 | |
| 308_D | 339_R | 1.509 | 1.00 | |
| 157_A | 160_V | 1.502 | 1.00 | |
| 9_V | 160_V | 1.494 | 1.00 | |
| 18_V | 287_V | 1.488 | 1.00 | |
| 7_A | 30_A | 1.488 | 1.00 | |
| 13_M | 302_V | 1.486 | 1.00 | |
| 176_I | 276_A | 1.484 | 1.00 | |
| 145_T | 283_R | 1.444 | 1.00 | |
| 20_C | 121_A | 1.434 | 1.00 | |
| 20_C | 64_L | 1.432 | 1.00 | |
| 69_D | 73_R | 1.419 | 1.00 | |
| 193_R | 261_K | 1.41 | 1.00 | |
| 292_H | 308_D | 1.393 | 0.99 | |
| 11_G | 16_L | 1.389 | 0.99 | |
| 20_C | 124_S | 1.377 | 0.99 | |
| 119_N | 122_H | 1.371 | 0.99 | |
| 11_G | 33_E | 1.369 | 0.99 | |
| 246_N | 250_N | 1.369 | 0.99 | |
| 135_L | 138_V | 1.367 | 0.99 | |
| 17_A | 21_G | 1.364 | 0.99 | |
| 285_A | 312_L | 1.364 | 0.99 | |
| 135_L | 170_L | 1.363 | 0.99 | |
| 161_I | 285_A | 1.359 | 0.99 | |
| 74_R | 112_V | 1.348 | 0.99 | |
| 9_V | 170_L | 1.344 | 0.99 | |
| 9_V | 135_L | 1.328 | 0.99 | |
| 20_C | 24_G | 1.326 | 0.99 | |
| 168_S | 171_R | 1.321 | 0.99 | |
| 32_L | 130_L | 1.32 | 0.99 | |
| 118_W | 131_A | 1.319 | 0.99 | |
| 8_I | 19_A | 1.316 | 0.99 | |
| 243_D | 247_R | 1.297 | 0.99 | |
| 140_W | 283_R | 1.275 | 0.99 | |
| 149_L | 153_S | 1.274 | 0.99 | |
| 17_A | 64_L | 1.273 | 0.99 | |
| 169_W | 172_N | 1.269 | 0.99 | |
| 4_V | 7_A | 1.253 | 0.99 | |
| 166_A | 293_T | 1.252 | 0.99 | |
| 130_L | 155_L | 1.252 | 0.99 | |
| 140_W | 145_T | 1.234 | 0.98 | |
| 51_S | 302_V | 1.234 | 0.98 | |
| 161_I | 287_V | 1.229 | 0.98 | |
| 29_V | 127_I | 1.228 | 0.98 | |
| 118_W | 129_L | 1.218 | 0.98 | |
| 68_Q | 73_R | 1.212 | 0.98 | |
| 177_P | 277_R | 1.209 | 0.98 | |
| 274_R | 293_T | 1.205 | 0.98 | |
| 147_L | 157_A | 1.196 | 0.98 | |
| 280_A | 329_Y | 1.185 | 0.98 | |
| 61_L | 66_V | 1.181 | 0.98 | |
| 24_G | 120_K | 1.18 | 0.98 | |
| 68_Q | 72_S | 1.17 | 0.97 | |
| 70_I | 116_A | 1.162 | 0.97 | |
| 280_A | 332_L | 1.156 | 0.97 | |
| 159_L | 285_A | 1.156 | 0.97 | |
| 294_I | 347_L | 1.155 | 0.97 | |
| 280_A | 336_E | 1.154 | 0.97 | |
| 5_D | 27_L | 1.153 | 0.97 | |
| 136_Q | 148_T | 1.146 | 0.97 | |
| 286_L | 290_A | 1.124 | 0.97 | |
| 311_E | 314_A | 1.107 | 0.96 | |
| 319_L | 334_R | 1.103 | 0.96 | |
| 242_E | 266_R | 1.101 | 0.96 | |
| 33_E | 131_A | 1.1 | 0.96 | |
| 74_R | 116_A | 1.1 | 0.96 | |
| 56_A | 300_Q | 1.092 | 0.96 | |
| 138_V | 174_A | 1.089 | 0.96 | |
| 285_A | 335_Y | 1.089 | 0.96 | |
| 67_W | 72_S | 1.086 | 0.96 | |
| 24_G | 124_S | 1.081 | 0.95 | |
| 170_L | 284_L | 1.078 | 0.95 | |
| 333_R | 337_R | 1.075 | 0.95 | |
| 318_R | 334_R | 1.074 | 0.95 | |
| 19_A | 29_V | 1.073 | 0.95 | |
| 294_I | 304_L | 1.073 | 0.95 | |
| 56_A | 307_M | 1.073 | 0.95 | |
| 233_E | 236_R | 1.07 | 0.95 | |
| 112_V | 115_Y | 1.07 | 0.95 | |
| 31_V | 129_L | 1.065 | 0.95 | |
| 63_R | 314_A | 1.064 | 0.95 | |
| 248_A | 251_I | 1.056 | 0.95 | |
| 344_A | 348_A | 1.053 | 0.95 | |
| 70_I | 113_I | 1.053 | 0.95 | |
| 315_E | 318_R | 1.052 | 0.95 | |
| 66_V | 120_K | 1.04 | 0.94 | |
| 32_L | 133_A | 1.039 | 0.94 | |
| 51_S | 110_N | 1.035 | 0.94 | |
| 244_E | 247_R | 1.031 | 0.94 | |
| 22_L | 27_L | 1.028 | 0.94 | |
| 251_I | 254_D | 1.02 | 0.93 | |
| 247_R | 250_N | 1.02 | 0.93 | |
| 162_G | 284_L | 1.014 | 0.93 | |
| 13_M | 306_F | 1.01 | 0.93 | |
| 121_A | 126_D | 1.005 | 0.93 | |
| 363_A | 367_L | 1.003 | 0.93 | |
| 4_V | 28_R | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4n9xA | 1 | 0.9975 | 100 | 0.21 | Contact Map | 0.7 |
| 4k22A | 2 | 0.91 | 100 | 0.279 | Contact Map | 0.746 |
| 2qa2A | 1 | 0.945 | 100 | 0.291 | Contact Map | 0.761 |
| 2qa1A | 1 | 0.945 | 100 | 0.301 | Contact Map | 0.798 |
| 2x3nA | 1 | 0.95 | 100 | 0.306 | Contact Map | 0.773 |
| 4k2xA | 2 | 0.9525 | 100 | 0.308 | Contact Map | 0.8 |
| 3fmwA | 3 | 0.9575 | 100 | 0.311 | Contact Map | 0.699 |
| 4k5sA | 1 | 0.9575 | 100 | 0.316 | Contact Map | 0.803 |
| 1pn0A | 4 | 0.96 | 100 | 0.318 | Contact Map | 0.774 |
| 1k0iA | 1 | 0.9525 | 100 | 0.328 | Contact Map | 0.699 |
Sequence Conservation (Image Generated using WebLogo v3)