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OPENSEQ.org
MSBA - Lipid A export ATP-binding/permease protein MsbA
UniProt: P60752 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10613
Length: 582 (570)
Sequences: 21920
Seq/Len: 38.46
MSBA
Paralog alert: 0.94 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: CYDC CYDD MDLA MDLB MSBA YDDA YOJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
460_M 470_L 5.186 1.00
346_N 361_N 5.178 1.00
370_K 547_E 4.795 1.00
343_E 365_K 4.589 1.00
367_P 370_K 4.584 1.00
345_R 399_E 4.355 1.00
562_H 572_Y 4.342 1.00
434_A 447_R 4.045 1.00
431_D 435_N 4.025 1.00
547_E 559_R 3.913 1.00
345_R 401_L 3.777 1.00
455_R 460_M 3.772 1.00
460_M 464_N 3.572 1.00
399_E 406_D 3.528 1.00
341_D 365_K 3.433 1.00
360_R 555_V 3.429 1.00
434_A 471_D 3.319 1.00
348_T 361_N 3.302 1.00
454_A 470_L 3.281 1.00
446_S 449_Q 3.269 1.00
344_F 347_V 3.085 1.00
434_A 438_A 3.033 1.00
569_R 573_A 3.023 1.00
386_A 535_I 2.938 1.00
437_I 454_A 2.931 1.00
573_A 577_K 2.896 1.00
447_R 451_E 2.847 1.00
441_R 449_Q 2.805 1.00
386_A 503_I 2.751 1.00
420_A 499_S 2.739 1.00
452_E 456_M 2.702 1.00
391_R 394_D 2.677 1.00
561_T 564_D 2.622 1.00
366_I 372_V 2.613 1.00
364_L 549_V 2.611 1.00
343_E 401_L 2.601 1.00
434_A 450_I 2.591 1.00
451_E 455_R 2.588 1.00
558_E 570_G 2.495 1.00
341_D 367_P 2.452 1.00
418_Q 500_P 2.439 1.00
437_I 450_I 2.415 1.00
451_E 460_M 2.386 1.00
411_T 414_S 2.376 1.00
468_N 472_T 2.345 1.00
558_E 569_R 2.344 1.00
441_R 444_Q 2.342 1.00
357_P 360_R 2.328 1.00
459_A 462_F 2.318 1.00
341_D 368_A 2.297 1.00
15_R 323_D 2.271 1.00
498_D 530_R 2.26 1.00
348_T 397_E 2.257 1.00
549_V 559_R 2.256 1.00
158_I 162_Y 2.23 1.00
344_F 364_L 2.221 1.00
394_D 408_R 2.207 1.00
371_T 545_A 2.155 1.00
558_E 568_H 2.15 1.00
53_D 280_T 2.109 1.00
438_A 450_I 2.054 1.00
524_D 544_K 2.053 1.00
451_E 464_N 2.052 1.00
19_T 103_R 2.052 1.00
560_G 564_D 2.05 1.00
452_E 455_R 2.036 1.00
53_D 282_G 2.017 1.00
348_T 357_P 1.999 1.00
346_N 363_N 1.998 1.00
372_V 547_E 1.974 1.00
552_E 571_V 1.974 1.00
366_I 533_L 1.926 1.00
454_A 463_I 1.912 1.00
350_T 357_P 1.909 1.00
453_A 457_A 1.887 1.00
438_A 447_R 1.885 1.00
350_T 396_D 1.878 1.00
374_L 385_I 1.862 1.00
359_L 362_I 1.845 1.00
448_E 451_E 1.83 1.00
342_V 533_L 1.83 1.00
406_D 409_E 1.766 1.00
23_F 99_T 1.763 1.00
449_Q 498_D 1.755 1.00
557_V 571_V 1.721 1.00
164_S 273_P 1.72 1.00
451_E 470_L 1.718 1.00
340_G 403_D 1.713 1.00
558_E 573_A 1.707 1.00
536_A 541_T 1.688 1.00
549_V 556_I 1.683 1.00
516_E 538_R 1.679 1.00
131_D 317_T 1.672 1.00
222_G 225_V 1.661 1.00
385_I 551_V 1.655 1.00
543_E 563_N 1.63 1.00
319_F 323_D 1.624 1.00
372_V 549_V 1.621 1.00
374_L 549_V 1.61 1.00
475_G 480_L 1.601 1.00
349_F 384_T 1.593 1.00
456_M 525_E 1.591 1.00
449_Q 452_E 1.59 1.00
107_H 111_M 1.579 1.00
433_V 489_I 1.579 1.00
361_N 555_V 1.576 1.00
552_E 557_V 1.575 1.00
371_T 534_V 1.569 1.00
458_Y 518_A 1.565 1.00
69_L 73_G 1.556 1.00
461_D 464_N 1.546 1.00
330_E 411_T 1.546 1.00
395_I 407_L 1.545 1.00
21_A 24_K 1.544 1.00
511_L 519_I 1.543 1.00
370_K 546_D 1.532 1.00
447_R 471_D 1.514 1.00
445_Y 496_L 1.509 1.00
566_L 576_H 1.498 1.00
454_A 460_M 1.491 1.00
390_T 421_L 1.467 1.00
437_I 496_L 1.444 1.00
525_E 528_K 1.443 1.00
378_S 515_S 1.443 1.00
341_D 403_D 1.437 1.00
400_I 407_L 1.436 1.00
199_T 236_R 1.435 1.00
272_F 276_M 1.423 1.00
107_H 326_Q 1.422 1.00
226_E 439_Y 1.418 1.00
49_K 286_V 1.416 1.00
373_A 545_A 1.416 1.00
367_P 547_E 1.405 0.99
564_D 568_H 1.405 0.99
483_G 488_R 1.401 0.99
194_K 316_Q 1.4 0.99
517_R 521_A 1.396 0.99
474_I 481_L 1.388 0.99
521_A 525_E 1.386 0.99
188_R 191_N 1.385 0.99
268_Y 272_F 1.383 0.99
442_T 445_Y 1.383 0.99
468_N 473_V 1.383 0.99
349_F 393_Y 1.38 0.99
447_R 450_I 1.364 0.99
441_R 445_Y 1.36 0.99
463_I 470_L 1.359 0.99
161_F 165_W 1.359 0.99
402_M 501_I 1.358 0.99
459_A 463_I 1.353 0.99
117_D 393_Y 1.341 0.99
438_A 445_Y 1.335 0.99
453_A 495_L 1.325 0.99
339_T 403_D 1.322 0.99
202_Q 236_R 1.317 0.99
548_I 562_H 1.315 0.99
161_F 168_S 1.313 0.99
456_M 495_L 1.308 0.99
449_Q 496_L 1.307 0.99
420_A 494_A 1.304 0.99
362_I 385_I 1.299 0.99
388_L 400_I 1.298 0.99
364_L 385_I 1.291 0.99
536_A 542_I 1.29 0.99
213_G 427_H 1.29 0.99
45_L 290_S 1.289 0.99
377_R 552_E 1.288 0.99
466_M 472_T 1.287 0.99
377_R 571_V 1.286 0.99
165_W 169_I 1.285 0.99
230_F 234_S 1.282 0.99
571_V 574_Q 1.282 0.99
362_I 556_I 1.271 0.99
430_N 473_V 1.271 0.99
218_L 223_Q 1.269 0.99
166_Q 278_S 1.249 0.99
373_A 542_I 1.246 0.98
454_A 459_A 1.245 0.98
228_K 232_K 1.232 0.98
180_I 184_V 1.223 0.98
347_V 395_I 1.223 0.98
462_F 485_Q 1.219 0.98
563_N 567_E 1.216 0.98
167_L 287_V 1.211 0.98
527_Q 532_S 1.211 0.98
349_F 388_L 1.206 0.98
445_Y 449_Q 1.205 0.98
224_E 228_K 1.196 0.98
551_V 556_I 1.196 0.98
345_R 363_N 1.191 0.98
206_S 233_V 1.189 0.98
134_Q 314_A 1.185 0.98
465_K 485_Q 1.181 0.98
342_V 402_M 1.178 0.98
65_V 69_L 1.176 0.98
104_L 321_I 1.174 0.98
343_E 404_G 1.173 0.98
464_N 469_G 1.166 0.97
448_E 452_E 1.165 0.97
331_G 334_V 1.165 0.97
348_T 360_R 1.164 0.97
405_H 410_Y 1.161 0.97
160_M 287_V 1.158 0.97
405_H 409_E 1.156 0.97
462_F 466_M 1.153 0.97
468_N 471_D 1.151 0.97
451_E 454_A 1.148 0.97
107_H 322_L 1.145 0.97
378_S 488_R 1.137 0.97
273_P 278_S 1.135 0.97
346_N 397_E 1.134 0.97
458_Y 515_S 1.132 0.97
437_I 489_I 1.128 0.97
330_E 412_L 1.128 0.97
110_G 326_Q 1.122 0.97
344_F 389_I 1.121 0.97
422_V 494_A 1.117 0.96
49_K 53_D 1.116 0.96
475_G 478_G 1.115 0.96
395_I 400_I 1.114 0.96
269_A 273_P 1.111 0.96
464_N 470_L 1.11 0.96
199_T 240_Q 1.107 0.96
210_M 226_E 1.106 0.96
226_E 229_R 1.105 0.96
412_L 416_R 1.105 0.96
481_L 489_I 1.104 0.96
389_I 533_L 1.102 0.96
366_I 531_T 1.098 0.96
15_R 319_F 1.097 0.96
562_H 566_L 1.095 0.96
331_G 409_E 1.09 0.96
344_F 385_I 1.088 0.96
120_S 123_T 1.086 0.96
372_V 533_L 1.083 0.96
341_D 404_G 1.081 0.95
280_T 283_T 1.08 0.95
343_E 363_N 1.078 0.95
434_A 470_L 1.077 0.95
22_P 99_T 1.076 0.95
117_D 387_S 1.074 0.95
371_T 532_S 1.066 0.95
432_T 435_N 1.066 0.95
199_T 202_Q 1.064 0.95
459_A 465_K 1.059 0.95
66_W 70_V 1.056 0.95
33_A 81_T 1.052 0.95
453_A 496_L 1.052 0.95
119_Q 123_T 1.048 0.94
36_L 81_T 1.047 0.94
422_V 491_I 1.043 0.94
452_E 498_D 1.043 0.94
123_T 201_G 1.035 0.94
28_I 32_V 1.034 0.94
458_Y 521_A 1.032 0.94
461_D 465_K 1.021 0.93
235_N 239_L 1.02 0.93
107_H 110_G 1.016 0.93
538_R 541_T 1.016 0.93
474_I 480_L 1.015 0.93
446_S 496_L 1.012 0.93
347_V 388_L 1.012 0.93
340_G 368_A 1.009 0.93
402_M 415_L 1.008 0.93
410_Y 415_L 1.001 0.92
102_R 106_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b60A411000.129Contact Map0.75
3b5xA211000.134Contact Map0.1
3qf4B10.99661000.135Contact Map0.727
4f4cA10.99831000.143Contact Map0.729
4a82A40.97771000.144Contact Map0.077
3qf4A10.99481000.153Contact Map0.746
2yl4A10.9881000.157Contact Map0.715
3g5uA20.99831000.16Contact Map0.675
3nh6A10.49831000.433Contact Map0.784
3vx4A20.46391000.499Contact Map0.843
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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