| UniProt: | P23886 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10012 | ||
| Length: | 573 (567) | ||
| Sequences: | 20191 | ||
| Seq/Len: | 35.61 |
| CYDC
Paralog alert: 0.94 [within 20: 0.60] - ratio of genomes with paralogs Cluster includes: CYDC CYDD MDLA MDLB MSBA YDDA YOJI |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 343_D | 358_G | 5.491 | 1.00 | |
| 456_E | 464_L | 5.328 | 1.00 | |
| 367_E | 541_Q | 4.909 | 1.00 | |
| 364_N | 367_E | 4.72 | 1.00 | |
| 340_T | 362_Q | 4.674 | 1.00 | |
| 342_R | 396_E | 4.468 | 1.00 | |
| 556_H | 566_Y | 4.263 | 1.00 | |
| 431_R | 443_D | 4.16 | 1.00 | |
| 428_A | 432_D | 4.114 | 1.00 | |
| 541_Q | 553_Q | 3.995 | 1.00 | |
| 342_R | 398_L | 3.852 | 1.00 | |
| 451_R | 456_E | 3.84 | 1.00 | |
| 456_E | 460_E | 3.715 | 1.00 | |
| 396_E | 403_P | 3.653 | 1.00 | |
| 357_K | 549_Q | 3.552 | 1.00 | |
| 442_S | 445_A | 3.475 | 1.00 | |
| 338_S | 362_Q | 3.47 | 1.00 | |
| 345_Q | 358_G | 3.461 | 1.00 | |
| 431_R | 465_N | 3.426 | 1.00 | |
| 450_L | 464_L | 3.246 | 1.00 | |
| 563_Q | 567_Y | 3.221 | 1.00 | |
| 431_R | 435_L | 3.155 | 1.00 | |
| 341_L | 344_V | 3.131 | 1.00 | |
| 383_L | 529_V | 3.089 | 1.00 | |
| 438_S | 445_A | 3.022 | 1.00 | |
| 443_D | 447_S | 3.006 | 1.00 | |
| 434_L | 450_L | 2.931 | 1.00 | |
| 417_S | 493_A | 2.813 | 1.00 | |
| 383_L | 497_L | 2.781 | 1.00 | |
| 448_E | 452_R | 2.775 | 1.00 | |
| 361_L | 543_I | 2.73 | 1.00 | |
| 555_T | 558_E | 2.695 | 1.00 | |
| 431_R | 446_L | 2.686 | 1.00 | |
| 447_S | 451_R | 2.669 | 1.00 | |
| 340_T | 398_L | 2.652 | 1.00 | |
| 363_V | 369_I | 2.641 | 1.00 | |
| 388_R | 391_D | 2.64 | 1.00 | |
| 552_E | 564_G | 2.586 | 1.00 | |
| 434_L | 446_L | 2.572 | 1.00 | |
| 338_S | 364_N | 2.518 | 1.00 | |
| 415_T | 494_P | 2.466 | 1.00 | |
| 408_N | 411_A | 2.441 | 1.00 | |
| 447_S | 456_E | 2.437 | 1.00 | |
| 552_E | 563_Q | 2.425 | 1.00 | |
| 338_S | 365_A | 2.398 | 1.00 | |
| 354_Q | 357_K | 2.395 | 1.00 | |
| 462_A | 466_S | 2.363 | 1.00 | |
| 455_L | 458_L | 2.357 | 1.00 | |
| 543_I | 553_Q | 2.298 | 1.00 | |
| 341_L | 361_L | 2.297 | 1.00 | |
| 391_D | 405_A | 2.281 | 1.00 | |
| 368_H | 539_F | 2.271 | 1.00 | |
| 345_Q | 394_Q | 2.264 | 1.00 | |
| 435_L | 446_L | 2.212 | 1.00 | |
| 492_D | 524_K | 2.209 | 1.00 | |
| 447_S | 460_E | 2.207 | 1.00 | |
| 552_E | 562_R | 2.188 | 1.00 | |
| 448_E | 451_R | 2.181 | 1.00 | |
| 518_A | 538_R | 2.138 | 1.00 | |
| 369_I | 541_Q | 2.046 | 1.00 | |
| 345_Q | 354_Q | 2.027 | 1.00 | |
| 343_D | 360_S | 2.013 | 1.00 | |
| 6_P | 319_D | 1.995 | 1.00 | |
| 347_T | 393_Q | 1.99 | 1.00 | |
| 363_V | 527_L | 1.988 | 1.00 | |
| 435_L | 443_D | 1.98 | 1.00 | |
| 450_L | 459_L | 1.978 | 1.00 | |
| 339_L | 527_L | 1.975 | 1.00 | |
| 546_D | 565_R | 1.97 | 1.00 | |
| 554_G | 558_E | 1.964 | 1.00 | |
| 356_L | 359_I | 1.956 | 1.00 | |
| 347_T | 354_Q | 1.944 | 1.00 | |
| 449_I | 453_V | 1.936 | 1.00 | |
| 153_I | 157_F | 1.936 | 1.00 | |
| 10_L | 98_Y | 1.909 | 1.00 | |
| 371_I | 382_L | 1.866 | 1.00 | |
| 403_P | 406_S | 1.863 | 1.00 | |
| 337_V | 400_N | 1.851 | 1.00 | |
| 551_I | 565_R | 1.843 | 1.00 | |
| 218_A | 221_R | 1.801 | 1.00 | |
| 543_I | 550_I | 1.789 | 1.00 | |
| 445_A | 492_D | 1.787 | 1.00 | |
| 444_E | 447_S | 1.782 | 1.00 | |
| 567_Y | 571_Q | 1.782 | 1.00 | |
| 315_S | 319_D | 1.773 | 1.00 | |
| 552_E | 567_Y | 1.738 | 1.00 | |
| 369_I | 543_I | 1.717 | 1.00 | |
| 530_T | 535_G | 1.696 | 1.00 | |
| 510_E | 532_R | 1.686 | 1.00 | |
| 457_K | 460_E | 1.682 | 1.00 | |
| 126_D | 313_R | 1.666 | 1.00 | |
| 358_G | 549_Q | 1.651 | 1.00 | |
| 382_L | 545_M | 1.649 | 1.00 | |
| 447_S | 464_L | 1.649 | 1.00 | |
| 346_F | 381_T | 1.641 | 1.00 | |
| 445_A | 448_E | 1.635 | 1.00 | |
| 102_K | 106_L | 1.635 | 1.00 | |
| 368_H | 528_M | 1.621 | 1.00 | |
| 454_G | 512_Q | 1.62 | 1.00 | |
| 159_D | 269_G | 1.615 | 1.00 | |
| 537_S | 557_A | 1.613 | 1.00 | |
| 443_D | 465_N | 1.612 | 1.00 | |
| 371_I | 543_I | 1.607 | 1.00 | |
| 430_L | 483_L | 1.604 | 1.00 | |
| 392_P | 404_I | 1.601 | 1.00 | |
| 40_G | 44_S | 1.581 | 1.00 | |
| 156_S | 163_A | 1.569 | 1.00 | |
| 441_S | 490_L | 1.566 | 1.00 | |
| 367_E | 540_Q | 1.554 | 1.00 | |
| 452_R | 519_E | 1.551 | 1.00 | |
| 450_L | 456_E | 1.55 | 1.00 | |
| 546_D | 551_I | 1.542 | 1.00 | |
| 469_G | 474_Q | 1.541 | 1.00 | |
| 560_L | 570_K | 1.533 | 1.00 | |
| 519_E | 522_R | 1.531 | 1.00 | |
| 326_F | 408_N | 1.516 | 1.00 | |
| 195_L | 232_Q | 1.51 | 1.00 | |
| 505_L | 513_I | 1.504 | 1.00 | |
| 399_L | 495_L | 1.496 | 1.00 | |
| 511_S | 515_E | 1.495 | 1.00 | |
| 14_H | 94_H | 1.493 | 1.00 | |
| 12_K | 15_K | 1.48 | 1.00 | |
| 190_Q | 312_V | 1.472 | 1.00 | |
| 397_I | 404_I | 1.466 | 1.00 | |
| 387_T | 418_V | 1.466 | 1.00 | |
| 462_A | 467_W | 1.457 | 1.00 | |
| 264_W | 268_G | 1.453 | 1.00 | |
| 268_G | 272_G | 1.45 | 1.00 | |
| 558_E | 562_R | 1.442 | 1.00 | |
| 459_L | 464_L | 1.434 | 1.00 | |
| 102_K | 322_P | 1.426 | 1.00 | |
| 364_N | 541_Q | 1.42 | 1.00 | |
| 434_L | 490_L | 1.415 | 1.00 | |
| 346_F | 390_W | 1.413 | 1.00 | |
| 44_S | 276_P | 1.413 | 1.00 | |
| 449_I | 489_L | 1.412 | 1.00 | |
| 443_D | 446_L | 1.411 | 1.00 | |
| 359_I | 550_I | 1.406 | 0.99 | |
| 435_L | 441_S | 1.4 | 0.99 | |
| 374_R | 565_R | 1.399 | 0.99 | |
| 338_S | 400_N | 1.396 | 0.99 | |
| 438_S | 441_S | 1.394 | 0.99 | |
| 468_L | 475_L | 1.393 | 0.99 | |
| 361_L | 382_L | 1.389 | 0.99 | |
| 209_G | 424_H | 1.378 | 0.99 | |
| 417_S | 488_A | 1.372 | 0.99 | |
| 530_T | 536_L | 1.363 | 0.99 | |
| 515_E | 519_E | 1.363 | 0.99 | |
| 370_A | 539_F | 1.358 | 0.99 | |
| 112_A | 390_W | 1.356 | 0.99 | |
| 455_L | 459_L | 1.356 | 0.99 | |
| 198_Q | 232_Q | 1.354 | 0.99 | |
| 156_S | 160_F | 1.353 | 0.99 | |
| 359_I | 382_L | 1.353 | 0.99 | |
| 427_S | 467_W | 1.343 | 0.99 | |
| 375_T | 509_T | 1.333 | 0.99 | |
| 452_R | 489_L | 1.327 | 0.99 | |
| 327_P | 406_S | 1.32 | 0.99 | |
| 385_Q | 397_I | 1.315 | 0.99 | |
| 445_A | 490_L | 1.313 | 0.99 | |
| 336_R | 400_N | 1.312 | 0.99 | |
| 542_I | 556_H | 1.3 | 0.99 | |
| 44_S | 278_A | 1.293 | 0.99 | |
| 374_R | 546_D | 1.291 | 0.99 | |
| 222_Y | 436_L | 1.29 | 0.99 | |
| 340_T | 401_D | 1.282 | 0.99 | |
| 36_L | 44_S | 1.268 | 0.99 | |
| 458_L | 479_E | 1.268 | 0.99 | |
| 224_T | 228_N | 1.267 | 0.99 | |
| 346_F | 385_Q | 1.256 | 0.99 | |
| 441_S | 445_A | 1.253 | 0.99 | |
| 344_V | 392_P | 1.25 | 0.99 | |
| 99_T | 317_L | 1.242 | 0.98 | |
| 565_R | 568_Q | 1.235 | 0.98 | |
| 545_M | 550_I | 1.23 | 0.98 | |
| 339_L | 399_L | 1.227 | 0.98 | |
| 462_A | 465_N | 1.217 | 0.98 | |
| 370_A | 536_L | 1.213 | 0.98 | |
| 460_E | 463_G | 1.212 | 0.98 | |
| 184_A | 187_S | 1.208 | 0.98 | |
| 557_A | 561_A | 1.208 | 0.98 | |
| 105_P | 322_P | 1.206 | 0.98 | |
| 521_M | 526_V | 1.205 | 0.98 | |
| 214_T | 219_S | 1.199 | 0.98 | |
| 429_T | 432_D | 1.198 | 0.98 | |
| 342_R | 360_S | 1.196 | 0.98 | |
| 345_Q | 357_K | 1.195 | 0.98 | |
| 102_K | 318_T | 1.193 | 0.98 | |
| 220_D | 224_T | 1.19 | 0.98 | |
| 202_Q | 229_T | 1.183 | 0.98 | |
| 450_L | 455_L | 1.179 | 0.98 | |
| 447_S | 450_L | 1.179 | 0.98 | |
| 341_L | 386_L | 1.176 | 0.98 | |
| 402_S | 406_S | 1.169 | 0.97 | |
| 369_I | 527_L | 1.165 | 0.97 | |
| 386_L | 527_L | 1.154 | 0.97 | |
| 129_T | 310_S | 1.153 | 0.97 | |
| 340_T | 396_E | 1.149 | 0.97 | |
| 434_L | 483_L | 1.149 | 0.97 | |
| 206_W | 222_Y | 1.148 | 0.97 | |
| 343_D | 394_Q | 1.148 | 0.97 | |
| 265_M | 269_G | 1.142 | 0.97 | |
| 368_H | 526_V | 1.139 | 0.97 | |
| 226_L | 230_E | 1.132 | 0.97 | |
| 431_R | 464_L | 1.131 | 0.97 | |
| 392_P | 397_I | 1.129 | 0.97 | |
| 454_G | 509_T | 1.126 | 0.97 | |
| 195_L | 236_A | 1.121 | 0.97 | |
| 444_E | 448_E | 1.121 | 0.97 | |
| 442_S | 490_L | 1.12 | 0.96 | |
| 326_F | 409_E | 1.12 | 0.96 | |
| 409_E | 413_R | 1.116 | 0.96 | |
| 469_G | 472_G | 1.11 | 0.96 | |
| 340_T | 360_S | 1.109 | 0.96 | |
| 115_R | 118_E | 1.104 | 0.96 | |
| 460_E | 464_L | 1.102 | 0.96 | |
| 162_L | 283_F | 1.101 | 0.96 | |
| 222_Y | 225_Q | 1.098 | 0.96 | |
| 419_V | 488_A | 1.097 | 0.96 | |
| 160_F | 164_F | 1.095 | 0.96 | |
| 363_V | 525_T | 1.095 | 0.96 | |
| 477_G | 482_R | 1.088 | 0.96 | |
| 556_H | 560_L | 1.087 | 0.96 | |
| 402_S | 407_L | 1.082 | 0.96 | |
| 338_S | 401_D | 1.079 | 0.95 | |
| 341_L | 382_L | 1.075 | 0.95 | |
| 449_I | 490_L | 1.071 | 0.95 | |
| 419_V | 485_I | 1.065 | 0.95 | |
| 155_L | 283_F | 1.065 | 0.95 | |
| 475_L | 483_L | 1.061 | 0.95 | |
| 454_G | 515_E | 1.058 | 0.95 | |
| 195_L | 198_Q | 1.056 | 0.95 | |
| 344_V | 385_Q | 1.053 | 0.95 | |
| 269_G | 274_A | 1.051 | 0.94 | |
| 118_E | 197_G | 1.05 | 0.94 | |
| 448_E | 492_D | 1.049 | 0.94 | |
| 102_K | 105_P | 1.044 | 0.94 | |
| 176_L | 180_L | 1.035 | 0.94 | |
| 396_E | 405_A | 1.033 | 0.94 | |
| 112_A | 384_Q | 1.032 | 0.94 | |
| 327_P | 330_Q | 1.03 | 0.94 | |
| 468_L | 474_Q | 1.03 | 0.94 | |
| 399_L | 412_L | 1.017 | 0.93 | |
| 114_Y | 118_E | 1.009 | 0.93 | |
| 431_R | 447_S | 1.007 | 0.93 | |
| 432_D | 435_L | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3qf4B | 1 | 0.9895 | 100 | 0.116 | Contact Map | 0.732 |
| 4a82A | 4 | 0.9948 | 100 | 0.122 | Contact Map | 0.079 |
| 3b5xA | 2 | 0.9895 | 100 | 0.125 | Contact Map | 0.104 |
| 3b60A | 4 | 0.9895 | 100 | 0.125 | Contact Map | 0.761 |
| 4f4cA | 1 | 0.9983 | 100 | 0.128 | Contact Map | 0.731 |
| 3qf4A | 1 | 0.9913 | 100 | 0.133 | Contact Map | 0.751 |
| 2yl4A | 1 | 0.9965 | 100 | 0.133 | Contact Map | 0.717 |
| 3g5uA | 2 | 0.9983 | 100 | 0.142 | Contact Map | 0.687 |
| 3nh6A | 1 | 0.4991 | 100 | 0.414 | Contact Map | 0.79 |
| 3vx4A | 2 | 0.4625 | 100 | 0.479 | Contact Map | 0.843 |
Sequence Conservation (Image Generated using WebLogo v3)