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YHDW - Putative amino-acid ABC transporter-binding protein YhdW
UniProt: P45766 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12834
Length: 341 (323)
Sequences: 609
Seq/Len: 1.89
YHDW
Paralog alert: 0.20 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
187_L 215_W 4.854 1.00
52_D 56_K 3.218 1.00
257_I 277_L 3.132 1.00
40_G 98_V 2.913 1.00
197_S 201_Q 2.847 1.00
68_V 100_L 2.82 1.00
249_M 308_I 2.703 1.00
211_N 214_E 2.576 1.00
263_D 300_K 2.461 1.00
248_A 295_A 2.432 1.00
150_C 192_C 2.432 1.00
39_C 65_C 2.378 1.00
199_Q 221_V 2.375 1.00
74_G 301_Q 2.31 1.00
63_D 312_N 2.301 1.00
118_A 236_D 2.21 1.00
283_D 286_K 2.119 0.99
36_F 80_K 2.11 0.99
66_R 81_Y 2.107 0.99
74_G 297_N 2.104 0.99
52_D 58_S 2.102 0.99
76_D 301_Q 2.084 0.99
310_E 315_S 2.084 0.99
293_K 297_N 2.039 0.99
250_L 335_Q 2.026 0.99
42_S 49_S 2.017 0.99
239_F 243_R 1.957 0.99
327_N 331_N 1.874 0.98
283_D 292_N 1.85 0.98
291_D 297_N 1.825 0.97
249_M 298_I 1.819 0.97
121_G 246_L 1.774 0.97
330_N 334_I 1.771 0.97
144_L 194_T 1.757 0.97
38_Q 80_K 1.744 0.96
263_D 296_Y 1.743 0.96
27_T 232_R 1.737 0.96
118_A 239_F 1.694 0.96
249_M 301_Q 1.67 0.95
151_I 161_V 1.665 0.95
188_E 209_L 1.646 0.95
109_S 288_L 1.634 0.94
233_R 240_S 1.618 0.94
39_C 150_C 1.617 0.94
65_C 150_C 1.598 0.93
275_A 281_E 1.578 0.93
93_L 98_V 1.574 0.93
34_K 38_Q 1.57 0.93
139_K 143_E 1.562 0.92
188_E 210_S 1.5 0.90
130_F 222_I 1.499 0.90
142_K 168_N 1.468 0.89
259_S 301_Q 1.459 0.89
177_F 183_S 1.458 0.88
156_D 160_N 1.399 0.86
241_I 290_L 1.397 0.85
84_L 98_V 1.39 0.85
38_Q 82_T 1.388 0.85
298_I 301_Q 1.385 0.85
246_L 250_L 1.38 0.85
128_I 196_A 1.38 0.85
45_L 201_Q 1.377 0.84
251_N 255_M 1.354 0.83
45_L 104_N 1.352 0.83
109_S 113_A 1.352 0.83
255_M 277_L 1.347 0.83
85_T 186_A 1.34 0.82
26_A 29_D 1.333 0.82
65_C 192_C 1.33 0.81
178_D 182_E 1.316 0.80
31_V 68_V 1.31 0.80
297_N 301_Q 1.301 0.79
134_D 213_A 1.297 0.79
120_T 243_R 1.292 0.79
138_L 216_I 1.26 0.76
123_T 308_I 1.246 0.75
156_D 225_E 1.244 0.75
145_D 171_K 1.231 0.74
39_C 192_C 1.229 0.74
108_T 111_R 1.228 0.74
317_S 320_K 1.223 0.73
64_I 246_L 1.223 0.73
177_F 186_A 1.219 0.73
245_T 298_I 1.216 0.73
64_I 123_T 1.209 0.72
24_A 29_D 1.206 0.72
117_M 230_V 1.203 0.71
315_S 322_K 1.2 0.71
29_D 32_Q 1.197 0.71
60_I 313_V 1.189 0.70
165_F 170_M 1.183 0.70
247_F 338_P 1.183 0.70
34_K 82_T 1.18 0.69
211_N 267_A 1.175 0.69
165_F 172_Y 1.175 0.69
123_T 246_L 1.165 0.68
337_A 340_V 1.164 0.68
275_A 280_K 1.157 0.67
67_G 249_M 1.151 0.67
122_V 149_V 1.15 0.66
203_Y 321_I 1.145 0.66
49_S 102_S 1.138 0.65
123_T 228_G 1.132 0.65
203_Y 217_V 1.108 0.62
159_L 341_R 1.104 0.62
74_G 291_D 1.101 0.62
298_I 308_I 1.097 0.61
179_R 183_S 1.096 0.61
148_T 173_T 1.094 0.61
251_N 328_L 1.091 0.60
64_I 68_V 1.09 0.60
84_L 92_A 1.087 0.60
45_L 86_A 1.086 0.60
321_I 335_Q 1.081 0.59
149_V 172_Y 1.079 0.59
25_G 30_A 1.075 0.59
269_P 275_A 1.072 0.58
140_S 143_E 1.067 0.58
101_L 230_V 1.065 0.58
100_L 262_V 1.064 0.58
251_N 273_D 1.064 0.58
268_N 275_A 1.064 0.58
113_A 237_E 1.062 0.57
236_D 239_F 1.059 0.57
121_G 228_G 1.058 0.57
56_K 217_V 1.055 0.57
25_G 169_N 1.055 0.57
73_F 82_T 1.051 0.56
119_F 230_V 1.048 0.56
43_D 85_T 1.041 0.55
30_A 33_K 1.04 0.55
125_Y 336_Y 1.034 0.54
28_L 31_V 1.031 0.54
60_I 64_I 1.029 0.54
237_E 241_I 1.027 0.54
37_V 79_V 1.025 0.53
64_I 242_V 1.024 0.53
250_L 337_A 1.021 0.53
247_F 337_A 1.021 0.53
157_T 174_P 1.02 0.53
22_A 25_G 1.02 0.53
36_F 82_T 1.013 0.52
271_T 274_M 1.011 0.52
68_V 242_V 1.008 0.52
257_I 265_K 1.006 0.51
194_T 317_S 1.003 0.51
282_G 292_N 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vhaA20.80651000.55Contact Map0.656
3hv1A20.76831000.567Contact Map0.561
2yjpA30.78591000.569Contact Map0.649
1xt8A20.80941000.569Contact Map0.652
3vv5A20.74491000.571Contact Map0.675
2ieeA20.76251000.573Contact Map0.569
3mpkA10.77131000.574Contact Map0.556
4i62A10.75071000.574Contact Map0.607
2v25A20.73311000.575Contact Map0.632
1pb7A10.75661000.576Contact Map0.34
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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