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GLTI - Glutamate/aspartate periplasmic-binding protein
UniProt: P37902 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12700
Length: 302 (248)
Sequences: 3759
Seq/Len: 15.16

GLTI
Paralog alert: 0.77 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_V 89_K 4.305 1.00
157_V 199_A 3.862 1.00
45_G 107_F 3.338 1.00
118_V 121_Q 3.203 1.00
246_K 250_D 2.975 1.00
41_V 87_Q 2.87 1.00
116_N 235_G 2.865 1.00
261_E 264_K 2.739 1.00
80_K 255_Q 2.583 1.00
146_K 150_N 2.568 1.00
124_A 237_M 2.562 1.00
254_A 258_T 2.534 1.00
43_V 89_K 2.529 1.00
128_D 254_A 2.509 1.00
101_L 107_F 2.447 1.00
238_L 249_M 2.298 1.00
155_A 180_R 2.292 1.00
111_C 236_C 2.201 1.00
184_A 193_T 2.191 1.00
238_L 246_K 2.123 1.00
165_E 183_S 2.121 1.00
263_E 267_D 2.113 1.00
116_N 121_Q 2.006 1.00
72_A 75_E 1.929 1.00
57_D 63_V 1.92 1.00
72_A 256_V 1.919 1.00
186_D 189_D 1.899 1.00
57_D 61_K 1.894 1.00
68_D 269_W 1.892 1.00
243_P 247_K 1.885 1.00
43_V 91_I 1.839 1.00
165_E 169_N 1.836 1.00
34_D 38_K 1.832 1.00
147_D 150_N 1.824 1.00
125_A 241_D 1.816 1.00
128_D 250_D 1.814 1.00
155_A 182_I 1.813 1.00
239_R 242_D 1.777 1.00
44_V 70_S 1.757 1.00
103_Q 123_Q 1.711 1.00
247_K 251_D 1.706 1.00
194_L 199_A 1.683 1.00
74_V 88_V 1.671 1.00
125_A 246_K 1.655 1.00
142_G 223_E 1.649 1.00
61_K 71_N 1.631 1.00
127_S 249_M 1.615 1.00
99_I 124_A 1.531 1.00
152_K 178_N 1.493 1.00
68_D 71_N 1.465 1.00
154_K 200_V 1.449 1.00
102_L 110_E 1.449 1.00
109_F 249_M 1.439 1.00
110_E 114_T 1.428 1.00
33_L 36_I 1.414 1.00
39_N 43_V 1.4 0.99
204_M 209_L 1.399 0.99
141_K 223_E 1.395 0.99
248_L 251_D 1.391 0.99
119_E 122_K 1.368 0.99
127_S 250_D 1.363 0.99
80_K 256_V 1.361 0.99
76_A 255_Q 1.351 0.99
93_I 101_L 1.349 0.99
68_D 268_K 1.342 0.99
72_A 261_E 1.337 0.99
256_V 259_S 1.337 0.99
248_L 252_T 1.328 0.99
44_V 88_V 1.299 0.99
264_K 267_D 1.299 0.99
34_D 37_A 1.296 0.99
103_Q 124_A 1.288 0.99
63_V 68_D 1.272 0.99
127_S 238_L 1.264 0.99
251_D 255_Q 1.26 0.99
35_K 39_N 1.259 0.99
140_K 197_G 1.259 0.99
116_N 129_T 1.243 0.98
105_G 239_R 1.237 0.98
158_V 165_E 1.221 0.98
107_F 110_E 1.219 0.98
70_S 111_C 1.213 0.98
66_S 130_I 1.21 0.98
55_Y 269_W 1.209 0.98
149_A 152_K 1.206 0.98
255_Q 259_S 1.205 0.98
166_V 170_K 1.202 0.98
73_I 252_T 1.201 0.98
46_H 112_G 1.174 0.98
40_G 86_L 1.174 0.98
156_V 201_A 1.161 0.97
65_Y 265_W 1.159 0.97
137_L 201_A 1.148 0.97
36_I 40_G 1.134 0.97
70_S 236_C 1.119 0.96
101_L 106_T 1.094 0.96
135_T 164_S 1.091 0.96
100_P 103_Q 1.09 0.96
117_N 120_R 1.089 0.96
118_V 122_K 1.087 0.96
97_N 101_L 1.078 0.95
99_I 114_T 1.074 0.95
256_V 261_E 1.074 0.95
193_T 198_R 1.072 0.95
261_E 265_W 1.066 0.95
81_L 86_L 1.064 0.95
71_N 90_L 1.063 0.95
71_N 75_E 1.058 0.95
139_T 143_G 1.053 0.95
140_K 143_G 1.052 0.95
192_R 195_E 1.05 0.94
159_T 162_T 1.049 0.94
151_L 201_A 1.049 0.94
69_Y 262_A 1.039 0.94
172_N 179_M 1.037 0.94
194_L 202_F 1.035 0.94
36_I 86_L 1.034 0.94
125_A 240_K 1.033 0.94
69_Y 256_V 1.033 0.94
93_I 107_F 1.024 0.93
109_F 238_L 1.023 0.93
169_N 183_S 1.022 0.93
48_E 92_P 1.02 0.93
48_E 62_V 1.014 0.93
138_L 209_L 1.013 0.93
157_V 184_A 1.009 0.93
137_L 203_M 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vhaA20.92381000.344Contact Map0.791
2ylnA10.86091000.395Contact Map0.802
1xt8A20.92721000.404Contact Map0.823
2yjpA30.90071000.404Contact Map0.806
3vv5A20.86091000.415Contact Map0.868
3hv1A20.87751000.416Contact Map0.748
4i62A10.85431000.418Contact Map0.778
4dz1A10.84441000.42Contact Map0.788
1pb7A10.85761000.421Contact Map0.548
2ieeA20.86421000.425Contact Map0.817

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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