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OPENSEQ.org
SELD - Selenide, water dikinase
UniProt: P16456 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10943
Length: 347 (322)
Sequences: 4233
Seq/Len: 13.15
SELD
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: HYPE SELD THIL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_R 333_E 4.488 1.00
174_L 308_A 3.32 1.00
309_V 317_V 3.028 1.00
64_I 97_G 3.025 1.00
318_K 328_L 2.724 1.00
313_A 316_E 2.724 1.00
175_F 318_K 2.672 1.00
77_P 147_P 2.608 1.00
170_A 336_P 2.591 1.00
251_D 254_A 2.574 1.00
78_F 127_Y 2.526 1.00
170_A 246_V 2.436 1.00
173_K 333_E 2.424 1.00
175_F 328_L 2.418 1.00
56_D 159_T 2.399 1.00
310_M 313_A 2.322 1.00
168_A 224_A 2.315 1.00
248_A 334_L 2.285 1.00
247_Q 335_V 2.259 1.00
315_N 319_A 2.235 1.00
182_I 185_L 2.221 1.00
174_L 248_A 2.209 1.00
172_C 223_K 2.191 1.00
173_K 330_A 2.188 1.00
127_Y 131_Q 2.171 1.00
311_P 333_E 2.17 1.00
39_D 98_K 2.157 1.00
221_G 313_A 2.15 1.00
223_K 310_M 2.142 1.00
314_E 330_A 2.138 1.00
173_K 311_P 2.138 1.00
173_K 314_E 2.135 1.00
240_M 308_A 2.085 1.00
188_A 288_M 2.081 1.00
237_L 250_V 2.074 1.00
53_A 137_A 2.065 1.00
60_G 160_E 2.034 1.00
127_Y 130_R 2.025 1.00
246_V 334_L 1.954 1.00
249_R 335_V 1.915 1.00
174_L 306_L 1.901 1.00
106_L 118_A 1.887 1.00
175_F 330_A 1.877 1.00
169_Q 310_M 1.863 1.00
237_L 248_A 1.861 1.00
241_C 248_A 1.82 1.00
60_G 159_T 1.811 1.00
82_R 128_A 1.785 1.00
129_C 136_L 1.77 1.00
66_T 153_V 1.72 1.00
43_L 62_S 1.707 1.00
120_E 123_E 1.699 1.00
318_K 330_A 1.698 1.00
62_S 159_T 1.676 1.00
225_M 305_L 1.67 1.00
123_E 127_Y 1.636 1.00
219_I 320_T 1.616 1.00
169_Q 223_K 1.603 1.00
158_P 161_R 1.564 1.00
316_E 319_A 1.559 1.00
66_T 92_I 1.549 1.00
219_I 316_E 1.537 1.00
52_A 95_M 1.533 1.00
172_C 334_L 1.532 1.00
61_T 158_P 1.53 1.00
233_L 306_L 1.525 1.00
74_V 203_T 1.506 1.00
247_Q 337_A 1.491 1.00
251_D 333_E 1.491 1.00
216_F 317_V 1.474 1.00
157_V 162_V 1.445 1.00
316_E 320_T 1.437 1.00
78_F 123_E 1.437 1.00
319_A 323_E 1.431 1.00
168_A 240_M 1.428 1.00
161_R 218_N 1.427 1.00
233_L 237_L 1.423 1.00
54_V 64_I 1.423 1.00
188_A 264_Y 1.4 0.99
128_A 131_Q 1.391 0.99
172_C 310_M 1.386 0.99
144_A 148_I 1.372 0.99
86_T 128_A 1.361 0.99
175_F 309_V 1.358 0.99
65_S 152_A 1.35 0.99
94_A 225_M 1.346 0.99
223_K 308_A 1.341 0.99
65_S 154_T 1.337 0.99
224_A 240_M 1.332 0.99
89_I 153_V 1.329 0.99
85_A 125_G 1.314 0.99
225_M 307_L 1.309 0.99
41_N 55_Y 1.308 0.99
108_W 118_A 1.303 0.99
314_E 318_K 1.295 0.99
54_V 95_M 1.287 0.99
315_N 318_K 1.285 0.99
257_K 262_E 1.274 0.99
167_T 223_K 1.273 0.99
82_R 86_T 1.266 0.99
78_F 120_E 1.262 0.99
319_A 322_A 1.258 0.99
318_K 322_A 1.254 0.99
237_L 241_C 1.253 0.99
168_A 334_L 1.252 0.99
175_F 314_E 1.251 0.99
330_A 333_E 1.251 0.99
126_R 130_R 1.242 0.98
256_P 262_E 1.239 0.98
56_D 60_G 1.238 0.98
179_P 182_I 1.237 0.98
62_S 157_V 1.232 0.98
92_I 153_V 1.214 0.98
168_A 308_A 1.213 0.98
252_Y 290_R 1.21 0.98
64_I 157_V 1.205 0.98
67_T 152_A 1.2 0.98
220_E 317_V 1.196 0.98
100_I 156_I 1.196 0.98
52_A 64_I 1.195 0.98
98_K 214_A 1.189 0.98
114_S 117_I 1.175 0.98
64_I 92_I 1.168 0.97
82_R 131_Q 1.168 0.97
92_I 97_G 1.165 0.97
36_K 130_R 1.164 0.97
163_K 225_M 1.154 0.97
129_C 134_I 1.152 0.97
182_I 258_L 1.151 0.97
58_G 61_T 1.148 0.97
76_N 204_E 1.144 0.97
84_A 149_F 1.136 0.97
88_A 153_V 1.131 0.97
256_P 329_T 1.122 0.97
174_L 334_L 1.121 0.97
228_V 236_H 1.115 0.96
54_V 162_V 1.113 0.96
71_M 74_V 1.11 0.96
98_K 218_N 1.108 0.96
297_C 302_S 1.108 0.96
119_R 123_E 1.107 0.96
164_K 167_T 1.105 0.96
215_S 324_F 1.098 0.96
288_M 296_L 1.076 0.95
103_I 125_G 1.075 0.95
241_C 246_V 1.075 0.95
50_D 165_N 1.074 0.95
39_D 55_Y 1.068 0.95
208_R 211_I 1.064 0.95
101_M 137_A 1.063 0.95
173_K 309_V 1.06 0.95
113_L 118_A 1.056 0.95
177_T 321_A 1.049 0.94
59_N 160_E 1.045 0.94
121_V 125_G 1.041 0.94
89_I 134_I 1.032 0.94
41_N 56_D 1.026 0.94
50_D 95_M 1.019 0.93
102_A 138_G 1.018 0.93
98_K 133_G 1.016 0.93
315_N 322_A 1.015 0.93
177_T 305_L 1.013 0.93
220_E 320_T 1.012 0.93
307_L 317_V 1.011 0.93
215_S 219_I 1.009 0.93
175_F 317_V 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3u0oA211000.195Contact Map0.762
2yydA20.97411000.231Contact Map0.723
3fd5A20.93951000.269Contact Map0.661
2z1eA10.88471000.346Contact Map0.744
2z1uA10.87611000.363Contact Map0.703
3m84A20.89911000.389Contact Map0.748
3p4eA10.91351000.391Contact Map0.722
2z01A10.88761000.392Contact Map0.726
3mcqA10.83571000.393Contact Map0.719
2btuA20.89631000.397Contact Map0.78
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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