| UniProt: | P0AGG0 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG20227 | ||
| Length: | 325 (318) | ||
| Sequences: | 5220 | ||
| Seq/Len: | 16.42 |
| THIL
Paralog alert: 0.79 [within 20: 0.16] - ratio of genomes with paralogs Cluster includes: HYPE SELD THIL |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 233_R | 295_Q | 3.925 | 1.00 | |
| 271_V | 279_L | 2.968 | 1.00 | |
| 43_A | 81_A | 2.948 | 1.00 | |
| 155_I | 270_T | 2.832 | 1.00 | |
| 62_A | 109_D | 2.756 | 1.00 | |
| 154_W | 292_C | 2.744 | 1.00 | |
| 235_D | 238_L | 2.708 | 1.00 | |
| 18_S | 112_N | 2.603 | 1.00 | |
| 154_W | 295_Q | 2.486 | 1.00 | |
| 275_N | 278_A | 2.364 | 1.00 | |
| 45_S | 134_I | 2.346 | 1.00 | |
| 231_G | 297_T | 2.293 | 1.00 | |
| 151_P | 298_A | 2.291 | 1.00 | |
| 151_P | 230_C | 2.218 | 1.00 | |
| 232_A | 296_M | 2.199 | 1.00 | |
| 156_Y | 280_D | 2.178 | 1.00 | |
| 153_D | 208_N | 2.105 | 1.00 | |
| 208_N | 272_P | 2.099 | 1.00 | |
| 225_V | 232_A | 2.074 | 1.00 | |
| 233_R | 297_T | 2.073 | 1.00 | |
| 35_N | 140_M | 2.058 | 1.00 | |
| 156_Y | 290_F | 2.052 | 1.00 | |
| 272_P | 275_N | 2.039 | 1.00 | |
| 154_W | 276_R | 2.028 | 1.00 | |
| 20_R | 82_D | 2.022 | 1.00 | |
| 276_R | 292_C | 2.001 | 1.00 | |
| 61_P | 128_L | 2.001 | 1.00 | |
| 280_D | 290_F | 1.999 | 1.00 | |
| 109_D | 112_N | 1.973 | 1.00 | |
| 44_I | 87_T | 1.968 | 1.00 | |
| 149_A | 209_S | 1.963 | 1.00 | |
| 66_Y | 110_L | 1.962 | 1.00 | |
| 221_L | 232_A | 1.931 | 1.00 | |
| 273_E | 295_Q | 1.928 | 1.00 | |
| 224_I | 270_T | 1.892 | 1.00 | |
| 156_Y | 292_C | 1.891 | 1.00 | |
| 221_L | 234_I | 1.888 | 1.00 | |
| 277_G | 281_V | 1.886 | 1.00 | |
| 233_R | 305_F | 1.872 | 1.00 | |
| 155_I | 232_A | 1.853 | 1.00 | |
| 230_C | 296_M | 1.851 | 1.00 | |
| 265_Y | 293_I | 1.845 | 1.00 | |
| 109_D | 113_Y | 1.835 | 1.00 | |
| 11_R | 101_E | 1.827 | 1.00 | |
| 163_D | 171_L | 1.79 | 1.00 | |
| 102_S | 105_D | 1.789 | 1.00 | |
| 154_W | 273_E | 1.789 | 1.00 | |
| 32_A | 119_I | 1.763 | 1.00 | |
| 40_Q | 139_P | 1.748 | 1.00 | |
| 63_D | 192_R | 1.73 | 1.00 | |
| 87_T | 120_G | 1.696 | 1.00 | |
| 155_I | 268_C | 1.689 | 1.00 | |
| 90_L | 100_L | 1.658 | 1.00 | |
| 150_K | 272_P | 1.646 | 1.00 | |
| 62_A | 102_S | 1.643 | 1.00 | |
| 84_A | 137_F | 1.633 | 1.00 | |
| 174_R | 252_E | 1.601 | 1.00 | |
| 138_V | 143_A | 1.584 | 1.00 | |
| 62_A | 105_D | 1.578 | 1.00 | |
| 156_Y | 271_V | 1.573 | 1.00 | |
| 39_K | 141_G | 1.57 | 1.00 | |
| 33_L | 43_A | 1.567 | 1.00 | |
| 41_T | 140_M | 1.563 | 1.00 | |
| 31_C | 79_M | 1.553 | 1.00 | |
| 278_A | 281_V | 1.547 | 1.00 | |
| 139_P | 142_R | 1.539 | 1.00 | |
| 114_Y | 196_R | 1.538 | 1.00 | |
| 39_K | 140_M | 1.525 | 1.00 | |
| 153_D | 296_M | 1.521 | 1.00 | |
| 85_W | 119_I | 1.509 | 1.00 | |
| 208_N | 270_T | 1.496 | 1.00 | |
| 111_L | 118_L | 1.493 | 1.00 | |
| 76_L | 81_A | 1.479 | 1.00 | |
| 235_D | 295_Q | 1.475 | 1.00 | |
| 45_S | 76_L | 1.448 | 1.00 | |
| 105_D | 109_D | 1.437 | 1.00 | |
| 63_D | 106_S | 1.433 | 1.00 | |
| 157_V | 265_Y | 1.427 | 1.00 | |
| 144_L | 210_A | 1.417 | 1.00 | |
| 48_T | 131_T | 1.406 | 0.99 | |
| 57_P | 127_P | 1.406 | 0.99 | |
| 210_A | 267_L | 1.4 | 0.99 | |
| 160_T | 163_D | 1.396 | 0.99 | |
| 206_L | 275_N | 1.395 | 0.99 | |
| 7_S | 11_R | 1.385 | 0.99 | |
| 231_G | 299_D | 1.381 | 0.99 | |
| 24_E | 41_T | 1.377 | 0.99 | |
| 40_Q | 137_F | 1.37 | 0.99 | |
| 150_K | 208_N | 1.369 | 0.99 | |
| 278_A | 282_A | 1.354 | 0.99 | |
| 196_R | 266_E | 1.353 | 0.99 | |
| 15_R | 101_E | 1.345 | 0.99 | |
| 148_G | 208_N | 1.345 | 0.99 | |
| 108_F | 112_N | 1.344 | 0.99 | |
| 153_D | 272_P | 1.344 | 0.99 | |
| 184_D | 192_R | 1.343 | 0.99 | |
| 149_A | 296_M | 1.335 | 0.99 | |
| 156_Y | 276_R | 1.333 | 0.99 | |
| 280_D | 292_C | 1.331 | 0.99 | |
| 44_I | 133_G | 1.324 | 0.99 | |
| 277_G | 280_D | 1.322 | 0.99 | |
| 210_A | 269_F | 1.321 | 0.99 | |
| 163_D | 242_S | 1.317 | 0.99 | |
| 292_C | 295_Q | 1.31 | 0.99 | |
| 82_D | 201_Q | 1.309 | 0.99 | |
| 276_R | 280_D | 1.304 | 0.99 | |
| 44_I | 135_H | 1.297 | 0.99 | |
| 217_L | 268_C | 1.292 | 0.99 | |
| 149_A | 224_I | 1.292 | 0.99 | |
| 69_L | 107_L | 1.277 | 0.99 | |
| 73_L | 134_I | 1.267 | 0.99 | |
| 31_C | 43_A | 1.263 | 0.99 | |
| 35_N | 39_K | 1.26 | 0.99 | |
| 43_A | 76_L | 1.256 | 0.99 | |
| 78_A | 210_A | 1.253 | 0.99 | |
| 68_A | 130_M | 1.249 | 0.99 | |
| 41_T | 138_V | 1.246 | 0.98 | |
| 221_L | 225_V | 1.244 | 0.98 | |
| 70_A | 110_L | 1.243 | 0.98 | |
| 72_N | 134_I | 1.241 | 0.98 | |
| 203_L | 279_L | 1.241 | 0.98 | |
| 217_L | 221_L | 1.231 | 0.98 | |
| 15_R | 105_D | 1.22 | 0.98 | |
| 88_L | 107_L | 1.215 | 0.98 | |
| 33_L | 143_A | 1.209 | 0.98 | |
| 142_R | 204_R | 1.208 | 0.98 | |
| 281_V | 285_H | 1.204 | 0.98 | |
| 73_L | 116_M | 1.197 | 0.98 | |
| 205_D | 282_A | 1.194 | 0.98 | |
| 110_L | 113_Y | 1.194 | 0.98 | |
| 235_D | 305_F | 1.188 | 0.98 | |
| 280_D | 284_G | 1.18 | 0.98 | |
| 149_A | 270_T | 1.171 | 0.98 | |
| 165_A | 261_G | 1.157 | 0.97 | |
| 158_T | 199_Q | 1.154 | 0.97 | |
| 281_V | 284_G | 1.143 | 0.97 | |
| 145_T | 148_G | 1.142 | 0.97 | |
| 197_I | 201_Q | 1.141 | 0.97 | |
| 41_T | 143_A | 1.137 | 0.97 | |
| 96_D | 99_W | 1.133 | 0.97 | |
| 46_T | 133_G | 1.133 | 0.97 | |
| 22_D | 34_L | 1.125 | 0.97 | |
| 270_T | 296_M | 1.12 | 0.96 | |
| 76_L | 134_I | 1.113 | 0.96 | |
| 241_F | 246_S | 1.108 | 0.96 | |
| 7_S | 10_A | 1.104 | 0.96 | |
| 91_T | 126_G | 1.103 | 0.96 | |
| 43_A | 138_V | 1.098 | 0.96 | |
| 240_P | 246_S | 1.091 | 0.96 | |
| 209_S | 224_I | 1.078 | 0.95 | |
| 163_D | 168_L | 1.073 | 0.95 | |
| 36_I | 137_F | 1.072 | 0.95 | |
| 154_W | 271_V | 1.069 | 0.95 | |
| 66_Y | 113_Y | 1.063 | 0.95 | |
| 92_L | 100_L | 1.062 | 0.95 | |
| 8_L | 12_Y | 1.062 | 0.95 | |
| 213_L | 220_D | 1.052 | 0.95 | |
| 86_L | 134_I | 1.048 | 0.94 | |
| 101_E | 105_D | 1.043 | 0.94 | |
| 174_R | 248_H | 1.037 | 0.94 | |
| 233_R | 303_L | 1.035 | 0.94 | |
| 66_Y | 70_A | 1.03 | 0.94 | |
| 86_L | 132_L | 1.028 | 0.94 | |
| 111_L | 116_M | 1.018 | 0.93 | |
| 33_L | 79_M | 1.017 | 0.93 | |
| 98_A | 102_S | 1.004 | 0.93 | |
| 184_D | 188_K | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3mcqA | 1 | 0.9785 | 100 | 0.161 | Contact Map | 0.73 |
| 3c9uA | 2 | 0.92 | 100 | 0.213 | Contact Map | 0.817 |
| 2yxzA | 4 | 0.9354 | 100 | 0.223 | Contact Map | 0.769 |
| 2z01A | 1 | 0.9446 | 100 | 0.314 | Contact Map | 0.74 |
| 2btuA | 2 | 0.9446 | 100 | 0.314 | Contact Map | 0.794 |
| 3m84A | 2 | 0.9354 | 100 | 0.318 | Contact Map | 0.791 |
| 3p4eA | 1 | 0.9262 | 100 | 0.332 | Contact Map | 0.724 |
| 3vtiC | 2 | 0.92 | 100 | 0.337 | Contact Map | 0.774 |
| 2yydA | 2 | 0.9015 | 100 | 0.34 | Contact Map | 0.737 |
| 2rb9A | 4 | 0.9354 | 100 | 0.35 | Contact Map | 0.776 |
Sequence Conservation (Image Generated using WebLogo v3)