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OPENSEQ.org
OXC - Probable oxalyl-CoA decarboxylase
UniProt: P0AFI0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14143
Length: 564 (540)
Sequences: 6632
Seq/Len: 12.28
OXC
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
504_K 507_D 5.117 1.00
58_G 88_A 4.351 1.00
236_E 256_H 3.904 1.00
473_N 539_N 3.766 1.00
378_A 523_R 3.452 1.00
24_D 70_K 3.332 1.00
514_Y 528_T 3.332 1.00
230_Q 323_A 3.267 1.00
518_T 521_E 2.983 1.00
230_Q 327_Q 2.965 1.00
218_L 231_L 2.839 1.00
208_L 275_M 2.831 1.00
204_A 299_I 2.826 1.00
515_N 541_V 2.793 1.00
517_T 521_E 2.673 1.00
320_G 325_S 2.637 1.00
514_Y 536_T 2.608 1.00
271_A 274_V 2.604 1.00
378_A 381_D 2.601 1.00
71_P 155_V 2.577 1.00
277_V 322_I 2.553 1.00
451_G 509_F 2.545 1.00
382_V 527_T 2.495 1.00
202_T 332_E 2.494 1.00
100_I 151_I 2.494 1.00
516_V 525_A 2.492 1.00
301_L 325_S 2.481 1.00
25_T 47_R 2.462 1.00
76_T 85_G 2.44 1.00
514_Y 525_A 2.336 1.00
62_A 66_F 2.317 1.00
512_V 534_K 2.274 1.00
146_A 164_L 2.258 1.00
255_T 409_Y 2.243 1.00
512_V 528_T 2.242 1.00
207_L 316_V 2.179 1.00
89_L 101_M 2.161 1.00
450_F 454_G 2.126 1.00
505_L 508_A 2.105 1.00
71_P 100_I 2.081 1.00
515_N 539_N 2.069 1.00
430_A 443_A 2.062 1.00
83_L 87_T 2.061 1.00
216_I 235_I 2.058 1.00
461_C 511_G 1.997 1.00
19_K 45_G 1.98 1.00
381_D 523_R 1.966 1.00
277_V 301_L 1.952 1.00
235_I 242_F 1.949 1.00
208_L 273_V 1.939 1.00
207_L 273_V 1.935 1.00
242_F 252_L 1.934 1.00
68_T 436_T 1.933 1.00
216_I 240_I 1.929 1.00
206_S 210_K 1.927 1.00
501_R 504_K 1.925 1.00
103_S 163_Y 1.919 1.00
434_S 466_P 1.908 1.00
14_I 147_L 1.907 1.00
425_I 429_Y 1.903 1.00
122_D 125_N 1.886 1.00
216_I 275_M 1.883 1.00
51_F 57_A 1.869 1.00
276_L 279_A 1.861 1.00
529_G 538_I 1.848 1.00
471_I 537_I 1.841 1.00
207_L 297_Q 1.798 1.00
102_I 166_L 1.779 1.00
139_Q 142_D 1.756 1.00
379_V 444_I 1.74 1.00
523_R 527_T 1.736 1.00
460_I 511_G 1.73 1.00
125_N 128_K 1.726 1.00
16_E 20_Q 1.72 1.00
197_C 200_S 1.704 1.00
232_R 236_E 1.691 1.00
393_N 396_A 1.679 1.00
415_L 433_A 1.678 1.00
28_G 48_Y 1.676 1.00
308_I 319_V 1.676 1.00
16_E 19_K 1.674 1.00
503_D 513_G 1.674 1.00
34_V 37_M 1.664 1.00
205_I 329_M 1.661 1.00
85_G 101_M 1.657 1.00
234_F 238_A 1.627 1.00
62_A 91_N 1.623 1.00
470_V 538_I 1.618 1.00
89_L 99_M 1.611 1.00
211_A 214_P 1.595 1.00
470_V 526_L 1.594 1.00
137_V 143_L 1.59 1.00
457_I 511_G 1.59 1.00
215_L 271_A 1.583 1.00
49_I 435_V 1.578 1.00
239_Q 258_L 1.556 1.00
434_S 440_P 1.542 1.00
512_V 536_T 1.54 1.00
131_A 163_Y 1.537 1.00
309_D 314_I 1.532 1.00
229_E 233_E 1.53 1.00
521_E 524_H 1.526 1.00
423_M 452_F 1.522 1.00
431_I 460_I 1.52 1.00
211_A 273_V 1.509 1.00
56_S 456_E 1.508 1.00
51_F 60_A 1.502 1.00
135_F 164_L 1.493 1.00
434_S 465_L 1.472 1.00
76_T 101_M 1.444 1.00
442_V 530_I 1.442 1.00
145_I 149_R 1.438 1.00
377_S 381_D 1.432 1.00
454_G 505_L 1.43 1.00
233_E 237_S 1.428 1.00
522_L 540_V 1.426 1.00
527_T 531_Q 1.42 1.00
507_D 512_V 1.417 1.00
25_T 435_V 1.412 1.00
14_I 166_L 1.407 0.99
237_S 330_L 1.401 0.99
21_N 148_A 1.4 0.99
503_D 515_N 1.395 0.99
511_G 537_I 1.395 0.99
380_R 407_D 1.394 0.99
32_I 36_D 1.393 0.99
440_P 530_I 1.387 0.99
235_I 252_L 1.384 0.99
237_S 334_K 1.382 0.99
47_R 463_Y 1.382 0.99
17_A 148_A 1.38 0.99
21_N 151_I 1.378 0.99
383_L 442_V 1.374 0.99
393_N 445_E 1.371 0.99
524_H 528_T 1.367 0.99
82_F 103_S 1.367 0.99
524_H 527_T 1.365 0.99
378_A 382_V 1.361 0.99
460_I 467_V 1.359 0.99
74_C 85_G 1.357 0.99
233_E 330_L 1.353 0.99
58_G 85_G 1.349 0.99
63_A 67_L 1.343 0.99
375_A 540_V 1.339 0.99
470_V 540_V 1.338 0.99
249_K 254_D 1.336 0.99
27_Y 64_S 1.332 0.99
196_P 325_S 1.322 0.99
12_H 40_H 1.32 0.99
203_S 206_S 1.319 0.99
370_L 375_A 1.318 0.99
142_D 145_I 1.314 0.99
517_T 541_V 1.314 0.99
374_N 378_A 1.314 0.99
49_I 463_Y 1.313 0.99
214_P 272_D 1.312 0.99
100_I 154_S 1.309 0.99
216_I 234_F 1.309 0.99
270_N 347_I 1.309 0.99
201_V 332_E 1.308 0.99
231_L 326_M 1.303 0.99
147_L 164_L 1.301 0.99
468_T 529_G 1.295 0.99
38_A 48_Y 1.293 0.99
260_A 267_A 1.287 0.99
374_N 519_T 1.284 0.99
132_K 160_G 1.28 0.99
478_Y 482_G 1.278 0.99
204_A 318_V 1.275 0.99
514_Y 538_I 1.271 0.99
198_P 328_G 1.268 0.99
108_R 169_N 1.267 0.99
140_P 173_A 1.259 0.99
395_G 398_T 1.259 0.99
458_E 462_R 1.255 0.99
56_S 453_S 1.254 0.99
389_I 433_A 1.252 0.99
525_A 538_I 1.25 0.99
222_A 231_L 1.249 0.99
450_F 537_I 1.247 0.99
218_L 222_A 1.243 0.98
71_P 151_I 1.24 0.98
24_D 47_R 1.237 0.98
522_L 526_L 1.236 0.98
347_I 351_H 1.227 0.98
33_P 36_D 1.221 0.98
273_V 299_I 1.219 0.98
443_A 469_I 1.216 0.98
395_G 400_D 1.214 0.98
200_S 203_S 1.207 0.98
513_G 537_I 1.206 0.98
131_A 134_A 1.2 0.98
86_L 126_A 1.199 0.98
230_Q 330_L 1.189 0.98
13_I 144_G 1.186 0.98
230_Q 326_M 1.186 0.98
413_R 439_S 1.183 0.98
13_I 175_M 1.183 0.98
205_I 209_A 1.182 0.98
9_D 12_H 1.182 0.98
466_P 534_K 1.179 0.98
17_A 147_L 1.177 0.98
516_V 521_E 1.177 0.98
58_G 74_C 1.175 0.98
393_N 449_A 1.173 0.98
382_V 523_R 1.173 0.98
12_H 16_E 1.168 0.97
233_E 327_Q 1.168 0.97
234_F 330_L 1.159 0.97
89_L 130_Y 1.155 0.97
90_A 420_W 1.153 0.97
167_P 170_V 1.151 0.97
93_T 161_G 1.15 0.97
244_P 259_S 1.15 0.97
374_N 522_L 1.147 0.97
135_F 146_A 1.141 0.97
506_M 513_G 1.14 0.97
277_V 326_M 1.138 0.97
204_A 316_V 1.137 0.97
235_I 258_L 1.129 0.97
529_G 536_T 1.128 0.97
23_I 73_I 1.124 0.97
395_G 399_L 1.123 0.97
86_L 130_Y 1.122 0.97
153_V 162_V 1.116 0.96
394_E 398_T 1.113 0.96
233_E 236_E 1.109 0.96
426_G 443_A 1.107 0.96
210_K 273_V 1.105 0.96
396_A 399_L 1.099 0.96
216_I 231_L 1.098 0.96
32_I 37_M 1.088 0.96
236_E 258_L 1.086 0.96
19_K 44_E 1.085 0.96
135_F 149_R 1.085 0.96
232_R 253_E 1.083 0.96
67_L 415_L 1.079 0.95
215_L 274_V 1.075 0.95
74_C 101_M 1.074 0.95
427_M 469_I 1.073 0.95
435_V 465_L 1.068 0.95
211_A 272_D 1.067 0.95
457_I 537_I 1.064 0.95
37_M 40_H 1.062 0.95
37_M 41_A 1.061 0.95
14_I 102_I 1.06 0.95
213_R 270_N 1.059 0.95
89_L 127_A 1.057 0.95
506_M 511_G 1.055 0.95
232_R 256_H 1.054 0.95
252_L 256_H 1.051 0.94
36_D 39_R 1.051 0.94
33_P 38_A 1.048 0.94
324_S 327_Q 1.047 0.94
516_V 522_L 1.044 0.94
65_G 98_P 1.044 0.94
506_M 537_I 1.041 0.94
349_N 352_K 1.04 0.94
154_S 162_V 1.037 0.94
301_L 318_V 1.036 0.94
293_A 296_T 1.034 0.94
454_G 509_F 1.034 0.94
434_S 438_G 1.032 0.94
479_R 482_G 1.031 0.94
503_D 539_N 1.03 0.94
389_I 394_E 1.03 0.94
323_A 327_Q 1.026 0.94
471_I 502_Y 1.024 0.93
254_D 259_S 1.022 0.93
230_Q 233_E 1.021 0.93
321_D 324_S 1.019 0.93
286_A 289_K 1.017 0.93
512_V 532_S 1.016 0.93
318_V 325_S 1.014 0.93
67_L 433_A 1.013 0.93
62_A 97_F 1.008 0.93
10_G 140_P 1.008 0.93
394_E 397_N 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2q28A211000.123Contact Map0.796
2c31A20.99471000.142Contact Map0.8
1t9bA20.98581000.172Contact Map0.833
1ybhA10.9771000.172Contact Map0.815
1ozhA40.96811000.172Contact Map0.8
2uz1A20.96991000.174Contact Map0.748
2ihtA40.95571000.175Contact Map0.81
2panA60.97521000.176Contact Map0.732
1q6zA10.91491000.187Contact Map0.783
3eyaA120.95391000.19Contact Map0.792
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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