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OPENSEQ.org
ILVB - Acetolactate synthase isozyme 1 large subunit
UniProt: P08142 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10494
Length: 562 (548)
Sequences: 6460
Seq/Len: 11.79
ILVB
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
502_Q 505_A 5.302 1.00
64_G 94_A 4.313 1.00
234_E 254_H 3.869 1.00
376_A 521_Q 3.659 1.00
470_N 537_H 3.509 1.00
512_C 526_E 3.394 1.00
29_K 76_K 3.393 1.00
228_R 328_D 3.381 1.00
516_N 519_D 3.3 1.00
228_R 332_A 3.218 1.00
204_A 304_I 2.879 1.00
73_T 433_N 2.845 1.00
376_A 379_A 2.842 1.00
513_D 539_R 2.837 1.00
218_L 229_V 2.798 1.00
325_A 330_V 2.755 1.00
208_I 280_I 2.699 1.00
77_P 159_Q 2.687 1.00
202_R 337_L 2.68 1.00
380_C 525_Q 2.647 1.00
512_C 534_A 2.642 1.00
515_N 519_D 2.631 1.00
282_L 327_V 2.622 1.00
276_A 279_L 2.547 1.00
306_V 330_V 2.526 1.00
253_A 405_N 2.521 1.00
106_I 155_F 2.462 1.00
510_E 532_G 2.416 1.00
514_L 523_S 2.409 1.00
30_I 53_R 2.398 1.00
448_M 507_F 2.392 1.00
426_A 440_C 2.389 1.00
512_C 523_S 2.36 1.00
510_E 526_E 2.323 1.00
82_A 91_L 2.221 1.00
150_V 168_I 2.197 1.00
447_L 451_I 2.163 1.00
207_M 321_V 2.104 1.00
95_I 107_C 2.083 1.00
379_A 521_Q 2.081 1.00
24_E 51_Q 2.069 1.00
433_N 436_R 2.065 1.00
206_A 210_A 2.061 1.00
17_E 45_A 2.054 1.00
503_I 506_G 2.039 1.00
68_Q 72_R 2.038 1.00
458_S 509_L 2.037 1.00
499_N 502_Q 2.029 1.00
77_P 106_I 2.007 1.00
216_L 233_A 1.986 1.00
386_I 429_A 1.977 1.00
89_T 93_T 1.97 1.00
207_M 278_L 1.97 1.00
521_Q 525_Q 1.959 1.00
430_A 463_D 1.953 1.00
216_L 238_L 1.945 1.00
74_D 432_A 1.938 1.00
513_D 537_H 1.928 1.00
233_A 240_T 1.909 1.00
57_A 63_A 1.904 1.00
129_G 132_I 1.887 1.00
282_L 306_V 1.851 1.00
390_D 442_S 1.85 1.00
281_V 284_A 1.849 1.00
207_M 302_K 1.836 1.00
468_L 535_L 1.818 1.00
501_M 511_T 1.805 1.00
21_H 25_Q 1.796 1.00
143_H 146_E 1.791 1.00
216_L 280_I 1.789 1.00
126_D 129_G 1.786 1.00
527_I 536_I 1.783 1.00
240_T 250_L 1.776 1.00
208_I 278_L 1.766 1.00
17_E 48_Q 1.764 1.00
109_T 167_W 1.759 1.00
377_V 441_F 1.743 1.00
313_L 324_Q 1.738 1.00
19_I 151_M 1.736 1.00
411_L 429_A 1.726 1.00
230_R 234_E 1.723 1.00
421_F 425_A 1.722 1.00
390_D 446_S 1.72 1.00
525_Q 529_N 1.714 1.00
21_H 24_E 1.702 1.00
108_I 170_I 1.685 1.00
227_A 231_E 1.68 1.00
375_N 379_A 1.675 1.00
430_A 437_K 1.655 1.00
95_I 105_L 1.65 1.00
235_K 335_I 1.632 1.00
33_G 54_H 1.623 1.00
237_Q 256_L 1.619 1.00
197_S 200_S 1.615 1.00
205_A 334_L 1.605 1.00
43_Y 54_H 1.594 1.00
141_V 147_L 1.59 1.00
454_M 509_L 1.588 1.00
55_I 431_L 1.575 1.00
68_Q 97_D 1.571 1.00
135_T 167_W 1.57 1.00
519_D 522_A 1.568 1.00
427_I 457_A 1.561 1.00
314_G 319_P 1.553 1.00
378_A 403_P 1.552 1.00
275_E 349_L 1.55 1.00
505_A 510_E 1.549 1.00
91_L 107_C 1.546 1.00
231_E 235_K 1.546 1.00
231_E 335_I 1.544 1.00
376_A 380_C 1.541 1.00
430_A 462_L 1.54 1.00
203_D 206_A 1.536 1.00
457_A 509_L 1.533 1.00
467_I 536_I 1.532 1.00
520_P 538_V 1.515 1.00
501_M 513_D 1.514 1.00
522_A 525_Q 1.509 1.00
382_D 385_A 1.508 1.00
258_L 272_I 1.503 1.00
510_E 534_A 1.502 1.00
467_I 524_L 1.5 1.00
29_K 53_R 1.491 1.00
522_A 526_E 1.477 1.00
211_A 214_P 1.473 1.00
233_A 250_L 1.469 1.00
139_Y 168_I 1.467 1.00
151_M 168_I 1.467 1.00
232_L 236_A 1.462 1.00
211_A 278_L 1.442 1.00
372_G 376_A 1.442 1.00
19_I 170_I 1.436 1.00
13_F 21_H 1.429 1.00
439_L 528_I 1.428 1.00
24_E 49_S 1.42 1.00
30_I 431_L 1.418 1.00
515_N 539_R 1.417 1.00
149_Q 153_D 1.415 1.00
26_Q 152_S 1.412 1.00
198_E 333_Q 1.404 0.99
62_G 453_E 1.403 0.99
437_K 528_I 1.4 0.99
69_G 73_T 1.4 0.99
419_M 449_M 1.393 0.99
57_A 66_I 1.385 0.99
409_Q 436_R 1.375 0.99
467_I 538_V 1.371 0.99
32_T 70_M 1.371 0.99
215_V 276_A 1.369 0.99
146_E 149_Q 1.36 0.99
278_L 304_I 1.358 0.99
216_L 232_L 1.356 0.99
14_T 17_E 1.352 0.99
373_L 538_V 1.347 0.99
82_A 107_C 1.346 0.99
372_G 517_E 1.34 0.99
136_K 164_G 1.34 0.99
380_C 521_Q 1.334 0.99
451_I 503_I 1.333 0.99
114_A 173_D 1.328 0.99
381_V 439_L 1.327 0.99
386_I 433_N 1.325 0.99
22_F 152_S 1.323 0.99
53_R 460_N 1.32 0.99
457_A 464_V 1.32 0.99
218_L 222_V 1.319 0.99
64_G 91_L 1.312 0.99
201_I 337_L 1.31 0.99
368_L 373_L 1.303 0.99
144_I 177_A 1.297 0.99
504_A 511_T 1.278 0.99
509_L 535_L 1.275 0.99
106_I 158_A 1.272 0.99
26_Q 155_F 1.267 0.99
88_A 109_T 1.262 0.99
99_R 165_P 1.259 0.99
222_V 229_V 1.258 0.99
512_C 536_I 1.248 0.99
247_L 252_K 1.24 0.98
368_L 538_V 1.238 0.98
465_K 527_I 1.236 0.98
242_M 257_S 1.225 0.98
232_L 335_I 1.224 0.98
514_L 519_D 1.224 0.98
18_F 179_F 1.223 0.98
231_E 234_E 1.219 0.98
520_P 524_L 1.214 0.98
80_C 91_L 1.211 0.98
523_S 536_I 1.21 0.98
385_A 437_K 1.209 0.98
39_I 42_V 1.206 0.98
235_K 339_E 1.202 0.98
234_E 256_L 1.198 0.98
55_I 460_N 1.197 0.98
214_P 277_D 1.193 0.98
454_M 535_L 1.191 0.98
372_G 520_P 1.188 0.98
171_P 174_V 1.186 0.98
205_A 209_N 1.182 0.98
62_G 450_N 1.177 0.98
382_D 437_K 1.176 0.98
447_L 535_L 1.173 0.98
511_T 535_L 1.173 0.98
231_E 339_E 1.172 0.98
17_E 21_H 1.17 0.97
196_F 330_V 1.169 0.97
92_V 130_I 1.167 0.97
77_P 155_F 1.166 0.97
204_A 323_I 1.163 0.97
16_A 45_A 1.162 0.97
348_Q 351_A 1.16 0.97
329_D 332_A 1.152 0.97
231_E 332_A 1.152 0.97
282_L 331_L 1.15 0.97
504_A 509_L 1.149 0.97
22_F 151_M 1.146 0.97
440_C 466_I 1.144 0.97
200_S 203_D 1.143 0.97
431_L 462_L 1.141 0.97
554_A 558_E 1.141 0.97
352_D 356_E 1.137 0.97
18_F 148_P 1.135 0.97
463_D 532_G 1.13 0.97
64_G 80_C 1.128 0.97
228_R 231_E 1.126 0.97
291_I 294_T 1.125 0.97
229_V 331_L 1.124 0.97
213_R 275_E 1.118 0.96
455_A 459_E 1.117 0.96
135_T 138_N 1.115 0.96
388_T 438_V 1.114 0.96
139_Y 150_V 1.112 0.96
28_I 79_V 1.109 0.96
510_E 530_R 1.109 0.96
157_I 166_V 1.103 0.96
323_I 330_V 1.101 0.96
445_G 474_L 1.098 0.96
328_D 332_A 1.093 0.96
215_V 279_L 1.092 0.96
96_A 416_L 1.089 0.96
14_T 178_V 1.086 0.96
92_V 134_I 1.085 0.96
527_I 534_A 1.077 0.95
430_A 434_P 1.075 0.95
216_L 229_V 1.072 0.95
233_A 256_L 1.07 0.95
70_M 432_A 1.067 0.95
422_G 440_C 1.067 0.95
230_R 254_H 1.066 0.95
216_L 282_L 1.065 0.95
211_A 277_D 1.064 0.95
501_M 505_A 1.062 0.95
351_A 354_Q 1.061 0.95
64_G 105_L 1.061 0.95
95_I 134_I 1.059 0.95
228_R 335_I 1.05 0.94
228_R 331_L 1.049 0.94
504_A 535_L 1.047 0.94
250_L 254_H 1.046 0.94
230_R 251_P 1.046 0.94
210_A 278_L 1.043 0.94
514_L 520_P 1.038 0.94
388_T 440_C 1.03 0.94
501_M 537_H 1.029 0.94
451_I 507_F 1.025 0.93
232_L 331_L 1.022 0.93
71_A 104_P 1.02 0.93
306_V 323_I 1.019 0.93
204_A 321_V 1.019 0.93
203_D 207_M 1.018 0.93
227_A 230_R 1.013 0.93
15_G 147_L 1.013 0.93
66_I 457_A 1.011 0.93
139_Y 153_D 1.011 0.93
344_A 348_Q 1.01 0.93
386_I 438_V 1.009 0.93
73_T 429_A 1.008 0.93
73_T 411_L 1.008 0.93
271_Y 275_E 1.007 0.93
137_H 150_V 1.002 0.92
503_I 507_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ybhA10.99291000.131Contact Map0.822
1t9bA20.99641000.143Contact Map0.841
2ihtA40.9681000.144Contact Map0.813
2panA60.99471000.145Contact Map0.738
1ozhA40.98581000.146Contact Map0.804
2uz1A20.97151000.155Contact Map0.752
3eyaA120.96621000.16Contact Map0.802
2pgnA20.96091000.162Contact Map0.783
1q6zA10.92351000.172Contact Map0.798
1v5eA10.97331000.175Contact Map0.79
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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