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OPENSEQ.org
ILVG - Acetolactate synthase isozyme 2 large subunit
UniProt: P00892 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10498
Length: 548 (544)
Sequences: 6474
Seq/Len: 11.90
ILVG
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: GCL ILVB ILVG ILVI MEND OXC POXB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
486_M 489_S 5.135 1.00
51_A 81_G 4.335 1.00
221_A 241_Y 3.84 1.00
454_D 521_H 3.788 1.00
360_Q 505_E 3.375 1.00
496_Q 510_T 3.34 1.00
215_A 315_N 3.293 1.00
17_N 63_K 3.214 1.00
500_R 503_Q 3.121 1.00
215_A 319_P 3.018 1.00
193_L 267_I 2.921 1.00
203_V 216_L 2.909 1.00
189_A 291_I 2.863 1.00
312_G 317_L 2.82 1.00
497_H 523_S 2.816 1.00
60_A 417_R 2.684 1.00
499_T 503_Q 2.683 1.00
293_M 317_L 2.656 1.00
269_V 314_L 2.601 1.00
496_Q 518_Y 2.587 1.00
360_Q 363_D 2.549 1.00
93_V 142_F 2.513 1.00
263_C 266_L 2.508 1.00
498_I 507_A 2.49 1.00
432_M 491_F 2.49 1.00
364_R 509_D 2.49 1.00
18_T 40_E 2.471 1.00
64_T 146_C 2.405 1.00
69_A 78_L 2.384 1.00
496_Q 507_A 2.266 1.00
137_I 155_V 2.26 1.00
410_A 424_C 2.259 1.00
187_E 324_P 2.253 1.00
494_H 510_T 2.247 1.00
240_D 389_T 2.216 1.00
494_H 516_G 2.203 1.00
82_L 94_A 2.167 1.00
431_F 435_V 2.137 1.00
76_T 80_T 2.108 1.00
192_M 308_V 2.077 1.00
55_I 59_R 2.075 1.00
497_H 521_H 2.07 1.00
487_L 490_A 2.059 1.00
201_L 220_L 2.019 1.00
370_V 413_A 2.016 1.00
64_T 93_V 2.014 1.00
220_L 227_A 2.014 1.00
442_K 493_I 2.012 1.00
5_Q 33_A 2.008 1.00
363_D 505_E 1.996 1.00
193_L 265_L 1.993 1.00
201_L 267_I 1.962 1.00
483_D 486_M 1.954 1.00
12_R 38_G 1.942 1.00
201_L 225_M 1.94 1.00
96_T 154_L 1.938 1.00
192_M 265_L 1.928 1.00
374_D 426_S 1.916 1.00
269_V 293_M 1.895 1.00
191_Q 195_K 1.894 1.00
414_Q 447_P 1.893 1.00
61_T 416_A 1.89 1.00
485_L 495_G 1.886 1.00
417_R 420_D 1.867 1.00
116_G 119_L 1.856 1.00
44_C 50_A 1.846 1.00
113_D 116_G 1.845 1.00
268_A 271_A 1.84 1.00
511_M 520_L 1.82 1.00
405_F 409_A 1.801 1.00
452_L 519_L 1.79 1.00
374_D 430_S 1.784 1.00
227_A 237_V 1.777 1.00
300_M 311_Q 1.773 1.00
192_M 289_S 1.773 1.00
7_V 138_M 1.769 1.00
95_I 157_I 1.735 1.00
9_H 13_A 1.723 1.00
361_L 425_I 1.723 1.00
5_Q 36_D 1.722 1.00
441_V 493_I 1.718 1.00
395_I 413_A 1.717 1.00
217_R 221_A 1.681 1.00
196_A 199_P 1.678 1.00
219_F 223_T 1.664 1.00
130_S 133_E 1.659 1.00
78_L 94_A 1.658 1.00
190_R 321_L 1.656 1.00
31_Y 41_H 1.648 1.00
82_L 92_V 1.641 1.00
505_E 509_D 1.633 1.00
9_H 12_R 1.622 1.00
21_G 41_H 1.615 1.00
451_V 508_L 1.614 1.00
224_K 243_Y 1.61 1.00
451_V 520_L 1.609 1.00
366_P 369_C 1.588 1.00
438_L 493_I 1.586 1.00
128_V 134_L 1.579 1.00
214_P 218_E 1.57 1.00
122_T 154_L 1.564 1.00
411_V 441_V 1.553 1.00
196_A 265_L 1.551 1.00
55_I 84_D 1.543 1.00
494_H 518_Y 1.536 1.00
222_A 322_Q 1.525 1.00
182_P 185_E 1.523 1.00
414_Q 421_T 1.521 1.00
362_S 387_A 1.52 1.00
403_M 433_M 1.514 1.00
49_G 437_E 1.497 1.00
200_M 263_C 1.496 1.00
42_L 415_V 1.477 1.00
423_V 512_L 1.473 1.00
44_C 53_A 1.473 1.00
20_F 57_Y 1.471 1.00
126_F 155_V 1.468 1.00
489_S 494_H 1.467 1.00
503_Q 506_A 1.456 1.00
265_L 291_I 1.451 1.00
356_L 360_Q 1.449 1.00
435_V 487_L 1.447 1.00
485_L 497_H 1.44 1.00
56_G 60_A 1.439 1.00
136_R 140_E 1.433 1.00
359_K 363_D 1.428 1.00
218_E 322_Q 1.428 1.00
357_L 522_V 1.423 1.00
414_Q 446_L 1.422 1.00
7_V 157_I 1.416 1.00
220_L 237_V 1.415 1.00
493_I 519_L 1.413 1.00
69_A 94_A 1.407 0.99
14_Q 139_A 1.405 0.99
245_L 259_A 1.403 0.99
218_E 222_A 1.402 0.99
301_N 306_A 1.401 0.99
262_E 333_H 1.389 0.99
506_A 510_T 1.388 0.99
40_E 444_K 1.38 0.99
365_K 423_V 1.372 0.99
123_K 151_G 1.369 0.99
451_V 522_V 1.365 0.99
360_Q 364_R 1.364 0.99
10_A 139_A 1.361 0.99
51_A 78_L 1.357 0.99
18_T 415_V 1.357 0.99
393_N 420_D 1.355 0.99
352_I 357_L 1.354 0.99
441_V 448_L 1.354 0.99
75_A 96_T 1.353 0.99
14_Q 142_F 1.346 0.99
509_D 513_N 1.342 0.99
188_Q 191_Q 1.342 0.99
67_C 78_L 1.34 0.99
234_L 239_A 1.335 0.99
138_M 155_V 1.333 0.99
504_V 522_V 1.332 0.99
449_K 511_M 1.328 0.99
131_L 164_A 1.323 0.99
5_Q 9_H 1.315 0.99
421_T 512_L 1.309 0.99
207_V 216_L 1.309 0.99
504_V 508_L 1.307 0.99
101_A 160_D 1.302 0.99
499_T 523_S 1.302 0.99
495_G 519_L 1.293 0.99
12_R 37_G 1.292 0.99
216_L 318_L 1.286 0.99
366_P 421_T 1.285 0.99
201_L 219_F 1.285 0.99
42_L 444_K 1.284 0.99
199_P 264_D 1.281 0.99
86_L 152_P 1.273 0.99
190_R 194_A 1.273 0.99
364_R 505_E 1.271 0.99
370_V 417_R 1.267 0.99
93_V 145_A 1.265 0.99
506_A 509_D 1.26 0.99
17_N 40_E 1.259 0.99
507_A 520_L 1.258 0.99
447_P 516_G 1.252 0.99
356_L 501_K 1.25 0.99
369_C 421_T 1.25 0.99
496_Q 520_L 1.242 0.98
229_C 244_Y 1.239 0.98
189_A 310_L 1.237 0.98
133_E 136_R 1.229 0.98
439_G 443_R 1.229 0.98
64_T 142_F 1.227 0.98
218_E 319_P 1.223 0.98
144_V 153_V 1.211 0.98
4_A 33_A 1.209 0.98
203_V 207_V 1.208 0.98
424_C 450_I 1.206 0.98
6_W 166_G 1.206 0.98
352_I 522_V 1.2 0.98
201_L 216_L 1.199 0.98
183_H 320_A 1.182 0.98
27_I 30_V 1.175 0.98
219_F 322_Q 1.172 0.98
186_V 324_P 1.171 0.98
79_I 117_L 1.169 0.97
498_I 503_Q 1.167 0.97
122_T 125_S 1.167 0.97
16_V 66_V 1.166 0.97
488_A 495_G 1.166 0.97
215_A 322_Q 1.165 0.97
2_N 5_Q 1.162 0.97
6_W 135_P 1.16 0.97
51_A 67_C 1.153 0.97
310_L 317_L 1.148 0.97
269_V 318_L 1.148 0.97
57_Y 416_A 1.147 0.97
511_M 518_Y 1.141 0.97
221_A 243_Y 1.141 0.97
431_F 519_L 1.141 0.97
10_A 138_M 1.139 0.97
356_L 504_V 1.135 0.97
185_E 188_Q 1.134 0.97
49_G 434_N 1.133 0.97
215_A 318_L 1.131 0.97
488_A 493_I 1.131 0.97
126_F 137_I 1.127 0.97
2_N 165_S 1.127 0.97
58_A 91_P 1.125 0.97
3_G 131_L 1.112 0.96
82_L 121_C 1.112 0.96
3_G 134_L 1.109 0.96
406_G 424_C 1.109 0.96
293_M 310_L 1.108 0.96
200_M 266_L 1.106 0.96
438_L 519_L 1.105 0.96
79_I 121_C 1.104 0.96
196_A 264_D 1.102 0.96
507_A 511_M 1.095 0.96
60_A 413_A 1.094 0.96
1_M 9_H 1.094 0.96
83_A 400_L 1.093 0.96
429_G 458_L 1.091 0.96
195_K 265_L 1.09 0.96
414_Q 418_P 1.086 0.96
435_V 491_F 1.086 0.96
278_T 281_L 1.08 0.95
239_A 244_Y 1.073 0.95
218_E 221_A 1.069 0.95
485_L 489_S 1.063 0.95
333_H 337_L 1.06 0.95
219_F 318_L 1.058 0.95
485_L 521_H 1.055 0.95
220_L 243_Y 1.054 0.95
217_R 241_Y 1.053 0.95
158_P 161_I 1.052 0.95
117_L 121_C 1.049 0.94
372_T 424_C 1.048 0.94
217_R 238_E 1.047 0.94
498_I 504_V 1.047 0.94
407_L 450_I 1.043 0.94
82_L 118_S 1.039 0.94
189_A 308_V 1.037 0.94
415_V 446_L 1.037 0.94
488_A 519_L 1.028 0.94
453_L 524_I 1.028 0.94
258_F 262_E 1.025 0.93
315_N 319_P 1.025 0.93
306_A 309_A 1.025 0.93
60_A 395_I 1.022 0.93
414_Q 516_G 1.017 0.93
198_K 262_E 1.016 0.93
425_I 453_L 1.016 0.93
115_L 125_S 1.015 0.93
238_E 241_Y 1.015 0.93
414_Q 419_N 1.012 0.93
126_F 140_E 1.01 0.93
494_H 514_S 1.007 0.93
189_A 265_L 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ybhA10.99451000.125Contact Map0.822
1ozhA40.98911000.125Contact Map0.803
2ihtA40.97081000.13Contact Map0.818
1t9bA20.99821000.132Contact Map0.848
2panA60.99821000.133Contact Map0.728
2uz1A20.98541000.142Contact Map0.755
2pgnA20.98361000.152Contact Map0.784
1q6zA10.95071000.155Contact Map0.797
3eyaA120.97631000.159Contact Map0.799
1v5eA10.98721000.168Contact Map0.8
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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