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OPENSEQ.org

RIDA - Enamine/imine deaminase
UniProt: P0AF93 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12524
Length: 128 (125)
Sequences: 4482
Seq/Len: 35.86

RIDA
Paralog alert: 0.59 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: RIDA RUTC TDCF YJGH YOAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_R 93_A 3.423 1.00
58_K 68_V 2.805 1.00
45_D 48_A 2.691 1.00
73_K 122_E 2.668 1.00
47_A 89_A 2.551 1.00
66_L 70_D 2.342 1.00
47_A 86_T 2.319 1.00
66_L 127_R 2.179 1.00
51_R 55_D 2.174 1.00
58_K 62_E 2.15 1.00
98_H 102_F 2.113 1.00
61_V 125_A 2.102 1.00
109_E 112_R 2.045 1.00
77_F 108_V 2 1.00
49_Q 118_K 1.983 1.00
76_V 87_V 1.907 1.00
22_D 127_R 1.905 1.00
33_I 117_V 1.851 1.00
55_D 94_F 1.842 1.00
23_L 72_V 1.723 1.00
74_T 123_A 1.716 1.00
52_Q 56_N 1.687 1.00
83_D 118_K 1.685 1.00
27_I 66_L 1.663 1.00
57_V 123_A 1.641 1.00
23_L 126_V 1.621 1.00
36_N 39_T 1.612 1.00
55_D 58_K 1.55 1.00
3_K 22_D 1.533 1.00
46_V 50_A 1.437 1.00
112_R 116_D 1.393 0.99
51_R 94_F 1.375 0.99
34_P 117_V 1.371 0.99
27_I 64_A 1.366 0.99
67_K 70_D 1.363 0.99
42_V 117_V 1.361 0.99
78_V 107_C 1.335 0.99
106_S 122_E 1.329 0.99
26_M 126_V 1.309 0.99
79_K 83_D 1.307 0.99
52_Q 55_D 1.297 0.99
34_P 53_S 1.279 0.99
86_T 89_A 1.271 0.99
81_L 109_E 1.247 0.99
22_D 25_N 1.231 0.98
28_I 124_I 1.212 0.98
71_I 95_F 1.21 0.98
88_N 105_R 1.209 0.98
78_V 87_V 1.193 0.98
77_F 106_S 1.185 0.98
71_I 123_A 1.179 0.98
90_T 93_A 1.145 0.97
83_D 86_T 1.138 0.97
47_A 90_T 1.122 0.97
91_Y 105_R 1.114 0.96
7_T 19_Q 1.101 0.96
61_V 66_L 1.086 0.96
44_A 48_A 1.068 0.95
80_D 83_D 1.067 0.95
29_T 60_I 1.064 0.95
50_A 87_V 1.063 0.95
68_V 71_I 1.063 0.95
22_D 27_I 1.047 0.94
75_T 122_E 1.036 0.94
62_E 67_K 1.034 0.94
54_L 94_F 1.025 0.93
36_N 41_E 1.023 0.93
79_K 118_K 1.021 0.93
20_G 60_I 1.015 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k0tA30.97661000.07Contact Map0.833
2dyyA120.97661000.071Contact Map0.953
1xrgA30.96881000.073Contact Map0.88
3vczA311000.075Contact Map0.89
2b33A20.97661000.078Contact Map0.812
1qahA20.97661000.079Contact Map0.674
1qu9A311000.08Contact Map0.876
3v4dA60.97661000.083Contact Map0.91
3m1xA10.96881000.083Contact Map0.667
3r0pA60.96881000.086Contact Map0.856

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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