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OPENSEQ.org

TDCF - Putative reactive intermediate deaminase TdcF
UniProt: P0AGL2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12757
Length: 129 (126)
Sequences: 4470
Seq/Len: 35.48

TDCF
Paralog alert: 0.59 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: RIDA RUTC TDCF YJGH YOAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_R 93_Q 3.411 1.00
58_K 68_V 2.826 1.00
73_K 122_E 2.685 1.00
45_D 48_D 2.665 1.00
47_Q 89_E 2.561 1.00
47_Q 86_T 2.346 1.00
66_L 70_D 2.344 1.00
66_L 127_R 2.21 1.00
51_R 55_E 2.198 1.00
58_K 62_V 2.157 1.00
98_H 102_Y 2.108 1.00
109_Q 112_R 2.074 1.00
61_V 125_A 2.07 1.00
77_F 108_V 2 1.00
49_Q 118_K 1.988 1.00
22_D 127_R 1.94 1.00
76_V 87_I 1.925 1.00
33_I 117_V 1.859 1.00
55_E 94_F 1.847 1.00
23_L 72_I 1.752 1.00
74_M 123_A 1.742 1.00
27_V 66_L 1.697 1.00
83_D 118_K 1.693 1.00
52_L 56_N 1.674 1.00
57_V 123_A 1.668 1.00
36_C 39_T 1.626 1.00
23_L 126_V 1.588 1.00
3_K 22_D 1.525 1.00
55_E 58_K 1.511 1.00
46_V 50_A 1.435 1.00
112_R 116_D 1.385 0.99
27_V 64_A 1.38 0.99
42_I 117_V 1.374 0.99
51_R 94_F 1.371 0.99
34_P 117_V 1.367 0.99
67_S 70_D 1.341 0.99
106_S 122_E 1.327 0.99
78_I 107_C 1.318 0.99
79_T 83_D 1.299 0.99
52_L 55_E 1.291 0.99
26_M 126_V 1.291 0.99
86_T 89_E 1.281 0.99
34_P 53_S 1.276 0.99
22_D 25_S 1.235 0.98
81_L 109_Q 1.233 0.98
88_N 105_R 1.219 0.98
28_F 124_I 1.217 0.98
71_I 95_F 1.215 0.98
77_F 106_S 1.204 0.98
78_I 87_I 1.198 0.98
90_V 93_Q 1.178 0.98
71_I 123_A 1.176 0.98
47_Q 90_V 1.164 0.97
44_A 48_D 1.127 0.97
83_D 86_T 1.11 0.96
29_T 60_I 1.099 0.96
7_T 19_Q 1.094 0.96
91_Y 105_R 1.092 0.96
68_V 71_I 1.092 0.96
61_V 66_L 1.086 0.96
80_D 83_D 1.074 0.95
75_T 122_E 1.073 0.95
50_A 87_I 1.059 0.95
22_D 27_V 1.058 0.95
36_C 41_E 1.046 0.94
20_G 60_I 1.031 0.94
47_Q 51_R 1.03 0.94
41_E 115_K 1.017 0.93
79_T 118_K 1.006 0.93
58_K 94_F 1.005 0.93
54_L 94_F 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2dyyA120.9691000.06Contact Map0.964
1xrgA30.96121000.064Contact Map0.868
3k0tA30.9691000.065Contact Map0.832
3vczA30.99221000.071Contact Map0.874
1qahA20.97671000.073Contact Map0.672
1qu9A30.99221000.075Contact Map0.864
3m1xA10.96121000.075Contact Map0.661
2b33A20.97671000.075Contact Map0.805
3r0pA60.96121000.078Contact Map0.858
3quwA10.9691000.08Contact Map0.728

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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