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OPENSEQ.org
DHSA - Succinate dehydrogenase flavoprotein subunit
UniProt: P0AC41 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10931
Length: 588 (570)
Sequences: 2760
Seq/Len: 4.84
DHSA
Paralog alert: 0.67 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DHSA FRDA NADB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
549_D 552_N 4.015 1.00
11_V 180_C 3.971 1.00
80_G 85_I 3.669 1.00
266_N 270_E 3.315 1.00
22_A 199_V 3.307 1.00
471_F 527_A 3.286 1.00
88_M 394_V 3.245 1.00
363_K 367_Q 3.207 1.00
86_E 90_K 3.037 1.00
166_A 225_M 3.004 1.00
270_E 275_R 2.992 1.00
266_N 296_E 2.904 1.00
534_T 545_F 2.874 1.00
17_G 46_T 2.874 1.00
271_R 282_D 2.866 1.00
253_V 257_C 2.8 1.00
477_G 534_T 2.782 1.00
8_F 34_A 2.78 1.00
26_I 419_L 2.728 1.00
161_F 193_F 2.725 1.00
491_R 524_Y 2.551 1.00
22_A 386_V 2.547 1.00
13_I 180_C 2.528 1.00
470_N 482_K 2.516 1.00
34_A 161_F 2.44 1.00
484_L 527_A 2.39 1.00
200_L 360_I 2.386 1.00
265_L 316_D 2.381 1.00
360_I 389_I 2.284 1.00
26_I 416_G 2.265 1.00
487_L 527_A 2.241 1.00
227_I 525_A 2.234 1.00
152_Q 155_K 2.225 1.00
91_T 414_A 2.223 1.00
471_F 483_G 2.211 1.00
477_G 481_A 2.157 1.00
17_G 408_L 2.15 1.00
384_F 418_H 2.145 1.00
87_Y 414_A 2.13 1.00
56_A 65_W 2.092 1.00
481_A 531_N 2.077 1.00
36_L 182_A 2.069 1.00
223_V 233_V 2.063 1.00
362_T 390_A 2.058 1.00
462_A 486_Q 2.057 1.00
144_A 147_H 2.041 1.00
67_W 124_K 2.027 1.00
9_D 196_R 2.02 1.00
202_T 222_G 2.004 1.00
199_V 419_L 1.994 1.00
245_G 352_T 1.967 1.00
367_Q 418_H 1.959 1.00
467_M 471_F 1.95 1.00
476_E 543_F 1.939 1.00
415_A 419_L 1.932 1.00
38_K 221_D 1.916 1.00
293_I 311_A 1.883 1.00
54_T 402_G 1.883 1.00
184_C 187_T 1.879 1.00
257_C 262_G 1.878 1.00
46_T 146_L 1.873 1.00
385_A 389_I 1.866 1.00
320_K 324_E 1.862 1.00
477_G 542_R 1.86 1.00
32_T 159_T 1.853 1.00
200_L 389_I 1.848 1.00
471_F 480_M 1.847 1.00
316_D 346_P 1.844 1.00
7_E 194_K 1.842 1.00
54_T 122_Q 1.829 1.00
168_D 228_R 1.824 1.00
263_Y 271_R 1.821 1.00
484_L 524_Y 1.813 1.00
43_R 48_S 1.785 1.00
77_D 548_R 1.773 1.00
10_A 199_V 1.737 1.00
254_T 257_C 1.727 1.00
228_R 518_N 1.725 1.00
34_A 193_F 1.723 1.00
8_F 11_V 1.722 1.00
357_M 539_A 1.72 1.00
153_N 160_I 1.715 1.00
234_Q 391_C 1.706 0.99
226_A 231_V 1.699 0.99
184_C 191_V 1.689 0.99
477_G 545_F 1.684 0.99
331_L 335_R 1.667 0.99
208_I 526_T 1.665 0.99
205_A 356_M 1.663 0.99
84_A 88_M 1.659 0.99
254_T 330_I 1.657 0.99
529_S 557_S 1.646 0.99
466_C 483_G 1.645 0.99
463_L 487_L 1.641 0.99
76_S 80_G 1.636 0.99
104_L 144_A 1.632 0.99
88_M 411_F 1.625 0.99
462_A 493_R 1.624 0.99
104_L 145_L 1.624 0.99
95_A 98_E 1.603 0.99
182_A 193_F 1.602 0.99
221_D 518_N 1.594 0.99
324_E 331_L 1.578 0.99
38_K 515_E 1.574 0.99
233_V 236_M 1.567 0.99
122_Q 402_G 1.566 0.99
84_A 364_V 1.562 0.99
10_A 26_I 1.551 0.99
488_K 524_Y 1.538 0.99
82_Q 86_E 1.526 0.99
274_E 280_A 1.524 0.99
177_V 198_T 1.519 0.99
264_L 349_V 1.516 0.99
38_K 219_T 1.508 0.98
412_G 416_G 1.505 0.98
232_P 369_L 1.504 0.98
200_L 383_L 1.502 0.98
68_H 403_N 1.49 0.98
320_K 343_V 1.488 0.98
84_A 394_V 1.487 0.98
295_I 299_E 1.485 0.98
15_A 37_S 1.484 0.98
265_L 346_P 1.481 0.98
175_G 381_P 1.477 0.98
470_N 483_G 1.476 0.98
491_R 521_E 1.475 0.98
85_I 89_C 1.473 0.98
13_I 200_L 1.472 0.98
476_E 479_A 1.467 0.98
69_M 73_V 1.463 0.98
484_L 528_V 1.463 0.98
199_V 386_V 1.459 0.98
68_H 72_T 1.454 0.98
454_E 493_R 1.454 0.98
176_A 382_G 1.428 0.98
486_Q 489_V 1.427 0.98
524_Y 528_V 1.424 0.98
46_T 408_L 1.417 0.97
331_L 343_V 1.415 0.97
22_A 415_A 1.405 0.97
362_T 411_F 1.405 0.97
210_Q 465_E 1.402 0.97
195_A 198_T 1.4 0.97
481_A 485_E 1.392 0.97
471_F 526_T 1.391 0.97
340_V 345_E 1.39 0.97
484_L 531_N 1.388 0.97
198_T 382_G 1.383 0.97
65_W 90_K 1.379 0.97
9_D 32_T 1.376 0.97
79_I 537_R 1.369 0.97
35_L 160_I 1.363 0.97
36_L 180_C 1.363 0.97
466_C 486_Q 1.362 0.97
170_V 192_Y 1.359 0.96
237_E 533_R 1.354 0.96
323_L 331_L 1.344 0.96
91_T 94_E 1.34 0.96
200_L 226_A 1.34 0.96
296_E 301_R 1.337 0.96
530_A 540_H 1.337 0.96
324_E 343_V 1.33 0.96
483_G 527_A 1.329 0.96
24_L 153_N 1.327 0.96
21_R 25_Q 1.317 0.96
100_E 114_I 1.313 0.95
69_M 86_E 1.312 0.95
57_L 135_A 1.297 0.95
10_A 419_L 1.294 0.95
226_A 360_I 1.293 0.95
65_W 69_M 1.292 0.95
263_Y 317_H 1.292 0.95
177_V 380_V 1.283 0.95
294_M 298_R 1.283 0.95
291_R 541_S 1.28 0.95
8_F 161_F 1.271 0.94
168_D 225_M 1.269 0.94
315_L 318_L 1.265 0.94
91_T 95_A 1.261 0.94
236_M 526_T 1.254 0.94
164_W 184_C 1.252 0.94
418_H 421_E 1.245 0.94
213_T 245_G 1.244 0.93
134_T 402_G 1.242 0.93
109_L 113_R 1.241 0.93
209_Y 471_F 1.238 0.93
25_Q 417_L 1.238 0.93
475_R 530_A 1.237 0.93
154_L 162_S 1.237 0.93
206_G 353_C 1.235 0.93
164_W 182_A 1.234 0.93
263_Y 282_D 1.227 0.93
368_A 385_A 1.227 0.93
25_Q 416_G 1.226 0.93
87_Y 411_F 1.225 0.93
18_A 386_V 1.223 0.93
276_Y 296_E 1.221 0.93
271_R 274_E 1.217 0.92
92_G 406_L 1.215 0.92
537_R 545_F 1.212 0.92
10_A 31_Q 1.197 0.92
272_F 293_I 1.19 0.91
72_T 403_N 1.19 0.91
73_V 80_G 1.188 0.91
272_F 282_D 1.18 0.91
8_F 32_T 1.177 0.91
466_C 490_I 1.175 0.91
122_Q 134_T 1.154 0.90
478_D 482_K 1.153 0.90
88_M 406_L 1.151 0.89
477_G 531_N 1.149 0.89
465_E 469_H 1.149 0.89
482_K 486_Q 1.144 0.89
95_A 413_R 1.144 0.89
11_V 198_T 1.144 0.89
470_N 486_Q 1.139 0.89
235_D 556_H 1.135 0.89
537_R 546_P 1.134 0.88
228_R 521_E 1.131 0.88
324_E 335_R 1.128 0.88
416_G 419_L 1.125 0.88
494_L 520_M 1.119 0.88
460_R 464_Q 1.119 0.88
169_L 198_T 1.112 0.87
555_C 568_R 1.108 0.87
58_G 62_E 1.102 0.87
232_P 361_P 1.101 0.86
335_R 343_V 1.097 0.86
20_M 35_L 1.096 0.86
386_V 415_A 1.094 0.86
365_T 418_H 1.091 0.86
205_A 526_T 1.089 0.86
224_G 228_R 1.088 0.86
323_L 343_V 1.081 0.85
264_L 273_M 1.08 0.85
21_R 95_A 1.08 0.85
121_G 357_M 1.08 0.85
53_I 145_L 1.076 0.85
481_A 484_L 1.075 0.85
65_W 89_C 1.074 0.85
224_G 518_N 1.074 0.85
165_Y 515_E 1.074 0.85
153_N 158_T 1.074 0.85
22_A 419_L 1.072 0.84
164_W 191_V 1.068 0.84
470_N 479_A 1.063 0.84
11_V 36_L 1.058 0.83
166_A 180_C 1.057 0.83
298_R 543_F 1.053 0.83
66_E 70_Y 1.051 0.83
532_F 566_M 1.047 0.82
12_V 33_C 1.039 0.82
20_M 153_N 1.037 0.82
93_P 97_L 1.035 0.81
73_V 85_I 1.033 0.81
205_A 239_W 1.032 0.81
320_K 344_K 1.028 0.81
262_G 315_L 1.028 0.81
56_A 89_C 1.025 0.81
197_A 422_S 1.025 0.81
83_D 364_V 1.023 0.80
231_V 383_L 1.019 0.80
319_G 343_V 1.018 0.80
470_N 527_A 1.018 0.80
274_E 282_D 1.017 0.80
537_R 544_D 1.011 0.79
104_L 148_T 1.011 0.79
11_V 34_A 1.01 0.79
143_H 147_H 1.008 0.79
21_R 98_E 1.007 0.79
270_E 296_E 1.005 0.79
201_A 386_V 1.005 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2h88A20.99491000.217Contact Map0.769
2bs2A20.96091000.234Contact Map0.767
2wdqA30.99831000.234Contact Map0.79
1kf6A20.95411000.254Contact Map0.78
1chuA10.88951000.326Contact Map0.775
3gyxA60.9151000.342Contact Map0.646
2e5vA20.79931000.383Contact Map0.804
1jnrA20.90651000.4Contact Map0.71
4c3xA80.65991000.611Contact Map0.686
1qo8A20.66161000.624Contact Map0.773
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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