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OPENSEQ.org
NADB - L-aspartate oxidase
UniProt: P10902 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10631
Length: 540 (520)
Sequences: 2693
Seq/Len: 5.18
NADB
Paralog alert: 0.67 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DHSA FRDA NADB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_C 83_V 3.49 1.00
12_L 182_A 3.479 1.00
360_D 364_R 3.226 1.00
451_V 501_V 3.192 1.00
84_E 88_S 3.128 1.00
23_L 201_V 3.052 1.00
457_T 508_K 3.023 1.00
450_Y 462_R 2.973 1.00
275_T 280_D 2.963 1.00
508_K 519_Y 2.942 1.00
86_V 381_L 2.899 1.00
457_T 461_E 2.872 1.00
157_L 195_C 2.864 1.00
271_R 275_T 2.73 1.00
258_L 262_L 2.698 1.00
14_I 182_A 2.672 1.00
471_Q 498_E 2.653 1.00
9_C 34_I 2.597 1.00
162_A 227_M 2.597 1.00
270_K 314_S 2.559 1.00
18_A 46_T 2.493 1.00
271_R 300_E 2.479 1.00
276_R 286_E 2.382 1.00
318_A 322_R 2.362 1.00
34_I 157_L 2.326 1.00
202_L 357_V 2.298 1.00
23_L 373_I 2.296 1.00
461_E 505_M 2.291 1.00
464_L 501_V 2.25 1.00
456_T 517_L 2.245 1.00
27_L 406_I 2.222 1.00
147_K 150_N 2.199 1.00
442_E 466_R 2.182 1.00
365_T 372_A 2.148 1.00
371_Y 405_D 2.127 1.00
8_S 196_H 2.121 1.00
186_N 189_K 2.111 1.00
467_I 501_V 2.094 1.00
32_Q 155_R 2.093 1.00
357_V 376_V 2.084 1.00
297_I 309_M 2.082 1.00
228_A 233_C 2.075 1.00
451_V 463_A 2.017 1.00
225_I 235_V 2.016 1.00
461_E 465_R 1.92 1.00
457_T 516_T 1.913 1.00
85_F 401_S 1.913 1.00
364_R 405_D 1.91 1.00
89_N 401_S 1.907 1.00
229_W 499_L 1.883 1.00
36_L 184_V 1.873 1.00
468_T 498_E 1.871 1.00
372_A 376_V 1.87 1.00
65_S 126_H 1.869 1.00
442_E 473_E 1.854 1.00
202_L 228_A 1.852 1.00
247_A 349_A 1.845 1.00
170_K 177_R 1.838 1.00
279_P 285_G 1.833 1.00
56_V 63_I 1.833 1.00
27_L 403_A 1.825 1.00
54_A 389_S 1.81 1.00
202_L 370_L 1.809 1.00
18_A 395_C 1.806 1.00
329_Y 333_L 1.8 1.00
466_R 469_M 1.796 1.00
464_L 502_R 1.792 1.00
299_H 303_R 1.783 1.00
234_R 366_D 1.765 1.00
204_T 224_G 1.763 1.00
139_E 142_T 1.763 1.00
10_D 198_K 1.75 1.00
164_D 230_R 1.733 1.00
148_A 156_V 1.729 1.00
314_S 343_P 1.711 1.00
34_I 195_C 1.71 1.00
451_V 460_L 1.684 1.00
457_T 519_Y 1.681 1.00
38_K 223_D 1.681 1.00
359_V 377_S 1.677 0.99
450_Y 463_A 1.675 0.99
318_A 340_T 1.673 0.99
462_R 466_R 1.662 0.99
177_R 368_E 1.662 0.99
172_G 177_R 1.634 0.99
447_M 451_V 1.632 0.99
456_T 459_R 1.626 0.99
202_L 376_V 1.623 0.99
458_K 462_R 1.615 0.99
450_Y 466_R 1.615 0.99
46_T 141_E 1.614 0.99
201_V 406_I 1.605 0.99
402_A 406_I 1.603 0.99
262_L 267_A 1.603 0.99
207_A 353_T 1.601 0.99
210_V 500_I 1.599 0.99
236_A 378_Y 1.59 0.99
443_L 467_I 1.585 0.99
471_Q 495_Q 1.585 0.99
80_R 84_E 1.578 0.99
297_I 346_I 1.566 0.99
230_R 492_N 1.558 0.99
186_N 193_E 1.553 0.99
446_F 463_A 1.549 0.99
184_V 195_C 1.544 0.99
102_V 140_V 1.543 0.99
451_V 500_I 1.534 0.99
268_Y 276_R 1.534 0.99
474_I 494_V 1.532 0.99
464_L 498_E 1.529 0.99
54_A 124_H 1.522 0.99
322_R 329_Y 1.513 0.99
36_L 182_A 1.513 0.99
86_V 398_Y 1.512 0.99
318_A 341_Q 1.507 0.99
259_T 262_L 1.502 0.99
298_D 302_K 1.499 0.99
10_D 32_Q 1.483 0.98
43_E 48_Y 1.476 0.98
74_G 78_C 1.471 0.98
498_E 502_R 1.46 0.98
93_C 96_W 1.457 0.98
9_C 12_L 1.457 0.98
82_A 361_D 1.456 0.98
235_V 238_L 1.45 0.98
89_N 92_S 1.449 0.98
75_A 522_L 1.447 0.98
354_C 513_L 1.439 0.98
322_R 340_T 1.434 0.98
446_F 466_R 1.43 0.98
166_I 194_T 1.428 0.98
9_C 157_L 1.404 0.98
215_T 247_A 1.403 0.98
201_V 373_I 1.399 0.98
124_H 389_S 1.398 0.98
405_D 408_R 1.396 0.98
450_Y 459_R 1.39 0.97
197_A 200_V 1.38 0.97
503_C 529_S 1.377 0.97
38_K 489_E 1.368 0.97
11_V 27_L 1.356 0.97
160_S 186_N 1.355 0.97
270_K 343_P 1.342 0.97
38_K 221_S 1.34 0.97
129_I 389_S 1.339 0.97
259_T 328_I 1.337 0.97
67_V 71_L 1.336 0.97
223_D 492_N 1.335 0.96
228_A 357_V 1.335 0.96
11_V 31_H 1.329 0.96
66_H 390_N 1.314 0.96
329_Y 340_T 1.311 0.96
14_I 202_L 1.308 0.96
362_H 405_D 1.306 0.96
82_A 86_V 1.306 0.96
109_Q 113_E 1.304 0.96
63_I 88_S 1.301 0.96
46_T 395_C 1.297 0.96
504_A 514_H 1.294 0.96
463_A 501_V 1.294 0.96
83_V 87_A 1.293 0.96
179_V 200_V 1.288 0.95
359_V 398_Y 1.285 0.95
11_V 201_V 1.275 0.95
57_F 130_L 1.272 0.95
178_R 369_G 1.272 0.95
321_I 329_Y 1.271 0.95
149_L 158_E 1.265 0.95
464_L 505_M 1.257 0.95
337_I 342_E 1.25 0.94
66_H 70_T 1.25 0.94
457_T 505_M 1.245 0.94
35_V 156_V 1.243 0.94
77_I 511_R 1.241 0.94
25_L 148_A 1.239 0.94
16_S 37_S 1.233 0.94
276_R 279_P 1.23 0.94
67_V 84_E 1.221 0.93
239_E 507_R 1.217 0.93
102_V 139_E 1.215 0.93
445_L 449_D 1.214 0.93
269_L 346_I 1.211 0.93
23_L 402_A 1.2 0.93
212_Q 445_L 1.197 0.93
124_H 129_I 1.188 0.92
399_G 403_A 1.187 0.92
160_S 184_V 1.185 0.92
22_S 26_R 1.183 0.92
63_I 67_V 1.182 0.92
208_S 350_A 1.18 0.92
82_A 381_L 1.179 0.92
268_Y 286_E 1.177 0.92
446_F 470_L 1.172 0.91
230_R 495_Q 1.17 0.91
165_L 200_V 1.169 0.91
359_V 372_A 1.169 0.91
338_D 341_Q 1.161 0.91
86_V 393_L 1.156 0.91
434_V 473_E 1.156 0.91
9_C 32_Q 1.155 0.91
277_F 297_I 1.155 0.91
200_V 369_G 1.153 0.91
19_A 373_I 1.15 0.90
56_V 87_A 1.144 0.90
449_D 466_R 1.141 0.90
95_Q 99_D 1.139 0.90
302_K 517_L 1.138 0.90
116_Y 130_L 1.138 0.90
280_D 300_E 1.127 0.89
203_A 373_I 1.127 0.89
90_A 393_L 1.125 0.89
441_H 445_L 1.122 0.89
455_R 504_A 1.121 0.89
322_R 333_L 1.117 0.89
98_I 116_Y 1.116 0.89
313_I 316_K 1.116 0.89
211_Y 451_V 1.11 0.88
9_C 155_R 1.108 0.88
405_D 409_R 1.103 0.88
11_V 406_I 1.094 0.87
363_G 402_A 1.087 0.87
295_R 515_F 1.086 0.87
238_L 500_I 1.085 0.87
270_K 312_D 1.084 0.87
207_A 241_N 1.084 0.87
26_R 404_E 1.078 0.86
329_Y 339_L 1.075 0.86
277_F 286_E 1.07 0.86
145_V 156_V 1.07 0.86
183_W 192_V 1.067 0.85
207_A 500_I 1.066 0.85
460_L 501_V 1.065 0.85
12_L 36_L 1.061 0.85
81_H 361_D 1.061 0.85
12_L 200_V 1.059 0.85
71_L 78_C 1.054 0.85
270_K 310_F 1.053 0.84
333_L 340_T 1.049 0.84
484_S 487_L 1.049 0.84
138_R 142_T 1.048 0.84
461_E 464_L 1.042 0.84
511_R 519_Y 1.041 0.84
268_Y 315_H 1.041 0.84
53_I 140_V 1.039 0.83
7_H 195_C 1.037 0.83
28_A 151_H 1.032 0.83
511_R 520_P 1.032 0.83
458_K 465_R 1.032 0.83
450_Y 501_V 1.029 0.83
85_F 398_Y 1.025 0.82
313_I 321_I 1.02 0.82
373_I 402_A 1.018 0.82
472_Q 475_D 1.018 0.82
468_T 502_R 1.014 0.81
302_K 449_D 1.013 0.81
102_V 143_T 1.009 0.81
226_A 230_R 1.005 0.80
160_S 193_E 1.005 0.80
199_A 371_Y 1.004 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1chuA10.99071000.23Contact Map0.77
2h88A20.97221000.243Contact Map0.778
2wdqA30.97221000.255Contact Map0.769
2bs2A20.97041000.256Contact Map0.746
1kf6A20.96851000.27Contact Map0.763
3gyxA60.94631000.325Contact Map0.63
2e5vA20.87041000.33Contact Map0.788
1jnrA20.93891000.379Contact Map0.664
4c3xA80.70191000.577Contact Map0.674
1qo8A20.70371000.597Contact Map0.753
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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